| Osmel Aguila | of | 27.330 | Philadelphia Phillies | Lehigh Valley (AAA) | Assigned to Lehigh Valley (AAA) |
| Ozzie Albies | SS | 20.157 | Atlanta Braves | Gwinnett (AAA) | Activated from disabled list |
| Jose Antequera | ss | 21.317 | Philadelphia Phillies | Reading (AA) | Assigned to Reading (AA) |
| Francisco Arcia | C | 27.272 | Los Angeles Angels | Mobile (AA) | Assigned to Mobile (AA) |
| Estarlin Arias | p | 23.022 | St. Louis Cardinals | Palm Beach (A+) | Assigned to Palm Beach (A+) |
| Daniel Bard | RP | 31.353 | New York Mets | St. Lucie (A+) | Assigned to St. Lucie (A+) |
| Matt Blandino | p | 21.319 | Cincinnati Reds | Dayton (A) | Assigned to Dayton (A) |
| Yimmi Brasoban | P | 22.356 | San Diego Padres | San Antonio (AA) | Activated from disabled list |
| Ryan Brett | 2B | 25.248 | Tampa Bay Rays | Durham (AAA) | Activated from disabled list |
| Joseph Camacho | p | 22.355 | Oakland Athletics | Beloit (A) | Assigned to Beloit (A) |
| Daniel Carbonell | OF | 26.076 | San Francisco Giants | San Jose (A+) | Activated from disabled list |
| Aroldis Chapman | CL | 29.106 | New York Yankees | Tampa (A+) | Assigned to Tampa (A+) for rehab |
| Jaye Chapman | P | 30.022 | Texas Rangers | Frisco (AA) | Reinstated to active roster |
| Alberti Chavez | 2B-3B | 21.328 | Cincinnati Reds | Pensacola (AA) | Assigned to Pensacola (AA) |
| William Cuevas | RP | 26.242 | Miami Marlins | New Orleans (AAA) | Assigned to New Orleans (AAA) |
| Paul DeJong | if | 23.315 | St. Louis Cardinals | Memphis (AAA) | Assigned to Memphis (AAA) |
| Ben Deluzio | ss | 22.308 | Arizona Diamondbacks | Kane County (A) | Activated from disabled list |
| Wilmer Difo | SS | 25.072 | Washington Nationals | Syracuse (AAA) | Assigned to Syracuse (AAA) |
| Daniel Fajardo | C | 22.206 | Baltimore Orioles | Delmarva (A) | Assigned to Delmarva (A) |
| Erick Fedde | P | 24.108 | Washington Nationals | Syracuse (AAA) | Assigned to Syracuse (AAA) |
| Anderson Feliz | 2B | 25.033 | Pittsburgh Pirates | Altoona (AA) | Assigned to Altoona (AA) |
| Victor Fernandez | of | 22.239 | Pittsburgh Pirates | West Virginia (A) | Activated from disabled list |
| Bryan Garcia | p | 22.055 | Detroit Tigers | Erie (AA) | Assigned to Erie (AA) |
| Domingo German | P | 24.313 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Assigned to Scranton/Wilkes-Barre (AAA) |
| Phil Gosselin | 2B | 28.253 | Pittsburgh Pirates | Indianapolis (AAA) | Assigned to Indianapolis (AAA) |
| Cameron Griffin | P | 25.354 | New York Mets | Columbia (A) | Assigned to Columbia (A) |
| Donovan Hand | RP | 31.054 | New York Mets | Las Vegas (AAA) | Assigned to Las Vegas (AAA) |
| Tyler Horan | OF | 26.193 | San Francisco Giants | Richmond (AA) | Activated from disabled list |
| Steve Johnson | RP | 29.287 | Baltimore Orioles | Norfolk (AAA) | Activated from disabled list |
| Spencer Kieboom | C | 26.089 | Washington Nationals | Syracuse (AAA) | Assigned to Syracuse (AAA) |
| Dusten Knight | P | 26.279 | San Francisco Giants | Sacramento (AAA) | Assigned to Sacramento (AAA) |
| Tom Layne | RP | 32.223 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Outrighted to minors |
| Randy LeBlanc | P | 25.098 | Minnesota Twins | Fort Myers (A+) | Assigned to Fort Myers (A+) |
| Brennan Leitao | p | 23.357 | St. Louis Cardinals | Palm Beach (A+) | Assigned to Palm Beach (A+) |
| Jake Lowery | C | 26.327 | Washington Nationals | Harrisburg (AA) | Assigned to Harrisburg (AA) |
| Tim Lynch | 1b | 24.010 | New York Yankees | Tampa (A+) | Assigned to Tampa (A+) |
| Justin Maffei | OF | 25.291 | Pittsburgh Pirates | Indianapolis (AAA) | Assigned to Indianapolis (AAA) |
| Jordan Mills | P | 25.033 | Washington Nationals | Potomac (A+) | Assigned to Potomac (A+) |
| Diego Moreno | RP | 29.328 | Tampa Bay Rays | Durham (AAA) | Assigned to Durham (AAA) for rehab |
