| Rubby De La Rosa | RP | 25.127 | Boston Red Sox | Boston Red Sox (MLB) | Recalled from Pawtucket (AAA) |
| Cole Gillespie | rf | 30.019 | Toronto Blue Jays | Toronto Blue Jays (MLB) | DL-15 Strained oblique |
| Erik Kratz | c | 34.024 | Toronto Blue Jays | Toronto Blue Jays (MLB) | Recalled from Buffalo (AAA) |
| Arismendy Alcantara | SS | 22.254 | Chicago Cubs | Chicago Cubs (MLB) | Recalled from Iowa (AAA) |
| Darwin Barney | 2b | 28.243 | Chicago Cubs | Chicago Cubs (MLB) | Placed on Paternity Leave list |
| Dillon Gee | SP | 28.072 | New York Mets | New York Mets (MLB) | Activated from DL |
| Jeff Manship | SP | 29.174 | Philadelphia Phillies | Philadelphia Phillies (MLB) | Activated from DL |
| Gerrit Cole | SP | 23.304 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | DL-15 Right lat soreness |
| Brandon Cumpton | SP | 25.235 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | Recalled from Indianapolis (AAA) |
| A.J. Pierzynski | c | 37.191 | Boston Red Sox | Boston Red Sox (MLB) | Designated for Assignment |
| Christian Vazquez | C | 23.322 | Boston Red Sox | Boston Red Sox (MLB) | Recalled from Pawtucket (AAA) |
| Dallas Beeler | P | 25.027 | Chicago Cubs | Chicago Cubs (MLB) | Recalled from Iowa (AAA) |
| Zoilo Almonte | lf | 25.029 | New York Yankees | New York Yankees (MLB) | Recalled from Scranton/Wilkes-Barre (AAA) |
| Masahiro Tanaka | P | 25.250 | New York Yankees | New York Yankees (MLB) | DL-15 Right elbow inflammation |
| Stephen Pryor | RP | 24.351 | Seattle Mariners | Seattle Mariners (MLB) | Recalled from Tacoma (AAA) |
| Matt Hague | 3B-1B | 28.323 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | Contract purchased from minors |
| Donnie Murphy | 3b | 31.121 | - | | Released by Rangers |
| Starling Marte | lf | 25.273 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | Placed on Bereavement list |
| Mayobanex Acosta | C | 26.232 | Tampa Bay Rays | Hudson Valley (A-) | Assigned to Hudson Valley (A-) |
| Gabriel Arias | P | 24.215 | Cleveland Indians | Columbus (AAA) | Assigned to Columbus (AAA) |
| Collin Balester | P | 28.033 | Pittsburgh Pirates | Bristol (Rk) | Assigned to Bristol (Rk) |
| Jose Berrios | P | 20.043 | Minnesota Twins | New Britain (AA) | Assigned to New Britain (AA) |
| Chris Berset | C | 26.164 | Cincinnati Reds | Louisville (AAA) | Activated from disabled list |
| Logan Billbrough | P | 24.339 | St. Louis Cardinals | Palm Beach (A+) | Assigned to Palm Beach (A+) |
| Bruce Billings | P | 28.233 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Assigned to Scranton/Wilkes-Barre (AAA) |
| Parker Bridwell | P | 22.342 | Baltimore Orioles | Frederick (A+) | Assigned to Frederick (A+) |
| Ronard Castillo | LF | 22.023 | St. Louis Cardinals | Peoria (A) | Activated from disabled list |
| Mike Clevinger | P | 23.200 | Los Angeles Angels | Inland Empire (A+) | Activated from disabled list |
| Jimmy Cordero | P | 22.264 | Toronto Blue Jays | Lansing (A) | Activated from disabled list |
| Bryan Brickhouse | P | 22.033 | Kansas City Royals | Idaho Falls (Rk) | DL-7 Injured |
| Angel Cuan | P | 25.041 | New York Mets | Binghamton (AA) | Activated from disabled list |
| Zack Dodson | P | 23.351 | Pittsburgh Pirates | Bradenton (A+) | Assigned to Bradenton (A+) |
| Garrett Cooper | IF | 23.196 | Milwaukee Brewers | Wisconsin (A) | DL-7 Injured |
| Tim Fedroff | CF-LF | 27.155 | Cleveland Indians | Akron (AA) | Assigned to Akron (AA) |
