| 1 | 5 | June-Reg | Justin Wayne | P | 21 | 6-3 | 200 | R | R | MLB | 2002-2004 | Stanford University | $2,950,000 |
| 3 | 75 | June-Reg | Grady Sizemore | OF | 17 | 6-2 | 205 | L | L | MLB | 2004-2009 | Cascade (Everett,WA) | $2,000,000 |
| 4 | 105 | June-Reg | Cliff Lee | P | 21 | 6-4 | 190 | L | L | MLB | 2002-2009 | University of Arkansas | $275,000 |
| 5 | 135 | June-Reg | Thomas Mitchell | P | 19 | 6-2 | 185 | R | R | A | | Bladenboro (Bladenboro,NC) | $155,000 |
| 6 | 165 | June-Reg | Shawn Hill | P | 19 | 6-2 | 185 | R | R | MLB | 2004-2009 | Bishop PF Reding (Georgetown,ON) | $115,000 |
| 7 | 195** | June-Reg | Wes Littleton | P | 17 | 6-3 | 200 | R | R | MLB | 2006-2008 | Vista (Vista,CA) | $0 |
| 8 | 225 | June-Reg | Phil Seibel | P | 21 | 6-1 | 195 | R | L | MLB | 2004-2004 | University of Texas | $15,000 |
| 9 | 255 | June-Reg | Benji Dequin | P | 20 | 5-10 | 170 | L | L | AA | | Gavilan College | $55,000 |
| 10 | 285 | June-Reg | Darryl Jenkins | OF | 19 | 6-2 | 180 | L | R | Rookie | | Plainfield (Plainfield,IL) | $60,000 |
| 11 | 315 | June-Reg | Seth Johnson | IF | 18 | 6-2 | 190 | R | R | A- | | Kelso (Kelso,WA) | |
| 12 | 345 | June-Reg | Jason Stevenson | P | 18 | 6-1 | 175 | L | L | AAA | | Sacramento City College | |
| 13 | 375 | June-Reg | Craig Kerner | OF | 21 | 6-1 | 190 | L | R | A+ | | SUNY-Cortland | |
| 14 | 405 | June-Reg | Ben Washburn | P | 21 | 6-2 | 200 | R | R | A+ | | University of Redlands | |
| 15 | 435 | June-Reg | Mike Rose | P | 23 | 6-3 | 215 | R | R | A | | Oral Roberts University | |
| 16 | 465 | June-Reg | Phil Downing | OF | 21 | 6-1 | 190 | L | L | A+ | | Arizona State University | |
| 17 | 495 | June-Reg | Derrick Depriest | P | 23 | 6-8 | 230 | R | R | AA | | University of North Carolina | |
| 18 | 525 | June-Reg | Jordan Griswold | P | 18 | 6-3 | 195 | L | L | Ind | | Shiloh (Snellville,GA) | |
| 19 | 555 | June-Reg | Justin Estel | P | 22 | 6-0 | 200 | R | R | A- | | Mississippi State University | |
| 20 | 585** | June-Reg | Fred Lewis | OF | 19 | 6-2 | 190 | L | R | MLB | 2006-2009 | Mississippi Gulf Coast Community College | |
| 21 | 615 | June-Reg | Joshua Vaughn | P | 19 | 6-3 | 165 | L | L | Rookie | | Cowley College | |
| 22 | 645 | June-Reg | Jason Bay | OF | 21 | 6-2 | 200 | R | R | MLB | 2003-2009 | Gonzaga University | |
| 23 | 675** | June-Reg | Reid Santos | P | 17 | 6-1 | 170 | L | L | AAA | | Castle (Kaneohe,HI) | |
| 24 | 705** | June-Reg | Eric Miller | IF | 22 | 6-2 | 175 | R | R | A+ | | Florida International University | |
| 25 | 735 | June-Reg | Michael Bolson | P | 22 | 6-5 | 205 | R | R | A- | | University of Wisconsin | |
