| Lance McCullers | SP | 22.224 | Houston Astros | Houston Astros (MLB) | Activated from DL |
| Jose Reyes | SS | 32.338 | Colorado Rockies | Colorado Rockies (MLB) | Suspension extended until May 31 |
| Dean Kiekhefer | RP | 26.341 | St. Louis Cardinals | St. Louis Cardinals (MLB) | Recalled from Memphis (AAA) |
| Cliff Pennington | 2B-SS | 31.333 | Los Angeles Angels | Los Angeles Angels (MLB) | DL-15 Left hamstring strain |
| Jefry Marte | 3B | 24.328 | Los Angeles Angels | Los Angeles Angels (MLB) | Recalled from Salt Lake (AAA) |
| Gregorio Petit | 2B | 31.155 | Los Angeles Angels | Los Angeles Angels (MLB) | Contract purchased from minors |
| Andrew Cashner | SP | 29.245 | San Diego Padres | San Diego Padres (MLB) | DL-15 Strained right hamstring |
| Daniel Descalso | SS-2B | 29.207 | Colorado Rockies | Colorado Rockies (MLB) | Activated from DL |
| Jabari Blash | LF | 26.314 | San Diego Padres | San Diego Padres (MLB) | Designated for Assignment |
| Christian Friedrich | SP | 28.311 | San Diego Padres | San Diego Padres (MLB) | Contract purchased from minors |
| Ross Ohlendorf | RP | 33.279 | Cincinnati Reds | Cincinnati Reds (MLB) | Suspended 3 games for hitting David Freese with a pitch |
| Gary Sanchez | C | 23.163 | New York Yankees | New York Yankees (MLB) | Recalled from Scranton/Wilkes-Barre (AAA) |
| Matt Bush | RP | 30.095 | Texas Rangers | Texas Rangers (MLB) | Contract purchased from minors |
| Tommy Joseph | 1B | 24.303 | Philadelphia Phillies | Philadelphia Phillies (MLB) | Contract purchased from minors |
| Matt McBride | C | 30.356 | Oakland Athletics | Oakland Athletics (MLB) | Recalled from Nashville (AAA) |
| Lonnie Chisenhall | RF-CF | 27.222 | Cleveland Indians | Cleveland Indians (MLB) | Placed on bereavement list |
| Tyler Naquin | CF | 25.020 | Cleveland Indians | Cleveland Indians (MLB) | Recalled from Columbus (AAA) |
| Matt Purke | P | 25.301 | Chicago White Sox | Chicago White Sox (MLB) | Contract purchased from minors |
| John Danks | SP | 31.029 | | | Released by White Sox |
| Cole Figueroa | 3B | 28.319 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | Recalled from Indianapolis (AAA) |
| Kyle Lohse | RP | 37.222 | Texas Rangers | Texas Rangers (MLB) | Signed to Minor League Contract |
| Billy Hamilton | CF | 25.247 | Cincinnati Reds | Cincinnati Reds (MLB) | Placed on bereavement list |
| Jose Peraza | SS | 22.014 | Cincinnati Reds | Cincinnati Reds (MLB) | Recalled from Louisville (AAA) |
| Javy Guerra | RP | 30.195 | Los Angeles Angels | Los Angeles Angels (MLB) | Designated for Assignment |
| Jason Castro | C | 28.331 | Houston Astros | Houston Astros (MLB) | Placed on paternity leave |
| Carlos Alonso | 2B | 28.089 | Philadelphia Phillies | Lehigh Valley (AAA) | Activated from disabled list |
| Tyler Anderson | P | 26.135 | Colorado Rockies | Hartford (AA) | Assigned to Hartford (AA) |
| Junior Arias | 3B | 24.126 | San Francisco Giants | San Jose (A+) | Assigned to San Jose (A+) |
| Landon Beck | P | 23.156 | St. Louis Cardinals | Palm Beach (A+) | Assigned to Palm Beach (A+) |
