| Troy Tulowitzki | SS | 34.240 | New York Yankees | Tampa (A+) | Transferred to 60-day DL |
| Michael Pineda | SP | 30.140 | Minnesota Twins | Minnesota Twins (MLB) | Activated from DL |
| Devin Smeltzer | P | 23.274 | Minnesota Twins | Rochester (AAA) | Assigned to Rochester (AAA) |
| Didi Gregorius | SS | 29.109 | New York Yankees | New York Yankees (MLB) | Activated from DL |
| Thairo Estrada | SS | 23.106 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Assigned to Scranton/Wilkes-Barre (AAA) |
| Allen Webster | P | 29.117 | Chicago Cubs | Chicago Cubs (MLB) | Transferred to 60-day DL |
| Craig Kimbrel | RP | 31.010 | Chicago Cubs | Iowa (AAA) | Signed to 3-year contract for 2019-2021 ($45m) [Free Agent] 10--16--16 |
| Dwight Smith | OF | 26.224 | Baltimore Orioles | Baltimore Orioles (MLB) | DL-7 Concussion |
| Anthony Santander | OF | 24.231 | Baltimore Orioles | Baltimore Orioles (MLB) | Recalled from Norfolk (AAA) |
| Dante Bichette | 3B | 26.254 | Washington Nationals | Washington Nationals (MLB) | Contract selected from High Point (Indy) |
| Jimmy Cordero | RP | 27.232 | Chicago White Sox | Charlotte (AAA) | Claimed off waivers from Mariners by White Sox |
| Tyler Kinley | RP | 28.127 | Miami Marlins | Miami Marlins (MLB) | Recalled from New Orleans (AAA) |
| Caleb Smith | P | 27.315 | Miami Marlins | Miami Marlins (MLB) | DL-10 Left hip inflammation |
| Jon Jay | LF | 34.084 | Chicago White Sox | Charlotte (AAA) | Assigned to Charlotte (AAA) for rehab |
| Taylor Hearn | P | 24.281 | Texas Rangers | Texas Rangers (MLB) | Transferred to 60-day DL |
| Tim Federowicz | C | 31.307 | Texas Rangers | Texas Rangers (MLB) | Traded from Indians to Rangers. Contract subsequently selected. |
| Travis Bergen | P | 25.242 | San Francisco Giants | San Jose (A+) | Assigned to San Jose (A+) for rehab |
| Hunter Wood | P | 25.299 | Tampa Bay Rays | Durham (AAA) | Assigned to Durham (AAA) |
| Sean Nolin | P | 29.163 | Seattle Mariners | Tacoma (AAA) | Contract purchased from Long Island (Indy) |
| Garrett Hampson | SS | 24.240 | Colorado Rockies | Albuquerque (AAA) | Assigned to Albuquerque (AAA) |
| Tayler Scott | P | 27.006 | Seattle Mariners | Seattle Mariners (MLB) | Contract purchased from minors |
| Mitch Haniger | RF | 28.166 | Seattle Mariners | Seattle Mariners (MLB) | DL-10 Ruptured testicle |
| Isiah Kiner-Falefa | SS | 24.076 | Texas Rangers | Texas Rangers (MLB) | DL-10 Right middle finger ligament sprain |
| Chris Rusin | RP | 32.228 | Colorado Rockies | Colorado Rockies (MLB) | Designated for Assignment |
| Charlie Blackmon | RF | 32.341 | Colorado Rockies | Colorado Rockies (MLB) | Activated from DL |
| Wade Davis | CL | 33.273 | Colorado Rockies | Colorado Rockies (MLB) | Activated from DL |
| Brady Rodgers | P | 28.263 | Houston Astros | Round Rock (AAA) | Assigned to Round Rock (AAA) |
| Cionel Perez | p | 23.047 | Houston Astros | Houston Astros (MLB) | Recalled from Round Rock (AAA) |
| Justin Upton | LF | 31.287 | Los Angeles Angels | Inland Empire (A+) | Assigned to Inland Empire (A+) for rehab |
| Ranger Suarez | p | 23.286 | Philadelphia Phillies | Philadelphia Phillies (MLB) | Recalled from Lehigh Valley (AAA) |
| Yacksel Rios | P | 25.345 | Philadelphia Phillies | Lehigh Valley (AAA) | Assigned to Lehigh Valley (AAA) |
| Zach Eflin | SP | 25.060 | Philadelphia Phillies | Philadelphia Phillies (MLB) | Activated from DL |
| Seranthony Dominguez | RP | 24.194 | Philadelphia Phillies | Philadelphia Phillies (MLB) | DL-10 Right UCL Injury |
| Michael Perez | C | 26.304 | Tampa Bay Rays | Durham (AAA) | Assigned to Durham (AAA) for rehab |