| Tyler Naquin | CF | 26.050 | Cleveland Indians | Columbus (AAA) | Activated from disabled list |
| Justin Nicolino | SP | 25.204 | Miami Marlins | Jupiter (A+) | Assigned to Jupiter (A+) for rehab |
| Emilio Pagan | P | 26.037 | Seattle Mariners | Tacoma (AAA) | Assigned to Tacoma (AAA) |
| Steve Pearce | LF | 34.061 | Toronto Blue Jays | Buffalo (AAA) | Assigned to Buffalo (AAA) for rehab |
| Francisco Pena | C | 27.244 | Baltimore Orioles | Norfolk (AAA) | Outrighted to minors |
| Juan Perez | P | 21.327 | St. Louis Cardinals | Peoria (A) | Assigned to Peoria (A) |
| Gregorio Petit | 2B | 32.185 | Toronto Blue Jays | Buffalo (AAA) | Assigned to Buffalo (AAA) |
| Brett Phillips | OF | 23.014 | Milwaukee Brewers | Colorado Springs (AAA) | Assigned to Colorado Springs (AAA) |
| Brooks Pounders | RP | 26.260 | Los Angeles Angels | Salt Lake (AAA) | Assigned to Salt Lake (AAA) |
| Juniel Querecuto | SS | 24.267 | San Francisco Giants | Sacramento (AAA) | Assigned to Sacramento (AAA) |
| Zac Reininger | P | 24.136 | Detroit Tigers | Erie (AA) | Assigned to Erie (AA) |
| Shane Robinson | LF | 32.226 | Los Angeles Angels | Salt Lake (AAA) | Assigned to Salt Lake (AAA) |
| Dereck Rodriguez | CF-RF | 25.008 | Minnesota Twins | Chattanooga (AA) | Assigned to Chattanooga (AA) |
| Joely Rodriguez | RP | 25.212 | Texas Rangers | Round Rock (AAA) | Traded from Phillies to Rangers for future considerations |
| Dalton Sawyer | p | 23.203 | Oakland Athletics | Beloit (A) | Assigned to Beloit (A) |
| Silento Sayles | CF | 22.077 | Cleveland Indians | Lynchburg (A+) | Assigned to Lynchburg (A+) |
| Forrest Snow | P | 28.165 | Milwaukee Brewers | Biloxi (AA) | Assigned to Biloxi (AA) |
| David Speer | P | 24.303 | Cleveland Indians | Columbus (AAA) | Assigned to Columbus (AAA) |
| John Stilson | P | 26.320 | Toronto Blue Jays | Buffalo (AAA) | Assigned to Buffalo (AAA) |
| Jason Stoffel | P | 28.271 | Pittsburgh Pirates | Indianapolis (AAA) | Assigned to Indianapolis (AAA) |
| Andrew Suarez | p | 24.275 | San Francisco Giants | Sacramento (AAA) | Assigned to Sacramento (AAA) |
| Darien Tubbs | of | 22.138 | Los Angeles Dodgers | Great Lakes (A) | Activated from disabled list |
| Adrian Valerio | ss | 20.092 | Pittsburgh Pirates | West Virginia (A) | Activated from disabled list |
| Logan Verrett | RP | 26.359 | Baltimore Orioles | Norfolk (AAA) | Assigned to Norfolk (AAA) |
| Kender Villegas | P | 24.005 | Toronto Blue Jays | New Hampshire (AA) | Assigned to New Hampshire (AA) |
| Alex Wimmers | RP | 28.224 | Minnesota Twins | Rochester (AAA) | Assigned to Rochester (AAA) |
| Josh Zeid | RP | 30.081 | St. Louis Cardinals | Memphis (AAA) | Reinstated to active roster |
| Kyle Zimmer | P | 25.274 | Kansas City Royals | Omaha (AAA) | Activated from disabled list |
| Nick Tepesch | SP | 28.244 | Minnesota Twins | Minnesota Twins (MLB) | Signed to Minor League Contract |
| Paolo Espino | P | 30.154 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Recalled from Colorado Springs (AAA) |
| Brandon Woodruff | P | 24.123 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Contract purchased from minors |
| Brandon Woodruff | P | 24.123 | Milwaukee Brewers | Milwaukee Brewers (MLB) | DL-10 Strained right hamstring |
| Edwin Jackson | SP | 33.278 | | | Refused minor league assignment, declared free agent |
| Mike Morin | RP | 26.041 | Los Angeles Angels | Los Angeles Angels (MLB) | Recalled from Salt Lake (AAA) |
| T.J. Rivera | 3B | 28.229 | New York Mets | New York Mets (MLB) | Recalled from Las Vegas (AAA) |
| Asdrubal Cabrera | SS | 31.212 | New York Mets | New York Mets (MLB) | DL-10 Sprained left thumb |
| Adrian Gonzalez | 1B | 35.036 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | DL-10 Lower back discomfort |
| Joc Pederson | CF | 25.053 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Activated from DL |