| Nolan Becker | P | 24.336 | Cincinnati Reds | Daytona (A+) | Activated from disabled list |
| Robert Benincasa | P | 25.251 | Washington Nationals | Potomac (A+) | Activated from disabled list |
| Blake Bivens | P | 20.277 | Tampa Bay Rays | Charlotte (A+) | Assigned to Charlotte (A+) |
| Brady Bowen | p | 23.294 | St. Louis Cardinals | Peoria (A) | Assigned to Peoria (A) |
| Matt Bower | p | 21.332 | Houston Astros | Lancaster (A+) | Assigned to Lancaster (A+) |
| Ben Carhart | 3B | 26.113 | Chicago Cubs | Iowa (AAA) | Activated from disabled list |
| Ryan Chaffee | P | 27.361 | Miami Marlins | Jacksonville (AA) | Assigned to Jacksonville (AA) |
| Yonny Chirinos | P | 22.139 | Tampa Bay Rays | Charlotte (A+) | Assigned to Charlotte (A+) |
| Jordan DeLorenzo | P | 23.248 | St. Louis Cardinals | Peoria (A) | Assigned to Peoria (A) |
| Cody Dent | SS | 24.287 | Washington Nationals | Hagerstown (A) | Assigned to Hagerstown (A) |
| Alex Dickerson | LF | 25.353 | San Diego Padres | El Paso (AAA) | Assigned to El Paso (AAA) |
| Carlos Duran | OF | 21.173 | Philadelphia Phillies | Lakewood (A) | Assigned to Lakewood (A) |
| Pedro Echemendia | p | 24.335 | St. Louis Cardinals | Springfield (AA) | Assigned to Springfield (AA) |
| Dietrich Enns | P | 24.364 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Assigned to Scranton/Wilkes-Barre (AAA) |
| Tommy Field | 2b | 29.081 | Minnesota Twins | Rochester (AAA) | Signed to Minor League Contract |
| Nick Frey | P | 24.258 | St. Louis Cardinals | Palm Beach (A+) | Assigned to Palm Beach (A+) |
| Tom Gavitt | c | 23.271 | Oakland Athletics | Beloit (A) | Assigned to Beloit (A) |
| J.R. Graham | RP | 26.120 | New York Yankees | Trenton (AA) | Traded from Twins to Yankees for future considerations |
| Joey Hawkins | 2b | 23.065 | St. Louis Cardinals | Palm Beach (A+) | Assigned to Palm Beach (A+) |
| Kevin Herget | P | 25.041 | St. Louis Cardinals | Springfield (AA) | Assigned to Springfield (AA) |
| Rainy Lara | P | 25.061 | New York Mets | Binghamton (AA) | Activated from disabled list |
| Corey Littrell | P | 24.054 | St. Louis Cardinals | Memphis (AAA) | Assigned to Memphis (AAA) |
| Derrick Loveless | CF | 23.068 | Toronto Blue Jays | Dunedin (A+) | Assigned to Dunedin (A+) |
| Joe McCarthy | of | 22.080 | Tampa Bay Rays | Bowling Green (A) | Activated from disabled list |
| Angel Mejia | P | 21.093 | San Diego Padres | Fort Wayne (A) | Assigned to Fort Wayne (A) |
| Elliot Morris | P | 24.018 | San Diego Padres | San Antonio (AA) | Assigned to San Antonio (AA) |
| Clayton Mortensen | RP | 31.034 | Kansas City Royals | Omaha (AAA) | Reinstated to active roster |
| Hutton Moyer | 2b | 23.014 | Los Angeles Angels | Inland Empire (A+) | Assigned to Inland Empire (A+) |
| Angel Nesbitt | P | 25.161 | Detroit Tigers | Toledo (AAA) | Assigned to Toledo (AAA) |
| Mike Ohlman | C | 25.151 | St. Louis Cardinals | Memphis (AAA) | Activated from disabled list |
| Shane Opitz | SS | 24.125 | Toronto Blue Jays | New Hampshire (AA) | Assigned to New Hampshire (AA) |
| Jarrett Parker | RF | 27.133 | San Francisco Giants | Sacramento (AAA) | Assigned to Sacramento (AAA) |
