| Scott Sizemore | 2b | 29.195 | New York Yankees | Scranton/Wilkes-Barre (AAA) | DL-7 Injured |
| Jeff Bianchi | 2b-3b | 27.286 | Milwaukee Brewers | Milwaukee Brewers (MLB) | DL-15 Strained right elbow |
| Danny Santana | SS | 23.253 | Minnesota Twins | Minnesota Twins (MLB) | Activated from DL |
| Carlos Beltran | RF | 37.085 | New York Yankees | New York Yankees (MLB) | Activated from DL |
| Tyler Pastornicky | 2b | 24.217 | Atlanta Braves | Atlanta Braves (MLB) | Recalled from Gwinnett (AAA) |
| Dan Uggla | 2b | 34.129 | - | | Released by Braves |
| Jake Buchanan | P | 24.297 | Houston Astros | Houston Astros (MLB) | Recalled from Oklahoma City (AAA) |
| Paco Rodriguez | RP | 23.093 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Recalled from Albuquerque (AAA) |
| Chris Nelson | 3b | 28.318 | San Diego Padres | San Diego Padres (MLB) | Contract purchased from minors |
| Kevin Gregg | RP | 36.028 | Miami Marlins | Miami Marlins (MLB) | DL-15 Right elbow inflammation |
| A.J. Ramos | RP | 27.301 | Miami Marlins | Miami Marlins (MLB) | Recalled from minor league rehab assignment |
| A.J. Ramos | CL | 27.301 | Miami Marlins | Miami Marlins (MLB) | Activated from DL |
| Justin Turner | ss-3b | 29.237 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Recalled from minor league rehab assignment |
| Justin Turner | ss-3b | 29.237 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Activated from DL |
| Carlos Pena | 1B | 36.062 | Texas Rangers | Texas Rangers (MLB) | Outrighted to minors |
| Jean Segura | ss | 24.123 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Reinstated from Bereavement List |
| Huston Street | RP | 30.351 | Los Angeles Angels | Los Angeles Angels (MLB) | Traded from Padres with Trevor Gott to Angels for Taylor Lindsey, R.J. Alvarez, Jose Rondon and Elliot Morris |
| Trevor Gott | P | 21.326 | Los Angeles Angels | Los Angeles Angels (MLB) | Traded from Padres with Huston Street to Angels for Taylor Lindsey, R.J. Alvarez, Jose Rondon and Elliot Morris |
| Taylor Lindsey | 2B | 22.229 | San Diego Padres | San Diego Padres (MLB) | Traded from Angels with R.J. Alvarez, Jose Rondon and Elliot Morris to Padres for Huston Street and Trevor Gott |
| Jose Rondon | SS | 20.137 | San Diego Padres | San Diego Padres (MLB) | Traded from Angels with R.J. Alvarez, Taylor Lindsey and Elliot Morris to Padres for Huston Street and Trevor Gott |
| Elliot Morris | P | 22.083 | San Diego Padres | San Diego Padres (MLB) | Traded from Angels with R.J. Alvarez, Jose Rondon and Taylor Lindsey to Padres for Huston Street and Trevor Gott |
| R.J. Alvarez | P | 23.040 | San Diego Padres | San Diego Padres (MLB) | Traded from Angels with Taylor Lindsey, Jose Rondon and Taylor Lindsey to Padres for Huston Street and Trevor Gott |
| Mayobanex Acosta | C | 26.241 | Tampa Bay Rays | Durham (AAA) | Assigned to Durham (AAA) |
| Jason Adam | P | 22.349 | Kansas City Royals | Omaha (AAA) | Assigned to Omaha (AAA) |
| Tim Adleman | P | 26.248 | Cincinnati Reds | Pensacola (AA) | Assigned to Pensacola (AA) |
| Yonder Alonso | 1b | 27.101 | San Diego Padres | Arizona Padres (Rk) | Assigned to AZL Padres (Rk) for rehab |
