| Jose Reyes | ss | 30.295 | Toronto Blue Jays | Toronto Blue Jays (MLB) | DL-15 Left hamstring tightness |
| Juan Francisco | 1b | 26.282 | | (MLB) | Signed to minor league contract |
| Eduardo Nunez | ss | 26.291 | New York Yankees | New York Yankees (MLB) | Designated for Assignment |
| Jonathan Diaz | 3b | 28.356 | Toronto Blue Jays | Toronto Blue Jays (MLB) | Contract purchased from minors |
| Michael Kirkman | RP | 27.195 | Texas Rangers | Texas Rangers (MLB) | Outrighted to minors |
| Chris Gimenez | 3B | 31.095 | Texas Rangers | Texas Rangers (MLB) | Designated for Assignment |
| Reed Johnson | lf | 37.114 | Miami Marlins | Miami Marlins (MLB) | Reinstated from suspension |
| Mookie Betts | SS | 21.176 | Boston Red Sox | Portland (AA) | Assigned to Portland (AA) |
| Blaine Boyer | P | 32.264 | San Diego Padres | El Paso (AAA) | Assigned to El Paso (AAA) |
| Leonel Campos | P | 26.259 | San Diego Padres | El Paso (AAA) | Assigned to El Paso (AAA) |
| Endy Chavez | rf | 36.053 | Seattle Mariners | Tacoma (AAA) | Assigned to Tacoma (AAA) |
| Frank De los Santos | P | 26.136 | Chicago White Sox | Birmingham (AA) | Signed to Minor League Contract |
| Ivan DeJesus | 2B | 26.336 | Baltimore Orioles | Norfolk (AAA) | Assigned to Norfolk (AAA) |
| Justin Germano | P | 31.238 | Texas Rangers | Round Rock (AAA) | Assigned to Round Rock (AAA) |
| Javy Guerra | RP | 28.152 | Chicago White Sox | Charlotte (AAA) | Assigned to Charlotte (AAA) |
| David Herndon | P | 28.209 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Assigned to Scranton/Wilkes-Barre (AAA) |
| Munenori Kawasaki | 2b | 32.302 | Toronto Blue Jays | Buffalo (AAA) | Assigned to Buffalo (AAA) |
| Blake Lalli | 1b | 30.325 | Arizona Diamondbacks | Reno (AAA) | Assigned to Reno (AAA) |
| Dario Pizzano | OF | 22.342 | Seattle Mariners | High Desert (A+) | Assigned to High Desert (A+) |
| Chance Ruffin | P | 25.205 | Seattle Mariners | Tacoma (AAA) | Assigned to Tacoma (AAA) |
| Kramer Sneed | P | 25.176 | Los Angeles Angels | Arkansas (AA) | Assigned to Arkansas (AA) |
| Bruedlin Suero | P | 24.032 | Tampa Bay Rays | Charlotte (A+) | Assigned to Charlotte (A+) |
| Andrew Russell | P | 29.339 | Atlanta Braves | Gwinnett (AAA) | DL-7 Injured |
| Andy Loomis | P | 28.127 | Baltimore Orioles | Bowie (AA) | DL-7 Injured |
| Austin Wood | P | 27.150 | Detroit Tigers | Toledo (AAA) | DL-7 Injured |
| Chance Ross | IF | 24.032 | Los Angeles Angels | Salt Lake (AAA) | DL-7 Injured |
| James Leverton | P | 27.323 | Miami Marlins | New Orleans (AAA) | DL-7 Injured |
| Jameson Taillon | P | 22.135 | Pittsburgh Pirates | Indianapolis (AAA) | DL-7 Recovering from Tommy John Surgery |
| Nick Struck | P | 24.176 | Chicago Cubs | Tennessee (AA) | |
| Nick Struck | P | 24.176 | | | Released by Cubs |
| Reggie Golden | RF-LF | 22.174 | | | Released by Cubs |
| Stephen Parker | 3B | 26.211 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Assignment unknown |
| Taylor Krick | C | 26.001 | Miami Marlins | Jacksonville (AA) | DL-7 Injured |
| AJ Kirby-Jones | 1B | 25.181 | | | Released by Padres |
| Adam Buschini | IF | 26.331 | San Diego Padres | San Antonio (AA) | DL-7 Injured |
| Angel Cuan | P | 24.307 | New York Mets | St. Lucie (A+) | Assignment unknown |
| Bobby Coyle | LF-RF | 25.026 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Assignment unknown |