| Anderson Feliz | 2B | 22.059 | New York Yankees | Tampa (A+) | Activated from disabled list |
| Daniel Fields | CF | 23.167 | Detroit Tigers | Erie (AA) | Assigned to Erie (AA) |
| Ryan Fisher | 3B | 26.076 | Miami Marlins | Gulf Coast Marlins (Rk) | Activated from disabled list |
| Trevor Foss | P | 24.236 | Los Angeles Angels | Inland Empire (A+) | Assigned to Inland Empire (A+) |
| Freddy Galvis | 3b | 24.237 | Philadelphia Phillies | Gulf Coast Phillies (Rk) | Activated from disabled list |
| Max Garner | P | 24.028 | Miami Marlins | Greensboro (A) | Assigned to Greensboro (A) |
| Brandon Dixon | IF | 22.162 | Los Angeles Dodgers | Rancho Cucamonga (A+) | DL-7 Injured |
| Anderson Gerdel | | 21.109 | St. Louis Cardinals | State College (A-) | Assigned to State College (A-) |
| Gonzalez Germen | RP | 26.290 | New York Mets | Las Vegas (AAA) | Assigned to Las Vegas (AAA) |
| Daniel Gibson | P | 22.267 | Arizona Diamondbacks | Visalia (A+) | Assigned to Visalia (A+) |
| Grant Green | 2b | 26.286 | Los Angeles Angels | Salt Lake (AAA) | Assigned to Salt Lake (AAA) |
| Michael Heesch | P | 24.055 | Chicago Cubs | Iowa (AAA) | Assigned to Iowa (AAA) |
| David Holmberg | P | 22.356 | Cincinnati Reds | Louisville (AAA) | Assigned to Louisville (AAA) |
| Zack Granite | OF | 21.295 | Minnesota Twins | Cedar Rapids (A) | DL-7 Injured |
| Kevin Johnson | P | 25.324 | Los Angeles Angels | Arkansas (AA) | Activated from disabled list |
| Cody Kendall | P | 24.209 | Texas Rangers | Myrtle Beach (A+) | Assigned to Myrtle Beach (A+) |
| Jared King | OF | 22.271 | New York Mets | St. Lucie (A+) | Assigned to St. Lucie (A+) |
| Andrew Lambo | rf | 25.332 | Pittsburgh Pirates | Jamestown (A-) | Assigned to Jamestown (A-) for rehab |
| Cliff Lee | SP | 35.313 | Philadelphia Phillies | Clearwater (A+) | Activated from disabled list |
| Jon Leroux | C | 23.293 | New York Mets | Brooklyn (A-) | Assigned to Brooklyn (A-) |
| Javier Lopez | SS | 19.299 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| Jose Lozada | 3B-SS | 28.192 | Washington Nationals | Harrisburg (AA) | Activated from disabled list |
| Josh Lucas | P | 23.246 | St. Louis Cardinals | Peoria (A) | Assigned to Peoria (A) |
| Greg Mahle | P | 21.083 | Los Angeles Angels | Burlington (A) | Assigned to Burlington (A) |
| Jamie Jarmon | OF | 20.018 | | | Announced retirement |
| Doug Mathis | P | 31.032 | Tampa Bay Rays | Hudson Valley (A-) | Assigned to Hudson Valley (A-) |
| Scott McGregor | P | 27.202 | Washington Nationals | Harrisburg (AA) | Activated from disabled list |
| Dillon McNamara | P | 22.277 | New York Yankees | Trenton (AA) | Assigned to Trenton (AA) |
| Aderlin Mejia | SS-2B | 22.058 | Minnesota Twins | Fort Myers (A+) | Activated from disabled list |
| Mason Melotakis | P | 23.011 | Minnesota Twins | New Britain (AA) | Assigned to New Britain (AA) |
| Rafael Montero | P | 23.265 | New York Mets | Gulf Coast Mets (Rk) | Assigned to GCL Mets (Rk) for rehab |
| Josh Mueller | P | 25.172 | Colorado Rockies | Tulsa (AA) | Assigned to Tulsa (AA) |
| Iden Nazario | P | 25.103 | St. Louis Cardinals | Springfield (AA) | Assigned to Springfield (AA) |
| Wil Nieves | c | 36.287 | Philadelphia Phillies | Clearwater (A+) | Assigned to Clearwater (A+) for rehab |
| Faustino Oguisten | 2B-SS | 23.173 | Los Angeles Dodgers | Great Lakes (A) | Assigned to Great Lakes (A) |
