| Jon Gray | SP | 24.150 | Colorado Rockies | Colorado Rockies (MLB) | DL-15 Abdominal strain |
| Jason Motte | RP | 33.285 | Colorado Rockies | Colorado Rockies (MLB) | DL-15 Right shoulder strain |
| Jason Gurka | RP | 28.084 | Colorado Rockies | Colorado Rockies (MLB) | Contract purchased from minors |
| Peter O'Brien | C | 25.262 | Arizona Diamondbacks | Arizona Diamondbacks (MLB) | Assigned to minors |
| Evan Marshall | P | 25.350 | Arizona Diamondbacks | Arizona Diamondbacks (MLB) | Assigned to minors |
| Enrique Burgos | RP | 25.131 | Arizona Diamondbacks | Arizona Diamondbacks (MLB) | Assigned to minors |
| Chris Capuano | RP | 36.228 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Contract purchased from minors |
| Yhonathan Barrios | RP | 24.124 | Milwaukee Brewers | Milwaukee Brewers (MLB) | DL-60 Strained right shoulder |
| Sean Nolin | SP | 26.098 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Transferred to 60-day DL |
| Will Smith | RP | 26.267 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Torn LCL in right knee |
| Sam Fuld | LF | 34.134 | Oakland Athletics | Oakland Athletics (MLB) | DL-15 Strained left shoulder |
| Eric Sogard | 2B | 29.316 | Oakland Athletics | Oakland Athletics (MLB) | DL-15 Cervical strain |
| RJ Alvarez | RP | 24.300 | Oakland Athletics | Oakland Athletics (MLB) | DL-15 Bone chips in right elbow |
| Henderson Alvarez | SP | 25.350 | Oakland Athletics | Oakland Athletics (MLB) | DL-15 Recovery from right shoulder surgery |
| Andrew Lambo | rf | 27.235 | Oakland Athletics | Oakland Athletics (MLB) | Assigned to minors |
| Aaron Thompson | RP | 29.034 | | | Released by Twins |
| Jefry Marte | 1B | 24.287 | Los Angeles Angels | Salt Lake (AAA) | Assigned to Salt Lake (AAA) |
| Rey Navarro | 2B-3B | 26.102 | Baltimore Orioles | Baltimore Orioles (MLB) | Assigned to minors |
| Shae Simmons | P | 25.212 | Atlanta Braves | Atlanta Braves (MLB) | DL-15 Recovery from right elbow surgery |
| Andrew McKirahan | RP | 26.054 | Atlanta Braves | Atlanta Braves (MLB) | DL-15 Torn left elbow ligament |
| Brayan Pena | C | 34.086 | St. Louis Cardinals | St. Louis Cardinals (MLB) | DL-15 Left knee surgery |
| Austin Hedges | C | 23.228 | San Diego Padres | San Diego Padres (MLB) | Assigned to minors |
| Eric Fryer | C | 30.220 | St. Louis Cardinals | St. Louis Cardinals (MLB) | Contract purchased from minors |
| John Mayberry | LF-RF | 32.104 | | | Released by Tigers |
| Kyle Parker | RF | 26.185 | | | Released by Rockies |
| Tyler Cravy | RP | 26.264 | Milwaukee Brewers | Colorado Springs (AAA) | Assigned to minors |
| Alex Liddi | 1b | 27.232 | | | Released by Orioles |
| Mike Carp | 1b | 29.277 | | | Released by Orioles |
| Jeff Bianchi | SS | 29.180 | Colorado Rockies | Colorado Rockies (MLB) | Signed to Minor League Contract |
| Jesse Biddle | P | 24.164 | Atlanta Braves | Atlanta Braves (MLB) | DL-15 Recovery from Tommy John surgery |
| Eduardo Rodriguez | SP | 22.361 | Boston Red Sox | Boston Red Sox (MLB) | DL-15 Dislocated right kneecap |
| Christian Vazquez | C | 25.225 | Boston Red Sox | Boston Red Sox (MLB) | DL-15 Recovering from April 2015 Tommy John surgery |
| Carson Smith | RP | 26.166 | Boston Red Sox | Boston Red Sox (MLB) | DL-15 Strained flexor mass in right forearm |
| Javier Baez | 2B | 23.123 | Chicago Cubs | Chicago Cubs (MLB) | DL-15 Left thumb contusion |
| Jumbo Diaz | P | 32.036 | Cincinnati Reds | Cincinnati Reds (MLB) | Recalled from Louisville (AAA) |