| Brad Moss | C | 24.173 | San Francisco Giants | Augusta (A) | Assigned to Augusta (A) |
| Brian Pearl | P | 25.319 | Cincinnati Reds | Cincinnati Reds (MLB) | Assignment unknown |
| Brooks Pounders | P | 23.187 | Kansas City Royals | Kansas City Royals (MLB) | Assignment unknown |
| Bryan Johns | 3B-2B | 25.134 | Boston Red Sox | Boston Red Sox (MLB) | Assignment unknown |
| David Vidal | 3B | 24.160 | Cincinnati Reds | Cincinnati Reds (MLB) | Assignment unknown |
| Everett Williams | LF | 23.182 | | | Released by Padres |
| Hamilton Bennett | P | 25.279 | New York Mets | Binghamton (AA) | DL-7 Injured |
| Jason Townsend | P | 25.196 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | Assignment unknown |
| Jiwan James | CF | 24.355 | Philadelphia Phillies | Clearwater (A+) | DL-7 Injured |
| Jose Valdez | P | 25.243 | | | Released by Giants |
| Josh Mueller | P | 25.073 | Colorado Rockies | Colorado Rockies (MLB) | Assignment unknown |
| Justin Dalles | C | 25.092 | | | Released by Phillies |
| Matt Swynenberg | P | 25.044 | Washington Nationals | Washington Nationals (MLB) | Assignment unknown |
| Taylor Rogers | P | 26.301 | San Francisco Giants | San Francisco Giants (MLB) | Assignment unknown |
| Chris Corrigan | P | 26.099 | | | Announced retirement |
| Ryan Verdugo | P | 26.357 | Kansas City Royals | Omaha (AAA) | DL-7 Injured |
| Michael Yastrzemski | OF | 23.221 | Baltimore Orioles | Delmarva (A) | Assigned to Delmarva (A) |
| Thomas Di Benedetto | SS | 28.149 | Baltimore Orioles | Baltimore Orioles (MLB) | DL-7 Injured |
| Adam Plutko | P | 22.181 | Cleveland Indians | Lake County (A) | Assigned to Lake County (A) |
| Eunchul Choi | P | 30.099 | Baltimore Orioles | Frederick (A+) | DL-7 Injured |
| Gabby Guerrero | P | 20.111 | Seattle Mariners | High Desert (A+) | Assigned to High Desert (A+) |
| Vicente Campos | P | 21.248 | New York Yankees | Tampa (A+) | DL-7 Injured |
| Rodolfo Pena | C | 35.025 | Pittsburgh Pirates | Indianapolis (AAA) | DL-7 Injured |
| Mike Reeves | C | 23.194 | Toronto Blue Jays | Dunedin (A+) | Assigned to Dunedin (A+) |
| Nathan Maldonado | C | 24.359 | Chicago Cubs | Daytona (A+) | DL-60 Injured |
| Sean Manaea | P | 22.060 | Kansas City Royals | Wilmington (A+) | Assigned to Wilmington (A+) |
| Aaron Judge | OF | 21.340 | New York Yankees | Charleston (sc) (A) | Assigned to Charleston (A+) |
| Drew Dosch | IF | 21.281 | Baltimore Orioles | Delmarva (A) | Assigned to Delmarva (A) |
| Felix Carvallo | P | 20.178 | Texas Rangers | Hickory (A) | Assigned to Hickory (A) |
| Jake Stone | P | 23.161 | St. Louis Cardinals | Peoria (A) | Assigned to Peoria (A) |
| Jen-Ho Tseng | P | 19.180 | Chicago Cubs | Kane County (A) | Assigned to Kane County (A) |
| Jimmy Reed | P | 23.104 | St. Louis Cardinals | Peoria (A) | Assigned to Peoria (A) |
| Luis Castillo | P | 21.110 | San Francisco Giants | Augusta (A) | Assigned to Augusta (A) |
| Michael Flores | P | 21.236 | Atlanta Braves | Rome (A) | Assigned to Rome (A) |
| Pete Perez | P | 23.114 | Atlanta Braves | Rome (A) | Assigned to Rome (A) |
| Steve Messner | P | 24.112 | San Francisco Giants | Augusta (A) | Assigned to Augusta (A) |
| Tony Rizzotti | P | 21.345 | San Diego Padres | Fort Wayne (A) | Assigned to Fort Wayne (A) |
| Victor Diaz | P | 20.177 | Milwaukee Brewers | Wisconsin (A) | Assigned to Wisconsin (A) |
| Alexi Amarista | IF | 24.360 | San Diego Padres | San Diego Padres (MLB) | (Changed position) |
