| Lucas Luetge | RP | 27.136 | Seattle Mariners | Seattle Mariners (MLB) | Recalled from Tacoma (AAA) |
| Kyle Hendricks | P | 24.215 | Chicago Cubs | Chicago Cubs (MLB) | Contract purchased from minors |
| Kristopher Negron | SS-CF | 28.159 | Cincinnati Reds | Cincinnati Reds (MLB) | Contract purchased from minors |
| Ehire Adrianza | SS | 24.323 | San Francisco Giants | San Francisco Giants (MLB) | Activated from DL |
| Brett Marshall | RP | 24.110 | Cincinnati Reds | Cincinnati Reds (MLB) | Designated for Assignment |
| Louis Coleman | RP | 28.097 | Kansas City Royals | Kansas City Royals (MLB) | Recalled from Omaha (AAA) |
| Jason Vargas | SP | 31.158 | Kansas City Royals | Kansas City Royals (MLB) | DL-15 Appendectomy |
| Carlos Beltran | rf | 37.077 | New York Yankees | New York Yankees (MLB) | DL-7 Concussion |
| Yangervis Solarte | 2B | 27.003 | New York Yankees | New York Yankees (MLB) | Recalled from Scranton/Wilkes-Barre (AAA) |
| Jaff Decker | lf | 24.137 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | Recalled from Indianapolis (AAA) |
| Nick Maronde | RP | 24.308 | Los Angeles Angels | Los Angeles Angels (MLB) | Designated for Assignment |
| Cory Rasmus | RP | 26.247 | Los Angeles Angels | Los Angeles Angels (MLB) | Recalled from Salt Lake (AAA) |
| Drew Rucinski | P | 25.192 | Los Angeles Angels | Los Angeles Angels (MLB) | Contract purchased from minors |
| C.J. Wilson | SP | 33.234 | Los Angeles Angels | Los Angeles Angels (MLB) | DL-15 Sprained right ankle |
| Matt West | P | 25.231 | Texas Rangers | Texas Rangers (MLB) | Recalled from Round Rock (AAA) |
| Yadier Molina | c | 31.362 | St. Louis Cardinals | St. Louis Cardinals (MLB) | DL-15 Torn ligament, right thumb |
| Audry Perez | C | 25.199 | St. Louis Cardinals | St. Louis Cardinals (MLB) | Recalled from Memphis (AAA) |
| Ramon Ramirez | RP | 32.313 | | | Refused Minor League Assignment, Granted Free Agency |
| Preston Guilmet | RP | 26.349 | Baltimore Orioles | Baltimore Orioles (MLB) | Recalled from Norfolk (AAA) |
| Carl Crawford | lf | 32.339 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Activated from DL |
| Collin Balester | P | 28.034 | Pittsburgh Pirates | Bradenton (A+) | Assigned to Bradenton (A+) |
| Jeremy Barfield | RF | 25.363 | Oakland Athletics | Midland (AA) | Activated from disabled list |
| Yhonathan Barrios | 3B | 22.222 | Pittsburgh Pirates | Bradenton (A+) | Assigned to Bradenton (A+) |
| Cam Bedrosian | P | 22.282 | Los Angeles Angels | Arkansas (AA) | Assigned to Arkansas (AA) |
| Dallas Beeler | P | 25.028 | Chicago Cubs | Iowa (AAA) | Assigned to Iowa (AAA) |
| Nick Benedetto | OF | 21.133 | Cincinnati Reds | Bakersfield (A+) | Assigned to Bakersfield (A+) |
| Andrew Brown | rf-lf | 24.241 | Colorado Rockies | Grand Junction (Rk) | Assigned to Grand Junction (Rk) |
| Colton Cain | P | 23.155 | Houston Astros | Corpus Christi (AA) | Assigned to Corpus Christi (AA) |