| Cory Luebke | P | 31.030 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | Contract purchased from minors |
| Pedro Florimon | 2B | 29.114 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | Designated for Assignment |
| Jung-Ho Kang | SS-3B | 28.364 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | DL-15 Knee |
| Jared Hughes | RP | 30.273 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | DL-15 Strained lat |
| Elias Diaz | C | 25.137 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | DL-15 Elbow |
| Cole Figueroa | 3B | 28.278 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | Contract purchased from minors |
| Matt Joyce | LF | 31.243 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | Contract purchased from minors |
| Jordan Walden | RP | 28.139 | St. Louis Cardinals | St. Louis Cardinals (MLB) | DL-15 Right shoulder inflammation |
| Luis Avilan | RP | 26.258 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Assigned to minors |
| Mitch Harris | RP | 30.147 | St. Louis Cardinals | St. Louis Cardinals (MLB) | DL-15 Nerve issues in right elbow |
| Lance Lynn | SP | 28.327 | St. Louis Cardinals | St. Louis Cardinals (MLB) | DL-60 Recovery from Tommy John Surgery |
| Jhonny Peralta | SS | 33.310 | St. Louis Cardinals | St. Louis Cardinals (MLB) | DL-15 Recovering from November 2015 Tommy John surgery |
| Ruben Tejada | SS | 26.158 | St. Louis Cardinals | St. Louis Cardinals (MLB) | DL-15 Strained left quad |
| Jake Goebbert | LF-RF | 28.192 | Pittsburgh Pirates | Indianapolis (AAA) | Designated for Assignment |
| John Holdzkom | P | 28.167 | Pittsburgh Pirates | Indianapolis (AAA) | Designated for Assignment |
| Reed Johnson | lf | 39.116 | | | Released by Nationals |
| Sean Burnett | RP | 33.198 | | | Released by Nationals |
| Luke Jackson | RP | 24.223 | Texas Rangers | Texas Rangers (MLB) | DL-15 Stress reaction, lower back |
| Josh Hamilton | LF | 34.317 | Texas Rangers | Texas Rangers (MLB) | DL-15 Recovery from left knee surgery |
| Chris Gimenez | C | 33.097 | Texas Rangers | Texas Rangers (MLB) | DL-15 Lower left leg infection |
| Yu Darvish | SP | 29.230 | Texas Rangers | Texas Rangers (MLB) | DL-15 Recovery from right elbow surgery |
| CJ Wilson | SP | 35.136 | Los Angeles Angels | Los Angeles Angels (MLB) | DL-15 Left shoulder inflammation |
| James Loney | 1B | 31.331 | | | Released by Rays |
| Neal Cotts | RP | 36.009 | Los Angeles Angels | Los Angeles Angels (MLB) | Signed to Minor League Contract |
| Jarrod Dyson | CF | 31.231 | Kansas City Royals | Kansas City Royals (MLB) | DL-15 Strained right oblique |
| Tim Collins | RP | 26.225 | Kansas City Royals | Kansas City Royals (MLB) | DL-60 Recovery from Tommy John Surgery |
| Chien-Ming Wang | RP | 36.003 | Kansas City Royals | Kansas City Royals (MLB) | Contract purchased from minors |
| Evan Scribner | RP | 30.258 | Seattle Mariners | Seattle Mariners (MLB) | DL-15 Right shoulder strain |
| Charlie Furbush | RP | 29.357 | Seattle Mariners | Seattle Mariners (MLB) | DL-15 Left biceps/shoulder tendinitis |
| Rob Brantly | C | 26.263 | Seattle Mariners | Seattle Mariners (MLB) | Designated for Assignment |
| Marco Estrada | SP | 32.273 | Toronto Blue Jays | Toronto Blue Jays (MLB) | DL-15 Back soreness |
| Devon Travis | 2B | 25.041 | Toronto Blue Jays | Toronto Blue Jays (MLB) | DL-15 Recovery from left shoulder surgery |
| Bo Schultz | RP | 30.190 | Toronto Blue Jays | Toronto Blue Jays (MLB) | DL-15 Recovery from hip surgery |
