| 521. | Chris Key | P | FLA | 22 | 10/30/1977 | 6-3 | 210 | R-L | AAA | | San Jose State University | 65 |
| 523. | Buck Coats | OF | CHC | 18 | 6/9/1982 | 6-3 | 195 | L-R | MLB | 2006-2008 | Valdosta High School (Valdosta,GA) | 9 |
| 524. | Thomas Saye | P | KC | 19 | 4/6/1981 | 6-0 | 180 | B-R | Rookie | | Newberry High School (Newberry,SC) | 7 |
| 525. | Jordan Griswold | P | MTL | 18 | 4/25/1982 | 6-3 | 195 | L-L | Rookie | | Shiloh High School (Snellville,GA) | 3 |
| 526. | Matthew Martunas | P | TB | 21 | 8/27/1978 | 6-2 | 180 | L-L | A- | | Presbyterian High School (Presbyterian) | |
| 528. | Emmanuel Valentin | P | DET | 17 | 10/11/1982 | 6-2 | 175 | R-R | Rookie | | Rafael Lopez Landron High School (Guayama,PR) | |
| 531. | Jonah Mcclanahan | OF | MIL | 19 | 3/25/1981 | 6-2 | 190 | R-R | A | | Monterey High School (Monterey,CA) | 9 |
| 534. | Kyle Sleeth | P | BAL | 18 | 12/20/1981 | 6-5 | 205 | R-R | AA | | Northglenn High School (Northglenn,CO) | 1 |
| 537. | Casey Kennedy | P | LA | 21 | 10/29/1978 | 6-1 | 195 | R-R | A+ | | University of Central Florida | 51 |
| 538. | Vince Perkins | P | TOR | 18 | 9/27/1981 | 6-5 | 225 | L-R | AA | | Lake City Community College | 16 |
| 540. | Matt O'Brien | P | OAK | 23 | 2/22/1977 | 5-10 | 170 | L-L | AAA | | Washington State University | 114 |
| 542. | Haas Pratt | 3B | BOS | 18 | 9/17/1981 | 6-3 | 225 | R-R | AAA | | Rancho Bernardo High School (San Diego,CA) | 10 |
| 543. | Jeff Schachleiter | P | CIN | 18 | 3/8/1982 | 6-4 | 215 | R-R | Rookie | | Colerain High School (Cincinnati,OH) | 6 |
| 545. | Mike Cox | p | NYM | 21 | 11/3/1978 | 5-11 | 195 | L-L | A+ | | University of Texas-Pan American | 28 |
| 546. | Jeremy Rogelstad | P | CLE | 21 | 11/29/1978 | 6-7 | 195 | R-R | A- | | San Jose State University | 66 |
| 548. | Josh Smith | P | NYY | 18 | 11/15/1981 | 6-4 | 230 | R-R | AAA | | Crawford High School (McGregor,TX) | 1 |
| 550. | Michael Davern | P | ATL | 18 | 11/22/1981 | 6-4 | 210 | R-R | Ind | | Brea-Olinda High School (Brea,CA) | 5 |