| Yelmison Peralta | P | 23.068 | Chicago White Sox | Winston-Salem (A+) | Assigned to Winston-Salem (A+) |
| Daniel Ramos | P | 23.065 | New York Yankees | Charleston (sc) (A) | DL-7 Injured |
| Jacob Taylor | P | 22.310 | Pittsburgh Pirates | West Virginia (A) | DL-7 Injured |
| Charlie Madden | C | 22.252 | Boston Red Sox | Greenville (A) | Activated from disabled list |
| Jake Simon | P | 21.109 | New York Mets | Columbia (A) | DL-7 Injured |
| Jay Jabs | 3B | 23.222 | New York Mets | Columbia (A) | Assigned to Columbia (A) |
| Oliver Nunez | SS | 23.078 | Kansas City Royals | Wilmington (A+) | Assigned to Wilmington (A+) |
| Austin DeCarr | P | 23.057 | New York Yankees | Charleston (sc) (A) | Assigned to Charleston (sc) (A) |
| Isaias Lucena | C | 23.176 | Boston Red Sox | Salem (A+) | Assigned to Salem (A+) |
| Ben Braymer | P | 24.012 | Washington Nationals | Potomac (A+) | Assigned to Potomac (A+) |
| Sergio Cubilete | P | 23.052 | Pittsburgh Pirates | West Virginia (A) | Activated from disabled list |
| Gabriel Bracamonte | C | 22.361 | - | | Released by Astros |
| Marcos Almonte | 3B | 22.043 | - | | Released by Astros |
| Miguel Angel Sierra | SS | 20.159 | Houston Astros | Quad Cities (A) | Assigned to Quad Cities (A) |
| Gian Paul Gonzalez | C | 22.120 | Cleveland Indians | Akron (AA) | Assigned to Akron (AA) |
| Nick Yarnall | OF | 23.205 | Los Angeles Dodgers | Rancho Cucamonga (A+) | Assigned to Rancho Cucamonga (A+) |
| Eric Peterson | 2B | 24.230 | Los Angeles Dodgers | Great Lakes (A) | Assigned to Great Lakes (A) |
| Zach Shepherd | SS | 22.239 | Detroit Tigers | Lakeland (A+) | Assigned to Lakeland (A+) |
| Cesar Gonzalez | OF | 22.345 | Detroit Tigers | West Michigan (A) | Assigned to West Michigan (A) |
| Cole Watts | P | 22.190 | - | | Released by Astros |
| Ty Tice | P | 21.310 | Toronto Blue Jays | Dunedin (A+) | Assigned to Dunedin (A+) |
| Kellin Deglan | C | 26.007 | New York Yankees | Tampa (A+) | Assigned to Tampa (A+) |
| William Ouellette | P | 24.314 | Toronto Blue Jays | Dunedin (A+) | DL-7 Injured |
| Blaise Salter | C | 24.319 | Detroit Tigers | Erie (AA) | Assigned to Erie (AA) |
| Reimin Ramos | P | 22.013 | Tampa Bay Rays | Charlotte (A+) | Assigned to Charlotte (A+) |
| Jimmy Kerrigan | OF | 24.055 | Minnesota Twins | Fort Myers (A+) | Assigned to Fort Myers (A+) |
| Curtis Taylor | P | 22.290 | Tampa Bay Rays | Montgomery (AA) | Assigned to Montgomery (AA) |
| Boo Vazquez | OF | 25.036 | - | | Released by Marlins |
| Anfernee Seymour | SS | 22.321 | Miami Marlins | Jupiter (A+) | Signed to Minor League Contract |
| Matt Crownover | P | 25.066 | Washington Nationals | Potomac (A+) | DL-7 Injured |
| Mariano Rivera | P | 24.218 | Washington Nationals | Potomac (A+) | Placed on temporarily inactive list |
| Roldani Baldwin | C | 22.055 | Boston Red Sox | Salem (A+) | DL-7 Injured |
| Brandon Downes | OF | 25.223 | Kansas City Royals | Northwest Arkansas (AA) | Assigned to Northwest Arkansas (AA) |
| Juan Soto | OF | 19.197 | Washington Nationals | Harrisburg (AA) | Assigned to Harrisburg (AA) |
| Alec Keller | OF | 25.362 | Washington Nationals | Potomac (A+) | Assigned to Potomac (A+) |
| Tyler Pearson | C | 26.025 | Chicago Cubs | Iowa (AAA) | Assigned to Iowa (AAA) |
| Jose Ruiz | C | 23.201 | Chicago White Sox | Birmingham (AA) | Assigned to Birmingham (AA) |
| Zach Reks | OF | 24.179 | Los Angeles Dodgers | Tulsa (AA) | Assigned to Tulsa (AA) |
| Roberto Baldoquin | SS | 23.361 | Los Angeles Angels | Inland Empire (A+) | Activated from disabled list |