| Chris Nichols | P | 23.223 | Philadelphia Phillies | Philadelphia Phillies (MLB) | Assignment unknown |
| Christopher Marlowe | P | 24.157 | San Francisco Giants | San Francisco Giants (MLB) | Assignment unknown |
| Devin Shines | CF | 24.321 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Assignment unknown |
| Donavan Tate | CF | 23.186 | San Diego Padres | San Diego Padres (MLB) | Assignment unknown |
| Juan Bautista | P | 20.289 | St. Louis Cardinals | St. Louis Cardinals (MLB) | Assignment unknown |
| Luke Bard | P | 23.139 | Minnesota Twins | Elizabethton (Rk) | DL-7 Injured (not officially on DL) |
| Matt Miller | P | 25.061 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Assignment unknown |
| Roidany Aguila | C | 23.161 | Arizona Diamondbacks | Arizona Diamondbacks (MLB) | Assignment unknown |
| Tyler Melling | P | 25.209 | St. Louis Cardinals | St. Louis Cardinals (MLB) | Assignment unknown |
| Alan Garcia | P | 23.097 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Assignment unknown |
| Andrew Cain | OF-P | 24.008 | San Francisco Giants | San Francisco Giants (MLB) | Assignment unknown |
| Andruth Ramirez | C | 25.022 | Washington Nationals | Washington Nationals (MLB) | Assignment unknown |
| Brandon Martin | SS | 20.220 | Tampa Bay Rays | Tampa Bay Rays (MLB) | Assignment unknown |
| Bryan Lippincott | 1B | 24.187 | Washington Nationals | Washington Nationals (MLB) | Assignment unknown |
| Casey Kalenkosky | 1B | 24.155 | Atlanta Braves | Atlanta Braves (MLB) | Assignment unknown |
| Derek De Young | P | 22.106 | Oakland Athletics | Oakland Athletics (MLB) | Assignment unknown |
| Geoff Perrott | C | 23.109 | Washington Nationals | Washington Nationals (MLB) | Assignment unknown |
| Jake Sisco | P | 22.114 | Cleveland Indians | Cleveland Indians (MLB) | Assignment unknown |
| Jeff Reynolds | 3b | 24.247 | New York Mets | New York Mets (MLB) | Assignment unknown |
| Jeremy Fitzgerald | P | 23.056 | Atlanta Braves | Atlanta Braves (MLB) | Assignment unknown |
| Jordan Leyland | 1B | 24.207 | Toronto Blue Jays | Toronto Blue Jays (MLB) | Assignment unknown |
| Keaton Briscoe | 2B | 22.324 | | | Announced retirement |
| Kenny Socorro | P | 24.303 | Chicago Cubs | Chicago Cubs (MLB) | Assignment unknown |
| Kris Richards | IF | 24.116 | Baltimore Orioles | Baltimore Orioles (MLB) | Assignment unknown |
| Leonard Lorenzo | P | 22.260 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Assignment unknown |
| Mason Hope | P | 21.278 | Miami Marlins | Miami Marlins (MLB) | Assignment unknown |
| Michael Aldrete | IF | 24.183 | St. Louis Cardinals | St. Louis Cardinals (MLB) | Assignment unknown |
| Michael Hamann | P | 23.090 | Chicago Cubs | Chicago Cubs (MLB) | Assignment unknown |
| Reid Scoggins | P | 23.257 | Los Angeles Angels | Los Angeles Angels (MLB) | Assignment unknown |
| Scott Griggs | P | 22.324 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Assignment unknown |
| Zachary Taylor | OF | 22.334 | Philadelphia Phillies | Philadelphia Phillies (MLB) | Assignment unknown |
| Breily Puerta | P | 21.288 | Cleveland Indians | Cleveland Indians (MLB) | Assignment unknown |
| Eric Nedeljkovic | P | 24.046 | Colorado Rockies | Colorado Rockies (MLB) | Placed on restricted list |
| Harmen Sidhu | P | 23.233 | Tampa Bay Rays | Tampa Bay Rays (MLB) | Assignment unknown |
