| 1 | 2 | June-Reg | Justin Verlander | P | 21 | 6-5 | 200 | R | R | MLB | 2005-2009 | Old Dominion University | $3,120,000 |
| 2 | 43 | June-Reg | Eric Beattie | P | 21 | 6-3 | 190 | R | R | A | | University of Tampa | $800,000 |
| 3 | 73 | June-Reg | Jeff Frazier | OF | 21 | 6-3 | 195 | R | R | AAA | | Rutgers University | $500,000 |
| 4 | 103 | June-Reg | Collin Mahoney | P | 21 | 6-3 | 235 | R | R | A | | Clemson University | $375,000 |
| 5 | 133 | June-Reg | Andrew Kown | P | 21 | 6-6 | 210 | R | R | AAA | | Georgia Tech | $224,500 |
| 6 | 163 | June-Reg | Brent Dlugach | SS | 21 | 6-5 | 200 | R | R | MLB | 2009-2009 | University of Memphis | $160,000 |
| 7 | 193** | June-Reg | Chris Carpenter | P | | | | | | - | | Bryan (Bryan,OH) | |
| 8 | 223 | June-Reg | Luke French | P | 18 | 6-4 | 220 | L | L | MLB | 2009-2009 | Heritage (Littleton,CO) | $92,000 |
| 9 | 253 | June-Reg | Brandon Timm | OF | 19 | 6-3 | 215 | R | R | A+ | | Broken Arrow (Broken Arrow,OK) | $62,500 |
| 10 | 283 | June-Reg | Cory Middleton | SS | 18 | 6-1 | 185 | R | R | A | | Escambia (Pensacola,FL) | $55,000 |
| 11 | 313 | June-Reg | Josh Kauten | P | 22 | 6-3 | 200 | R | R | A+ | | Illinois State University | |
| 12 | 343 | June-Reg | Cole Miller | C | 19 | 5-11 | 200 | R | R | Rookie | | College of The Siskiyous | |
| 13 | 373 | June-Reg | Brooks Colvin | 3B | 22 | 5-10 | 170 | R | R | A | | Missouri State University | |
| 14 | 403 | June-Reg | James Skelton | C | 18 | 5-11 | 165 | L | R | AA | | West Covina (West Covina,CA) | |
| 15 | 433 | June-Reg | Matt O'Brien | P | 21 | 6-3 | 215 | R | R | AAA | | Florida Atlantic University | |
| 16 | 463 | June-Reg | Steve Young | 2B | 22 | 5-9 | 165 | B | R | A | | Princeton University | |
| 17 | 493 | June-Reg | Dan Konecny | P | 22 | 6-4 | 210 | R | R | A | | Northwestern University | |
| 18 | 523** | June-Reg | Chris Martin | P | 18 | 6-7 | 175 | R | R | - | | Arlington (Arlington,TX) | |
| 19 | 553 | June-Reg | Tyler Jacobson | P | 21 | 6-2 | 205 | R | R | A- | | Central Arizona College | |
| 20 | 583 | June-Reg | Ed Clelland | P | 22 | 6-0 | 165 | L | L | A+ | | Gonzaga University | |
| 21 | 613 | June-Reg | Matt Righter | P | 22 | 6-5 | 190 | R | R | AAA | | Johns Hopkins University | |
| 22 | 643 | June-Reg | Thomas Royals | P | | | | | | - | | Pearl River Community College | |
| 23 | 673 | June-Reg | Vince Berry | OF | 20 | 5-9 | 170 | R | R | Ind | | Triton College | |
| 24 | 703 | June-Reg | Jordan Foster | OF | 22 | 6-1 | 205 | R | R | AAA | | Lamar University | |
| 25 | 733 | June-Reg | Robbie Tulk | P | 22 | 5-11 | 180 | L | R | A- | | University of California-Davis | |
| 26 | 763 | June-Reg | Thad McBurrows | P | 18 | 6-1 | 205 | L | L | College | | Lake Wales (Lake Wales,FL) | |
| 27 | 793 | June-Reg | Dominic Carmosino | P | | | | | | A- | | Oakland University | |
| 28 | 823 | June-Reg | Brian Hensen | P | 21 | 6-4 | 170 | L | L | AA | | Elon University | |
| 29 | 853 | June-Reg | Octavio Amezquita | SS | 22 | 6-0 | 165 | R | R | A+ | | University of the Pacific | |
| 30 | 883 | June-Reg | Josh Lee | 1B | 21 | 6-4 | 220 | L | L | A | | McMurry University | |
| 31 | 913 | June-Reg | Leonardo Grullon | OF | 22 | 6-3 | 210 | R | R | A- | | University of South Florida | |
| 32 | 943 | June-Reg | Nate Bumstead | P | 22 | 6-2 | 215 | R | R | AA | | Louisiana State University | |
| 33 | 973 | June-Reg | Kevin Brower | P | 22 | 5-11 | 190 | R | R | Ind | | University of North Carolina | |
| 34 | 1003 | June-Reg | Dallas Trahern | P | 18 | 6-3 | 190 | R | R | AAA | | Owasso (Owasso,OK) | $160,000 |
| 35 | 1033 | June-Reg | Clay Britton | OF | | | | | | College | | Weatherford College | |
| 36 | 1063** | June-Reg | Travis Debondt | OF | 20 | 6-4 | 200 | L | L | College | | Bakersfield College | |
| 37 | 1093 | June-Reg | Ramon Navarro | SS | | | | | | Ind | | Triton College | |
| 38 | 1123 | June-Reg | Jamaal Peoples | OF | | | | | | - | | Philadelphia (Philadelphia,MS) | |
| 39 | 1153** | June-Reg | Adrian Bowens | SS | | 6-3 | 190 | R | R | College | | Lumberton (Lumberton,MS) | |
| 40 | 1183 | June-Reg | Kevin McAtee | 1B | | | | | | - | | Regis Jesuit (Aurora,CO) | |
| 41 | 1213 | June-Reg | Bryan Sheffield | OF | | | | | | - | | Williston (Williston,FL) | |
| 42 | 1242 | June-Reg | Trenton Lare | P | 19 | 6-4 | 220 | L | L | A+ | | Coffeyville Community College | |
| 43 | 1271 | June-Reg | Chris Schwinden | P | 17 | 6-3 | 190 | R | R | A+ | | Golden West (Visalia,CA) | |
| 44 | 1300 | June-Reg | Tyler Fockler | P | 18 | | | | | College | | Scotts Valley (Scotts Valley,CA) | |
| 45 | 1329 | June-Reg | Lionel Roberts | 1B | 22 | 5-11 | 190 | R | R | Rookie | | John McDonogh (New Orleans,LA) | |
| 46 | 1358 | June-Reg | Alec Sheppard | P | 18 | 6-3 | 190 | R | R | - | | Colorado Springs Christian School (Colorado Springs,CO) | |
| 47 | 1387 | June-Reg | Rene Recio | P | | | | | | Ind | | Oral Roberts University | |
| 48 | 1416 | June-Reg | Bernard Williams | OF | 19 | 5-8 | 160 | B | R | College | | East Marion (Columbia,MS) | |
| 49 | 1444 | June-Reg | Dominic De La Osa | SS | 18 | 6-0 | 205 | R | R | A | | Archbishop Carroll (Miami,FL) | |
| 50 | 1472 | June-Reg | Maxwell Leon | 2B | 20 | 5-11 | 190 | B | R | AAA | | South Mountain Community College | |