| Luis Garcia | RP | 27.127 | Philadelphia Phillies | Philadelphia Phillies (MLB) | Activated from DL |
| Cesar Jimenez | RP | 29.206 | Philadelphia Phillies | Philadelphia Phillies (MLB) | Designated for Assignment |
| Eddie Butler | P | 23.085 | Colorado Rockies | Colorado Rockies (MLB) | Contract purchased from minors |
| Danny Worth | 3B | 28.249 | Detroit Tigers | Detroit Tigers (MLB) | Outrighted to minors |
| Michael Almanzar | 1B | 23.186 | Baltimore Orioles | Baltimore Orioles (MLB) | Transferred to 60-day DL |
| Tim Berry | P | 23.080 | Baltimore Orioles | Baltimore Orioles (MLB) | Recalled from Bowie (AA) |
| Miguel Gonzalez | RP | 30.010 | Baltimore Orioles | Baltimore Orioles (MLB) | DL-15 Strained right oblique |
| Evan Meek | P | 31.025 | Baltimore Orioles | Baltimore Orioles (MLB) | Contract purchased from minors |
| Miguel Rojas | SS-2B | 25.102 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Contract purchased from minors |
| Chris Withrow | RP | 25.066 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Transferred to 60-day DL |
| Jedd Gyorko | 2b | 25.256 | San Diego Padres | San Diego Padres (MLB) | DL-15 Plantar fasciitis, left foot |
| Matt Cain | SP | 29.248 | San Francisco Giants | San Francisco Giants (MLB) | Activated from DL |
| David Huff | RP | 29.288 | San Francisco Giants | San Francisco Giants (MLB) | Designated for Assignment |
| Eric Stults | SP | 34.180 | San Diego Padres | San Diego Padres (MLB) | Reinstated from Bereavement |
| Luis Ayala | RP | 36.145 | Toronto Blue Jays | Toronto Blue Jays (MLB) | Signed to minor league contract |
| Ronny Cedeno | ss | 31.124 | Philadelphia Phillies | Philadelphia Phillies (MLB) | Contract purchased from minors |
| James Adduci | LF-DH | 29.022 | Texas Rangers | Round Rock (AAA) | Assigned to Round Rock (AAA) for rehab assignent |
| Jesus Aguilar | 1B | 23.341 | Cleveland Indians | Columbus (AAA) | Assigned to Columbus (AAA) |
| Aaron Barbosa | 2B | 22.053 | Seattle Mariners | Clinton (A) | Activated from disabled list |
| Collin Cargill | P | 26.244 | Miami Marlins | Jacksonville (AA) | Assigned to Jacksonville (AA) |
| Francisco Cervelli | c | 28.092 | New York Yankees | Tampa (A+) | Activated from disabled list |
| Garrett Cooper | IF | 23.163 | Milwaukee Brewers | Wisconsin (A) | Assigned to Wisconsin (A) |
| Rehiner Cordova | 2B | 20.146 | Miami Marlins | Greensboro (A) | Assigned to Greensboro (A) |
| Josh Davis | p | 23.215 | Chicago Cubs | Kane County (A) | Assigned to Kane County (A) |
| Edison Frias | P | 23.170 | Houston Astros | Quad Cities (A) | Assigned to Quad Cities (A) |
| Sam Fuld | lf-rf | 32.198 | Minnesota Twins | New Britain (AA) | Assigned to New Britain (AA) for rehab |
| Giovanny Gallegos | P | 22.297 | New York Yankees | Charleston (sc) (A) | Activated from disabled list |
| Gonzalez Germen | RP | 26.257 | New York Mets | St. Lucie (A+) | Assigned to St. Lucie (A+) for rehab |
| Gio Gonzalez | SP | 28.260 | Washington Nationals | Potomac (A+) | Assigned to Potomac (A+) for rehab |
| Evan Grills | P | 21.358 | Houston Astros | Quad Cities (A) | Assigned to Quad Cities (A) |
| Preston Guilmet | RP | 26.315 | Baltimore Orioles | Norfolk (AAA) | Assigned to Norfolk (AAA) |
| Kurt Heyer | P | 23.134 | St. Louis Cardinals | Springfield (AA) | Assigned to Springfield (AA) |
| A.J. Holland | P | 24.173 | Atlanta Braves | Rome (A) | Assigned to Rome (A) |
| Jeff Kobernus | cf | 25.341 | Washington Nationals | Hagerstown (A) | Assigned to Hagerstown (A) for rehab |
| Ryan Kussmaul | P | 27.260 | Chicago White Sox | Charlotte (AAA) | Assigned to Charlotte (AAA) |
| Joe Leonard | 3B | 25.284 | Atlanta Braves | Gwinnett (AAA) | Assigned to Gwinnett (AAA) |
| Vincent Mazzaro | RP | 27.252 | Pittsburgh Pirates | Indianapolis (AAA) | Assigned to Indianapolis (AAA) |
| Whit Merrifield | LF-2B | 25.133 | Kansas City Royals | Omaha (AAA) | Assigned to Omaha (AAA) |
| Derrick Mitchell | CF | 27.152 | Atlanta Braves | Mississippi (AA) | Assigned to Mississippi (AA) |
| Sean Nolin | SP | 24.162 | Toronto Blue Jays | Buffalo (AAA) | Activated from disabled list |
| Lee Orr | RF | 25.226 | San Diego Padres | San Antonio (AA) | Activated from disabled list |
| James Pazos | P | 23.032 | New York Yankees | Trenton (AA) | Assigned to Trenton (AA) |
