| Zach Davies | SP | 25.196 | Milwaukee Brewers | Biloxi (AA) | Assigned to Biloxi (AA) for rehab |
| Yacksel Rios | P | 25.056 | Philadelphia Phillies | Lehigh Valley (AAA) | Assigned to Lehigh Valley (AAA) |
| Jeff Samardzija | SP | 33.211 | San Francisco Giants | Richmond (AA) | Assigned to Richmond (AAA) for rehab |
| Chris Stewart | C | 36.184 | Atlanta Braves | Atlanta Braves (MLB) | Contract purchased from minors |
| Michael Reed | OF | 25.277 | Atlanta Braves | Gwinnett (AAA) | Assigned to Gwinnett (AAA) |
| Chris Rabago | IF-C | 25.122 | New York Yankees | Trenton (AA) | Claimed off waivers from Rockies by Yankees and assigned to Trenton (AA) |
| Aroldis Chapman | RP | 30.176 | New York Yankees | New York Yankees (MLB) | DL-10 Left knee tendinitis |
| Chance Adams | RP | 24.012 | New York Yankees | New York Yankees (MLB) | Recalled from Scranton/Wilkes-Barre (AAA) |
| Yairo Munoz | 2B | 23.211 | St. Louis Cardinals | St. Louis Cardinals (MLB) | Activated from DL |
| Daniel Poncedeleon | P | 26.219 | St. Louis Cardinals | Memphis (AAA) | Assigned to Memphis (AAA) |
| Marcell Ozuna | LF | 27.283 | St. Louis Cardinals | St. Louis Cardinals (MLB) | DL-10 Right shoulder inflammation |
| Brian McCann | C | 34.184 | Houston Astros | Corpus Christi (AA) | Assigned to Corpus Christi (AA) for rehab |
| Kingston Liniak | CF | 18.285 | Detroit Tigers | Gulf Coast Tigers (East) (Rk) | Assigned to Gulf Coast Tigers (East) (Rk) |
| Filyer Sanchez | P | 21.195 | Atlanta Braves | Florida (A+) | Assigned to Florida (A+) |
| Moises Perez | SS | 21.035 | Los Angeles Dodgers | Arizona Dodgers (Rk) | Assigned to Arizona Dodgers (Rk) |
| Chesny Young | IF | 25.320 | Chicago Cubs | Arizona Cubs (Rk) | Assigned to Arizona Cubs (Rk) |
| Ruben Cardenas | OF | 20.316 | Cleveland Indians | Mahoning Valley (A-) | Assigned to Mahoning Valley (A-) |
| Dominic Taccolini | P | 23.328 | San Diego Padres | Arizona Padres (Rk) | Assigned to Arizona Padres (Rk) |
| Michael Cooper | 1B | 19.026 | Cleveland Indians | Mahoning Valley (A-) | Assigned to Mahoning Valley (A-) |
| Eury Perez | OF | 28.084 | San Francisco Giants | Arizona Giants (Rk) | Assigned to Arizona Giants (Rk) |
| Jose Chacin | P | 21.150 | Los Angeles Dodgers | Great Lakes (A) | Assigned to Great Lakes (A) |
| Luis Gil | P | 20.080 | New York Yankees | Staten Island (A-) | Assigned to Staten Island (A-) |
| L.A. Woodard | IF | 21.070 | New York Mets | Brooklyn (A-) | Assigned to Brooklyn (A-) |
| Jonathan Machado | OF | 19.213 | St. Louis Cardinals | State College (A-) | Assigned to State College (A-) |
| Eric Gonzalez | C | 21.354 | Chicago Cubs | South Bend (A) | Assigned to South Bend (A) |
| Gabe Mosser | P | -- | San Diego Padres | Fort Wayne (A) | Assigned to Fort Wayne (A) |
| Slater Lee | P | 23.170 | Oakland Athletics | Beloit (A) | Assigned to Beloit (A) |
| Justin Garza | P | 24.155 | Cleveland Indians | Lynchburg (A+) | Assigned to Lynchburg (A+) |
| Tre' Gantt | OF | 22.104 | Cleveland Indians | Lake County (A) | Assigned to Lake County (A) |
| Mitch Reeves | IF-OF | 23.277 | Cleveland Indians | Lake County (A) | Assigned to Lake County (A) |
| Jasseel De la Cruz | P | 21.057 | Atlanta Braves | Rome (A) | DL-7 Injured |
| Walter Borkovich | P | 23.050 | Atlanta Braves | Rome (A) | Assigned to Rome (A) |
| Michael Cantu | C | 22.360 | San Diego Padres | Fort Wayne (A) | Assigned to Fort Wayne (A) |