| Christopher Perry | P | 23.359 | St. Louis Cardinals | Palm Beach (A+) | Assigned to Palm Beach (A+) |
| Brent Peterson | SS | 21.262 | Cincinnati Reds | Bakersfield (A+) | Activated from disabled list |
| Josmil Pinto | C | 25.100 | Minnesota Twins | Rochester (AAA) | Activated from disabled list |
| David Popkins | OF | 24.235 | St. Louis Cardinals | Palm Beach (A+) | Assigned to Palm Beach (A+) |
| James Ramsey | OF-IF | 24.202 | St. Louis Cardinals | Springfield (AA) | Activated from disabled list |
| Jimmy Reyes | P | 25.124 | Texas Rangers | Round Rock (AAA) | Assigned to Round Rock (AAA) |
| Dustin Richardson | P | 30.182 | Los Angeles Angels | Salt Lake (AAA) | Activated from disabled list |
| Richard Rodriguez | P | 24.127 | Houston Astros | Oklahoma City (AAA) | Assigned to Oklahoma City (AAA) |
| B.J. Rosenberg | RP | 28.295 | Philadelphia Phillies | Lehigh Valley (AAA) | Assigned to Lehigh Valley (AAA) |
| Chris Rusin | SP | 27.260 | Chicago Cubs | Iowa (AAA) | Assigned to Iowa (AAA) |
| Eric Ruth | P | 23.286 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Assigned to Scranton/Wilkes-Barre (AAA) |
| River Stevens | IF | 22.181 | San Diego Padres | Lake Elsinore (A+) | Assigned to Lake Elsinore (A+) |
| Logan Taylor | P | 22.209 | New York Mets | Savannah (A) | Activated from disabled list |
| Clete Thomas | cf | 30.238 | Philadelphia Phillies | Gulf Coast Phillies (Rk) | Activated from disabled list |
| Derek Toadvine | IF | 22.111 | New York Yankees | Tampa (A+) | Assigned to Tampa (A+) |
| Matt Tracy | P | 25.225 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Assigned to Scranton/Wilkes-Barre (AAA) |
| Sam Tuivailala | 3B | 21.263 | St. Louis Cardinals | Springfield (AA) | Assigned to Springfield (AA) |
| Angel Villalona | IF | 23.330 | San Francisco Giants | Arizona Giants (Rk) | Assigned to AZL Giants (Rk) for rehab |
| Tsuyoshi Wada | P | 33.138 | Chicago Cubs | Iowa (AAA) | Assigned to Iowa (AAA) |
| Logan Wade | 2B | 22.239 | Minnesota Twins | Cedar Rapids (A) | Assigned to Cedar Rapids (A) |
| Brady Wager | P | 23.234 | Baltimore Orioles | Aberdeen (A-) | Assigned to Aberdeen (A-) |
| Taijuan Walker | P | 21.330 | Seattle Mariners | Tacoma (AAA) | Assigned to Tacoma (AAA) |
| Chris Wallace | C | 26.073 | Cleveland Indians | Columbus (AAA) | Activated from disabled list |
| Blake Wood | P | 28.335 | Kansas City Royals | Wilmington (A+) | Assigned to Wilmington (A+) |
| John Wooten | 3B | 23.171 | Washington Nationals | Auburn (A-) | Activated from disabled list |
| Brandon Workman | RP | 25.330 | Boston Red Sox | Pawtucket (AAA) | Assigned to Pawtucket (AAA) |
| Eric Yardley | P | 23.325 | San Diego Padres | San Antonio (AA) | Assigned to San Antonio (AA) |
| Alex Liddi | 1b | 25.329 | Los Angeles Dodgers | Chattanooga (AA) | Assigned to Chattanooga (AA) |
| Chaz Roe | RP | 27.273 | Miami Marlins | New Orleans (AAA) | DL-7 Injured |
| Kensuke Tanaka | lf | 33.050 | Texas Rangers | Round Rock (AAA) | DL-7 Injured |
| Adalberto Mejia | P | 21.019 | San Francisco Giants | Richmond (AA) | DL-7 Injured |
| Greg Peavey | P | 25.363 | New York Mets | Binghamton (AA) | Placed on temporary inactive list |
| Taylor Krick | C | 26.100 | Miami Marlins | New Orleans (AAA) | DL-7 Injured |
| Will Piwnica-Worms | OF | 24.099 | Washington Nationals | Potomac (A+) | DL-7 Injured |
| Eric Wooten | P | 24.113 | New York Yankees | Trenton (AA) | DL-7 Injured |