| Aaron Loup | RP | 28.106 | Toronto Blue Jays | Toronto Blue Jays (MLB) | DL-15 Left elbow soreness |
| Cole Gillespie | RF | 31.287 | Miami Marlins | Miami Marlins (MLB) | Designated for Assignment |
| Brad Hand | RP | 26.014 | Miami Marlins | Miami Marlins (MLB) | Designated for Assignment |
| Chris Narveson | RP | 34.104 | Miami Marlins | Miami Marlins (MLB) | Contract purchased from minors |
| Dustin McGowan | RP | 34.010 | Miami Marlins | Miami Marlins (MLB) | Contract purchased from minors |
| Craig Breslow | RP | 35.238 | Miami Marlins | Miami Marlins (MLB) | Contract purchased from minors |
| Carter Capps | RP | 25.239 | Miami Marlins | Miami Marlins (MLB) | DL-60 Right elbow surgery |
| Raudel Lazo | RP | 26.356 | Miami Marlins | Miami Marlins (MLB) | DL-15 Left shoulder strain |
| Michael Dunn | RP | 30.315 | Miami Marlins | Miami Marlins (MLB) | DL-15 Left forearm strain |
| Jeremy Hazelbaker | LF-CF | 28.233 | St. Louis Cardinals | St. Louis Cardinals (MLB) | Contract purchased from minors |
| Adam Rosales | SS-3B | 32.319 | San Diego Padres | San Diego Padres (MLB) | Contract purchased from minors |
| Jairo Diaz | RP | 24.312 | Colorado Rockies | Colorado Rockies (MLB) | DL-60 Right elbow surgery |
| Daniel Descalso | 2B | 29.166 | Colorado Rockies | Colorado Rockies (MLB) | DL-15 Fractured left hand |
| Tyler Matzek | P | 25.166 | Colorado Rockies | Colorado Rockies (MLB) | DL-15 Anxiety disorder |
| Tyler Anderson | P | 26.094 | Colorado Rockies | Colorado Rockies (MLB) | DL-15 Recovery from left elbow surgery |
| Robbie Erlin | SP | 25.177 | San Diego Padres | San Diego Padres (MLB) | Assigned to minors |
| Jose Pirela | 2B | 26.133 | San Diego Padres | San Diego Padres (MLB) | Assigned to minors |
| Jordan Pacheco | 1B | 30.063 | Cincinnati Reds | Cincinnati Reds (MLB) | Contract purchased from minors |
| Mason Williams | CF | 24.226 | New York Yankees | New York Yankees (MLB) | DL-15 Recovery from right shoulder surgery |
| Bryan Mitchell | RP | 24.350 | New York Yankees | New York Yankees (MLB) | DL-15 Fractured left big toe |
| Greg Bird | 1B | 23.145 | New York Yankees | New York Yankees (MLB) | DL-15 Torn right labrum |
| Charlie Culberson | SS | 26.358 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Contract purchased from minors |
| Hyun-Jin Ryu | SP | 29.009 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | DL-15 Recovery from left shoulder surgery |
| Josh Ravin | RP | 28.073 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | DL-15 Broken left forearm |
| Howie Kendrick | 2B | 32.266 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | DL-15 Strained left calf |
| Yasmani Grandal | 1B | 27.146 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | DL-15 Right forearm soreness |
| Alex Guerrero | 3B | 29.104 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | DL-15 Left knee contusion |
| Andre Ethier | RF | 33.358 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | DL-15 Fractured right tibia |
| Mike Bolsinger | SP | 28.065 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | DL-15 Strained left oblique |
| Brett Anderson | SP | 28.062 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | DL-60 Surgery on bulging disc |
| Brandon Workman | RP | 27.233 | Boston Red Sox | Boston Red Sox (MLB) | DL-15 Recovery from right elbow surgery |
| Logan Kensing | RP | 33.274 | Detroit Tigers | Detroit Tigers (MLB) | Contract purchased from minors |
| Marlon Byrd | LF-RF | 38.216 | Cleveland Indians | Cleveland Indians (MLB) | Contract purchased from minors |
