| 278. | Shaun Cumberland | OF | TB | 18 | 8/1/1984 | 6-3 | 180 | L-R | AA | | Monsignor Pace High School (Miami,FL) | 27 |
| 279. | Tyler Morrison | P | MIL | 18 | 5/1/1985 | 6-0 | 200 | R-R | Rookie | | Glendora High School (Glendora,CA) | 13 |
| 280. | Sean Henry | OF | DET | 17 | 8/18/1985 | 5-10 | 154 | R-R | AA | | Armijo High School (Fairfield,CA) | 1 |
| 282. | Luis Cota | P | KC | 17 | 8/19/1985 | 6-1 | 180 | R-R | A+ | | Sunnyside High School (Tucson,AZ) | 5 |
| 284. | Jacob Duncan | OF | BAL | 21 | 11/20/1981 | 5-11 | 195 | L-L | A+ | | Texas Christian University | 67 |
| 285. | John Peabody | OF | PIT | 17 | 8/24/1985 | 6-4 | 215 | R-R | A- | | Rancho Bernardo High School (San Diego,CA) | 15 |
| 287. | Marc Kaiser | P | COL | 21 | 5/7/1982 | 6-2 | 205 | R-R | AAA | | Lewis-Clark State College | 78 |
| 291. | Andy D'Alessio | 1B | CIN | 18 | 9/23/1984 | 6-3 | 196 | L-R | A+ | | Barron Collier High School (Naples,FL) | 7 |
| 293. | J.T. Restko | 3B | FLA | 18 | 12/15/1984 | 6-5 | 185 | R-R | AAA | | Marist High School (Chicago,IL) | 5 |
| 296. | Mike Cox | 3B | SEA | 22 | 11/11/1980 | 6-1 | 185 | R-R | AA | | Florida Atlantic University | 40 |
| 298. | Chris Marini | P | MIN | 20 | 2/11/1983 | 6-1 | 190 | L-L | A+ | | Glendale Community College | 40 |
| 300. | Patrice LePage | C | ANA | 18 | 7/10/1984 | 6-1 | 205 | L-R | Rookie | | Edouard Montpetit High School (Montreal,QC) | 14 |
| 301. | Phil Sobkow | P | LA | 22 | 6/17/1981 | 6-5 | 220 | B-R | A | | Central Missouri State University | 23 |
| 304. | T.J. Beam | P | NYY | 22 | 8/28/1980 | 6-7 | 215 | R-R | MLB | 2006-2006 | University of Mississippi | 88 |
| 306. | Adam Bass | P | ARI | 21 | 7/31/1981 | 6-6 | 210 | R-R | Intl | | University of Alabama-Huntsville | 5 |