| Jake Holmes | ss | 19.003 | Philadelphia Phillies | Gulf Coast Phillies (Rk) | Signed out of draft (Arizona HS) |
| Mac Sceroler | p | 22.087 | Cincinnati Reds | Billings (Rk) | Signed out of draft (Southeastern LA) |
| Jose Albertos | p | 18.240 | Chicago Cubs | Eugene (A-) | Assigned to Eugene (A-) |
| Greg Allen | OF | 24.112 | Cleveland Indians | Akron (AA) | Assigned to Akron (AA) |
| Yoan Aybar | of | 20.002 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| Tyler Badamo | P | 24.331 | Arizona Diamondbacks | Visalia (A+) | Assigned to Visalia (A+) |
| Chris Baker | ss | 22.218 | San Diego Padres | Lake Elsinore (A+) | Activated from disabled list |
| Juan Barriento | of | 21.068 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| Johan Belisario | P | 23.326 | Detroit Tigers | Gulf Coast Tigers (East) (Rk) | Assigned to Gulf Coast Tigers (East) (Rk) |
| Garrett Benge | 3b | 21.190 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| Tyler Benson | of | 21.018 | San Diego Padres | Tri-City (A-) | Assigned to Tri-City (A-) |
| Ihan Bernal | c | 20.258 | Houston Astros | Corpus Christi (AA) | Assigned to Corpus Christi (AA) |
| Gustavo Campero | c | 19.288 | New York Yankees | Gulf Coast Yankees (Rk) | Assigned to Gulf Coast Yankees (Rk) |
| Jheyson Caraballo | p | 21.263 | Houston Astros | Gulf Coast Astros (Rk) | Assigned to Gulf Coast Astros (Rk) |
| Rusney Castillo | LF | 29.302 | Boston Red Sox | Pawtucket (AAA) | Activated from disabled list |
| Ricardo Cespedes | of | 19.315 | New York Mets | Brooklyn (A-) | Assigned to Brooklyn (A-) |
| Miles Chambers | p | 23.256 | New York Yankees | Gulf Coast Yankees (Rk) | Activated from disabled list |
| Tyler Cloyd | SP-RP | 30.050 | Seattle Mariners | Everett (A-) | Activated from disabled list |
| Taylor Cole | P | 27.319 | Toronto Blue Jays | Gulf Coast Blue Jays (Rk) | Activated from disabled list |
| Zach Collier | CF | 26.300 | Washington Nationals | Harrisburg (AA) | Assigned to Harrisburg (AA) |
| Gavin Collins | c | 21.354 | Cleveland Indians | Lynchburg (A+) | Assigned to Lynchburg (A+) |
| Daniel Corcino | P | 26.313 | Los Angeles Dodgers | Rancho Cucamonga (A+) | Activated from disabled list |
| Collin Cowgill | LF | 31.044 | San Diego Padres | Arizona Padres (Rk) | Activated from disabled list |
| Kutter Crawford | p | 21.095 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| Rookie Davis | P | 24.067 | Cincinnati Reds | Pensacola (AA) | Assigned to Pensacola (AA) |
| Enmanuel De Jesus | p | 20.207 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| Sam Dexter | ss | 23.120 | Chicago White Sox | Winston-Salem (A+) | Assigned to Winston-Salem (A+) |
| Imeldo Diaz | ss | 19.245 | St. Louis Cardinals | State College (A-) | Assigned to State College (A-) |
| Nick Duron | p | 21.157 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| Cody Ege | RP | 26.058 | Los Angeles Angels | Salt Lake (AAA) | Activated from disabled list |
| Stanley Espinal | if | 20.232 | St. Louis Cardinals | State College (A-) | Assigned to State College (A-) |
| Tyler Fallwell | p | 21.240 | Kansas City Royals | Lexington (A) | Assigned to Lexington (A) |