| 26 | 765 | June-Reg | Scott Russo | P | 22 | 6-2 | 180 | L | L | A+ | | Penn State University | |
| 27 | 795** | June-Reg | Leonard Landeros | P | 19 | 6-3 | 215 | L | L | AAA | | College of the Sequoias | |
| 28 | 825 | June-Reg | Ryan Ellis | | 21 | 6-0 | 180 | R | R | A- | | Point Park College | |
| 29 | 855** | June-Reg | Jim Brauer | P | 17 | 6-4 | 205 | R | R | AA | | Carmel (Carmel,IN) | |
| 30 | 885 | June-Reg | Danny Sauer | P | 21 | 6-3 | 190 | R | R | Rookie | | Modesto Junior College | |
| 31 | 915 | June-Reg | Nick Schnabel | IF | 22 | 5-9 | 170 | R | R | AA | | East Carolina University | |
| 32 | 945 | June-Reg | Christopher Bye | P | 22 | 5-11 | 190 | R | R | A+ | | St. Mary's College of California | |
| 33 | 975 | June-Reg | Justin Pouk | | 17 | 6-2 | 200 | R | R | College | | Streator Township (Streator,IL) | |
| 34 | 1005 | June-Reg | Nick Currin | P-RF | 18 | | 0 | | | - | | Putnam (Milwaukie,OR) | |
| 35 | 1035 | June-Reg | Russell Jeanson-Martin | 3B | | | 0 | | | - | | Edouard Montpetit (Montreal,QC) | |
| 36 | 1065** | June-Reg | Chad Scarbery | P | 19 | 6-3 | 215 | R | R | AAA | | Freed-Hardeman University | |
| 37 | 1095 | June-Reg | Derek Adams | P | | | 0 | | | - | | Sultana (Hesperia,CA) | |
| 38 | 1125 | June-Reg | Luis Rosas | SS | 18 | 5-11 | 175 | R | R | Rookie | | Dr Pila (Bayamon,PR) | |
| 39 | 1155 | June-Reg | Johnny King | | | | | | | College | | Teutopolis (Teutopolis,IL) | |
| 40 | 1185** | June-Reg | Ivan Naccarata | H | 18 | 6-0 | 190 | L | R | A+ | | Edouard Montpetit (Montreal,QC) | |
| 41 | 1214 | June-Reg | Toby Barnett | | 20 | 6-2 | 205 | R | R | Rookie | | College of Southern Idaho | |
| 42 | 1243 | June-Reg | Zach Brooks | | 19 | 6-3 | 215 | R | R | College | | Columbia Basin College | |
| 43 | 1272 | June-Reg | Alexandre Groleau | P | | | 0 | | | - | | Seminole State College | |
| 44 | 1300 | June-Reg | Anthony Ferrari | P | 22 | 5-9 | 165 | L | L | MLB | 2003-2003 | Lewis-Clark State College | |
| 45 | 1326** | June-Reg | Jeff Karstens | P | 17 | 6-3 | 170 | R | R | MLB | 2006-2009 | Mount Miguel (Spring Valley,CA) | |
| 46 | 1351 | June-Reg | Scott Jensen | | | | | | | College | | Clovis West (Fresno,CA) | |
| 47 | 1375 | June-Reg | Jimmy Gulden | | | | | | | College | | Lewisburg Area (Lewisburg,PA) | |
| 48 | 1396** | June-Reg | Pierre Blount | OF | 19 | 6-3 | 200 | R | R | A- | | Riverside Community College | |
| 49 | 1416** | June-Reg | Victor Rosario | OF | 19 | 5-9 | 175 | L | R | A | - | Lake City Community College | |
| 50 | 1436 | June-Reg | Robert Brethauer | P | 17 | 6-4 | 225 | L | L | - | | Bishop O'Dowd (Oakland,CA) | |