| # | Player Name | Pos | Team | Age | Born | Ht | Wt | B-T | High Level | MLB Years | Drafted From | # |
| 608. | Casey Hudspeth | P | TB | 18 | 10/1/1984 | 5-11 | 165 | R-R | A+ | | Sarasota High School (Sarasota,FL) | 41 |
| 609. | Taylor Meier | P | MIL | 18 | 4/2/1985 | 6-6 | 205 | R-R | College | | Orangewood Christian High School (Maitland,FL) | 1 |
| 610. | Jake Ford | 3B | DET | 22 | 2/18/1981 | 6-0 | 220 | R-R | A- | | Spalding University (Ky.) | 1 |
| 611. | Brett Burnham | SS | SD | 22 | 1/1/1981 | 5-10 | 190 | R-R | A- | | University of Connecticut | 57 |
| 612. | Irving Falu | 2B | KC | 20 | 6/6/1983 | 6-0 | 165 | B-R | AAA | | Indian Hills Community College-Centerville | 85 |
| 613. | Reid Willett | P | CHC | 21 | 3/25/1982 | 6-5 | 205 | R-R | A | | University of Rhode Island | 11 |
| 614. | David Cash | SS | BAL | 17 | 11/22/1985 | 6-3 | 180 | B-R | A | | Northside Christian High School (St. Petersburg,FL) | 1 |
| 615. | Clayton Hamilton | P | PIT | 21 | 6/15/1982 | 6-5 | 200 | R-R | AA | | Penn State University | 52 |
| 616. | Marc LaMacchia | P | TEX | 21 | 3/27/1982 | 6-0 | 195 | R-R | AA | | Florida State University | 173 |
| 617. | Ryan Fox | OF | COL | 22 | 10/13/1980 | 6-3 | 220 | R-R | A+ | | University of Arkansas | 134 |
| 618. | Adam Brandenburg | P | CLE | 21 | 8/17/1981 | 6-5 | 225 | L-L | AA | | Kennesaw State University | 19 |
| 619. | Travis Garcia | SS | NYM | 21 | 4/18/1982 | 6-3 | 215 | R-R | A+ | | Iona College | 20 |
| 620. | Mark Sopko | P | TOR | 21 | 12/16/1981 | 6-0 | 200 | R-R | A+ | | Arizona State University | 331 |
| 621. | Todd Nicholas | P | CIN | 20 | 7/30/1982 | 6-2 | 208 | R-L | College | | Mississippi State University | 124 |
| 622. | Matt Lenderman | C | CHW | 19 | 4/18/1984 | 5-11 | 205 | R-R | Rookie | | Plano East High School (Plano,TX) | 6 |
| 623. | Brandon Tripp | OF | FLA | 18 | 4/2/1985 | 6-2 | 200 | L-R | A+ | | | |
| 624. | Michael Dennison | P | BOS | 22 | 1/9/1981 | 6-0 | 200 | R-R | A+ | | Wichita State University | 118 |
| 625. | Caleb McConnell | P | PHI | 22 | 5/14/1981 | 6-4 | 210 | R-R | A- | | University of Louisiana-Monroe | 2 |
| 626. | Casey Craig | OF | SEA | 18 | 1/12/1985 | 5-10 | 185 | L-R | AA | | Granite Hills High School (El Cajon,CA) | 22 |
| 627. | Joe Bisenius | P | MTL | 20 | 9/18/1982 | 6-5 | 210 | R-R | MLB | 2007-2007 | Iowa Western Community College | 37 |
| 628. | Scott Leffler | C | MIN | 18 | 8/7/1984 | 6-2 | 210 | R-R | A- | | Dunedin High School (Dunedin,FL) | 4 |
| 629. | Kerri Fair | OF | HOU | 21 | 2/20/1982 | 5-11 | 190 | R-R | A- | | Jacksonville State University | 47 |
| 630. | Josh Land | OF | ANA | 18 | 2/6/1985 | 6-1 | 185 | L-L | A | | Milton High School (Milton,FL) | 3 |
| 631. | Travis Denker | 2B | LA | 17 | 8/5/1985 | 5-11 | 190 | R-R | MLB | 2008-2008 | Brea-Olinda High School (Brea,CA) | 6 |
| 632. | Braedyn Pruitt | SS | OAK | 18 | 3/23/1985 | 6-2 | 175 | L-R | A+ | | Kings Academy High School (West Palm Beach,FL) | 3 |
| 633. | Sean Watson | P | SF | 17 | 7/24/1985 | 6-3 | 215 | R-R | AA | | Florida Christian High School (Miami,FL) | 4 |
| 634. | Richard Brindle | P | NYY | 18 | 7/7/1984 | 6-2 | 180 | R-R | - | | Peru High School (Peru,IN) | 1 |
| 635. | Jason Burch | P | STL | 20 | 10/15/1982 | 6-5 | 200 | R-R | AA | | University of Nebraska | 109 |
| 636. | Chad Clark | P | ARI | 22 | 7/30/1980 | 6-6 | 220 | R-R | A- | | Azusa Pacific University (Calif.) | 24 |
| 637. | Brooks Brown | P | ATL | 18 | 6/20/1985 | 6-3 | 188 | L-R | AA | | Portal High School (Portal,GA) | 1 |
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