| Devon Fisher | C | 21.065 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| Billy Fleming | 2B | 24.288 | New York Yankees | Trenton (AA) | Assigned to Trenton (AA) |
| Juan Florentino | p | 20.300 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| Ti'Quan Forbes | SS | 20.313 | Texas Rangers | Down East (A+) | Assigned to Down East (A+) |
| Mike Ford | P | 25.001 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Assigned to Scranton/Wilkes-Barre (AAA) |
| Mike Franco | P | 25.228 | Tampa Bay Rays | Montgomery (AA) | Assigned to Montgomery (AA) |
| Tyler Frohwirth | p | 23.295 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| Carlos Garay | C | 22.273 | Texas Rangers | Down East (A+) | Assigned to Down East (A+) |
| Rony Garcia | p | 19.198 | New York Yankees | Charleston (sc) (A) | Assigned to Charleston (sc) (A) |
| Ryan Garton | RP | 27.212 | Tampa Bay Rays | Durham (AAA) | Activated from disabled list |
| Angel German | p | 21.041 | Los Angeles Dodgers | Great Lakes (A) | Activated from disabled list |
| Nicholos Hamilton | of | 19.213 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| Yonardo Herdenez | p | 21.289 | Toronto Blue Jays | Bluefield (Rk) | Assigned to Bluefield (Rk) |
| Elieser Hernandez | P | 22.063 | Houston Astros | Gulf Coast Astros (Rk) | Activated from disabled list |
| J.J. Hoover | RP | 29.327 | Arizona Diamondbacks | Arizona Diamondbacks (Rk) | Assigned to Arizona Diamondbacks (Rk) for rehab |
| Colt Hynes | RP | 32.007 | Los Angeles Dodgers | Oklahoma City (AAA) | Assigned to Oklahoma City (AAA) |
| Brian Johnson | SP | 26.210 | Boston Red Sox | Pawtucket (AAA) | Assigned to Pawtucket (AAA) for rehab |
| Janson Junk | p | 21.172 | New York Yankees | Gulf Coast Yankees (Rk) | Assigned to Gulf Coast Yankees (Rk) |
| Brian Keller | p | 23.014 | New York Yankees | Tampa (A+) | Assigned to Tampa (A+) |
| Jon Keller | P | 24.331 | Baltimore Orioles | Aberdeen (A-) | Assigned to Aberdeen (A-) |
| Jake Kelzer | p | 24.005 | Philadelphia Phillies | Lakewood (A) | Assigned to Lakewood (A) |
| Nick King | ss | 23.235 | Pittsburgh Pirates | West Virginia (A-) | Assigned to West Virginia (A-) |
| Tyler Ladendorf | 2B | 29.120 | Chicago White Sox | Charlotte (AAA) | Activated from disabled list |
| Raiwinson Lameda | of | 21.272 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| Rafael Lara | p | 22.025 | New York Yankees | Gulf Coast Yankees (Rk) | Activated from disabled list |
| Charles Leblanc | ss | 21.032 | Texas Rangers | Hickory (A) | Assigned to Hickory (A) |
| Dominic LoBrutto | p | 21.035 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| Charlie Madden | c | 21.308 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| Starling Marte | CF | 28.269 | Pittsburgh Pirates | Indianapolis (AAA) | Assigned to Indianapolis (AAA) for rehab |
| Joan Martinez | p | 20.310 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| Jeremy McKinney | p | 22.209 | Washington Nationals | Auburn (A-) | Assigned to Auburn (A-) |
| Kevin Medrano | IF | 27.045 | Arizona Diamondbacks | Jackson (AA) | Assigned to Jackson (AA) |
| Trevor Megill | p | 23.212 | San Diego Padres | Lake Elsinore (A+) | Assigned to Lake Elsinore (A+) |