| Cody Bellinger | 1B | 19.005 | Los Angeles Dodgers | Ogden (Rk) | Assigned to Ogden (Rk) |
| Jeremy Berg | P | 28.001 | St. Louis Cardinals | Springfield (AA) | Assigned to Springfield (AA) |
| Seth Blair | P | 25.137 | St. Louis Cardinals | Springfield (AA) | Assigned to Springfield (AA) |
| Brett Bochy | P | 26.326 | San Francisco Giants | Arizona Giants (Rk) | Activated from disabled list |
| Rod Boykin | CF | 19.092 | San Diego Padres | Arizona Padres (Rk) | Assigned to Arizona Padres (Rk) |
| John Cannon | C | 24.068 | Los Angeles Dodgers | Albuquerque (AAA) | Activated from disabled list |
| Fabio Castillo | P | 25.149 | Cincinnati Reds | Pensacola (AA) | Assigned to Pensacola (AA) |
| Garrett Cooper | IF | 23.205 | Milwaukee Brewers | Brevard County (A+) | Assigned to Brevard County (A+) |
| Jaff Decker | lf | 24.145 | Pittsburgh Pirates | Indianapolis (AAA) | Assigned to Indianapolis (AAA) |
| Dariel Delgado | P | 20.326 | Baltimore Orioles | Delmarva (A) | Assigned to Delmarva (A) |
| David Denson | 1B | 19.182 | Milwaukee Brewers | Wisconsin (A) | Assigned to Wisconsin (A) |
| Scott Elbert | P | 28.339 | Los Angeles Dodgers | Albuquerque (AAA) | Assigned to Albuquerque (AAA) for rehab |
| Irving Falu | 2b-ss | 31.042 | Milwaukee Brewers | Nashville (AAA) | Assigned to Nashville (AAA) |
| Daniel Fields | CF | 23.176 | Detroit Tigers | Toledo (AAA) | Assigned to Toledo (AAA) |
| Chone Figgins | 3B | 36.177 | Los Angeles Dodgers | Albuquerque (AAA) | Assigned to Albuquerque (AAA) for rehab |
| Brandon Fry | P | 21.112 | San Diego Padres | Eugene (A-) | Assigned to Eugene (A-) |
| Kyuji Fujikawa | RP | 33.362 | Chicago Cubs | Kane County (A) | Assigned to Kane County (A) for rehab |
| Phil Gosselin | 2b | 25.288 | Atlanta Braves | Gwinnett (AAA) | Assigned to Gwinnett (AAA) |
| Dreily Guerrero | 2B-3B | 23.279 | Boston Red Sox | Salem (A+) | Activated from disabled list |
| Ryan Gunther | P | 23.243 | Atlanta Braves | Danville (Rk) | Assigned to Danville (Rk) |
| Jedd Gyorko | 2b | 25.298 | San Diego Padres | El Paso (AAA) | Assigned to El Paso (AAA) for rehab |
| Chris Herrmann | c | 26.237 | Minnesota Twins | Rochester (AAA) | Assigned to Rochester (AAA) |
| Rich Hill | RP | 34.129 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Assigned to Scranton/Wilkes-Barre (AAA) |
| Travis Jankowski | OF | 23.033 | San Diego Padres | Arizona Padres (Rk) | Activated from disabled list |
| Chad Jenkins | RP | 26.209 | Toronto Blue Jays | Buffalo (AAA) | Assigned to Buffalo (AAA) |
| Jon Keller | P | 21.344 | Baltimore Orioles | Frederick (A+) | Assigned to Frederick (A+) |
| Jayson Langfels | 3B | 25.335 | Colorado Rockies | Tulsa (AA) | Activated from disabled list |
| Smerling Lantigua | | 20.165 | Texas Rangers | Frisco (AA) | Assigned to Frisco (AA) |
| Zach Larson | OF | 20.283 | Minnesota Twins | Cedar Rapids (A) | Assigned to Cedar Rapids (A) |
| Tyler Lyons | SP | 26.148 | St. Louis Cardinals | Memphis (AAA) | Assigned to Memphis (AAA) |
| Parker Markel | P | 23.306 | Tampa Bay Rays | Montgomery (AA) | Assigned to Montgomery (AA) |
| Josh McElwee | P | 25.036 | Texas Rangers | Myrtle Beach (A+) | Assigned to Myrtle Beach (A+) |