| Jonathan Walsh | OF | 23.138 | Los Angeles Angels | Los Angeles Angels (MLB) | Assignment unknown |
| Jovany Lopez | P | 23.021 | | | Signed with Veracruz (Mexican) |
| Matt Reistetter | C | 21.331 | Washington Nationals | Auburn (A-) | DL-60 Tommy John Surgery |
| Samuel Gonzalez | C | 25.036 | Pittsburgh Pirates | Gulf Coast Pirates (Rk) | DL-7 Injured |
| Tyler Johnson | P | 23.257 | Oakland Athletics | Oakland Athletics (MLB) | Assignment unknown |
| Adam Westmoreland | P | 24.081 | Miami Marlins | Miami Marlins (MLB) | Assignment unknown |
| Adonis Pacheco | OF | 22.262 | Minnesota Twins | Minnesota Twins (MLB) | Assignment unknown |
| Alejandro Flores | P | 20.188 | San Francisco Giants | Dominican Giants (Rk) | Assigned to DSL Giants (Rk) |
| Ryan Kinsella | C-1B | 22.013 | Arizona Diamondbacks | Arizona Diamondbacks (MLB) | Assignment unknown |
| Alwin Delgado | 3B-SS | 21.149 | Detroit Tigers | Dominican Tigers (Rk) | Assigned to DSL Tigers (Rk) |
| Andrew Patterson | C | 20.202 | Los Angeles Angels | Los Angeles Angels (MLB) | Assignment unknown |
| Angel Mejias | P | 20.153 | Chicago Cubs | Chicago Cubs (MLB) | Assigned to VSL Cubs (Vsl) |
| Christopher Tamarez | 3B | 20.158 | New York Yankees | Dominican Yankees (Rk) | Assigned to DSL Yankees (Rk) |
| David Villegas | P | 21.187 | | | Signed with Tabasco (Mexican) |
| Franklyn Vargas | P | 19.223 | San Diego Padres | Dominican Padres (Rk) | Assigned to DSL Padres (Rk) |
| Franmy Pena | C | 21.297 | Milwaukee Brewers | Dominican Brewers (Rk) | Assigned to DSL Brewers (Rk) |
| Gerardo Ramirez | P | 20.074 | | | Signed with Veracruz (Mexican) |
| Jose Mujica | P | 17.276 | Tampa Bay Rays | Tampa Bay Rays (MLB) | Assignment unknown |
| Keurin Feliz | P | 23.227 | San Francisco Giants | San Francisco Giants (MLB) | Assignment unknown |
| Luis Guillen | P | 20.106 | Chicago Cubs | Dominican Cubs (Rk) | Suspended |
| Mattia Mercuri | 2B | 19.224 | Atlanta Braves | Dominican Braves (Rk) | Assigned to DSL Braves (Rk) |
| Melchor Urquides | P | 18.250 | Seattle Mariners | Dominican Mariners (Rk) | Assigned to DSL Mariners (Rk) |
| Michael Giuffre | 2B | 23.108 | Cleveland Indians | Arizona Indians (Rk) | Placed on restricted list |
| Miguel Brito | 3B-1B | 21.202 | Seattle Mariners | Seattle Mariners (MLB) | Assignment unknown |
| Neritzon Osorio | P | 20.093 | Seattle Mariners | Seattle Mariners (MLB) | Assigned to VSL Mariners (Rk) |
| Phildrick Llewellyn | C | 20.188 | Baltimore Orioles | Dominican Orioles (Rk) | Assigned to DSL Orioles (Rk) |
| Shaq Green-Thompson | OF | 19.345 | Boston Red Sox | Boston Red Sox (MLB) | Assignment unknown |
| Will White | P | 20.257 | Miami Marlins | Gulf Coast Marlins (Rk) | Placed on temporary inactive list |
| Hank Yates | IF-OF | 23.164 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Assignment unknown |
| Raul Navarro | SS | 22.056 | Arizona Diamondbacks | Visalia (A+) | DL-7 Injured |
| Jorge Rivera | P | 23.153 | Baltimore Orioles | Baltimore Orioles (MLB) | DL-7 Injured |
| Stetson Allie | 3B | 23.019 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | Assigned to extended spring training |
| Trey McNutt | P | 24.242 | Chicago Cubs | Chicago Cubs (MLB) | DL-60 Shoulder surgery |
| Zack Von Rosenberg | P | 23.189 | Pittsburgh Pirates | Jamestown (A-) | Assigned to Jamestown (A-) |
| Brian Diemer | P | 26.007 | | | Assignment unknown |