| Samuel Miranda | c | 19.318 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| Joseph Monge | RF | 22.048 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| Jose Morales | P | 22.143 | Washington Nationals | Hagerstown (A) | Assigned to Hagerstown (A) |
| Jhonatan Munoz | p | 17.330 | New York Yankees | Gulf Coast Yankees (Rk) | Assigned to Gulf Coast Yankees (Rk) |
| Brett Netzer | 2b | 21.031 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| Tanner Nishioka | 3b | 22.256 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| Durin O'Linger | p | 23.268 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| Jared Oliver | p | 24.154 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| Michael Osinski | 3b | 21.336 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| Mitchell Osnowitz | P | 26.003 | Miami Marlins | Batavia (A-) | Activated from disabled list |
| Hunter Owen | of | 23.286 | Pittsburgh Pirates | West Virginia (A) | Assigned to West Virginia (A) |
| Bryan Ozuna | p | 23.114 | Arizona Diamondbacks | Arizona Diamondbacks (Rk) | Assigned to Arizona Diamondbacks (Rk) |
| Kevin Padlo | 3B | 20.355 | Tampa Bay Rays | Gulf Coast Rays (Rk) | Assigned to Gulf Coast Rays (Rk) |
| Yorvin Pantoja | p | 19.286 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| Wily Peralta | SP | 28.058 | Milwaukee Brewers | Colorado Springs (AAA) | Assigned to Colorado Springs (AAA) for rehab |
| Luis Perdomo | 1b | 20.045 | Washington Nationals | Gulf Coast Nationals (Rk) | Assigned to Gulf Coast Nationals (Rk) |
| Brallan Perez | 2B | 21.160 | Texas Rangers | Hickory (A) | Assigned to Hickory (A) |
| Danienger Perez | ss | 20.241 | New York Yankees | Pulaski (Rk) | Assigned to Pulaski (Rk) |
| Dillon Peters | P | 24.308 | Miami Marlins | Gulf Coast Marlins (Rk) | Assigned to Gulf Coast Marlins (Rk) |
| Adonis Pichardo | p | 21.087 | Pittsburgh Pirates | Bristol (Rk) | Assigned to Bristol (Rk) |
| Yohel Pozo | c | 20.021 | Texas Rangers | Hickory (A) | Assigned to Hickory (A) |
| Cal Quantrill | p | 22.145 | San Diego Padres | Arizona Padres (Rk) | Assigned to Arizona Padres (Rk) |
| Luis Ramirez | p | 21.221 | Houston Astros | Gulf Coast Astros (Rk) | Assigned to Gulf Coast Astros (Rk) |
| Denyi Reyes | p | 20.245 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| Frankie Rios | ss | 22.039 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| Tim Roberson | C | 27.351 | Boston Red Sox | Pawtucket (AAA) | Activated from disabled list |
| Francisco Rodriguez | CL | 35.179 | Washington Nationals | Harrisburg (AA) | Signed to Minor League Contract |
| Greg Ross | P | 27.302 | Washington Nationals | Syracuse (AAA) | Reinstated to active roster |
| Casey Sadler | P | 26.357 | Pittsburgh Pirates | Altoona (AA) | Assigned to Altoona (AA) |
| Vin Santarsiero | p | 23.207 | Los Angeles Dodgers | Great Lakes (A) | Activated from disabled list |
| Craig Schlitter | P | 25.050 | Colorado Rockies | Hartford (AA) | Assigned to Hartford (AA) |
| Nick Sciortino | c | 21.350 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| Sam Selman | P | 26.233 | Kansas City Royals | Omaha (AAA) | Assigned to Omaha (AAA) |
| Logan Shore | p | 22.189 | Oakland Athletics | Arizona Athletics (Rk) | Activated from disabled list |