| Shane Carle | P | 22.315 | Pittsburgh Pirates | Bradenton (A+) | Assigned to Bradenton (A+) |
| David Carpenter | P | 26.313 | Los Angeles Angels | Salt Lake (AAA) | Assigned to Salt Lake (AAA) |
| Luis Chirinos | P | 24.079 | Los Angeles Dodgers | Great Lakes (A) | Activated from disabled list |
| Carlos Contreras | P | 23.183 | Cincinnati Reds | Louisville (AAA) | Assigned to Louisville (AAA) |
| Brandon Cumpton | SP | 25.236 | Pittsburgh Pirates | Indianapolis (AAA) | Assigned to Indianapolis (AAA) |
| Matt Curry | 1B | 25.348 | Pittsburgh Pirates | Indianapolis (AAA) | Assigned to Indianapolis (AAA) |
| Toby DeMello | C | 24.188 | Seattle Mariners | High Desert (A+) | Assigned to High Desert (A+) |
| David Denson | 1B | 19.174 | Milwaukee Brewers | Arizona Brewers (Rk) | Assigned to Arizona Brewers (Rk) |
| Cody Dent | SS | 22.344 | Washington Nationals | Potomac (A+) | Assigned to Potomac (A+) |
| Ryan Dent | SS | 25.117 | Boston Red Sox | Portland (AA) | Assigned to Portland (AA) |
| Julio DePaula | P | 31.191 | Baltimore Orioles | Bowie (AA) | Assigned to Bowie (AA) |
| Bobby Doran | P | 25.111 | Chicago White Sox | Charlotte (AAA) | Assigned to Charlotte (AAA) |
| Carlos Duran | | 22.047 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| Sean Dwyer | 1B | 22.218 | Colorado Rockies | Tri-City (A-) | Assigned to Tri-City (A-) |
| Adam Ehrlich | C | 21.209 | St. Louis Cardinals | Palm Beach (A+) | Assigned to Palm Beach (A+) |
| Josh Fellhauer | LF | 26.108 | Cincinnati Reds | Pensacola (AA) | Activated from disabled list |
| Dan Fiorito | SS | 23.324 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Assigned to Scranton/Wilkes-Barre (AAA) |
| Trey Haley | P | 24.019 | Cleveland Indians | Arizona Indians (Rk) | Assigned to Arizona Indians (Rk) |
| Michael Heesch | P | 24.056 | Chicago Cubs | Kane County (A) | Assigned to Kane County (A) |
| John Hicks | C | 24.313 | Seattle Mariners | Tacoma (AAA) | Assigned to Tacoma (AAA) |
| Phillip Irwin | P | 27.135 | Texas Rangers | Round Rock (AAA) | Assigned to Round Rock (AAA) |
| Tommy Joseph | C | 22.360 | Philadelphia Phillies | Gulf Coast Phillies (Rk) | Activated from disabled list |
| Matt Kimbrel | P | 24.119 | Atlanta Braves | Rome (A) | Assigned to Rome (A) |
| Ricky Knapp | P | 22.051 | New York Mets | Savannah (A) | Assigned to Savannah (A) |
| Zach Larson | OF | 20.275 | Minnesota Twins | Gulf Coast Twins (Rk) | Activated from disabled list |
| Jeff Lorick | P | 26.205 | Chicago Cubs | Tennessee (AA) | Activated from disabled list |
| Austin Maddox | C | 23.058 | Boston Red Sox | Lowell (A-) | Assigned to Lowell (A-) |
| Jeff Malm | 1B | 23.252 | Tampa Bay Rays | Montgomery (AA) | Assigned to Montgomery (AA) |
| Justin Maxwell | rf | 30.247 | Kansas City Royals | Omaha (AAA) | Assigned to Omaha (AAA) |
| Blake McFarland | P | 26.159 | Toronto Blue Jays | New Hampshire (AA) | Assigned to New Hampshire (AA) |
