| Curt Casali | C | 26.216 | Tampa Bay Rays | Tampa Bay Rays (MLB) | Recalled from Durham (AAA) |
| Sergio Santos | RP | 31.345 | New York Yankees | New York Yankees (MLB) | Contract purchased from minors |
| Esmil Rogers | RP | 29.303 | New York Yankees | New York Yankees (MLB) | Outrighted to minors |
| Justin Verlander | SP | 32.113 | Detroit Tigers | Detroit Tigers (MLB) | Activated from DL |
| Kendry Flores | P | 23.202 | Miami Marlins | New Orleans (AAA) | Assigned to New Orleans (AAA) |
| Mat Latos | SP | 27.187 | Miami Marlins | Miami Marlins (MLB) | Activated from DL |
| Steven Cishek | RP | 28.360 | Miami Marlins | Miami Marlins (MLB) | Recalled from Jacksonville (AA) |
| Andre Rienzo | SP | 27.008 | Miami Marlins | New Orleans (AAA) | Assigned to New Orleans (AAA) |
| Drew Rucinski | P | 26.165 | Los Angeles Angels | Salt Lake (AAA) | Assigned to Salt Lake (AAA) |
| Jason Vargas | SP | 32.131 | Kansas City Royals | Kansas City Royals (MLB) | DL-15 Left flexor strain |
| Brandon Finnegan | RP | 22.060 | Kansas City Royals | Kansas City Royals (MLB) | Recalled from Omaha (AAA) |
| C.C. Lee | RP | 28.235 | Cleveland Indians | Columbus (AAA) | Assigned to Columbus (AAA) |
| Scott Atchison | RP | 39.076 | Cleveland Indians | Cleveland Indians (MLB) | Activated from DL |
| Dayan Viciedo | lf | 26.095 | Oakland Athletics | Oakland Athletics (MLB) | Signed to Minor League Contract |
| Mike Broadway | P | 28.075 | San Francisco Giants | San Francisco Giants (MLB) | Contract purchased from minors |
| Hunter Pence | RF | 32.061 | San Francisco Giants | San Francisco Giants (MLB) | DL-15 Sore left wrist tendonitis |
| Erik Goeddel | P | 26.175 | New York Mets | New York Mets (MLB) | DL-15 Strained right elbow |
| Danny Muno | SS | 26.124 | New York Mets | New York Mets (MLB) | Recalled from Las Vegas (AAA) |
| Ian Krol | RP | 24.035 | Detroit Tigers | Detroit Tigers (MLB) | Recalled from Toledo (AAA) |
| Angel Nesbitt | P | 24.191 | Detroit Tigers | Toledo (AAA) | Assigned to Toledo (AAA) |
| Derek Dietrich | 1B | 25.330 | Miami Marlins | Miami Marlins (MLB) | Recalled from New Orleans (AAA) |
| Mikie Mahtook | CF | 25.195 | Tampa Bay Rays | Durham (AAA) | Assigned to Durham (AAA) |
| Enny Romero | P | 24.140 | Tampa Bay Rays | Tampa Bay Rays (MLB) | Recalled from Durham (AAA) |
| Javier Baez | SS | 22.194 | Chicago Cubs | Iowa (AAA) | DL-7 Fractured left ring finger |
| Kirk Nieuwenhuis | lf | 27.311 | New York Mets | New York Mets (MLB) | Claimed off waivers from Angels by Mets |
| Jose Ramirez | P | 25.143 | New York Yankees | New York Yankees (MLB) | Recalled from Scranton/Wilkes-Barre (AAA) |
| Jacob Lindgren | P | 22.093 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Assigned to Scranton/Wilkes-Barre (AAA) |
| Edwin Escobar | P | 23.052 | Boston Red Sox | Pawtucket (AAA) | Activated from DL and assigned to Pawtucket (AAA) |
| J.C. Ramirez | RP | 26.301 | Arizona Diamondbacks | Arizona Diamondbacks (MLB) | Designated for Assignment |
| Allen Webster | SP | 25.123 | Arizona Diamondbacks | Arizona Diamondbacks (MLB) | Recalled from Reno (AAA) |
| Trevor Gott | RP | 22.291 | Los Angeles Angels | Los Angeles Angels (MLB) | Contract purchased from minors |
| Darin Ruf | rf-lf | 28.320 | Philadelphia Phillies | Lehigh Valley (AAA) | Assigned to Lehigh Valley (AAA) |
| Domonic Brown | RF | 27.284 | Philadelphia Phillies | Philadelphia Phillies (MLB) | Recalled from Lehigh Valley (AAA) |