| Luis Silva | 2b | 22.005 | Toronto Blue Jays | Dunedin (A+) | Activated from disabled list |
| Juan Soto | of | 18.253 | Washington Nationals | Hagerstown (A) | Assigned to Hagerstown (A) |
| Josh Staumont | p | 23.196 | Kansas City Royals | Northwest Arkansas (AA) | Assigned to Northwest Arkansas (AA) |
| Tyrone Taylor | OF | 23.164 | Milwaukee Brewers | Arizona Brewers (Rk) | Activated from disabled list |
| Andrew Thurman | P | 25.208 | Los Angeles Dodgers | Tulsa (AA) | Assigned to Tulsa (AA) |
| Ashur Tolliver | P | 29.163 | Houston Astros | Fresno (AAA) | Assigned to Fresno (AAA) |
| Christopher Torres | ss | 19.149 | Seattle Mariners | Everett (A-) | Assigned to Everett (A-) |
| Alberto Triunfel | SS | 23.154 | Los Angeles Angels | Mobile (AA) | Activated from disabled list |
| Mike Trout | CF | 25.333 | Los Angeles Angels | Inland Empire (A+) | Assigned to Inland Empire (A+) for rehab |
| Seth Varner | P | 25.160 | Cincinnati Reds | Daytona (A+) | Assigned to Daytona (A+) |
| Kender Villegas | P | 24.027 | Toronto Blue Jays | New Hampshire (AA) | Assigned to New Hampshire (AA) |
| Thad Weber | RP | 32.280 | Colorado Rockies | Albuquerque (AAA) | Activated from disabled list |
| Matt Whatley | c | 21.180 | Texas Rangers | Spokane (A-) | Assigned to Spokane (A-) |
| Tyler Wilson | RP | 27.283 | Baltimore Orioles | Norfolk (AAA) | Assigned to Norfolk (AAA) |
| Kolten Wong | 2B | 26.268 | St. Louis Cardinals | Springfield (AA) | Assigned to Springfield (AA) for rehab |
| Jordan Wren | of | 23.285 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| Angel Yepez | P | 22.069 | Tampa Bay Rays | Bowling Green (A) | Activated from disabled list |
| Lukas Young | p | 20.344 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| Yeyson Yrizarri | SS | 20.153 | Texas Rangers | Down East (A+) | Assigned to Down East (A+) |
| Arodys Vizcaino | RP | 26.234 | Atlanta Braves | Atlanta Braves (MLB) | DL-10 Strained right index finger |
| Matt Wisler | SP | 24.296 | Atlanta Braves | Atlanta Braves (MLB) | Recalled from Gwinnett (AAA) |
| Huston Street | CL | 33.338 | Los Angeles Angels | Los Angeles Angels (MLB) | DL-10 Right adductor/groin strain |
| Eduardo Paredes | P | 22.121 | Los Angeles Angels | Los Angeles Angels (MLB) | Recalled from Salt Lake (AAA) |
| Joe Musgrove | SP | 24.213 | Houston Astros | Houston Astros (MLB) | Recalled from Fresno (AAA) |
| Tom Layne | RP | 32.245 | | | Released by Yankees |
| Ryan Flaherty | SS | 30.343 | Baltimore Orioles | Baltimore Orioles (MLB) | Transferred to 60-day DL |
| Matt Den Dekker | RF-CF | 29.330 | Detroit Tigers | Detroit Tigers (MLB) | Designated for Assignment |
| James Adduci | RF | 32.051 | Detroit Tigers | Toledo (AAA) | Activated from DL and assigned to Toledo (AAA) |
| Alex Presley | RF-LF | 31.345 | Detroit Tigers | Detroit Tigers (MLB) | Activated from DL |
| Jurickson Profar | LF | 24.135 | Texas Rangers | Texas Rangers (MLB) | Recalled from Round Rock (AAA) |
| Elvis Andrus | SS | 28.313 | Texas Rangers | Texas Rangers (MLB) | Placed on paternity leave list |
| Ariel Hernandez | P | 25.125 | Cincinnati Reds | Cincinnati Reds (MLB) | Recalled from Louisville (AAA) |