| Kevan Smith | C | 30.344 | Los Angeles Angels | Los Angeles Angels (MLB) | Activated from DL |
| Carlos Rodon | SP | 26.179 | Chicago White Sox | Chicago White Sox (MLB) | Transferred to 60-day DL |
| Dee Gordon | CF | 31.046 | Seattle Mariners | Tacoma (AAA) | Assigned to Tacoma (AAA) for rehab |
| Vidal Nuno | P | 31.317 | Tampa Bay Rays | Durham (AAA) | Signed to Minor League Contract |
| Wilfredo Tovar | SS | 27.301 | Los Angeles Angels | Los Angeles Angels (MLB) | Contract purchased from minors |
| Dustin Garneau | C | 31.299 | Los Angeles Angels | Los Angeles Angels (MLB) | Designated for Assignment |
| Jaime Barria | SP | 22.324 | Los Angeles Angels | Salt Lake (AAA) | Assigned to Salt Lake (AAA) |
| Jose Castillo | RP | 23.149 | San Diego Padres | Lake Elsinore (A+) | Assigned to Lake Elsinore (A+) for rehab |
| Matt Carasiti | P | 27.320 | | | Released by Cubs |
| Matt Carasiti | P | 27.320 | Seattle Mariners | Tacoma (AAA) | Signed to Minor League Contract |
| Dallas Keuchel | SP | 31.158 | Atlanta Braves | Gwinnett (AAA) | Signed to 1-year contract for 2019-2019 ($13m) [Free Agent] |
| Darren O'Day | RP | 36.228 | Atlanta Braves | Atlanta Braves (MLB) | Transferred to 60-day DL |
| Fernando Villegas | OF | 20.344 | Miami Marlins | Greensboro (A) | Assigned to Greensboro (A) |
| Matt Morrow | IF | 23.150 | Pittsburgh Pirates | Bradenton (A+) | Assigned to Bradenton (A+) |
| Brett Bond | C | 23.236 | Los Angeles Angels | Arizona Angels (Rk) | Assigned to Arizona Angels (Rk) |
| Dylan Harris | 3B | 24.131 | Cincinnati Reds | Daytona (A+) | Assigned to Daytona (A+) |
| Narciso Crook | RF | 23.331 | Cincinnati Reds | Louisville (AAA) | Assigned to Louisville (AAA) |
| Ernesto Liberatore | C | 23.073 | Cincinnati Reds | Billings (Rk) | Assigned to Billings (Rk) |
| Robert Tyler | P | 23.355 | Colorado Rockies | Lancaster (A+) | Assigned to Lancaster (A+) |
| Kevin Malisheski | P | 21.273 | Los Angeles Dodgers | Rancho Cucamonga (A+) | Assigned to Rancho Cucamonga (A+) |
| Trevor Casanova | C | 22.350 | Minnesota Twins | Elizabethton (Rk) | Assigned to Elizabethton (Rk) |
| Seth Corry | P | 20.216 | San Francisco Giants | Augusta (A) | Assigned to Augusta (A) |
| Blake Rivera | P | 21.149 | San Francisco Giants | Salem-Keizer (A-) | Assigned to Salem-Keizer (A-) |
| Austin Moore | P | 24.351 | Colorado Rockies | Boise (A-) | Assigned to Boise (A-) |
| Ryan Haug | C | 24.160 | Pittsburgh Pirates | West Virginia (A-) | Assigned to West Virginia (A-) |
| Yusniel Padron-Artilles | P | 21.207 | Boston Red Sox | Lowell (A-) | Assigned to Lowell (A-) |
| Colby Bortles | 3B | 24.071 | Detroit Tigers | Connecticut (A-) | Assigned to Connecticut (A-) |
| Ryan Shetter | P | 22.094 | Atlanta Braves | Rome (A) | Assigned to Rome (A) |
| Matt Hartman | P | 23.100 | Atlanta Braves | Florida (A+) | Assigned to Florida (A+) |
| Jake Irvin | P | 22.109 | Washington Nationals | Hagerstown (A) | Activated from disabled list |
| Oddanier Mosqueda | P | 20.032 | Boston Red Sox | Greenville (A) | Activated from disabled list |
| Tomas Alastre | P | 20.361 | Washington Nationals | Hagerstown (A) | DL-7 Injured |
| Cameron Hill | P | 25.014 | Cleveland Indians | Lake County (A) | Assigned to Lake County (A) |
| Aaron Pinto | P | 22.339 | Cleveland Indians | Lynchburg (A+) | Assigned to Lynchburg (A+) |
| Zach Mort | P | 22.016 | Chicago Cubs | South Bend (A) | DL-7 Injured |
| James Reeves | P | 26.000 | New York Yankees | Tampa (A+) | Assigned to Tampa (A+) |
| Nick Nelson | P | 23.185 | New York Yankees | Trenton (AA) | Assigned to Trenton (AA) |
| Trevor Lane | P-OF | 25.042 | New York Yankees | Tampa (A+) | Assigned to Tampa (A+) |