| Diomar Lopez | P | 21.146 | San Diego Padres | Lake Elsinore (A+) | Assigned to Lake Elsinore (A+) |
| Logan Landon | P | 25.082 | Los Angeles Dodgers | Rancho Cucamonga (A+) | Assigned to Rancho Cucamonga (A+) |
| Lake Bachar | P | 22.342 | San Diego Padres | San Antonio (AA) | Assigned to San Antonio (AA) |
| Richie Fecteau | 2B | 24.054 | Los Angeles Angels | Inland Empire (A+) | DL-7 Injured |
| Dario Pizzano | OF | 27.015 | Seattle Mariners | Arkansas (AA) | Activated from disabled list |
| Alfredo Escalera-Maldonado | OF | 23.082 | Kansas City Royals | Northwest Arkansas (AA) | DL-7 Injured |
| Andrew Aplin | OF | 27.050 | Seattle Mariners | Arkansas (AA) | DL-7 Injured |
| Jacob Scavuzzo | OF | 24.115 | Los Angeles Dodgers | Oklahoma City (AAA) | Assigned to Oklahoma City (AAA) |
| Brian Moran | P | 29.222 | Los Angeles Dodgers | Tulsa (AA) | Assigned to Tulsa (AA) |
| Josh Sborz | P | 24.144 | Los Angeles Dodgers | Oklahoma City (AAA) | Assigned to Oklahoma City (AAA) |
| Jesse Scholtens | P | 24.034 | San Diego Padres | El Paso (AAA) | Assigned to El Paso (AAA) |
| Wade Wass | C | 26.230 | Los Angeles Angels | Mobile (AA) | DL-7 Injured |
| Marty Herum | 1B | 26.146 | Arizona Diamondbacks | Jackson (AA) | Activated from disabled list |
| Zach Jones | P | 27.157 | Minnesota Twins | Chattanooga (AA) | DL-7 Injured |
| Casey Crosby | P | 29.235 | Minnesota Twins | Chattanooga (AA) | Assigned to Chattanooga (AA) |
| Francisco Arcia | C | 28.238 | Los Angeles Angels | Mobile (AA) | Assigned to Mobile (AA) |
| Dylan Moore | IF | 25.281 | Milwaukee Brewers | Colorado Springs (AAA) | Assigned to Colorado Springs (AAA) |
| Jorge Rondon | P | 30.084 | - | | Released by White Sox |
| Jordan Harrison | P | 27.031 | Tampa Bay Rays | Durham (AAA) | Assigned to Durham (AAA) |
| J.T. Brubaker | P | 24.174 | Pittsburgh Pirates | Indianapolis (AAA) | Assigned to Indianapolis (AAA) |
| Ryan Mountcastle | SS | 21.081 | Baltimore Orioles | Bowie (AA) | Activated from disabled list |
| Ray Black | P | 27.318 | San Francisco Giants | Sacramento (AAA) | Assigned to Sacramento (AAA) |
| Dominic DeMasi | P | 24.357 | Cleveland Indians | Columbus (AAA) | Assigned to Columbus (AAA) |
| Daniel Salters | C | 25.094 | Cleveland Indians | Columbus (AAA) | Assigned to Columbus (AAA) |
| Corey Taylor | P | 25.122 | New York Mets | Binghamton (AA) | Assigned to Binghamton (AA) |
| Ranfi Casimiro | P | 25.298 | Philadelphia Phillies | Lehigh Valley (AAA) | Assigned to Lehigh Valley (AAA) |
| Bruce Caldwell | 2B | 26.165 | New York Yankees | Trenton (AA) | Assigned to Trenton (AA) |
| Vince Conde | IF | 24.209 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Assigned to Scranton/Wilkes-Barre (AAA) |
| Gabriel Quintana | 3B | 25.245 | Detroit Tigers | Toledo (AAA) | Assigned to Toledo (AAA) |
| Scott Copeland | P | 30.147 | New York Mets | Las Vegas (AAA) | Assigned to Las Vegas (AAA) |
| Chris Jensen | P | 27.222 | Colorado Rockies | Hartford (AA) | Assigned to Hartford (AA) |
| Adrian Marin | SS | 24.063 | Baltimore Orioles | Norfolk (AAA) | Assigned to Norfolk (AAA) |
| Daniel McGrath | P | 23.307 | Boston Red Sox | Lowell (A-) | Assigned to Lowell (A-) |
| Tanner Nishioka | 2B | 23.200 | Boston Red Sox | Portland (AA) | Assigned to Portland (AA) |
| Dillon McNamara | P | 26.217 | San Francisco Giants | Richmond (AA) | Assigned to Richmond (AA) |
| Max Schuh | P | 26.058 | - | | Released by Rockies |
| Wirkin Estevez | P | 26.056 | Washington Nationals | Harrisburg (AA) | DL-7 Injured |
