| 497. | Matt Macri | SS | MIN | 19 | 5/29/1982 | 6-2 | 200 | R-R | MLB | 2008-2008 | Dowling High School (West Des Moines,IA) | 3 |
| 499. | Michael Navaroli | P | TB | 20 | 11/17/1980 | 6-3 | 220 | R-R | A+ | | Indian River Community College | 140 |
| 500. | Ryan Hutchison | P | PHI | 22 | 8/9/1978 | 6-0 | 205 | R-R | AAA | | Western Kentucky University | 31 |
| 504. | Tim Morley | P | PIT | 18 | 10/27/1982 | 6-2 | 190 | L-L | College | | Adlai Stevenson High School (Lincolnshire,IL) | 2 |
| 507. | Dan Smith | P | DET | 22 | 11/29/1978 | 6-4 | 215 | R-R | A+ | | University of Miami (Florida) | 170 |
| 508. | Justin Wilson | P | MIL | 19 | 5/22/1982 | 6-2 | 195 | L-L | Rookie | | Chandler High School (Chandler,AZ) | 9 |
| 511. | Chris Neylan | P | TOR | 18 | 9/27/1982 | 6-6 | 190 | R-L | A- | | Steinert High School (Trenton,NJ) | 4 |
| 513. | Michael Grant | P | BOS | 21 | 11/12/1979 | 6-1 | 190 | R-R | A- | | Danville Area Community College | 2 |
| 514. | Judd Songster | P | COL | 21 | 12/26/1979 | 6-3 | 195 | R-R | AAA | | University of Southern Colorado | 14 |
| 516. | Richard Bartel | P | CIN | 18 | 2/3/1983 | 6-5 | 190 | R-R | Rookie | | Grapevine High School (Grapevine,TX) | 4 |
| 521. | Pete Montrenes | P | OAK | 21 | 1/23/1980 | 6-3 | 190 | R-R | Ind | | University of Mississippi | 82 |
| 523. | Jason McCurdy | P | CHW | 18 | 12/14/1982 | 6-3 | 170 | L-L | Rookie | | South Dade High School (Homestead,FL) | 3 |
| 524. | Josh Merrigan | P | STL | 23 | 6/30/1978 | 6-4 | 225 | L-L | A+ | | Oklahoma State University | 156 |