| Simon Mercedes | P | 22.152 | Boston Red Sox | Salem (A+) | Activated from disabled list |
| Luke Montz | dh | 31.011 | Oakland Athletics | Sacramento (AAA) | Activated from disabled list |
| Nick Moore | 3B | 21.221 | Boston Red Sox | Salem (A+) | Assigned to Salem (A+) |
| Shawn Morimando | P | 21.240 | Cleveland Indians | Akron (AA) | Assigned to Akron (AA) |
| Reymond Nunez | 1B | 23.296 | New York Yankees | Charleston (sc) (A) | Assigned to Charleston (Sc) (A) |
| Aaron Poreda | P | 27.290 | Texas Rangers | Round Rock (AAA) | Assigned to Round Rock (AAA) |
| Jorge Reyes | P | 26.224 | Atlanta Braves | Mississippi (AA) | Assigned to Mississippi (AA) |
| Dante Rosenberg | C | 24.013 | St. Louis Cardinals | Memphis (AAA) | Assigned to Memphis (AAA) |
| Bryson Smith | CF | 25.213 | Cincinnati Reds | Pensacola (AA) | Assigned to Pensacola (AA) |
| Andres Sotillo | | 20.202 | Toronto Blue Jays | Gulf Coast Blue Jays (Rk) | Assigned to Gulf Coast Blue Jays (Rk) |
| Cole Sulser | P | 24.128 | Cleveland Indians | Carolina (A+) | Assigned to Carolina (A+) |
| Travis Tartamella | C | 26.214 | St. Louis Cardinals | Springfield (AA) | Assigned to Springfield (AA) |
| Taylor Teagarden | c | 30.210 | New York Mets | St. Lucie (A+) | Assigned to St. Lucie (A+) for rehab |
| Carlos Triunfel | ss | 24.141 | Los Angeles Dodgers | Albuquerque (AAA) | Assigned to Albuquerque (AAA) |
| Ryan Verdugo | P | 27.099 | Boston Red Sox | Pawtucket (AAA) | Assigned to Pawtucket (AAA) |
| Angel Villalona | IF | 23.339 | San Francisco Giants | Richmond (AA) | Assigned to Richmond (AA) |
| Nick Vincent | RP | 28.006 | San Diego Padres | El Paso (AAA) | Assigned to El Paso (AAA) for rehab |
| Chris Volstad | RP | 27.298 | Los Angeles Angels | Salt Lake (AAA) | Assigned to Salt Lake (AAA) |
| Brett Wallace | 1b | 27.326 | Toronto Blue Jays | Buffalo (AAA) | Assigned to Buffalo (AAA) |
| Chad Wallach | P | 22.257 | Miami Marlins | Jupiter (A+) | Assigned to Jupiter (A+) |
| Chien-Ming Wang | SP | 34.109 | Chicago White Sox | Charlotte (AAA) | Assigned to Charlotte (AAA) |
| Collin Wiles | P | 20.049 | Texas Rangers | Hickory (A) | Assigned to Hickory (A) |
| Fabian Williamson | P | 25.271 | Cincinnati Reds | Pensacola (AA) | Assigned to Pensacola (AA) |
| K.J. Woods | RF | 19.009 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| John Wooten | 3B | 23.180 | Washington Nationals | Hagerstown (A) | Assigned to Hagerstown (A) |
| Elliot Johnson | 2b | 30.131 | Cleveland Indians | Columbus (AAA) | DL-7 Injured |
| Juan Abreu | P | 29.101 | | | Released by Dodgers |
| Justin Marks | P | 26.188 | Texas Rangers | Round Rock (AAA) | DL-7 Injured |
| Omir Santos | C | 33.080 | Pittsburgh Pirates | Indianapolis (AAA) | DL-7 Injured |
| Randy Wolf | P | 37.330 | | | Released by Orioles |
| Brett Brach | P | 26.111 | | | Released by Nationals |
| Giancarlo Alvarado | P | 36.175 | New York Mets | Las Vegas (AAA) | DL-7 Injured |
| Matt Curry | 1B | 25.356 | Pittsburgh Pirates | Indianapolis (AAA) | DL-7 Injured |
| Michael Olmsted | P | 27.077 | | | Released by Red Sox |
| Paul Demny | P | 24.349 | Washington Nationals | Harrisburg (AA) | DL-7 Injured |
| Tim Alderson | P | 25.257 | | | Released by Orioles |