| Ollie Linton | LF | 28.093 | Cleveland Indians | Akron (AA) | DL-7 Injured |
| Duanel Jones | 3B | 21.059 | San Diego Padres | Lake Elsinore (A+) | DL-7 Injured |
| John Nester | C | 25.042 | San Diego Padres | Lake Elsinore (A+) | DL-7 Injured |
| Leonel Santiago | P | 24.198 | | | Released by Rays |
| Engelb Vielma | SS | 20.017 | Minnesota Twins | Cedar Rapids (A) | DL-7 Injured |
| Kyle Hooper | P | 23.042 | Los Angeles Dodgers | Great Lakes (A) | DL-7 Injured |
| Andres Aguilar | OF | 20.178 | | | Released by Orioles |
| Fidencio Flores | P | 22.303 | | | Released by Cardinals |
| Justin Maxwell | rf | 30.246 | Kansas City Royals | Kansas City Royals (MLB) | Outrighted to minors |
| Duke Welker | RP | 28.149 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | Designated for Assignment |
| Rich Hill | RP | 34.120 | - | | Released by Angels |
| Robelys Reyes | 2B | 23.349 | St. Louis Cardinals | State College (A-) | Assigned to State College (A-) |
| Justin Garcia | P | 21.296 | Cleveland Indians | Lake County (A) | Assigned to Lake County (A) |
| James Buckelew | P | 22.340 | Miami Marlins | Myrtle Beach (A+) | Assigned to Myrtle Beach (A+) |
| Branden Cogswell | IF | 21.178 | Oakland Athletics | Beloit (A) | Signed out of draft (Virginia) |
| Jake Reed | P | 21.283 | Minnesota Twins | Cedar Rapids (A) | Assigned to Cedar Rapids (A) |
| Keith Curcio | OF | 21.193 | Atlanta Braves | Danville (Rk) | Assigned to Danville (Rk) |
| Luke Curtis | P | 22.191 | Milwaukee Brewers | Wisconsin (A) | Assigned to Wisconsin (A) |
| Mike Papi | OF | 21.293 | Cleveland Indians | Mahoning Valley (A-) | Signed out of draft (Virginia) |
| Patrick Kaminska | P | 23.154 | Texas Rangers | Hickory (A) | Assigned to Hickory (A) |
| Bo Thompson | IF | 21.354 | New York Yankees | Gulf Coast Yankees (Rk) | Assigned to GCL Yankees (Rk) |
| Matt Trowbridge | P | 21.107 | Baltimore Orioles | Gulf Coast Orioles (Rk) | Signed out of draft (Central Michigan) |
| Nathan Thornhill | P | 22.287 | Philadelphia Phillies | Gulf Coast Phillies (Rk) | Signed out of draft (Texas) |
| Seth Harrison | OF | 21.352 | San Francisco Giants | Arizona Giants (Rk) | Signed out of draft (UL Lafayette) |
| Tommy Thorpe | P | 21.292 | Chicago Cubs | Arizona Cubs (Rk) | Signed out of draft (Oregon) |
| Brandon Downes | OF | 21.283 | Kansas City Royals | Idaho Falls (Rk) | Signed out of draft (Virginia) |
| Darius Day | OF | 19.318 | Texas Rangers | Arizona Rangers (Rk) | Signed out of draft (Illinois HS) |
| Gilberto Ramirez | OF | 21.237 | Washington Nationals | Gulf Coast Nationals (Rk) | Assigned to GCL Nationals (Rk) |
| Mat Batts | P | 23.003 | Minnesota Twins | Elizabethton (Rk) | Assigned to Elizabethton (Rk) |
| Michael Velasquez | P | 21.131 | Tampa Bay Rays | Gulf Coast Rays (Rk) | Assigned to GCL Rays (Rk) |
| Ronald Soto | C | 19.277 | Baltimore Orioles | Dominican Orioles (Rk) | Assigned to DSL Orioles (Rk) |
| Ryan Plourde | C-OF | 22.134 | Chicago White Sox | Arizona White Sox (Rk) | Signed out of draft (Fairfield) |
| Tyler Painton | P | 22.140 | Oakland Athletics | Arizona Athletics (Rk) | Assigned to AZL Athletics (Rk) |
| Zach Sullivan | SS | 18.226 | Miami Marlins | Gulf Coast Marlins (Rk) | Signed out of draft (New York HS) |
| Zacrey Law | OF | 18.001 | Tampa Bay Rays | Gulf Coast Rays (Rk) | Signed out of draft (Texas HS) |
| Bradley Wallace | P | 21.300 | Tampa Bay Rays | Hudson Valley (A-) | Placed on temporary inactive list |