| Taylor Davis | C | 28.163 | Chicago Cubs | Iowa (AAA) | DL-7 Injured |
| Seth Maness | P | 29.208 | - | | Released by Royals |
| Kyle Hoppy | CF | 27.002 | Chicago Cubs | Iowa (AAA) | Assigned to Iowa (AAA) |
| Kyle Lohse | P | 39.218 | - | | Released by Royals |
| Billy Burns | OF | 28.253 | Kansas City Royals | Omaha (AAA) | Assigned to Omaha (AAA) |
| Cody Hall | P | 30.125 | Tampa Bay Rays | Durham (AAA) | DL-7 Injured |
| Jake Reed | P | 25.223 | Minnesota Twins | Rochester (AAA) | Activated from disabled list |
| Brandon Finnegan | SP | 25.026 | Cincinnati Reds | Louisville (AAA) | Assigned to Louisville (AAA) |
| Jabari Blash | RF | 28.310 | Los Angeles Angels | Salt Lake (AAA) | Assigned to Salt Lake (AAA) |
| Brett Cecil | RP | 31.312 | St. Louis Cardinals | Memphis (AAA) | Assigned to Memphis (AAA) for rehab |
| Ben Lively | P | 26.066 | Philadelphia Phillies | Lehigh Valley (AAA) | Assigned to Lehigh Valley (AAA) for rehab |
| Boone Logan | RP | 33.270 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Activated from DL |
| Merandy Gonzalez | p | 22.214 | Miami Marlins | Jacksonville (AA) | Assigned to Jacksonville (AA) |
| Elieser Hernandez | P | 23.007 | Miami Marlins | Miami Marlins (MLB) | Activated from DL |
| Dan Altavilla | RP | 25.244 | Seattle Mariners | Arkansas (AA) | Assigned to Arkansas (AA) for rehab |
| Ryan Lamarre | CF | 29.170 | Minnesota Twins | Rochester (AAA) | Assigned to Rochester (AAA) |
| Byron Buxton | CF | 24.143 | Minnesota Twins | Minnesota Twins (MLB) | Activated from DL |
| Jorge Lopez | SP | 25.089 | Milwaukee Brewers | Colorado Springs (AAA) | Assigned to Colorado Springs (AAA) |
| Billy McKinney | CF | 23.260 | New York Yankees | Tampa (A+) | Assigned to Tampa (A+) for rehab |
| Greg Bird | 1B | 25.182 | New York Yankees | Tampa (A+) | Assigned to Tampa (A+) for rehab |
| Brandon Drury | 3B | 25.262 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Assigned to Scranton/Wilkes-Barre (AAA) for rehab |
| Mike Mayers | RP | 26.156 | St. Louis Cardinals | St. Louis Cardinals (MLB) | Recalled from Memphis (AAA) |
| Carlos Martinez | SP | 26.232 | St. Louis Cardinals | St. Louis Cardinals (MLB) | DL-10 Right latissimus strain |
| Johnny Cueto | SP | 32.084 | San Francisco Giants | San Francisco Giants (MLB) | Transferred to 60-day DL |
| Jose Valdez | RP | 28.070 | San Francisco Giants | San Francisco Giants (MLB) | Contract purchased from minors |
| Josh Osich | RP | 29.249 | San Francisco Giants | Sacramento (AAA) | Activated from DL and assigned to Sacramento (AAA) |
| Derek Law | P | 27.238 | San Francisco Giants | Sacramento (AAA) | DL-10 Injured |
| Jake Thompson | SP | 24.099 | Philadelphia Phillies | Philadelphia Phillies (MLB) | Recalled from Lehigh Valley (AAA) |
| Zac Curtis | RP | 25.310 | Philadelphia Phillies | Lehigh Valley (AAA) | Assigned to Lehigh Valley (AAA) |
| Keynan Middleton | RP | 24.240 | Los Angeles Angels | Los Angeles Angels (MLB) | Activated from DL |
| Juan Moreno | 2B | 23.174 | - | | Released by Angels |
| J.B. Wendelken | P | 25.047 | Oakland Athletics | Nashville (AAA) | Assigned to Nashville (AAA) |
| Darren Seferina | 2B | 24.106 | Milwaukee Brewers | Biloxi (AA) | Signed to Minor League Contract |
| Tyler Olson | P | 28.220 | Cleveland Indians | Cleveland Indians (MLB) | Placed on paternity leave list |
| Darren Seferina | 2B | 24.106 | Milwaukee Brewers | Biloxi (AA) | Assigned to Biloxi (AA) |
| Kyle Lohse | P | 39.218 | | | Announced retirement |
| Blake Smith | P | 23.156 | | | Announced retirement |
