| 1 | 9 | June-Reg | Michael Cuddyer | SS | 18 | 6-2 | 202 | R | R | MLB | 2001-2009 | Great Bridge (Chesapeake,VA) | $1,850,000 |
| 1 | 50 | June-Reg | Matt LeCroy | C | 21 | 6-2 | 225 | R | R | MLB | 2000-2007 | Clemson University | $775,000 |
| 2 | 61 | June-Reg | Michael Restovich | OF | 18 | 6-4 | 233 | R | R | MLB | 2002-2007 | Mayo (Rochester,MN) | $650,000 |
| 3 | 93** | June-Reg | Greg Withelder | P | 18 | 6-3 | 200 | R | L | A+ | | Strath Haven (Wallingford,PA) | |
| 4 | 123 | June-Reg | Bob Davies | P | 21 | 6-1 | 195 | R | R | A+ | | Marietta College | |
| 5 | 153 | June-Reg | Peter Blake | P | 18 | 6-1 | 220 | R | L | A | | Indianola (Indianola,IA) | |
| 6 | 183 | June-Reg | Nate Melson | P | 18 | 6-6 | 192 | R | R | Rookie | | Rogers (Rogers,AR) | |
| 7 | 213 | June-Reg | Matt Carnes | P | 21 | 6-3 | 205 | R | R | AAA | | University of Arkansas | |
| 8 | 243 | June-Reg | Ben Thomas | P | 21 | 6-3 | 190 | L | L | Rookie | | Wichita State University | |
| 9 | 273 | June-Reg | Jon Schaeffer | C | 21 | 6-1 | 197 | R | R | AA | | Stanford University | |
| 10 | 303 | June-Reg | Josh Gandy | P | 21 | 6-1 | 203 | R | L | A+ | | University of Georgia | |
| 11 | 333 | June-Reg | Matt Jurgena | P | 21 | 6-3 | 185 | R | R | Rookie | | Hastings College | |
| 12 | 363 | June-Reg | Lateef Vaughn | SS | 21 | 5-9 | 175 | R | R | A+ | | Long Beach State University | |
| 13 | 393 | June-Reg | Deshawn Southward | OF | 19 | 5-11 | 187 | R | R | A | | Pasco (Dade City,FL) | |
| 14 | 423** | June-Reg | Eddy Furniss | 1B | 21 | 6-2 | 220 | L | L | AA | | Louisiana State University | |
| 15 | 453** | June-Reg | Jake Weber | OF | 21 | 5-11 | 188 | L | R | AAA | | North Carolina State University | |
| 16 | 483** | June-Reg | Jordan Gerk | p | 17 | 6-1 | 180 | L | L | AAA | | Klo (Kelowna,BC) | |
| 17 | 513** | June-Reg | Kevin Frederick | p-3B | 20 | 6-1 | 210 | R | L | MLB | 2002-2004 | Creighton University | |
| 18 | 543 | June-Reg | Ray Underhill | p | 18 | 6-4 | 185 | R | R | Rookie | | DeLand (DeLand,FL) | |
| 19 | 573 | June-Reg | Kevin Stuart | p | | | | | | - | | Golden West College | |
| 20 | 603 | June-Reg | Billy Coleman | p | 21 | 6-0 | 170 | R | R | Ind | | Western Michigan University | |
| 21 | 633 | June-Reg | J.C. Romero | p | 21 | 5-11 | 195 | B | L | MLB | 1999-2009 | University of Mobile | |
| 22 | 663** | June-Reg | Dan Boyd | 3B | 18 | 6-0 | 185 | R | R | A+ | | Pasco (Dade City,FL) | |
| 23 | 693 | June-Reg | Tim Sturdy | p | 18 | 6-2 | 183 | R | R | AAA | | La Cueva (Albuquerque,NM) | |
| 24 | 723 | June-Reg | Creston Whitaker | OF | 18 | 5-10 | 165 | B | R | College | | Jesuit College Prep (Dallas,TX) | |
| 25 | 753** | June-Reg | Adam Johnson | p | 17 | 6-2 | 210 | R | R | MLB | 2001-2003 | Torrey Pines (San Diego,CA) | |