| AJ Griffin | SP | 27.137 | Oakland Athletics | Nashville (AAA) | Activated from DL and assigned to Nashville (AAA) |
| Sean Doolittle | RP | 28.260 | Oakland Athletics | Oakland Athletics (MLB) | Transferred to 60-day DL |
| Ryan Arrowood | IF-P | 24.293 | Colorado Rockies | New Britain (AA) | Assigned to New Britain (AA) |
| Connor Bach | P | 22.354 | Washington Nationals | Hagerstown (A) | Assigned to Hagerstown (A) |
| Austin Bibens-Dirkx | P | 30.045 | Toronto Blue Jays | New Hampshire (AA) | Assigned to New Hampshire (AA) |
| J.C. Boscan | C | 35.170 | Kansas City Royals | Omaha (AAA) | Activated from disabled list |
| Jed Bradley | P | 25.001 | Milwaukee Brewers | Biloxi (AA) | Assigned to Biloxi (AA) |
| Lendy Castillo | RP | 26.066 | Texas Rangers | Frisco (AA) | Assigned to Frisco (AA) |
| Austin Chubb | C | 26.057 | Los Angeles Dodgers | Rancho Cucamonga (A+) | Activated from disabled list |
| Rainiero Coa | C | 22.161 | New York Yankees | Charleston (sc) (A) | Assigned to Charleston (sc) (A) |
| Josmar Cordero | | 23.277 | Los Angeles Dodgers | Rancho Cucamonga (A+) | Assigned to Rancho Cucamonga (A+) |
| Kelly Dugan | RF | 24.268 | Philadelphia Phillies | Clearwater (A+) | Activated from disabled list |
| Shawon Dunston | CF | 22.128 | Chicago Cubs | Myrtle Beach (A+) | Activated from disabled list |
| Micah Gibbs | C | 26.321 | Kansas City Royals | Northwest Arkansas (AA) | Assigned to Northwest Arkansas (AA) |
| Chad Girodo | P | 24.127 | Toronto Blue Jays | New Hampshire (AA) | Assigned to New Hampshire (AA) |
| Cristian Gomez | | 19.154 | Los Angeles Dodgers | Great Lakes (A) | Assigned to Great Lakes (A) |
| Juan Graterol | C | 26.119 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Assigned to Scranton/Wilkes-Barre (AAA) |
| Juan Grullon | P | 25.101 | Texas Rangers | Frisco (AA) | Assigned to Frisco (AA) |
| Jake Johansen | P | 24.141 | Washington Nationals | Potomac (A+) | Activated from disabled list |
| Hunter Jones | OF | 23.301 | Chicago White Sox | Kannapolis (A) | Activated from disabled list |
| Andrew Kittredge | P | 25.088 | Seattle Mariners | Tacoma (AAA) | Assigned to Tacoma (AAA) |
| Tyler Knigge | P | 26.229 | Philadelphia Phillies | Reading (AA) | Assigned to Reading (AA) |
| Will Lamb | P | 24.277 | Texas Rangers | Round Rock (AAA) | Assigned to Round Rock (AAA) |
| Radhames Liz | P | 32.003 | Pittsburgh Pirates | Indianapolis (AAA) | Assigned to Indianapolis (AAA) |
| Seth Mejias-Brean | IF | 24.069 | Cincinnati Reds | Pensacola (AA) | Activated from disabled list |
| John Mincone | P | 25.325 | New York Mets | Binghamton (AA) | Assigned to Binghamton (AA) |
| Yoanner Negrin | P | 31.045 | Chicago Cubs | Iowa (AAA) | Assigned to Iowa (AAA) |
| Faustino Oguisten | 2B-SS | 24.147 | Los Angeles Dodgers | Tulsa (AA) | Assigned to Tulsa (AA) |
| Corey Ray | P | 22.180 | Kansas City Royals | Lexington (A) | Assigned to Lexington (A) |
| Colin Rea | P | 24.347 | San Diego Padres | San Antonio (AA) | Activated from disabled list |
| Justin Ruggiano | cf | 33.062 | Seattle Mariners | Tacoma (AAA) | Outrighted to minors |
| Nate Samson | 3B-2B | 27.299 | Los Angeles Dodgers | Tulsa (AA) | Activated from disabled list |
| Grant Sides | P | 25.356 | Cleveland Indians | Akron (AA) | Activated from disabled list |
| Skyler Stromsmoe | SS-LF | 31.075 | San Francisco Giants | Sacramento (AAA) | Activated from disabled list |
| Erik Swanson | P | 21.282 | Texas Rangers | Frisco (AA) | Assigned to Frisco (AA) |
| Jose Valdespina | P | 23.083 | Texas Rangers | High Desert (A+) | Activated from disabled list |
