| Greg Allen | CF | 25.126 | Cleveland Indians | Columbus (AAA) | Assigned to Columbus (AAA) |
| Jesse Chavez | RP | 34.333 | Chicago Cubs | Chicago Cubs (MLB) | Traded from Rangers to Cubs for Tyler Thomas |
| Tyler Thomas | P | 22.210 | Texas Rangers | Hickory (A) | Traded from Cubs to Rangers for Jesse Chavez |
| Clay Buchholz | SP | 33.339 | Arizona Diamondbacks | Visalia (A+) | Assigned to Visalia (A+) for rehab |
| Tyler Fallwell | p | 22.254 | Philadelphia Phillies | Philadelphia Phillies (MLB) | Signed to Minor League Contract |
| Brandon Morrow | RP | 33.358 | Chicago Cubs | Chicago Cubs (MLB) | DL-10 Right biceps tendinitis |
| Andrew Toles | LF | 26.056 | Los Angeles Dodgers | Oklahoma City (AAA) | Assigned to Oklahoma City (AAA) |
| James Norwood | P | 24.207 | Chicago Cubs | Chicago Cubs (MLB) | Recalled from Iowa (AAA) |
| Albert Almora | CF | 24.094 | Chicago Cubs | Chicago Cubs (MLB) | Reinstated to active roster |
| Gary Sanchez | C | 25.229 | New York Yankees | New York Yankees (MLB) | Activated from DL |
| Santiago Casilla | RP | 35.134 | | | Released by Athletics |
| Michael Reed | OF | 25.243 | Atlanta Braves | Atlanta Braves (MLB) | Recalled from Gwinnett (AAA) |
| Danny Santana | SS | 27.254 | Atlanta Braves | Atlanta Braves (MLB) | Designated for Assignment |
| Jeremy Hazelbaker | CF-LF | 30.340 | Minnesota Twins | Minnesota Twins (MLB) | Traded from Rays to Twins for cash |
| Jonny Venters | P | 33.121 | Tampa Bay Rays | Charlotte (A+) | Assigned to Charlotte (A+) for rehab |
| David Dahl | LF | 24.109 | Colorado Rockies | Albuquerque (AAA) | Assigned to Albuquerque (AAA) for rehab |
| Edwar Ramirez | P | 20.126 | St. Louis Cardinals | Gulf Coast Cardinals (Rk) | Assigned to Gulf Coast Cardinals (Rk) |
| Christopher Torres | SS | 20.163 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| Chaz Hebert | P | 25.318 | New York Yankees | Gulf Coast Yankees (Rk) | Assigned to Gulf Coast Yankees (Rk) |
| Wesley Benjamin | P | 24.358 | Texas Rangers | Arizona Rangers (Rk) | Assigned to Arizona Rangers (Rk) |
| Nick Hanson | P | 20.039 | Cincinnati Reds | Arizona Reds (Rk) | Assigned to Arizona Reds (Rk) |
| Kwang-Min Kwon | OF | 20.219 | Chicago Cubs | Arizona Cubs (Rk) | Assigned to Arizona Cubs (Rk) |
| Billy Cooke | OF-IF | 22.297 | Seattle Mariners | Arizona Mariners (Rk) | Assigned to Arizona Mariners (Rk) |
| Luis Rijo | P | 19.316 | New York Yankees | Tampa (A+) | Assigned to Tampa (A+) |
| Yoiber Marquina | C | 22.167 | Seattle Mariners | Pulaski (Rk) | Assigned to Pulaski (Rk) |
| Ryan Dobson | IF | 23.078 | Arizona Diamondbacks | Kane County (A) | Assigned to Kane County (A) |
| Lukas Young | P | 21.358 | Boston Red Sox | Lowell (A-) | Assigned to Lowell (A-) |
| Bubba Hollins | 3B | 22.226 | Miami Marlins | Greensboro (A) | Assigned to Greensboro (A) |
| Robbie Glendinning | IF | 22.287 | Pittsburgh Pirates | West Virginia (A) | Assigned to West Virginia (A) |