| Carlos Santana | 1B-RF | 31.088 | Cleveland Indians | Cleveland Indians (MLB) | Placed on paternity leave list |
| Abraham Almonte | RF-CF | 28.014 | Cleveland Indians | Cleveland Indians (MLB) | Activated from DL |
| Alan Busenitz | P | 26.317 | Minnesota Twins | Minnesota Twins (MLB) | Recalled from Rochester (AAA) |
| Hector Santiago | SP | 29.202 | Minnesota Twins | Minnesota Twins (MLB) | DL-10 Upper thoracic back pain |
| Ryan Lavarnway | C | 29.333 | Oakland Athletics | Oakland Athletics (MLB) | Contract purchased from minors |
| Josh Phegley | C | 29.144 | Oakland Athletics | Oakland Athletics (MLB) | Placed on paternity leave list |
| Devin Mesoraco | C | 29.016 | Cincinnati Reds | Cincinnati Reds (MLB) | DL-10 Left shoulder strain |
| Brandon Snyder | LF | 30.224 | Washington Nationals | Syracuse (AAA) | DL-7 Injured |
| Carter Capps | RP | 26.332 | San Diego Padres | El Paso (AAA) | DL-7 Injured |
| Tayron Guerrero | RP | 26.177 | Miami Marlins | Jacksonville (AA) | Placed on temporary inactive list |
| Logan Taylor | P | 25.205 | New York Mets | Las Vegas (AAA) | DL-7 Injured |
| Louis Silverio | OF | 23.202 | Chicago White Sox | Winston-Salem (A+) | DL-7 Injured |
| Richelson Pena | P | 23.279 | Texas Rangers | Down East (A+) | Placed on temporary inactive list |
| Art Charles | 1B | 26.237 | Milwaukee Brewers | Biloxi (AA) | DL-7 Injured |
| Jose Queliz | C | 24.332 | Arizona Diamondbacks | Visalia (A+) | DL-7 Injured |
| Joseph Odom | C | 25.178 | Atlanta Braves | Mississippi (AA) | DL-7 Injured |
| Omar Obregon | SS | 23.078 | Atlanta Braves | Mississippi (AA) | DL-7 Injured |
| Ryan McNeil | P | 23.154 | Chicago Cubs | Tennessee (AA) | DL-7 Injured |
| Tyler Herb | P | 25.068 | San Francisco Giants | San Francisco Giants (MLB) | Traded from Mariners to Giants for cash considerations |
| Andrew Calica | of | 23.122 | Cleveland Indians | Lynchburg (A+) | DL-7 Injured |
| Austin Wilson | OF | 25.149 | | | Released by Cardinals |
| Cody Sedlock | p | 22.016 | Baltimore Orioles | Frederick (A+) | DL-7 Injured |
| J.J. Gould | ss | 23.317 | | | Released by Marlins |
| Mitch Horacek | P | 25.215 | Baltimore Orioles | Frederick (A+) | DL-7 Injured |
| Sam Haggerty | 2b | 23.040 | Cleveland Indians | Lynchburg (A+) | DL-7 Injured |
| Enmanuel Garcia | 1b | 22.347 | | | Released by Phillies |
| Cesar Gonzalez | of | 22.035 | Detroit Tigers | Gulf Coast Tigers (East) (Rk) | DL-7 Injured |
| Dean Aldridge | P | 22.341 | Detroit Tigers | Gulf Coast Tigers (East) (Rk) | DL-7 Injured |
| Francys Peguero | p | 21.275 | Washington Nationals | Gulf Coast Nationals (Rk) | DL-7 Injured |
| Jon Reid | p | 22.007 | | | Released by Nationals |
| Jonas Lantigua | 1B | 22.202 | | | Released by Mariners |
| Joseph Baltrip | p | 22.140 | | | Released by Nationals |
| Zach Daly | of | 23.204 | | | Released by Marlins |
| Daniel Padilla | of | 20.139 | Los Angeles Dodgers | Arizona Dodgers (Rk) | DL-60 Injured |
| Franklin Arias | of | 20.177 | Detroit Tigers | Gulf Coast Tigers (East) (Rk) | DL-7 Injured |
| Joey Harris | c | 23.142 | Washington Nationals | Gulf Coast Nationals (Rk) | DL-7 Injured |
| Leif Strom | p | 20.049 | Washington Nationals | Gulf Coast Nationals (Rk) | DL-7 Injured |