| Andrew Bellatti | P | 27.307 | New York Yankees | Trenton (AA) | Assigned to Trenton (AA) |
| Bo Bichette | SS | 21.094 | Toronto Blue Jays | Dunedin (A+) | Assigned to Dunedin (A+) for rehab |
| Frank Schwindel | C-1B | 26.343 | Detroit Tigers | Lakeland (A+) | Assigned to Lakeland (A+) |
| Graham Spraker | P | 24.080 | Toronto Blue Jays | Dunedin (A+) | Assigned to Dunedin (A+) |
| Brayden Bouchey | P | 23.261 | Toronto Blue Jays | Dunedin (A+) | DL-7 Injured |
| Bryan Mata | P | 20.035 | Boston Red Sox | Salem (A+) | Activated from disabled list |
| Jordan Procyshen | C | 26.088 | Los Angeles Dodgers | Rancho Cucamonga (A+) | Assigned to Rancho Cucamonga (A+) |
| Leonardo Crawford | P | 22.125 | Los Angeles Dodgers | Rancho Cucamonga (A+) | DL-7 Injured |
| Jose Marte | P | 22.358 | San Francisco Giants | San Jose (A+) | Activated from disabled list |
| Kyle Survance | OF | 25.183 | Los Angeles Angels | Inland Empire (A+) | Activated from disabled list |
| Kyle Finnegan | P | 27.277 | Oakland Athletics | Las Vegas (AAA) | Assigned to Las Vegas (AAA) |
| Josh Thole | C | 32.222 | Los Angeles Dodgers | Tulsa (AA) | Assigned to Tulsa (AA) |
| Alberti Chavez | 2B-3B | 23.322 | Cincinnati Reds | Chattanooga (AA) | Assigned to Chattanooga (AA) |
| Aaron Slegers | P | 26.276 | Tampa Bay Rays | Montgomery (AA) | Assigned to Montgomery (AA) |
| Bailey Clark | P | 24.186 | Chicago Cubs | Tennessee (AA) | Activated from disabled list |
| Tyler Stephenson | C | 22.295 | Cincinnati Reds | Chattanooga (AA) | Placed on temporarily inactive list |
| Cassidy Brown | C | 24.321 | Cincinnati Reds | Chattanooga (AA) | Activated from disabled list |
| Ibandel Isabel | OF | 23.353 | Cincinnati Reds | Chattanooga (AA) | DL-7 Injured |
| Dario Pizzano | OF | 28.043 | - | | Released by Binghamton |
| Anderson Feliz | 3B | 27.027 | Baltimore Orioles | Norfolk (AAA) | Assigned to Norfolk (AAA) |
| Dylan Hardy | IF-OF | 22.138 | Boston Red Sox | Pawtucket (AAA) | Assigned to Pawtucket (AAA) |
| Ashton Goudeau | P | 26.319 | Colorado Rockies | Hartford (AA) | DL-7 Injured |
| Reid Humphreys | SS | 24.198 | Colorado Rockies | Hartford (AA) | Activated from disabled list |
| Vince Fernandez | OF | 23.318 | Colorado Rockies | Hartford (AA) | Placed on restricted list |
| Jorge Saez | C | 28.283 | New York Yankees | Trenton (AA) | DL-7 Injured |
| Brandon Gold | 3B-P | 24.264 | Colorado Rockies | Hartford (AA) | Reinstated to active roster |
| Justin De Fratus | P | 31.230 | Los Angeles Dodgers | Oklahoma City (AAA) | Activated from disabled list |
| Daniel Corcino | P | 28.285 | Los Angeles Dodgers | Oklahoma City (AAA) | DL-7 Injured |
| Matt Snyder | 1B | 28.355 | Miami Marlins | New Orleans (AAA) | DL-7 Injured |
| Vidal Nuno | P | 31.317 | Tampa Bay Rays | Durham (AAA) | Assigned to Durham (AAA) |
| Mike Miller | 3B | 29.253 | Boston Red Sox | Pawtucket (AAA) | DL-7 Injured |
| Dioner Navarro | C | 35.119 | Cleveland Indians | Columbus (AAA) | Activated from disabled list |
| Mitch Moreland | 1B | 33.274 | Boston Red Sox | Boston Red Sox (MLB) | Activated from DL |
| Casey Sadler | P | 28.329 | Tampa Bay Rays | Tampa Bay Rays (MLB) | Recalled from Durham (AAA) |
| Cristian Reyes | P | 24.261 | - | | Released by Arizona Angels |
| Joel Urena | P | 19.295 | - | | Released by Arizona Rangers |
| Kenny Koplove | P-IF | 25.309 | - | | Released by Boise |
| Brian Brown | P | 23.037 | - | | Released by Lowell |
| Kacey Murphy | P | 22.137 | - | | Announced retirement |
| Ryan Weber | P | 28.299 | Boston Red Sox | Pawtucket (AAA) | Assigned to Pawtucket (AAA) |
