| 519. | Oscar Montes | P | MIL | 18 | 2/10/1985 | 6-3 | 220 | R-R | Rookie | | Flanagan High School (Pembroke Pines,FL) | 2 |
| 520. | Josh Wahpepah | P | DET | 18 | 7/17/1984 | 6-4 | 185 | R-R | A+ | | Cowley County Community College | 27 |
| 521. | Greg Conden | P | SD | 22 | 7/24/1980 | 6-3 | 220 | R-R | AA | | George Washington University | 24 |
| 523. | Trey Johnston | 3B | CHC | 17 | 7/4/1985 | 5-11 | 190 | R-R | AA | | Schaumburg High School (Schaumburg,IL) | 6 |
| 524. | Jason Furrow | P | BAL | 18 | 12/31/1984 | 6-4 | 185 | R-L | Ind | | Judson High School (Converse,TX) | 6 |
| 526. | Cain Byrd | P | TEX | 19 | 1/6/1984 | 6-3 | 185 | R-R | A | | Southwood High School (Shreveport,LA) | 4 |
| 529. | Kyle McCulloch | P | NYM | 18 | 3/20/1985 | 6-2 | 170 | R-R | AA | | Bellaire High School (Bellaire,TX) | 25 |
| 530. | Ryan Roberts | 3B | TOR | 22 | 9/19/1980 | 5-10 | 190 | R-R | MLB | 2006-2007 | University of Texas-Arlington | 24 |
| 531. | Kyle Smith | OF | CIN | 22 | 5/17/1981 | 6-2 | 205 | R-R | A+ | | Houston Baptist University | 5 |
| 533. | Craig Lybarger | P | FLA | 20 | 10/7/1982 | 6-0 | 190 | L-L | A- | | Jefferson State Community College | 12 |
| 537. | Eduardo Nunez | SS | MTL | 17 | 9/21/1985 | 6-2 | 170 | R-R | A+ | | American Military Academy High School (American Military Academy,San Sebastian,PR) | |
| 538. | Eli Tintor | C | MIN | 18 | 12/24/1984 | 6-2 | 195 | R-R | A+ | | Hibbing High School (Hibbing,MN) | 4 |
| 540. | Fernando Rodriguez | P | ANA | 19 | 6/18/1984 | 6-3 | 210 | R-R | AA | | University of Texas-El Paso | 18 |
| 541. | A.J. Ellis | C | LA | 22 | 4/9/1981 | 6-3 | 240 | R-R | AAA | | Austin Peay State University | 19 |
| 542. | Billy Becher | 1B | OAK | 21 | 3/8/1982 | 6-5 | 230 | L-R | Ind | | New Mexico State University | 49 |
| 545. | Jose Virgil | OF | STL | 22 | 3/28/1981 | 5-11 | 215 | B-R | A- | | Oklahoma State University | 168 |
| 547. | Keith Weiser | P | ATL | 18 | 9/21/1984 | 6-2 | 195 | R-L | A+ | | Talawanda High School (Oxford,OH) | 2 |