| Josh Smith | P | 28.281 | Boston Red Sox | Lowell (A-) | Assigned to Lowell (A-) |
| Telmito Agustin | OF | 21.283 | Washington Nationals | Potomac (A+) | Assigned to Potomac (A+) |
| Angel Padron | P | 20.306 | Boston Red Sox | Greenville (A) | Assigned to Greenville (A) |
| Tyler Thomas | P | 22.210 | Texas Rangers | Hickory (A) | Assigned to Hickory (A) |
| Chris Sharpe | OF | 22.043 | Pittsburgh Pirates | West Virginia (A) | DL-7 Injured |
| Isaias Lucena | C | 23.246 | Boston Red Sox | Greenville (A) | DL-7 Injured |
| Charlie Madden | C | 22.322 | Boston Red Sox | Greenville (A) | Activated from disabled list |
| Blake Tiberi | IF | 23.153 | New York Mets | St. Lucie (A+) | Assigned to St. Lucie (A+) |
| Rodrigo Ayarza | 2B | 23.149 | Miami Marlins | Jupiter (A+) | Assigned to Jupiter (A+) |
| Cameron Ming | P | 22.078 | Baltimore Orioles | Bowie (AA) | Assigned to Bowie (AA) |
| Jonathan Hennigan | P | 23.326 | Philadelphia Phillies | Clearwater (A+) | Assigned to Clearwater (A+) |
| Olbis Parra | P | 23.291 | San Francisco Giants | Richmond (AA) | Assigned to Richmond (AA) |
| Tyler Fallwell | P | 22.254 | Philadelphia Phillies | Lakewood (A) | Assigned to Lakewood (A) |
| Ricky Surum | IF | 23.224 | New York Yankees | Charleston (sc) (A) | Assigned to Charleston (sc) (A) |
| Micah Brown | SS | 22.071 | Miami Marlins | Jupiter (A+) | Assigned to Jupiter (A+) |
| Rigoberto Terrazas | 3B | 22.099 | New York Mets | Columbia (A) | Activated from disabled list |
| Jazz Chisholm | SS | 20.168 | Arizona Diamondbacks | Visalia (A+) | Assigned to Visalia (A+) |
| JaVon Shelby | SS | 23.074 | - | | Released by A's |
| Ranfi Casimiro | P | 26.003 | Philadelphia Phillies | Reading (AA) | Assigned to Reading (AA) |
| Vladimir Guerrero | OF | 19.125 | Toronto Blue Jays | New Hampshire (AA) | Assigned to New Hampshire (AA) |
| J.C. Millan | OF | 22.183 | Miami Marlins | Jupiter (A+) | DL-7 Injured |
| Tom Hackimer | P | 24.021 | Minnesota Twins | Fort Myers (A+) | DL-7 Injured |
| Willy Ortiz | P | 22.365 | Tampa Bay Rays | Charlotte (A+) | DL-7 Injured |
| Logan Warmoth | IF | 22.317 | Toronto Blue Jays | Dunedin (A+) | Activated from disabled list |
| Gary Cornish | P | 24.179 | New York Mets | St. Lucie (A+) | DL-7 Injured |
| Adam Atkins | P | 24.314 | New York Mets | St. Lucie (A+) | Activated from disabled list |
| Gabriel Lino | C | 25.063 | Philadelphia Phillies | Reading (AA) | Assigned to Reading (AA) |
| J.J. Franco | SS | 26.168 | New York Mets | Binghamton (AA) | Assigned to Binghamton (AA) |
| Nash Knight | IF | 25.302 | Toronto Blue Jays | Dunedin (A+) | Assigned to Dunedin (A+) |
| Santiago Espinal | SS | 23.248 | Toronto Blue Jays | New Hampshire (AA) | Assigned to New Hampshire (AA) |
| AJ Simcox | SS | 24.027 | Detroit Tigers | Lakeland (A+) | Assigned to Lakeland (A+) |
| Isaac Paredes | SS | 19.151 | Detroit Tigers | Erie (AA) | Assigned to Erie (AA) |
