| 1 | 28 | June-Reg | Daric Barton | C | 17 | 6-0 | 220 | L | R | MLB | 2007-2009 | Marina (Huntington Beach,CA) | $975,000 |
| 2 | 65 | June-Reg | Stuart Pomeranz | P | 18 | 6-7 | 220 | R | R | AA | | Houston (Germantown,TN) | $570,000 |
| 3 | 95 | June-Reg | Dennis Dove | P | 21 | 6-4 | 200 | R | R | MLB | 2007-2007 | Georgia Southern University | $400,000 |
| 4 | 125 | June-Reg | Mark Michael | P | 20 | 6-5 | 210 | R | R | A+ | | University of Delaware | $220,000 |
| 5 | 155 | June-Reg | Brandon Yarbrough | C | 18 | 6-2 | 175 | L | R | AAA | | Richmond (Rockingham,NC) | $175,000 |
| 6 | 185 | June-Reg | Matt Weagle | P | 20 | 6-3 | 200 | R | R | Ind | | Franklin Pierce University | $128,000 |
| 7 | 215 | June-Reg | Brendan Ryan | SS | 21 | 6-2 | 195 | R | R | MLB | 2007-2009 | Lewis-Clark State College | $100,000 |
| 8 | 245 | June-Reg | Matt Pagnozzi | C | 20 | 6-3 | 200 | R | R | MLB | 2009-2009 | Central Arizona College | $105,000 |
| 9 | 275 | June-Reg | Justin Garza | P | 20 | 6-0 | 185 | R | R | AA | | Seminole State College | $80,000 |
| 10 | 305 | June-Reg | Tom Blair | P | 21 | 6-1 | 200 | L | L | AA | | University of Oklahoma | $45,000 |
| 11 | 335 | June-Reg | Nate Kopszywa | P | 21 | 6-6 | 230 | R | R | Rookie | | Crichton College | |
| 12 | 365 | June-Reg | Calvin Beamon | OF | 19 | 6-1 | 190 | L | L | A | | College of Southern Nevada | |
| 13 | 395 | June-Reg | Kainoa Obrey | 3B | 22 | 6-2 | 225 | R | R | A- | | Brigham Young University | |
| 14 | 425** | June-Reg | Ian Kennedy | P | 18 | 5-11 | 185 | R | R | MLB | 2007-2009 | La Quinta (Westminster,CA) | |
| 15 | 455 | June-Reg | Anthony Reyes | P | 21 | 6-2 | 215 | R | R | MLB | 2005-2009 | USC | |
| 16 | 485 | June-Reg | Omar Pena | SS | 21 | 5-10 | 165 | R | R | A+ | | Northeastern University | |
| 17 | 515 | June-Reg | Kevin House | OF | 20 | 5-11 | 195 | R | R | A- | | University of Memphis | |
| 18 | 545 | June-Reg | Jose Virgil | OF | 22 | 5-11 | 215 | B | R | A- | | Oklahoma State University | |
| 19 | 575 | June-Reg | Jason Motte | C | 21 | 6-0 | 200 | R | R | MLB | 2008-2009 | Iona College | |
| 20 | 605 | June-Reg | Jordan Pals | P | 22 | 6-8 | 205 | R | R | AA | | Eastern Illinois University | |
| 21 | 635 | June-Reg | Jason Burch | P | 20 | 6-5 | 200 | R | R | AA | | University of Nebraska | |
| 22 | 665** | June-Reg | Derik Drewett | P | 18 | 6-5 | 185 | R | R | College | | Watson Chapel (Pine Bluff,AR) | |
| 23 | 695 | June-Reg | Matt Blanton | P | 22 | 6-4 | 210 | L | L | A- | | Hendrix College | |
| 24 | 725 | June-Reg | Tee Thomas | 2B | 22 | 5-11 | 185 | R | R | A- | | Mississippi Valley State University | |
| 25 | 755 | June-Reg | Tavaris Gary | OF | 21 | 6-1 | 185 | L | L | Rookie | | Cumberland University | |
| 26 | 785 | June-Reg | Levi Webber | OF | 21 | 6-5 | 225 | R | R | A- | | Oregon State University | |
| 27 | 815 | June-Reg | Jason John | P | 21 | 6-5 | 240 | R | R | A- | | Grayson County College | |
| 28 | 845 | June-Reg | Tanner Wootan | 2B | 20 | 6-1 | 190 | B | R | A- | | Chandler-Gilbert Community College | |
| 29 | 875 | June-Reg | Brantley Jordan | P | 22 | 6-0 | 195 | L | L | AA | | University of Texas | |
| 30 | 905** | June-Reg | Matt Lane | P | 18 | 6-8 | 225 | R | R | A | | Iowa Western Community College | |
| 31 | 935 | June-Reg | Mike Tamulionis | P | 22 | 6-1 | 175 | R | R | College | | St. John's University | |
| 32 | 965 | June-Reg | Derek Roper | P | 22 | 6-6 | 200 | R | R | A | | University of Missouri | |
| 33 | 995 | June-Reg | Casey Grimm | OF | 22 | 6-0 | 210 | L | R | A- | | Seton Hall University | |
| 34 | 1025** | June-Reg | Kevin Mulvey | P | 18 | 6-1 | 170 | R | R | MLB | 2009-2009 | Bishop Ahr (Edison,NJ) | |
| 35 | 1055 | June-Reg | Peter Eberhardt | P | 21 | 6-3 | 215 | R | R | A- | | Cerritos College | |
| 36 | 1085 | June-Reg | John Powell | P | 18 | 6-5 | 201 | R | R | Rookie | | Carl Albert State College | |
| 37 | 1115 | June-Reg | Sal Frisella | OF | 22 | 6-0 | 220 | R | R | A | | Southern Illinois University | |
| 38 | 1145 | June-Reg | Brett Sinkbeil | P | 18 | 6-4 | 185 | R | R | AAA | | Page (Sand Springs,OK) | |
| 39 | 1175 | June-Reg | T.J. Brewer | P | 18 | 6-2 | 200 | R | R | AAA | | Bloomington South (Bloomington,IN) | |
| 40 | 1205 | June-Reg | Peter Soteropoulos | P | 21 | 6-1 | 210 | L | L | A | | University of Connecticut | |
| 41 | 1234** | June-Reg | Ryan Castellanos | 3B | 18 | 6-1 | 210 | R | R | College | | Silverado (Las Vegas,NV) | |
| 42 | 1263 | June-Reg | Roydrick Merritt | OF | 17 | 6-0 | 187 | L | L | AA | | Nimitz (Houston,TX) | |
| 43 | 1291 | June-Reg | Max Scherzer | P | 18 | 6-3 | 190 | R | R | MLB | 2008-2009 | Parkway Central (Chesterfield,MO) | |
| 44 | 1319 | June-Reg | Ryan Reichelderfer | 1B | 19 | 6-6 | 225 | R | R | - | | University of Arkansas-Fort Smith | |
| 45 | 1346 | June-Reg | Josh Markham | P | 18 | 6-2 | 185 | L | L | Rookie | | Riverdale (Murfreesboro,TN) | |
| 46 | 1373 | June-Reg | Kam Mickolio | P | 19 | 6-9 | 256 | R | R | MLB | 2008-2009 | College of Eastern Utah | |
| 47 | 1400 | June-Reg | Tobirus Bell | OF | 19 | 5-9 | 170 | R | R | - | | John Wood Community College | |