| 317. | Josh Renick | 2B | MIN | 22 | 12/28/1978 | 5-9 | 180 | R-R | AA | | Middle Tennessee State University | 38 |
| 318. | Geovany Soto | C-1B | CHC | 18 | 1/20/1983 | 6-1 | 190 | R-R | MLB | 2005-2008 | American Military Acad. High School (PR) | |
| 319. | Mark Worrell | P | TB | 18 | 3/8/1983 | 6-1 | 190 | R-R | MLB | 2008-2008 | John Leonard High School (Greenacres,FL) | 8 |
| 320. | Matt Sweeney | P | PHI | 18 | 2/25/1983 | 6-2 | 180 | R-R | AA | | Steinert High School (Trenton,NJ) | 3 |
| 323. | John Hardy | SS | BAL | 18 | 9/28/1982 | 6-2 | 180 | R-R | A | | Centennial High School (Boise,ID) | 1 |
| 326. | D.J. Houlton | P | HOU | 21 | 8/12/1979 | 6-4 | 220 | R-R | MLB | 2005-2007 | University of the Pacific | 40 |
| 328. | David Slevin | 2B | MIL | 20 | 5/23/1981 | 5-10 | 170 | R-R | A- | | Indian River High School (IN CC) | |
| 329. | Jonathan Shull | P | ANA | 19 | 6/23/1982 | 6-3 | 200 | R-R | Rookie | | Eastside High School (Eastside,IN) | 1 |
| 330. | Marcus Nettles | OF | SD | 21 | 5/15/1980 | 5-11 | 185 | L-L | AA | | University of Miami (Florida) | 168 |
| 331. | Sean Gamble | OF | TOR | 18 | 6/23/1983 | 6-0 | 183 | L-L | A | | Davis High School (Montgomery,AL) | 1 |
| 341. | J.R. Crider | P | OAK | 21 | 12/7/1979 | 6-1 | 195 | R-R | A+ | | Lewis-Clark State College | 75 |
| 342. | David Mattox | P | NYM | 21 | 5/24/1980 | 6-2 | 180 | R-R | AA | | Anderson College (South Carolina) | 12 |
| 345. | Anthony Lerew | P | ATL | 18 | 10/28/1982 | 6-3 | 210 | L-R | MLB | 2005-2007 | Northern High School (Wellsville,PA) | 1 |
| 346. | Derin McMains | IF | SF | 21 | 11/3/1979 | 6-0 | 180 | B-R | AAA | | University of Arkansas-Little Rock | 5 |