| 26 | 783 | June-Reg | Dan Morris | p | | | | | | - | | Ayersville (Defiance,OH) | |
| 27 | 813** | June-Reg | Daylan Holt | OF | 18 | 6-1 | 200 | R | R | AAA | | Mesquite (Mesquite,TX) | |
| 28 | 843 | June-Reg | David Shank | p | 17 | 6-2 | 195 | R | R | Ind | | Miramonte (Orinda,CA) | |
| 29 | 873 | June-Reg | Aaron Jaworowski | 1B | 21 | 6-3 | 210 | L | R | A | | University of Missouri | |
| 30 | 903 | June-Reg | Nate Stevens | SS | | | | | | - | | Keystone (Keystone,FL) | |
| 31 | 933 | June-Reg | Mike Cosgrove | p | 21 | 6-2 | 195 | R | R | AAA | | University of Tennessee | |
| 32 | 963** | June-Reg | Trevor Mote | SS | 17 | 6-1 | 190 | B | R | A+ | | Kingman (Kingman,AZ) | |
| 33 | 993** | June-Reg | Nick Punto | SS | 19 | 5-9 | 170 | B | R | MLB | 2001-2009 | Saddleback College | |
| 34 | 1023 | June-Reg | Marques Tuiasosopo | 3B | | | | | | - | | Woodinville (Woodinville,WA) | |
| 35 | 1053 | June-Reg | Craig Hawkins | p | | | | | | - | | Notre Dame (Burlington,ON) | |
| 36 | 1083 | June-Reg | Brian Fitts | p | 20 | 6-2 | 175 | R | R | A | | Volunteer State Community College | |
| 37 | 1113 | June-Reg | Pat Stenger | p | 18 | 6-6 | 196 | R | R | Ind | | St. Ignatius (Cleveland,OH) | |
| 38 | 1143 | June-Reg | Bryan Melson | C | 22 | 6-1 | 193 | R | R | Ind | | University of North Florida | |
| 39 | 1173 | June-Reg | Isaiah Haynes | Of | | | | | | - | | Vanden (Fairfield,CA) | |
| 40 | 1203** | June-Reg | Casey Fuller | p | 18 | 6-6 | 210 | L | L | A+ | | Dixon (Dixon,CA) | |
| 41 | 1233** | June-Reg | Corey Richardson | of | 20 | 6-0 | 165 | B | R | AA | | Northeast Texas Community College | |
| 42 | 1260 | June-Reg | Russel Bratton | p | | | | | | - | | University of Memphis | |
| 43 | 1284** | June-Reg | Justin Smith | p | 17 | 6-5 | 210 | B | R | Rookie | | Seward County Community College | |
| 44 | 1306 | June-Reg | Josh Reese | p | 18 | 6-1 | 205 | R | R | Rookie | | Lincoln County (Fayetteville,TN) | |
| 45 | 1327 | June-Reg | Matt Booth | p | | | | | | - | | Henry Clay (Lexington,KY) | |
| 46 | 1347 | June-Reg | Aaron Miller | p | 20 | 6-3 | 235 | R | L | A | | Campbell University | |
| 47 | 1366 | June-Reg | Joe Foote | p | 17 | 6-4 | 203 | R | R | AA | | Park View (Sterling,VA) | |
| 48 | 1384 | June-Reg | Jason McConnell | 2B | 21 | 5-9 | 170 | B | R | A+ | | University of Arkansas | |
| 49 | 1401 | June-Reg | David Justice | SS | | | | | | College | | Washington (Pensacola,FL) | |
| 50 | 1417** | June-Reg | Tagg Bozied | C | 17 | 6-3 | 210 | R | R | AAA | | | |
| 51 | 1432 | June-Reg | Clinton Bailey | p | | | | | | - | | | |
| 52 | 1446 | June-Reg | Richard Durrett | 1B | 19 | 6-5 | 190 | | | - | | El Paso Community College | |
| 53 | 1460 | June-Reg | Shawn Stiffler | p | | | | | | - | | Somerset (Somerset,PA) | |