| A.J. Pettersen | 2B | 25.199 | Minnesota Twins | Fort Myers (A+) | Assigned to Fort Myers (A+) |
| J.J. Putz | RP | 37.104 | Arizona Diamondbacks | Reno (AAA) | Assigned to Reno (AAA) for rehab |
| Josh Richardson | P | 22.310 | San Diego Padres | Lake Elsinore (A+) | Assigned to Lake Elsinore (A+) |
| Robert Rogers | P | 23.224 | Los Angeles Dodgers | Rancho Cucamonga (A+) | Assigned to Rancho Cucamonga (A+) |
| Eddie Rosario | CF | 22.252 | Minnesota Twins | New Britain (AA) | Assigned to New Britain (AA) |
| Lance Rymel | C | 24.035 | Chicago Cubs | Tennessee (AA) | Assigned to Tennessee (AA) |
| Carlos Sanchez | C | 20.213 | Atlanta Braves | Rome (A) | Assigned to Rome (A) |
| Blake Schwartz | P | 24.240 | Washington Nationals | Potomac (A+) | Activated from disabled list |
| Ronnie Shaban | IF-P | 24.090 | St. Louis Cardinals | Springfield (AA) | Activated from disabled list |
| Andy Simunic | 2B-RF | 28.303 | Atlanta Braves | Gwinnett (AAA) | Signed to Minor League Contract |
| Tim Smalling | 2B-SS | 26.236 | Colorado Rockies | Colorado Springs (AAA) | Activated from disabled list |
| Hainley Statia | SS-3B | 28.138 | Milwaukee Brewers | Huntsville (AA) | Assigned to Huntsville (AA) |
| Cesar Vargas | | 22.159 | New York Yankees | Tampa (A+) | Assigned to Tampa (A+) |
| Josh Vitters | 3b | 24.283 | Chicago Cubs | Iowa (AAA) | Activated from disabled list |
| Danny Worth | 3B | 28.249 | Detroit Tigers | Toledo (AAA) | Assigned to Toledo (AAA) |
| Brandon Snyder | LF | 27.195 | Boston Red Sox | Pawtucket (AAA) | DL-7 Injured |
| Chris Leroux | RP | 30.053 | New York Yankees | Scranton/Wilkes-Barre (AAA) | DL-7 Injured |
| Joel Pineiro | P | 35.254 | | | Released by Cubs |
| Christian Marrero | 1B | 27.311 | Chicago White Sox | Birmingham (AA) | DL-7 Injured |
| Johnnie Lowe | P | 29.077 | Milwaukee Brewers | Nashville (AAA) | DL-7 Injured |
| Jose Almarante | P | 25.230 | St. Louis Cardinals | Memphis (AAA) | DL-7 Injured |
| Nik Turley | P | 24.268 | New York Yankees | Scranton/Wilkes-Barre (AAA) | DL-7 Injured |
| Anthony Bemboom | C | 24.139 | Los Angeles Angels | Burlington (A) | DL-7 Injured |
| Anthony Ferrara | P | 24.277 | | | Released by Cardinals |
| Carlos Garay | C | 19.244 | Texas Rangers | Arizona Rangers (Rk) | Assigned to AZL Rangers (Rk) |
| Charlie Valerio | C | 23.211 | Cleveland Indians | Akron (AA) | DL-7 Injured |
| Rainy Lara | P | 23.084 | New York Mets | Binghamton (AA) | DL-7 Injured |
| Tyler Sample | P | 24.344 | Pittsburgh Pirates | Altoona (AA) | DL-7 Injured |
| JaDamion Williams | RF | 23.198 | Minnesota Twins | Cedar Rapids (A) | DL-7 Injured |
| Tony Amezcua | P | 23.010 | Cincinnati Reds | Billings (Rk) | Assigned to Billings (Rk) |
| Mark Appel | P | 22.327 | Houston Astros | Lancaster (A+) | Placed on temporarily inactive list |
| Mike Clevinger | P | 23.167 | Los Angeles Angels | Inland Empire (A+) | DL-7 Injured |
| Robby Rowland | P | 22.174 | Pittsburgh Pirates | Bradenton (A+) | DL-7 Injured |
| Ryan Battaglia | C | 21.342 | Cleveland Indians | Mahoning Valley (A-) | Assigned to Mahoning Valley (A-) |
| Tyler Tewell | C | 22.325 | Atlanta Braves | Lynchburg (A+) | DL-7 Injured |
| Cesar Galvez | 2B | 22.318 | Colorado Rockies | Tri-City (A-) | Assigned to Tri-CIty (A-) |
| Ismael Dionicio | 3b | 22.323 | Los Angeles Angels | Burlington (A) | DL-7 Injured |
| Justin Viele | 2B-SS | 23.205 | Baltimore Orioles | Aberdeen (A-) | Assigned to Aberdeen (A-) |
| Shane Rowland | C | 22.197 | Cleveland Indians | Mahoning Valley (A-) | Assigned to Mahoning Valley (A-) |
| Travious Relaford | SS | 22.024 | San Francisco Giants | San Francisco Giants (MLB) | Assignment unknown |
| Jarrett Grube | P | 32.213 | Los Angeles Angels | Los Angeles Angels (MLB) | Recalled from Salt Lake (AAA) |
| Jarrett Grube | P | 32.213 | Los Angeles Angels | Los Angeles Angels (MLB) | Outrighted to minors |
| Brooks Raley | RP | 25.342 | Los Angeles Angels | Los Angeles Angels (MLB) | Recalled from Salt Lake (AAA) |
| Brooks Raley | RP | 25.342 | Los Angeles Angels | Los Angeles Angels (MLB) | Outrighted to minors |
| Carlos Santana | dh-c | 28.059 | Cleveland Indians | Cleveland Indians (MLB) | Activated from DL |
| Michael Brady | P | 27.077 | Los Angeles Angels | Arkansas (AA) | Outrighted to Arkansas (AA) |