| Roberto Pena | C | 23.340 | Houston Astros | Corpus Christi (AA) | Assigned to Corpus Christi (AA) |
| Gavin Pittore | p | 22.238 | Los Angeles Dodgers | Great Lakes (A) | Activated from disabled list |
| Jaider Rocha | p | 22.356 | Chicago White Sox | Kannapolis (A) | Assigned to Kannapolis (A) |
| Eric Ruth | P | 25.230 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Assigned to Scranton/Wilkes-Barre (AAA) |
| Alex Sanabia | SP | 27.248 | Chicago Cubs | Iowa (AAA) | Assigned to Iowa (AAA) |
| Gary Sanchez | C | 23.163 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Assigned to Scranton/Wilkes-Barre (AAA) |
| Juan Santos | P | 20.258 | Houston Astros | Quad Cities (A) | Assigned to Quad Cities (A) |
| Slade Smith | P | 25.230 | Detroit Tigers | Lakeland (A+) | Activated from disabled list |
| Brandon Snyder | LF | 29.172 | Atlanta Braves | Gwinnett (AAA) | Activated from disabled list |
| Mick VanVossen | p | 23.196 | Washington Nationals | Hagerstown (A) | Assigned to Hagerstown (A) |
| Jake Yacinich | IF | 23.073 | Los Angeles Angels | Burlington (A) | Activated from disabled list |
| Eric Yardley | P | 25.269 | San Diego Padres | El Paso (AAA) | Assigned to El Paso (AAA) |
| Matt Den Dekker | RF-CF | 28.278 | Washington Nationals | Washington Nationals (MLB) | Recalled from Syracuse (AAA) as 26th man |
| Michael Brantley | LF | 28.365 | Cleveland Indians | Cleveland Indians (MLB) | DL-15 Right shoulder inflammation |
| Brandon Morrow | SP | 31.292 | San Diego Padres | San Diego Padres (MLB) | Assigned to extended spring training |
| Tim Melville | P | 26.217 | Cincinnati Reds | Louisville (AAA) | DL-7 Injured |
| Brett Doe | IF-C | 25.336 | | | Released by Twins |
| Heiker Meneses | SS-2B | 24.318 | Minnesota Twins | Rochester (AAA) | DL-7 Injured |
| Hunter Redman | C | 23.262 | San Diego Padres | San Diego Padres (MLB) | Assigned to extended spring training |
| Jacob Wilson | IF | 25.289 | St. Louis Cardinals | Memphis (AAA) | DL-7 Injured |
| Jose Casilla | P | 26.358 | San Francisco Giants | Sacramento (AAA) | DL-7 Injured |
| Steve Perakslis | P | 25.119 | Chicago Cubs | Iowa (AAA) | Placed on temporary inactive list |
| Marc Wik | CF | 23.300 | Houston Astros | Lancaster (A+) | Suspended 50 games for violation of Minor League drug policy |
| Cory Jones | P | 24.237 | Baltimore Orioles | Frederick (A+) | DL-7 Injured |
| Jackson Lowery | p | 23.295 | Toronto Blue Jays | Toronto Blue Jays (MLB) | Assigned to extended spring training |
| Jared Miller | P | 22.266 | Arizona Diamondbacks | Visalia (A+) | Placed on temporary inactive list |
| Jimmy Pickens | OF-C | 24.057 | | | Released by Reds |
| Nate Abel | p | 23.193 | Toronto Blue Jays | Toronto Blue Jays (MLB) | Assigned to extended spring training |
| Jose Siri | OF | 20.297 | Cincinnati Reds | Billings (Rk) | Assigned to Billings (Rk) |
| Marcus Crescentini | p | 23.139 | Los Angeles Dodgers | Great Lakes (A) | DL-7 Injured |
| Michael Boyle | p | 22.032 | Los Angeles Dodgers | Great Lakes (A) | DL-7 Injured |
| Narciso Crook | RF | 20.307 | Cincinnati Reds | Dayton (A) | DL-7 Injured |