| Tyler Saladino | SS | 24.363 | Chicago White Sox | Charlotte (AAA) | DL-7 Injured |
| Tyson Blaser | C-1B | 26.223 | New York Yankees | Trenton (AA) | DL-7 Injured |
| Andy Moye | P | 26.311 | Milwaukee Brewers | Huntsville (AA) | DL-7 Injured |
| Angel Cuan | P | 25.050 | New York Mets | Binghamton (AA) | DL-7 Injured |
| Blake Schwartz | P | 24.282 | Washington Nationals | Potomac (A+) | DL-7 Injured |
| Clayton Blackburn | P | 21.193 | San Francisco Giants | Richmond (AA) | DL-7 Injured |
| Keury De la cruz | CF | 22.233 | Boston Red Sox | Portland (AA) | DL-7 Injured |
| Lance Ray | RF-1B | 24.319 | Minnesota Twins | New Britain (AA) | DL-7 Injured |
| Manuel Barreda | P | 25.283 | | | Released by Yankees |
| Zach Wilson | 3B | 23.346 | New York Yankees | Trenton (AA) | DL-7 Injured |
| Jose Adames | p | 21.182 | Miami Marlins | Palm Beach (A+) | Assigned to Batavia (A-) |
| Mike Adams | P | 23.287 | Boston Red Sox | Greenville (A) | DL-7 Injured |
| Mike Ford | P | 22.014 | New York Yankees | Charleston (sc) (A) | DL-7 Injured |
| Nathan Hass | C | 20.133 | Atlanta Braves | Rome (A) | DL-7 Injured |
| Ian Stewart | 3B | 29.104 | Los Angeles Angels | Los Angeles Angels (MLB) | Designated for Assignment |
| Donnie Murphy | 3b | 31.130 | Cincinnati Reds | Cincinnati Reds (MLB) | Signed to minor league contract |
| Josh Fellhauer | LF | 26.116 | Milwaukee Brewers | Huntsville (AA) | Traded from Reds to Brewers |
| Carlos Pena | 1B | 36.062 | Texas Rangers | Texas Rangers (MLB) | Designated for Assignment |
| Geovany Soto | c | 31.179 | Texas Rangers | Texas Rangers (MLB) | Activated from DL |
| A.J. Pierzynski | c | 37.200 | - | | Cleared Waivers and Became a Free Agent |
| James Simmons | P | 27.292 | Washington Nationals | Syracuse (AAA) | Assigned to Syracuse (AAA) |
| Michael Yastrzemski | OF | 23.329 | Baltimore Orioles | Bowie (AA) | Assigned to Bowie (AA) |
| Yeims Mendoza | P | 21.141 | Miami Marlins | Gulf Coast Marlins (Rk) | Assigned to GCL Marlins (Rk) |
| Tyler Wood | P | 22.275 | San Diego Padres | Arizona Padres (Rk) | Assigned to AZL Padres (Rk) |
| Keith Curcio | OF | 21.202 | Atlanta Braves | Danville (Rk) | DL-60 Injured |
| Alec Keller | OF | 22.066 | Washington Nationals | Auburn (A-) | DL-60 Injured |
| Chris Hoo | C | 22.150 | Miami Marlins | Batavia (A-) | Signed out of draft (Cal Poly) |
| Kyle McKenzie | P | 23.308 | Tampa Bay Rays | Hudson Valley (A-) | Assigned to Hudson Valley (A-) |
| Nick Kiel | P | 21.230 | Seattle Mariners | Arizona Mariners (Rk) | Assigned to AZL Mariners (Rk) |
| Jake Bowey | C | 18.002 | Houston Astros | Dominican Astros (Rk) | Assigned to DSL Astros (Rk) |
| Sam Hentges | P | 18.000 | Cleveland Indians | Arizona Indians (Rk) | Signed out of draft (Minnesota HS) |
| Starlyng Sanchez | P | 19.346 | Houston Astros | Gulf Coast Astros (Rk) | Assigned to GCL Astros (Rk) |
| Tom Verdi | IF | 22.107 | Seattle Mariners | Pulaski (Rk) | Assigned to Pulaski (Rk) |
| Yhoan Acosta | P | 19.031 | Houston Astros | Gulf Coast Astros (Rk) | Assigned to GCL Astros (Rk) |
| Eddie Butler | SP | 23.127 | Colorado Rockies | Colorado Springs (AAA) | Assigned to Colorado Springs (AAA) for rehab |