| Justin Twine | SS | 22.286 | Miami Marlins | Jacksonville (AA) | Assigned to Jacksonville (AA) |
| Estevan Florial | OF | 20.236 | New York Yankees | Tampa (A+) | Activated from disabled list |
| Matt Reistetter | C | 26.075 | Washington Nationals | Syracuse (AAA) | Assigned to Syracuse (AAA) |
| Alec Bettinger | P | 23.006 | Milwaukee Brewers | Carolina (A+) | Activated from disabled list |
| Alec Crawford | P | 26.191 | - | | Released by Brewers |
| Parker Curry | P | 24.240 | Los Angeles Dodgers | Tulsa (AA) | Assigned to Tulsa (AA) |
| Raymel Flores | SS | 23.300 | - | | Released by Diamondbacks |
| Shea Spitzbarth | P | 23.288 | Los Angeles Dodgers | Tulsa (AA) | Assigned to Tulsa (AA) |
| Logan Bawcom | P | 29.259 | Los Angeles Dodgers | Oklahoma City (AAA) | Assigned to Oklahoma City (AAA) |
| Elier Hernandez | RF-OF | 23.240 | Kansas City Royals | Omaha (AAA) | Assigned to Omaha (AAA) |
| Tyler Pike | P | 24.174 | Atlanta Braves | Mississippi (AA) | DL-7 Injured |
| Isan Diaz | SS | 22.053 | Miami Marlins | New Orleans (AAA) | Assigned to New Orleans (AAA) |
| Gunnar Heidt | IF | 25.310 | Toronto Blue Jays | Buffalo (AAA) | Assigned to Buffalo (AAA) |
| Champ Stuart | OF | 25.281 | New York Mets | Binghamton (AA) | DL-7 Injured |
| Mike Connolly | P | 26.262 | San Francisco Giants | Richmond (AA) | Assigned to Richmond (AA) |
| Daniel Salters | C | 25.164 | Cleveland Indians | Columbus (AAA) | Assigned to Columbus (AAA) |
| Ryan McBroom | 1B | 26.101 | New York Yankees | Trenton (AA) | Assigned to Trenton (AA) |
| Shawn O'Malley | SS | 30.204 | Colorado Rockies | Albuquerque (AAA) | Placed on temporarily inactive list |
| Cito Culver | SS | 25.327 | Miami Marlins | New Orleans (AAA) | DL-7 Injured |
| Justin De Fratus | P | 30.272 | Los Angeles Dodgers | Oklahoma City (AAA) | DL-7 Injured |
| Rusney Castillo | OF | 30.316 | Boston Red Sox | Pawtucket (AAA) | Activated from disabled list |
| Miguel Socolovich | P | 31.360 | Atlanta Braves | Gwinnett (AAA) | Activated from disabled list |
| Jeremy Hazelbaker | OF | 30.340 | Minnesota Twins | Rochester (AAA) | Assigned to Rochester (AAA) |
| Jordan Lyles | RP | 27.273 | San Diego Padres | El Paso (AAA) | Assigned to El Paso (AAA) for rehab |
| Brad Hand | RP | 28.121 | Cleveland Indians | Cleveland Indians (MLB) | Traded from Padres with Adam Cimber to Indians for Francisco Mejia |
| Adam Cimber | P | 27.338 | Cleveland Indians | Cleveland Indians (MLB) | Traded from Padres with Brad Hand to Padres for Francisco Mejia |
| Francisco Mejia | C | 22.266 | San Diego Padres | San Diego Padres (MLB) | Traded from Indians to Padres for Brad Hand and Adam Cimber |
| Kyle Higashioka | C | 28.090 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Assigned to Scranton/Wilkes-Barre (AAA) |
| Dalton Higgins | P | 22.346 | New York Yankees | Charleston (sc) (A) | Placed on temporarily inactive list |
