| 1 | 12 | June-Reg | Jered Weaver | P | 21 | 6-7 | 205 | R | R | MLB | 2006-2009 | Long Beach State University | $4,000,000 |
| 4 | 113** | June-Reg | Patrick White | OF | 18 | 6-1 | 185 | L | L | - | | Daphne (Daphne,AL) | |
| 5 | 143 | June-Reg | Luis Rivera | OF | 17 | 6-0 | 185 | R | R | A- | | Ramon Villa Mayo (Rio Piedras,PR) | $185,000 |
| 6 | 173 | June-Reg | Josh LeBlanc | 2B | 22 | 6-2 | 185 | L | R | A+ | | Southern University | $115,000 |
| 7 | 203 | June-Reg | Bill Layman | P | 21 | 6-3 | 205 | R | R | A | | University of North Florida | $120,000 |
| 8 | 233 | June-Reg | Freddy Sandoval | SS | 21 | 6-1 | 200 | B | R | MLB | 2008-2009 | University of San Diego | $84,000 |
| 9 | 263 | June-Reg | Hainley Statia | SS | 18 | 5-10 | 160 | B | R | AAA | | Trinity Christian Academy (Lake Worth,FL) | $90,000 |
| 10 | 293 | June-Reg | Doug Reinhardt | 3B | 18 | 6-3 | 210 | R | R | A- | | Santa Margarita Catholic (Rancho Santa Margarita,CA) | $65,000 |
| 11 | 323 | June-Reg | Cliff Remole | 1B | 21 | 6-0 | 195 | L | L | AAA | | Georgia Tech | |
| 12 | 353 | June-Reg | Tyler Johnson | OF | 18 | 6-2 | 218 | R | R | A | | Haskell (Haskell,OK) | |
| 13 | 383 | June-Reg | Drew Toussaint | 3B | 21 | 6-2 | 185 | R | R | AA | | Southern University | |
| 14 | 413 | June-Reg | Nick Adenhart | P | 17 | 6-4 | 190 | R | R | MLB | 2008-2009 | Williamsport (Williamsport,MD) | $700,000 |
| 15 | 443 | June-Reg | Adam Crabtree | P | 19 | 6-5 | 205 | R | R | College | | Phillips Academy (Andover,MA) | |
| 16 | 473 | June-Reg | Chris Waters | P | 22 | 6-2 | 205 | R | R | A | | University of North Florida | |
| 17 | 503 | June-Reg | Ryan Aldridge | P | 20 | 6-2 | 188 | R | R | AA | | Middle Georgia College | |
| 18 | 533 | June-Reg | Mark Trumbo | P | 18 | 6-5 | 210 | R | R | AA | | Villa Park (Orange,CA) | $1,425,000 |
| 19 | 563 | June-Reg | David Hernandez | P | 19 | 6-0 | 175 | R | R | A | | Miami-Dade College | |
| 20 | 593 | June-Reg | D.T. McDowell | OF | 18 | 6-0 | 190 | R | R | Rookie | | Tucker (Tucker,GA) | |
| 21 | 623** | June-Reg | Stan Posluszny | OF | | 6-3 | 220 | L | L | A | | West Virginia University | |
| 22 | 653 | June-Reg | Matt Moore | 3B | 19 | 6-3 | | | | - | | Newhall (Newhall,CA) | |
| 23 | 683 | June-Reg | Ben Johnson | C | 22 | 6-0 | 205 | B | R | AAA | | University of Washington | |
| 24 | 713 | June-Reg | Nate Sutton | 2B | 21 | 6-0 | 195 | L | R | AAA | | University of California-Santa Barbara | |
| 25 | 743 | June-Reg | Casey Mutter | P | 22 | 6-4 | 230 | R | R | A | | Cal State San Bernardino | |
| 26 | 773 | June-Reg | Jaime Douglas | P | 21 | 6-4 | 205 | L | L | A | | University of Central Florida | |
| 27 | 803 | June-Reg | Martin Maldonado | C | 17 | 6-1 | 180 | R | R | AAA | | Dr. Juan J. Nunez (Naguabo,PR) | |
| 28 | 833 | June-Reg | Cristen Tapia | 1B | 18 | 6-0 | 205 | L | R | College | | Tucson (Tucson,AZ) | |
| 29 | 863 | June-Reg | Bill Edwards | P | 23 | 6-3 | 185 | R | R | AA | | University of Memphis | |
| 30 | 893 | June-Reg | Alan Horne | P | 21 | 6-4 | 195 | R | R | AAA | | Chipola College | |
| 31 | 923 | June-Reg | Ricky Bambino | C | 20 | 6-2 | 205 | R | R | Ind | | Sierra College | |
| 32 | 953 | June-Reg | Brooks Shankle | 3B | 21 | 6-3 | 200 | R | R | AAA | | University of Texas-San Antonio | |
| 33 | 983 | June-Reg | Frederic Carney | P | 21 | 6-3 | 220 | R | R | Rookie | | Regis University | |
| 34 | 1013 | June-Reg | Bobby Cassevah | P | 18 | 6-3 | 195 | R | R | AA | | Monsignor Pace (Miami,FL) | |
| 35 | 1043 | June-Reg | Nick Green | P | 19 | 6-4 | 188 | R | R | AAA | | Darton College | |
| 36 | 1073 | June-Reg | John Mariotti | P | 19 | 6-0 | 225 | L | R | AA | | Gulf Coast Community College | |
| 37 | 1103 | June-Reg | Clayton Trenary | OF | 20 | | | R | R | - | | Central Florida Community College | |
| 38 | 1133 | June-Reg | Richard Giannotti | OF | 20 | 6-3 | 180 | R | R | A | | University of Miami | |
| 39 | 1163 | June-Reg | Mike Sweeney | P | 21 | 6-1 | 210 | L | L | Rookie | | St. Petersburg College | |
| 40 | 1193 | June-Reg | Steve Marek | P | 20 | 6-2 | 200 | R | R | AAA | | San Jacinto College | $800,000 |
| 41 | 1223 | June-Reg | William Cooper | P | | | | | | - | | Shelton State Community College | |
| 42 | 1252 | June-Reg | Pat Warfle | OF | 18 | 6-0 | 180 | R | R | Ind | | Daytona State College | |
| 43 | 1281 | June-Reg | Chris Lombardo | P | | | | | | - | | Etiwanda (Etiwanda,CA) | |
| 44 | 1310 | June-Reg | Grant Harper | OF | 18 | 6-1 | 185 | R | R | Ind | | San Pedro (San Pedro,CA) | |
| 45 | 1339 | June-Reg | Andrew Colon | P | | | | | | - | | Choctawhatchee (Fort Walton Beach,FL) | |
| 46 | 1368** | June-Reg | Marquez Smith | 3B | 19 | 5-10 | 200 | R | R | AA | | Daytona State College | $0 |
| 47 | 1397 | June-Reg | Erik Davis | P | 17 | 6-4 | 200 | R | R | A | | Mountain View (El Monte,CA) | |
| 48 | 1426** | June-Reg | Julian Laurean | 2B | | | | | | AAA | | Chandler-Gilbert Community College | |
| 49 | 1454 | June-Reg | Nick Dashnaw | P | | | | | | - | | Santa Clara (Santa Clara,CA) | |
| 50 | 1482 | June-Reg | Abel Nieves | 2B | 18 | 5-11 | 175 | R | R | AAA | | Middle Georgia College | |