| 253. | Joe Hicks | OF | PIT | 18 | 4/22/1984 | 5-11 | 170 | R-R | A- | | Forest Brook High School (Houston,TX) | 6 |
| 254. | Chris Leroux | C | TB | 18 | 4/14/1984 | 6-6 | 210 | L-R | A+ | | St. Joseph High School (Mississauga,ON) | 1 |
| 255. | Steve Booth | C | CIN | 22 | 8/14/1979 | 6-1 | 190 | R-R | A | | University of San Francisco | 49 |
| 258. | Matt Tupman | C | KC | 22 | 11/25/1979 | 6-0 | 190 | L-R | MLB | 2008-2008 | University of Massachusetts at Lowell | 4 |
| 259. | Edwin Walker | P | MIL | 18 | 10/26/1983 | 6-3 | 190 | R-L | Ind | | Highlands High School (San Antonio,TX) | 2 |
| 264. | Caleb Maher | OF | ANA | 19 | 3/22/1983 | 6-2 | 190 | R-R | A+ | | Ceres High School (Ceres,CA) | 3 |
| 266. | Russell Savickas | P | TOR | 18 | 7/30/1983 | 6-4 | 170 | R-R | AAA | | Johnston High School (Johnston,RI) | 2 |
| 267. | Christian Colonel | SS | NYM | 20 | 12/25/1981 | 6-2 | 210 | R-R | AAA | | College of Southern Idaho | 89 |
| 268. | Tyler Pelland | P | BOS | 18 | 10/9/1983 | 6-0 | 190 | R-L | AAA | | Mount Abraham High School (Bristol,VT) | 1 |
| 269. | Rob Harrand | P | PHI | 22 | 1/11/1980 | 6-5 | 205 | R-R | A- | | San Diego State University | 147 |
| 273. | Adam Greenberg | OF | CHC | 21 | 2/21/1981 | 5-9 | 170 | L-L | MLB | 2005-2005 | University of North Carolina | 121 |
| 275. | Nick Starnes | P | ATL | 18 | 5/14/1984 | 6-3 | 200 | R-R | College | | Graham High School (Graham,NC) | 2 |