| Brett Stephens | OF | 23.123 | - | | Announced retirement |
| Zach Coppola | OF | 24.071 | - | | Announced retirement |
| Jaff Decker | OF | 28.146 | - | | Released by Nationals |
| Zach Coppola | OF | 24.071 | - | | Announced retirement |
| Miles Mikolas | RP | 29.330 | St. Louis Cardinals | St. Louis Cardinals (MLB) | Reinstated to active roster |
| Matt Bowman | RP | 27.049 | St. Louis Cardinals | Memphis (AAA) | Assigned to Memphis (AAA) |
| Luke Weaver | SP | 24.332 | St. Louis Cardinals | St. Louis Cardinals (MLB) | Recalled from Memphis (AAA) |
| John Brebbia | RP | 28.050 | St. Louis Cardinals | St. Louis Cardinals (MLB) | Recalled from Memphis (AAA) |
| Rafael Devers | 3B | 21.268 | Boston Red Sox | Boston Red Sox (MLB) | Activated from DL |
| Bobby Poyner | p | 25.230 | Boston Red Sox | Pawtucket (AAA) | Assigned to Pawtucket (AAA) |
| James Norwood | P | 24.207 | Chicago Cubs | Iowa (AAA) | Assigned to Iowa (AAA) |
| Anthony Bass | RP | 30.261 | Chicago Cubs | Chicago Cubs (MLB) | DL-10 Right mid-thoracic strain |
| Luke Farrell | p | 27.042 | Chicago Cubs | Chicago Cubs (MLB) | Recalled from Iowa (AAA) |
| Dillon Maples | P | 26.071 | Chicago Cubs | Chicago Cubs (MLB) | Recalled from Iowa (AAA) |
| Domingo Acevedo | P | 24.046 | New York Yankees | New York Yankees (MLB) | Recalled from Trenton (AA) |
| Domingo German | P | 25.349 | New York Yankees | New York Yankees (MLB) | Recalled from Scranton/Wilkes-Barre (AAA) |
| Harrison Musgrave | P | 26.138 | Colorado Rockies | Albuquerque (AAA) | Assigned to Albuquerque (AAA) for rehab |
| Jake Junis | RP | 25.306 | Kansas City Royals | Kansas City Royals (MLB) | Activated from DL |
| Brett Stephens | OF | 23.123 | - | | Announced retirement |
| Zach Coppola | OF | 24.071 | - | | Announced retirement |
| Brett Stephens | OF | 23.123 | - | | Announced retirement |
| Zach Coppola | OF | 24.071 | - | | Announced retirement |
| Marc Rzepczynski | P | 32.345 | | | Refused minor league assignment, declared free agent |
| Kyle Isbel | OF | 21.138 | Kansas City Royals | Lexington (A) | Assigned to Lexington (A) |
| Alex King | SS | 22.290 | Arizona Diamondbacks | Hillsboro (A-) | Assigned to Hillsboro (A-) |
| Gunnar Schubert | SS | 22.061 | Miami Marlins | Greensboro (A) | Assigned to Greensboro (A) |
| Garrett Suchey | P | 23.236 | Kansas City Royals | Lexington (A) | Activated from disabled list |
| Grant Anderson | P | 21.028 | Seattle Mariners | Arizona Mariners (Rk) | Assigned to Arizona Mariners (Rk) |
| Antonio Hernandez | P | 18.296 | Los Angeles Dodgers | Rancho Cucamonga (A+) | Assigned to Rancho Cucamonga (A+) |
| Elian Leyva | P | 29.124 | Atlanta Braves | Mississippi (AA) | Assigned to Mississippi (AA) |
| Justin Grimm | P | 29.337 | Seattle Mariners | Tacoma (AAA) | Assigned to Tacoma (AAA) |
| Logan Gillaspie | P | 21.093 | Milwaukee Brewers | Arizona Brewers (Rk) | Assigned to Arizona Brewers (Rk) |