| Moises Bello | 3b | 20.022 | Detroit Tigers | Gulf Coast Tigers (East) (Rk) | DL-7 Injured |
| Trey Turner | p | 21.020 | Washington Nationals | Gulf Coast Nationals (Rk) | DL-7 Injured |
| Brian Glowicki | p | 22.259 | Chicago Cubs | Eugene (A-) | Signed out of draft (Minnesota) |
| Casey Ryan | p | 23.046 | Chicago Cubs | Eugene (A-) | Signed out of draft (Hawaii) |
| Connor Seabold | p | 21.163 | Philadelphia Phillies | Williamsport (A-) | Signed out of draft (Cal State Fullerton) |
| Damon Jones | p | 22.278 | Philadelphia Phillies | Williamsport (A-) | Signed out of draft (Washington State) |
| David Parkinson | p | 21.204 | Philadelphia Phillies | Williamsport (A-) | Signed out of draft (Mississippi) |
| Kyle Dohy | p | 20.291 | Philadelphia Phillies | Williamsport (A-) | Signed out of draft (Citrus) |
| Marty Anderson | p | 24.173 | New York Mets | Brooklyn (A-) | Assigned to Brooklyn (A-) |
| Nick Choruby | of | 22.239 | Washington Nationals | Auburn (A-) | Signed out of draft (Texas A&M) |
| Spencer Howard | p | 20.342 | Philadelphia Phillies | Williamsport (A-) | Signed out of draft (Cal Poly) |
| Austin Guibor | of | 22.067 | Washington Nationals | Gulf Coast Nationals (Rk) | Signed out of draft (Fresno State) |
| Josh Rolette | c | 21.045 | Cleveland Indians | Arizona Indians (Rk) | Signed out of draft (Kansas State) |
| Logan Warmoth | ss | 21.303 | Toronto Blue Jays | Gulf Coast Blue Jays (Rk) | Signed out of draft (North Carolina) |
| Mike Baumann | p | 21.299 | Baltimore Orioles | Gulf Coast Orioles (Rk) | Signed out of draft (Jacksonville) |
| Mitch Schulewitz | p | 22.190 | Kansas City Royals | Arizona Royals (Rk) | Signed as undrafted free agent (Illinois-Chicago) |
| Quincy Nieporte | 1b | 22.341 | Philadelphia Phillies | Gulf Coast Phillies (Rk) | Signed out of draft (Florida State) |
| Raphael Gladu | of | 22.012 | New York Mets | Kingsport (Rk) | Signed out of draft (Louisiana Tech) |
| Turner Larkins | p | 21.242 | Toronto Blue Jays | Bluefield (Rk) | Signed out of draft (Texas A&M) |
| Rubby De La Rosa | SP | 28.123 | Arizona Diamondbacks | Arizona Diamondbacks (MLB) | DL-10 Right shoulder inflammation |
| Jake Barrett | RP | 25.349 | Arizona Diamondbacks | Arizona Diamondbacks (MLB) | Recalled from Reno (AAA) |
| Grant Dayton | RP | 29.223 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | DL-10 Neck stiffness |
| Scott Van Slyke | LF | 30.346 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Recalled from Oklahoma City (AAA) |
| Brian Johnson | SP | 26.210 | Boston Red Sox | Pawtucket (AAA) | Activated from DL and assigned to Pawtucket (AAA) |
| David Washington | 1B | 26.227 | Baltimore Orioles | Norfolk (AAA) | Designated for Assignment |
| Johnny Giavotella | 2B | 29.361 | Baltimore Orioles | Baltimore Orioles (MLB) | Contract purchased from minors |
| Marcus Semien | SS | 26.291 | Oakland Athletics | Oakland Athletics (MLB) | Activated from DL |
| Jharel Cotton | SP | 25.168 | Oakland Athletics | Oakland Athletics (MLB) | DL-10 Bliter on right thumb |
| Andrew Triggs | SP | 28.111 | Oakland Athletics | Oakland Athletics (MLB) | Transferred to 60-day DL |