| Sam Tuivailala | RP | 24.237 | St. Louis Cardinals | St. Louis Cardinals (MLB) | Recalled from Memphis (AAA) |
| Jhonny Peralta | 3B | 35.016 | | | Released by Cardinals |
| Travis Shaw | 1B | 27.058 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Reinstated from Bereavement list |
| Marco Gonzales | P | 25.118 | St. Louis Cardinals | St. Louis Cardinals (MLB) | Recalled from Memphis (AAA) |
| Brent Suter | RP | 27.288 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Recalled from Colorado Springs (AAA) |
| Rob Scahill | RP | 30.118 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Designated for Assignment |
| Justin Marks | RP | 29.153 | Los Angeles Dodgers | Oklahoma City (AAA) | Outrighted to minors |
| Rafael Martin | RP | 33.028 | Washington Nationals | Syracuse (AAA) | Outrighted to minors |
| Emilio Bonifacio | RF | 32.051 | | | Granted free agency |
| Ryan Strausborger | CF | 29.101 | Minnesota Twins | Chattanooga (AA) | DL-7 Injured |
| Alex Blackford | P | 26.209 | Los Angeles Angels | Mobile (AA) | DL-7 Injured |
| Carlos Arroyo | OF | 23.350 | | | Released by Rangers |
| Elvis Rubio | OF | 22.346 | Detroit Tigers | Gulf Coast Tigers West (Rk) | Assigned to GCL Tigers West (Rk) |
| Brandon Peterson | P | 25.264 | | | Released by Angels |
| Hutton Moyer | 2b | 24.044 | Los Angeles Angels | Mobile (AA) | Placed on temporary inactive list |
| James Buckelew | P | 25.314 | Miami Marlins | Gulf Coast Marlins (Rk) | Assigned to GCL Marlins (Rk) |
| Joe Filomeno | P | 24.164 | Texas Rangers | Frisco (AA) | Placed on temporary inactive list |
| Luis Tejada | 1B | 24.244 | | | Released by Angels |
| Shane McCain | OF | 25.314 | Texas Rangers | Frisco (AA) | Placed on temporary inactive list |
| Tyler Carpenter | P | 25.109 | Los Angeles Angels | Mobile (AA) | DL-7 Injured |
| Anthony Shew | p | 23.222 | St. Louis Cardinals | State College (A-) | Assigned to State College (A-) |
| Brad Haynal | C | 25.297 | Miami Marlins | Jupiter (A+) | Placed on temporary inactive list |
| Brandon Lowe | 2b | 22.342 | Tampa Bay Rays | Charlotte (A+) | DL-7 Injured |
| Connor Myers | of | 23.130 | Chicago Cubs | Eugene (A-) | Assigned to Eugene (A-) |
| Conor Fisk | P | 25.070 | Toronto Blue Jays | Dunedin (A+) | DL-7 Injured |
| Junnell Ledezma | 1b | 21.217 | Detroit Tigers | Gulf Coast Tigers West (Rk) | Assigned to GCL Tigers |
| Max Pentecost | C | 24.095 | Toronto Blue Jays | Dunedin (A+) | DL-7 Injured |
| Alexis Olmeda | c | 23.069 | Arizona Diamondbacks | Kane County (A) | DL-7 Injured |
| Cesar Ventura | p | 22.091 | Cleveland Indians | Mahoning Valley (A-) | Assigned to Mahoning Valley (Rk) |
| Emmanuel Ramirez | p | 22.333 | San Diego Padres | Tri-City (A-) | Assigned to Tri-City (A-) |
| Jaret Hellinger | p | 20.207 | Atlanta Braves | Danville (Rk) | Assigned to Danville (Rk) |
| Jose Herrera | C | 20.109 | Arizona Diamondbacks | Kane County (A) | DL-7 Injured |
| Joshua Palacios | of | 21.319 | Toronto Blue Jays | Lansing (A) | DL-7 Injured |
| Kolton Mahoney | p | 25.024 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| Max Kuhns | p | 22.306 | New York Mets | Columbia (A) | DL-7 Injured |
| Michael Letkewicz | p | 23.133 | Cleveland Indians | Lake County (A) | DL-7 Injured |
| Rene Pinto | c | 20.223 | Tampa Bay Rays | Bowling Green (A) | DL-7 Injured |
| Tyler Watson | p | 20.022 | Washington Nationals | Hagerstown (A) | Placed on temporary inactive list |
| Yanio Perez | of | 21.308 | Texas Rangers | Down East (A+) | Assigned to Down East (A+) |
| Elvis Alvarado | of | 18.110 | Washington Nationals | Dominican Nationals (Rk) | Assigned to DSL Nationals (Rk) |
| Gabe Howell | ss | 19.093 | | | Released by Braves |
| Javier Monzon | ss | 24.127 | | | Released by Blue Jays |
| Chris Parmelee | 1B | 29.110 | | | Released by Athletics |