| John Rooney | P | 21.206 | Los Angeles Dodgers | Great Lakes (A) | DL-7 Injured |
| Brayan Morales | CF | 22.258 | Los Angeles Dodgers | Great Lakes (A) | |
| Garrett Hope | C | 24.238 | Los Angeles Dodgers | Great Lakes (A) | |
| Max Herrmann | P | 25.036 | Los Angeles Angels | Burlington (A) | Activated from disabled list |
| Gabriel Mejia | OF | 23.023 | Cleveland Indians | Lake County (A) | DL-7 Injured |
| Riley Richert | P-OF | 21.206 | Los Angeles Dodgers | Great Lakes (A) | |
| Andres Luna | OF | 21.036 | St. Louis Cardinals | Peoria (A) | Activated from disabled list |
| Yariel Gonzalez | 2B | 24.082 | St. Louis Cardinals | Peoria (A) | DL-7 Injured |
| Nick Jobst | P | 24.124 | Los Angeles Angels | Burlington (A) | DL-7 Injured |
| MacKenzie Gore | P | 19.179 | San Diego Padres | Fort Wayne (A) | DL-7 Injured |
| Brady Feigl | P | 22.269 | Oakland Athletics | Beloit (A) | DL-7 Injured |
| Oscar Gonzalez | OF | 20.224 | Cleveland Indians | Lake County (A) | DL-7 Injured |
| Christian Donahue | IF | 23.110 | Chicago Cubs | Myrtle Beach (A+) | Assigned to Myrtle Beach (A+) |
| Brendan Feldmann | P | 24.137 | Houston Astros | Buies Creek (A+) | Assigned to Buies Creek (A+) |
| Hunter Jarmon | OF | 23.173 | San Diego Padres | Lake Elsinore (A+) | Assigned to Lake Elsinore (A+) |
| Bryce Denton | 3B | 21.021 | St. Louis Cardinals | Palm Beach (A+) | DL-7 Injured |
| Edwin Lora | 2B | 22.343 | Washington Nationals | Potomac (A+) | DL-7 Injured |
| Andruw Monasterio | SS | 21.084 | Washington Nationals | Potomac (A+) | |
| Nick Sandlin | P | 21.224 | Cleveland Indians | Akron (AA) | Assigned to Akron (AA) |
| Justin Steele | P | 23.042 | Chicago Cubs | Tennessee (AA) | Assigned to Tennessee (AA) |
| Jared Oliver | P | 25.202 | Boston Red Sox | Salem (A+) | Assigned to Salem (A+) |
| Darwinzon Hernandez | P | 21.248 | Boston Red Sox | Portland (AA) | Assigned to Portland (AA) |
| Marcus Brakeman | P | 24.068 | Los Angeles Angels | Inland Empire (A+) | DL-7 Injured |
| Anthony Mciver | P | 26.136 | Seattle Mariners | Tacoma (AAA) | Assigned to Tacoma (AAA) |
| Brock Dykxhoorn | P | 24.051 | Houston Astros | Fresno (AAA) | Assigned to Fresno (AAA) |
| Tommy Edman | IF | 23.105 | St. Louis Cardinals | Springfield (AA) | Assigned to Springfield (AA) |
| Daury Torrez | P | 25.072 | Chicago Cubs | Tennessee (AA) | Activated from disabled list |
| Clint Coulter | C | 25.023 | Milwaukee Brewers | Colorado Springs (AAA) | Assigned to Colorado Springs (AAA) |
| Bryant Flete | 2B | 25.203 | Chicago White Sox | Charlotte (AAA) | Assigned to Charlotte (AAA) |
| Allen Webster | P | 28.193 | Chicago Cubs | Iowa (AAA) | Assigned to Iowa (AAA) |
| Sal Giardina | C | 26.114 | Atlanta Braves | Gwinnett (AAA) | Assigned to Gwinnett (AAA) |
| Colton Turner | P | 27.217 | Chicago White Sox | Charlotte (AAA) | Assigned to Charlotte (AAA) |
| Duncan Robinson | P | 24.260 | Chicago Cubs | Iowa (AAA) | Assigned to Iowa (AAA) |
| Ronnie Jebavy | OF | 24.097 | San Francisco Giants | Richmond (AA) | Activated from disabled list |
| John Polonius | SS-2B | 27.221 | San Francisco Giants | Richmond (AA) | DL-7 Injured |
| Cody Martin | P | 28.352 | New York Mets | Las Vegas (AAA) | DL-7 Injured |
| Antonio Nunez | SS | 25.224 | Houston Astros | Fresno (AAA) | DL-7 Injured |
| Brett Oberholtzer | P | 29.052 | Colorado Rockies | Albuquerque (AAA) | Placed on temporarily inactive list |
