| 461. | Scott Hicks | 1B | FLA | 20 | 6/6/1980 | 6-4 | 210 | L-R | A+ | | Lake Sumter Community College | 2 |
| 463. | Chad Corona | 3B | CHC | 18 | 5/18/1982 | 6-4 | 227 | R-R | College | | Santa Fe Christian High School (Solana Beach,CA) | 1 |
| 464. | Joey Baker | P | KC | 21 | 8/30/1978 | 6-5 | 200 | R-R | A | | San Jose State University | 64 |
| 466. | James Shields | P | TB | 18 | 12/20/1981 | 6-3 | 190 | R-R | MLB | 2006-2008 | Hart High School (Newhall,CA) | 14 |
| 467. | Jose Vasquez | OF | COL | 17 | 12/12/1982 | 6-3 | 220 | L-L | A | | Booker High School (Sarasota,FL) | 4 |
| 468. | Ryan Schroyer | P | DET | 18 | 9/28/1981 | 6-1 | 215 | R-R | AAA | | Canyon del Oro High School (Tucson,AZ) | 6 |
| 469. | Chuck Lawton | P | SD | 18 | 9/25/1981 | 6-1 | 180 | R-R | Ind | | Palatka High School (Palatka,FL) | 10 |
| 470. | John Raburn | SS | ANA | 21 | 2/16/1979 | 6-1 | 165 | R-R | AAA | | University of South Florida | 69 |
| 473. | Jutt Hileman | OF | STL | 18 | 7/13/1981 | 6-1 | 185 | R-R | A+ | | Palmyra High School (Palmyra,PA) | 3 |
| 475. | Jeremy Hudson | P | PHI | 20 | 3/15/1980 | 6-7 | 210 | R-R | A+ | | Jefferson State Community College | 10 |
| 481. | Anthony Pannone | P | SF | 18 | 7/7/1981 | 6-3 | 210 | R-R | AAA | | Seward County Community College | 19 |
| 482. | Josh Thigpen | P | BOS | 18 | 6/27/1982 | 6-4 | 195 | R-R | A | | Rogers High School (Killen,AL) | 1 |
| 483. | Jason Arnold | P | CIN | 21 | 5/2/1979 | 6-3 | 210 | R-R | AAA | | University of Central Florida | 50 |
| 484. | Anthony Mongeluzzo | OF | TEX | 21 | 11/23/1978 | 6-1 | 210 | R-R | A | | Florida Atlantic University | 27 |
| 487. | Monte Mansfield | P | HOU | 19 | 3/22/1981 | 6-4 | 215 | R-R | AA | | Riverside Community College | 64 |