| Dillon McNamara | P | 22.278 | New York Yankees | Staten Island (A-) | Assigned to Staten Island (A-) |
| Sam Mende | 3B | 24.182 | San Francisco Giants | Salem-Keizer (A-) | Activated from disabled list |
| Joseph Michaud | c | 23.097 | Oakland Athletics | Beloit (A) | Assigned to Beloit (A) |
| Parker Morin | C | 23.008 | Kansas City Royals | Northwest Arkansas (AA) | Assigned to Northwest Arkansas (AA) |
| Jack Murphy | C | 26.095 | Toronto Blue Jays | Buffalo (AAA) | Assigned to Buffalo (AAA) |
| John Nester | C | 25.043 | San Diego Padres | Arizona Padres (Rk) | Activated from disabled list |
| Bud Norris | SP | 29.130 | Baltimore Orioles | Bowie (AA) | Assigned to Bowie (AA) |
| Chad Oberacker | LF | 25.177 | Oakland Athletics | Stockton (A+) | Assigned to Stockton (A+) |
| Andy Otamendi | P | 22.056 | Pittsburgh Pirates | West Virginia (A) | Assigned to West Virginia (A) |
| Joc Pederson | LF | 22.080 | Los Angeles Dodgers | Albuquerque (AAA) | Activated from disabled list |
| Juan Perez | LF | 27.239 | San Francisco Giants | Fresno (AAA) | Assigned to Fresno (AAA) |
| Kendrick Perkins | LF | 22.302 | Boston Red Sox | Salem (A+) | Assigned to Salem (A+) |
| Matt Pierpont | IF-P | 23.166 | Colorado Rockies | Asheville (A) | Assigned to Asheville (A) |
| Rich Poythress | 1B | 26.334 | Atlanta Braves | Mississippi (AA) | Assigned to Mississippi (AA) |
| Stephen Pryor | RP | 24.352 | Seattle Mariners | Tacoma (AAA) | Assigned to Tacoma (AAA) |
| Jasvir Rakkar | P | 23.074 | Chicago Cubs | Iowa (AAA) | Assigned to Iowa (AAA) |
| Robby Rowland | P | 22.208 | Pittsburgh Pirates | West Virginia (A) | Assigned to West Virginia (A) |
| Carlos Sanchez | C | 20.247 | Atlanta Braves | Danville (Rk) | Assigned to Danville (Rk) |
| Jeffry Santos | SS | 21.187 | Houston Astros | Greeneville (Rk) | Assigned to Greeneville (Rk) |
| Joe Scanio | P | 24.161 | St. Louis Cardinals | State College (A-) | Assigned to State College (A-) |
| Francisco Sosa | LF | 24.133 | Colorado Rockies | Modesto (A+) | Assigned to Modesto (A+) |
| Matt Spring | C | 29.245 | Boston Red Sox | Pawtucket (AAA) | Assigned to Pawtucket (AAA) |
| Travis Tartamella | C | 26.206 | St. Louis Cardinals | Memphis (AAA) | Assigned to Memphis (AAA) |
| Luis Tejada | 1B | 21.271 | San Diego Padres | Lake Elsinore (A+) | Activated from disabled list |
| Matt Tracy | P | 25.226 | New York Yankees | Trenton (AA) | Assigned to Trenton (AA) |
| Tyler Vail | P | 21.129 | Atlanta Braves | Danville (Rk) | Assigned to Danville (Rk) |
| Anthony Vasquez | P | 27.294 | Baltimore Orioles | Bowie (AA) | Assigned to Bowie (AA) |
| Gerwuins Velazco | C | 22.277 | St. Louis Cardinals | Springfield (AA) | Assigned to Springfield (AA) |
| Dane De la Rosa | RP | 31.159 | Los Angeles Angels | Salt Lake (AAA) | DL-7 Injured |
| Jake Boyd | P | 24.185 | Los Angeles Angels | Inland Empire (A+) | DL-7 Injured |