| Chris Shaw | 1B | 24.306 | San Francisco Giants | Sacramento (AAA) | Activated from disabled list |
| Allen Craig | 1B | 34.035 | San Diego Padres | El Paso (AAA) | Placed on temporarily inactive list |
| Cody Decker | 1B | 31.217 | Arizona Diamondbacks | Reno (AAA) | DL-7 Injured |
| Logan Taylor | P | 26.253 | New York Mets | Las Vegas (AAA) | Reinstated to active roster |
| Alberto Rosario | C | 31.224 | Arizona Diamondbacks | Reno (AAA) | Reinstated to active roster |
| Jan Vazquez | C | 27.115 | Colorado Rockies | Albuquerque (AAA) | Activated from disabled list |
| Ruben Alaniz | P | 27.069 | Tampa Bay Rays | Durham (AAA) | Placed on temporarily inactive list |
| Justin Nicolino | P | 26.274 | Cincinnati Reds | Louisville (AAA) | Activated from disabled list |
| Jaycob Brugman | OF | 26.217 | Baltimore Orioles | Norfolk (AAA) | DL-7 Injured |
| Adrian Marin | SS | 24.167 | Baltimore Orioles | Norfolk (AAA) | DL-7 Injured |
| Ryan McBroom | 1B | 26.135 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Activated from disabled list |
| Taylor Motter | OF | 28.338 | - | | Released by Twins |
| Chris Devenski | RP | 27.282 | Houston Astros | Corpus Christi (AA) | Assigned to Corpus Christi (AA) for rehab |
| Addison Russell | SS | 24.211 | Chicago Cubs | Chicago Cubs (MLB) | DL-10 Sprained left middle finger |
| Rajai Davis | CF | 37.307 | Cleveland Indians | Cleveland Indians (MLB) | DL-10 Non-baseball medical condition |
| Edwin Encarnacion | DH | 35.227 | Cleveland Indians | Cleveland Indians (MLB) | Activated from DL |
| Stephen Strasburg | SP | 30.033 | Washington Nationals | Washington Nationals (MLB) | Activated from DL |
| Adrian Sanchez | 2B | 28.006 | Washington Nationals | Syracuse (AAA) | Assigned to Syracuse (AAA) |
| Nick Rumbelow | RP | 26.351 | Seattle Mariners | Seattle Mariners (MLB) | Recalled from Tacoma (AAA) |
| Ross Detwiler | P | 32.169 | Seattle Mariners | Seattle Mariners (MLB) | Designated for Assignment |
| Keon Broxton | CF | 28.107 | Milwaukee Brewers | Wisconsin (A) | Assigned to Wisconsin (A) |
| Matt Albers | RP | 35.214 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Activated from DL |
| Jose Abreu | 1B | 31.205 | Chicago White Sox | Chicago White Sox (MLB) | DL-10 Lower abdominal and groin surgery |
| Ryan Burr | P | 24.086 | Chicago White Sox | Chicago White Sox (MLB) | Contract purchased from minors |
| Jose Rondon | SS | 24.172 | Chicago White Sox | Chicago White Sox (MLB) | Recalled from Charlotte (AAA) |
| Jose Taveras | p | 24.289 | Philadelphia Phillies | Lehigh Valley (AAA) | Designated for Assignment |
| Luis Avilan | RP | 29.034 | Philadelphia Phillies | Philadelphia Phillies (MLB) | Traded from Phillies to White Sox for Felix Paulino |
| Felix Paulino | P | 23.151 | Chicago White Sox | Chicago White Sox (MLB) | Traded from Phillies to White Sox for Luis Avilan |
| Joe Ross | SP | 25.093 | Washington Nationals | Harrisburg (AA) | Assigned to Harrisburg (AA) for rehab |
| Zach Eflin | SP | 24.136 | Philadelphia Phillies | Philadelphia Phillies (MLB) | Recalled from Lehigh Valley (AAA) |
| Bryson Brigman | SS | 23.064 | Miami Marlins | Jacksonville (AA) | Assigned to Jacksonville (AA) |
| Casey Coleman | P | 31.050 | Chicago Cubs | Iowa (AAA) | DL-7 Injured |
| Daniel Camarena | P | 25.286 | San Francisco Giants | Sacramento (AAA) | DL-7 Injured |
| Zach McAllister | RP | 30.258 | | | Refused minor league assignment, declared free agent |
