| # | Player Name | Pos | Team | Age | Born | Ht | Wt | B-T | High Level | MLB Years | Drafted From | # |
| 42. | Blair Johnson | P | PIT | 18 | 3/25/1984 | 6-4 | 200 | R-R | A+ | | Washburn High School (Topeka,KS) | 3 |
| 43. | Jason Pridie | OF | TB | 18 | 10/9/1983 | 6-1 | 195 | L-R | AAA | | Prescott High School (Prescott,AZ) | 8 |
| 44. | Joey Votto | 3B | CIN | 18 | 9/10/1983 | 6-3 | 200 | L-R | MLB | 2007-2008 | | 1 |
| 45. | Corey Shafer | C | BAL | 19 | 12/17/1982 | 6-2 | 215 | L-L | A | | Choctaw High School (Choctaw,OK) | 5 |
| 46. | Darrell Rasner | P | MTL | 21 | 1/13/1981 | 6-3 | 210 | R-R | MLB | 2005-2008 | University of Nevada | 69 |
| 47. | Adam Donachie | C | KC | 18 | 3/3/1984 | 6-2 | 170 | R-R | AA | | Timber Creek High School (Orlando,FL) | 1 |
| 48. | Joshua Murray | SS | MIL | 17 | 8/12/1984 | 6-2 | 180 | R-R | A+ | | Jesuit High School (Tampa,FL) | 22 |
| 49. | Brent Clevlen | OF | DET | 18 | 10/27/1983 | 6-2 | 190 | R-R | MLB | 2006-2008 | Westwood High School (Austin,TX) | 11 |
| 50. | Micah Owings | P | COL | 19 | 9/28/1982 | 6-5 | 220 | R-R | MLB | 2007-2008 | Bishop Kenny High School (Jacksonville,FL) | 11 |
| 51. | Zach Hammes | P | LA | 18 | 5/15/1984 | 6-6 | 220 | R-R | AAA | | Iowa City High School (Iowa City,IA) | 2 |
| 52. | Robert Andino | SS | FLA | 18 | 4/25/1984 | 6-0 | 170 | R-R | MLB | 2005-2008 | Southridge High School (Miami,FL) | 7 |
| 53. | Kevin Jepsen | P | ANA | 17 | 7/26/1984 | 6-3 | 200 | R-R | AAA | | Bishop Manogue High School (Reno,NV) | 2 |
| 54. | Michael Johnson | 1B | SD | 22 | 6/25/1980 | 6-3 | 215 | L-R | AAA | | Clemson University | 143 |
| 55. | David Bush | P | TOR | 22 | 11/9/1979 | 6-2 | 210 | R-R | MLB | 2004-2008 | Wake Forest University | 60 |
| 56. | Brian Dopirak | 1B | CHC | 18 | 12/20/1983 | 6-4 | 220 | R-R | AA | | Dunedin High School (Dunedin,FL) | 1 |
| 57. | Jon Lester | P | BOS | 18 | 1/7/1984 | 6-3 | 200 | L-L | MLB | 2006-2008 | Bellarmine Prep High School (Tacoma,WA) | 3 |
| 58. | Zach Segovia | P | PHI | 19 | 4/11/1983 | 6-1 | 220 | R-R | MLB | 2007-2007 | Forney High School (Forney,TX) | 1 |
| 59. | Jeremy Reed | OF | CHW | 21 | 6/15/1981 | 6-0 | 160 | L-L | MLB | 2004-2008 | Long Beach State University | 118 |
| 60. | Jonathan Broxton | P | LA | 18 | 6/16/1984 | 6-4 | 240 | R-R | MLB | 2005-2008 | Burke County High School (Waynesboro,GA) | 1 |
| 61. | Jesse Crain | P | MIN | 20 | 7/5/1981 | 6-1 | 200 | R-R | MLB | 2004-2008 | University of Houston | 79 |
| 62. | Justin Jones | P | CHC | 17 | 9/25/1984 | 6-3 | 225 | L-L | AA | | Kellam High School (Virginia Beach,VA) | 2 |
| 63. | Brian Slocum | P | CLE | 21 | 3/27/1981 | 6-4 | 190 | R-R | MLB | 2006-2006 | Villanova University | 42 |
| 64. | Brian McCann | C | ATL | 18 | 2/20/1984 | 6-3 | 190 | L-R | MLB | 2005-2008 | Duluth High School (Duluth,GA) | 2 |
| 65. | James Greene | SS | ATL | | | | 0 | - | - | | St. Thomas Aquinas High School (Fort Lauderdale,FL) | 17 |
| 66. | Fred Lewis | OF | SF | 21 | 12/9/1980 | 6-2 | 190 | L-R | MLB | 2006-2008 | Southern University | 65 |
| 67. | Steve Stanley | OF | OAK | 22 | 12/23/1979 | 5-8 | 155 | L-L | AAA | - | University of Notre Dame | 60 |
| 68. | Christopher Snyder | C | ARI | 21 | 2/12/1981 | 6-3 | 220 | R-R | MLB | 2004-2008 | University of Houston | 80 |
| 69. | Josh Womack | OF | SEA | 18 | 1/5/1984 | 6-1 | 185 | L-L | AAA | | Crawford High School (San Diego,CA) | 13 |
| 70. | Mitch Talbot | P | HOU | 18 | 10/17/1983 | 6-2 | 175 | R-R | AAA | | Canyon View High School (Cedar City,UT) | 1 |
| 71. | Brandon Weeden | P | NYY | 18 | 10/14/1983 | 6-4 | 190 | R-R | A+ | | Edmond Santa Fe High School (Edmond,OK) | 1 |
| 72. | Pat Osborn | 3B | CLE | 21 | 2/27/1981 | 6-3 | 210 | R-R | AA | | University of Florida | 113 |
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