| Jeremy Berg | P | 27.358 | | | Released by Angels |
| Logan Verrett | P | 24.021 | New York Mets | Las Vegas (AAA) | DL-7 Injured |
| Timothy Crabbe | P | 26.141 | Cincinnati Reds | Louisville (AAA) | DL-7 Injured |
| Chris Petrini | P | 27.149 | | | Released by Orioles |
| Daniel Stumpf | P | 23.187 | Kansas City Royals | Wilmington (A+) | DL-7 Injured |
| Andrew Thurman | P | 22.213 | Houston Astros | Quad Cities (A) | DL-7 Injured |
| D.J. Snelten | P | 22.042 | San Francisco Giants | Augusta (A) | DL-7 Injured |
| Harold Ramirez | OF | 19.307 | Pittsburgh Pirates | West Virginia (A) | DL-7 Injured |
| Ryan Tuntland | 3B | 23.071 | San Francisco Giants | Augusta (A) | DL-7 Injured |
| Yasiel Balaguert | OF | 21.189 | Chicago Cubs | Kane County (A) | DL-7 Injured |
| Anthony Tzamtzis | P | 23.248 | | | Released by Rays |
| John Alexander | 1B | 21.076 | | | Released by Rays |
| Mike Connolly | IF | 22.253 | San Francisco Giants | Arizona Giants (Rk) | DL-7 Injured |
| Ravel Santana | CF | 22.070 | | | Released by Astros |
| Tyler Gauthier | P | 22.037 | | | Released by Rays |
| Mark Lowe | RP | 31.033 | Cleveland Indians | Cleveland Indians (MLB) | Outrighted to minors |
| Alex Guerrero | IF | 27.202 | Los Angeles Dodgers | Arizona Dodgers (Rk) | Assigned to AZL Dodgers (Rk) for rehab |
| Jeff Barkley | P | 24.003 | St. Louis Cardinals | Johnson City (Rk) | Assigned to Johnson City (Rk) |
| Steve Nyisztor | IF | 23.069 | Arizona Diamondbacks | Hillsboro (A-) | Assigned to Hillsboro (A-) |
| Calvin Graves | OF | 23.114 | Chicago Cubs | Boise (A-) | Assigned to Boise (A-) |
| Whit Mayberry | P | 24.042 | Detroit Tigers | Gulf Coast Tigers (East) (Rk) | Signed out of draft (Virginia) |
| Adam Ravenelle | P | 21.278 | Detroit Tigers | Gulf Coast Tigers (East) (Rk) | Assigned to GCL Tigers (Rk) |
| Artie Lewicki | P | 22.093 | Detroit Tigers | Gulf Coast Tigers (East) (Rk) | Signed out of draft (Virginia) |
| Kleiber Rivas | C | 19.018 | San Francisco Giants | Arizona Giants (Rk) | Assigned to AZL Giants (Rk) |
| Justin McCalvin | P | 22.056 | Tampa Bay Rays | Hudson Valley (A-) | Assigned to Hudson Valley (A-) |
| Matt Trowbridge | P | 21.108 | Baltimore Orioles | Aberdeen (A-) | Assigned to Aberdeen (A-) |
| Ryan Williams | P | 22.252 | Chicago Cubs | Boise (A-) | Assigned to Boise (A-) |
| Blake Austin | C | 22.009 | Atlanta Braves | Gulf Coast Braves (Rk) | Signed out of draft (Auburn) |
| Derek Peterson | IF | 23.126 | Baltimore Orioles | Gulf Coast Orioles (Rk) | Assigned to GCL Orioles (Rk) |
| Jean Cosme | P | 18.047 | Baltimore Orioles | Gulf Coast Orioles (Rk) | Signed out of draft (Puerto Rico) |
| Jordan Holloway | P | 18.027 | Miami Marlins | Gulf Coast Marlins (Rk) | Signed out of draft (Colorado HS) |
| Anthony Alford | OF | 19.355 | Toronto Blue Jays | Lansing (A) | Placed on temporary inactive list |