| Matt Williams | SS | 25.288 | St. Louis Cardinals | Memphis (AAA) | Activated from disabled list |
| Cole Wiper | P | 23.010 | Texas Rangers | High Desert (A+) | Activated from disabled list |
| Alexi Casilla | 2b | 30.328 | Tampa Bay Rays | Durham (AAA) | DL-7 Injured |
| Chien-Ming Wang | SP | 35.074 | Atlanta Braves | Gwinnett (AAA) | DL-7 Injured |
| Ehire Adrianza | SS | 25.296 | San Francisco Giants | Sacramento (AAA) | DL-7 Injured |
| Eric Stults | SP | 35.187 | Los Angeles Dodgers | Ogden (Rk) | Assigned to Ogden (Rk) |
| Hector Ambriz | RP | 31.015 | | | Released by Nationals |
| Jake Dunning | RP | 26.305 | San Francisco Giants | Sacramento (AAA) | DL-7 Injured |
| Jason Lane | P | 38.173 | San Diego Padres | El Paso (AAA) | DL-7 Injured |
| Joe Benson | CF | 27.100 | Atlanta Braves | Gwinnett (AAA) | DL-7 Injured |
| Andy Ferguson | P | 26.284 | Kansas City Royals | Arizona Royals (Rk) | Assigned to AZL Royals (Rk) |
| Audy Ciriaco | 3B | 27.363 | Cleveland Indians | Columbus (AAA) | DL-7 Injured |
| Hunter Morris | 1B | 26.249 | Pittsburgh Pirates | Indianapolis (AAA) | DL-7 Injured |
| Jonas Dufek | P | 26.348 | Houston Astros | Fresno (AAA) | Placed on temporary inactive list |
| Jonathan Galvez | 2B | 24.146 | | | Released by Yankees |
| Kevin Munson | P | 26.161 | Arizona Diamondbacks | Reno (AAA) | DL-7 Injured |
| Mike Nesseth | P | 27.055 | | | Released by Braves |
| Mitch Lively | P | 29.279 | Washington Nationals | Syracuse (AAA) | Placed on temporary inactive list |
| Anthony Hewitt | RF | 26.047 | Baltimore Orioles | Frederick (A+) | DL-7 Injured |
| Cody Winiarski | P | 25.290 | Chicago White Sox | Birmingham (AA) | DL-7 Injured |
| Colin Moran | 3B-1B | 22.255 | Houston Astros | Corpus Christi (AA) | DL-7 Injured |
| Danny Oh | OF-1B | 25.167 | New York Yankees | Trenton (AA) | DL-7 Injured |
| Jarrett Miller | P | 25.258 | | | Released by Orioles |
| Kevin Perez | P | 21.316 | Washington Nationals | Auburn (A-) | Assigned to Auburn (A-) |
| Luis Liberato | OF | 19.178 | Seattle Mariners | Everett (A-) | Assigned to Everett (A-) |
| Ronarsy Ledesma | 3B | 22.055 | Baltimore Orioles | Aberdeen (A-) | Assigned to Aberdeen (A-) |
| Travious Relaford | SS | 23.031 | San Francisco Giants | Augusta (A) | DL-7 Injured |
| Travis Witherspoon | CF | 26.058 | Los Angeles Dodgers | Rancho Cucamonga (A+) | DL-7 Injured |
| Connor Overton | P | 21.324 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| David Lyon | C | 25.145 | Texas Rangers | High Desert (A+) | DL-7 Injured |
| Yoel Mecias | P | 21.245 | Philadelphia Phillies | Philadelphia Phillies (MLB) | Assigned to extended spring training |
| Collin Wiles | P | 21.014 | Texas Rangers | Texas Rangers (MLB) | Assigned to extended spring training |
| Jake Gatewood | SS | 19.262 | Milwaukee Brewers | Helena (Rk) | Assigned to Helena (Rk) |
| Monte Harrison | OF | 19.308 | Milwaukee Brewers | Helena (Rk) | Assigned to Helena (Rk) |
| Peter Miller | P | 23.047 | | | Announced retirement |
| Ramon Del Orbe | P | 23.117 | San Francisco Giants | Augusta (A) | DL-7 Injured |
| Sam Johns | P | 23.337 | Washington Nationals | Auburn (A-) | Assigned to Auburn (A-) |
| Brad Wieck | P | 23.243 | San Diego Padres | Fort Wayne (A) | Traded from Mets to Padres as PTBNL in Alex Torres trade |
| Steven Tolleson | SS | 31.225 | Toronto Blue Jays | Buffalo (AAA) | Assigned to Buffalo (AAA) for rehab |
| Jonathan Meyer | 3B | 24.224 | | | Released by Padres |