| Akeel Morris | RP | 24.233 | Atlanta Braves | Atlanta Braves (MLB) | Recalled from Gwinnett (AAA) |
| David Robertson | CL | 32.087 | Chicago White Sox | Chicago White Sox (MLB) | Reinstated from paternity leave list |
| Michael Ynoa | RP | 25.285 | Chicago White Sox | Charlotte (AAA) | Designated for Assignment |
| Michael Reed | OF | 24.229 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Recalled from Biloxi (AA) |
| Mason Williams | CF | 25.319 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Outrighted to minors |
| Yadiel Rivera | SS | 25.064 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Recalled from Colorado Springs (AAA) |
| Eric Sogard | 2B | 31.044 | Milwaukee Brewers | Milwaukee Brewers (MLB) | DL-10 Left ankle strain |
| Sal Romano | SP | 23.266 | Cincinnati Reds | Cincinnati Reds (MLB) | Recalled from Louisville (AAA) |
| John Lackey | SP | 38.255 | Chicago Cubs | Chicago Cubs (MLB) | DL-10 Plantar fasciitis |
| Kyle Schwarber | LF | 24.122 | Chicago Cubs | Chicago Cubs (MLB) | Recalled from Iowa (AAA) |
| Blaine Hardy | RP | 30.113 | Detroit Tigers | Detroit Tigers (MLB) | Recalled from Toledo (AAA) |
| Daniel Norris | SP | 24.071 | Detroit Tigers | Detroit Tigers (MLB) | DL-10 Left groin strain |
| J.D. Martin | P | 34.184 | | | Released by Nationals |
| Nick Hagadone | RP | 31.185 | | | Released by Mariners |
| Alfredo Gonzalez | C | 24.357 | Chicago White Sox | Birmingham (AA) | DL-7 Injured |
| Beau Amaral | OF | 26.144 | | | Released by Reds |
| Ivan Castillo | ss | 22.036 | Cleveland Indians | Lynchburg (A+) | DL-7 Injured |
| Juan Perez | SS | 25.247 | Cincinnati Reds | Louisville (AAA) | DL-7 Injured |
| Ryan Matranga | c | 22.185 | | | Announced retirement |
| Willians Astudillo | c | 25.265 | Arizona Diamondbacks | Reno (AAA) | DL-7 Injured |
| Alonzo Gonzalez | P | 25.172 | Toronto Blue Jays | New Hampshire (AA) | Placed on temporary inactive list |
| Ryan Hissey | c | 23.088 | Toronto Blue Jays | Dunedin (A+) | DL-7 Injured |
| Travis Lakins | p | 23.006 | Boston Red Sox | Portland (AA) | DL-7 Injured |
| Boomer White | 2b | 23.342 | San Diego Padres | Lake Elsinore (A+) | DL-7 Injured |
| Branden Becker | ss | 20.295 | Baltimore Orioles | Aberdeen (A-) | DL-60 Injured |
| Brock Burke | P | 20.335 | Tampa Bay Rays | Charlotte (A+) | DL-7 Injured |
| Carl Wise | 3b | 23.041 | Toronto Blue Jays | Dunedin (A+) | DL-7 Injured |
| Cristian Paulino | 2B | 25.305 | San Francisco Giants | Augusta (A) | DL-7 Injured |
| Mike Meyers | SS | 23.189 | Boston Red Sox | Salem (A+) | DL-7 Injured |
| Rodrigo Takahashi | P | 20.163 | Arizona Diamondbacks | Visalia (A+) | DL-7 Injured |
| Kyle Wilcox | p | 23.021 | Seattle Mariners | Clinton (A) | DL-7 Injured |
| Logan Crouse | p | 20.215 | Los Angeles Dodgers | Great Lakes (A) | DL-7 Injured |
| Enmanuel Mercedes | p | 19.208 | Miami Marlins | Dominican Marlins (Rk) | Assigned to DSL Marlins (Rk) |
| Yeremin Lara | p | 18.241 | Miami Marlins | Dominican Marlins (Rk) | Assigned to DSL Marlins (Rk) |
| Alfred Pujols | 3b | 18.242 | New York Yankees | Dominican Yankees (Rk) | Assigned to DSL Yankees (Rk) |
| Pedro Alfonseca | of | 19.304 | Cleveland Indians | Arizona Indians (Rk) | DL-7 Injured |