| Giovanni Soto | P | 24.321 | Cleveland Indians | Cleveland Indians (MLB) | Designated for Assignment |
| Zach Walters | SS | 26.210 | Cleveland Indians | Columbus (AAA) | Designated for Assignment |
| Matt Thornton | RP | 39.200 | San Diego Padres | San Diego Padres (MLB) | Contract purchased from minors |
| Buddy Baumann | P | 28.116 | San Diego Padres | San Diego Padres (MLB) | DL-15 Lower back strain |
| Michael Brantley | LF | 28.324 | Cleveland Indians | Cleveland Indians (MLB) | DL-15 Recovery from right shoulder surgery |
| Jimmy Paredes | DH | 27.129 | Baltimore Orioles | Baltimore Orioles (MLB) | DL-15 Strained left wrist |
| Brian Matusz | RP | 29.051 | Baltimore Orioles | Baltimore Orioles (MLB) | DL-15 Back discomfort |
| Kevin Gausman | SP | 25.087 | Baltimore Orioles | Baltimore Orioles (MLB) | DL-15 Right shoulder tendinitis |
| Munenori Kawasaki | 3B | 34.304 | Chicago Cubs | Iowa (AAA) | Assigned to Iowa (AAA) |
| Miguel Gonzalez | SP | 31.311 | Chicago White Sox | Chicago White Sox (MLB) | Signed to Minor League Contract |
| Alex Wilson | RP | 29.151 | Detroit Tigers | Detroit Tigers (MLB) | DL-15 Right shoulder soreness |
| Daniel Norris | P | 22.343 | Detroit Tigers | Detroit Tigers (MLB) | DL-15 Lower back strain |
| Angel Nesbitt | P | 25.120 | Detroit Tigers | Toledo (AAA) | DL-15 Sprained right ankle |
| Cameron Maybin | CF | 28.365 | Detroit Tigers | Detroit Tigers (MLB) | DL-15 Fractured left wrist |
| Blaine Hardy | RP | 29.020 | Detroit Tigers | Detroit Tigers (MLB) | DL-15 Left shoulder impingement |
| Jeff Ferrell | RP | 25.131 | Detroit Tigers | Detroit Tigers (MLB) | DL-15 Right shoulder impingement |
| Christian Villanueva | 3B | 24.289 | Chicago Cubs | Chicago Cubs (MLB) | DL-15 Right fibular fracture |
| Dallas Beeler | SP | 26.295 | Chicago Cubs | Chicago Cubs (MLB) | DL-15 Right shoulder inflammation |
| Aaron Brooks | SP | 25.341 | Chicago Cubs | Chicago Cubs (MLB) | DL-15 Hip contusion |
| Kyle Skipworth | C | 26.033 | Cincinnati Reds | Cincinnati Reds (MLB) | DL-15 Recovery from ankle surgery |
| Yorman Rodriguez | RF | 23.231 | Cincinnati Reds | Cincinnati Reds (MLB) | DL-15 Hamstring strain |
| Michael Lorenzen | RP | 24.090 | Cincinnati Reds | Cincinnati Reds (MLB) | DL-15 Sprained right UCL |
| Jon Moscot | SP | 24.232 | Cincinnati Reds | Cincinnati Reds (MLB) | DL-15 Strained intercostal muscle |
| John Lamb | SP | 25.267 | Cincinnati Reds | Cincinnati Reds (MLB) | DL-15 Recovery from back surgery |
| Anthony DeSclafani | SP | 25.350 | Cincinnati Reds | Cincinnati Reds (MLB) | DL-15 Strained right oblique |
| Tyler Holt | CF | 27.024 | Cincinnati Reds | Cincinnati Reds (MLB) | Recalled from Louisville (AAA) |
| Jose Peraza | SS | 21.338 | Cincinnati Reds | Louisville (AAA) | Assigned to Louisville (AAA) |
| Ramon Cabrera | C | 26.149 | Cincinnati Reds | Cincinnati Reds (MLB) | Assigned to minors |
| Alexi Amarista | LF | 26.362 | San Diego Padres | El Paso (AAA) | Assigned to El Paso (AAA) |
| Scott Oberg | RP | 26.021 | Colorado Rockies | Albuquerque (AAA) | Assigned to Albuquerque (AAA) |
| Ryan Tepera | RP | 28.152 | Toronto Blue Jays | Buffalo (AAA) | Assigned to Buffalo (AAA) |
| Tyler Krieger | ss | 22.077 | Cleveland Indians | Lake County (A) | Assigned to Lake County (A) |
| Max Moroff | SS | 22.325 | Pittsburgh Pirates | Indianapolis (AAA) | Assigned to Indianapolis (AAA) |
| Jason Rogers | 1B | 28.021 | Pittsburgh Pirates | Indianapolis (AAA) | Assigned to Indianapolis (AAA) |
