| Miguel Tejada | 2b | 39.085 | Kansas City Royals | Kansas City Royals (MLB) | Suspended for 105 games for violation of MLB drug program |
| Taylor Jordan | SP | 24.213 | Washington Nationals | Washington Nationals (MLB) | DL-15 Lower back strain |
| Tyler Moore | 1b-lf | 26.200 | Washington Nationals | Washington Nationals (MLB) | Recalled from Syracuse (AAA) |
| Trevor Cahill | SP-RP | 25.170 | Arizona Diamondbacks | Arizona Diamondbacks (MLB) | Activated from DL |
| Chaz Roe | RP | 26.313 | Arizona Diamondbacks | Reno (AAA) | Optioned to Reno (AAA) |
| Jesse Crain | RP | 32.044 | Tampa Bay Rays | Tampa Bay Rays (MLB) | Transferred to 60-day DL |
| Brandon Gomes | RP | 29.034 | Tampa Bay Rays | Tampa Bay Rays (MLB) | Activated from DL |
| Luke Scott | dh | 35.054 | Tampa Bay Rays | Tampa Bay Rays (MLB) | DL-15 Lower back spasms |
| Jesus Sucre | c | 25.110 | Seattle Mariners | Tacoma (AAA) | Activated from DL and optioned to Tacoma (AAA) |
| Nick Hundley | c | 29.345 | San Diego Padres | San Diego Padres (MLB) | Reinstated from Paternity Leave list |
| Chris Robinson | C | 29.098 | San Diego Padres | Tucson (AAA) | Optioned to Tucson (AAA) |
| Rafael Betancourt | RP | 38.111 | Colorado Rockies | Colorado Rockies (MLB) | Activated from DL |
| Manuel Corpas | RP | 30.258 | Colorado Rockies | Colorado Springs (AAA) | Optioned to Colorado Springs (AAA) |
| Jake Petricka | RP | 25.074 | Chicago White Sox | Chicago White Sox (MLB) | Contract purchased from Charlotte (AAA) |
| Ramon Troncoso | RP | 30.183 | Chicago White Sox | Chicago White Sox (MLB) | DL-15 Pericarditis [Heart condition] |
| Bartolo Colon | SP | 38.086 | Oakland Athletics | Oakland Athletics (MLB) | DL-15 Left groin strain [Throwing while on flat ground] |
| Tommy Milone | SP | 26.183 | Oakland Athletics | Oakland Athletics (MLB) | Recalled from Sacramento (AAA) |
| Dustin Richardson | P | 29.222 | Los Angeles Angels | Salt Lake (AAA) | DL-7 Right calf strain |
| Nate Robertson | P | 35.349 | Texas Rangers | Round Rock (AAA) | Placed on temporary inactive list |
| Richard Seidel | P | 25.350 | Milwaukee Brewers | Nashville (AAA) | DL-7 Injured |
| Brian Bogusevic | cf | 29.182 | Chicago Cubs | Iowa (AAA) | Assigned to Iowa (AAA) for rehab |
| Brooks Brown | P | 28.059 | Pittsburgh Pirates | Indianapolis (AAA) | DL-7 Injured |
| Buddy Carlyle | P | 35.240 | New York Mets | Buffalo (AAA) | DL-7 Injured |
| Jan Vazquez | C | 22.111 | Los Angeles Dodgers | Chattanooga (AA) | DL-7 Injured |
| Mark Williams | P | 24.006 | Milwaukee Brewers | Huntsville (AA) | DL-7 Injured |
| Jared Schlehuber | 1B-P | 24.237 | Kansas City Royals | Wilmington (A+) | DL-7 Injured |
| Carter Bell | 3B | 23.067 | Arizona Diamondbacks | South Bend (A) | DL-7 Injured |
| Beau Maggi | C | 22.280 | Kansas City Royals | Lexington (A) | DL-7 Injured |
| Juan Ramirez | RF | 22.355 | Chicago White Sox | Kannapolis (A) | DL-7 Injured |
| Yunior Ortega | P | 22.008 | Boston Red Sox | Greenville (A) | DL-7 Injured |
| Miguel Montero | c | 31.040 | Arizona Diamondbacks | Arizona Diamondbacks (Rk) | Assigned to Arizona Diamondbacks (Rk) for rehab |
| Ryan Bolden | LF-RF | 21.336 | | | Announced retirement |
| Brett Carroll | RF | 30.319 | Pittsburgh Pirates | Indianapolis (AAA) | Activated from DL |
| Keon Barnum | 1B | 20.214 | Chicago White Sox | Kannapolis (A) | Activated from DL |
| Cory Brownsten | C | 25.076 | Atlanta Braves | Lynchburg (A+) | Activated from DL |
| Brady Rodgers | P | 22.335 | Houston Astros | Lancaster (A+) | Activated from DL |
| Scott Richmond | P | 33.354 | Texas Rangers | Round Rock (AAA) | Activated from DL |
| Greg Burke | RP | 30.331 | New York Mets | New York Mets (MLB) | Recalled from Las Vegas (AAA) |
| Jenrry Mejia | SP | 23.311 | New York Mets | New York Mets (MLB) | DL-15 Right elbow discomfort |
| Kris Johnson | RP | 28.308 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | Contract purchased from Indianapolis (AAA) |
| Andrew Lambo | rf | 25.007 | Pittsburgh Pirates | Indianapolis (AAA) | Optioned to Indianapolis (AAA) |
| Doug Mathis | P | 30.072 | Pittsburgh Pirates | Indianapolis (AAA) | Traded from Marlins to Pirates for future considerations |
| Mike Zagurski | RP | 30.203 | Oakland Athletics | Sacramento (AAA) | Signed to minor league contract |
| Jeremy Bleich | P | 26.061 | New York Yankees | Trenton (AA) | Placed on temporary inactive list |
| John Murrian | C | 25.064 | Detroit Tigers | Toledo (AAA) | Assigned to Toledo (AAA) |
| Desmond Jennings | cf | 26.292 | Tampa Bay Rays | Charlotte (A+) | Assigned to Charlotte (A+) for rehab |
| Griff Erickson | C | 25.160 | Los Angeles Dodgers | Chattanooga (AA) | Assigned to Chattanooga (AA) |
| Greg Miclat | SS-2B | 26.026 | Texas Rangers | Arizona Rangers (Rk) | Assigned to Arizona Rangers (Rk) for rehab |
| Jose Ceballos | C | 24.234 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| A.J. Jimenez | C | 23.109 | Toronto Blue Jays | Buffalo (AAA) | Assigned to Buffalo (AAA) |
| Juan Crousset | LF-RF | 23.110 | Colorado Rockies | Tulsa (AA) | Assigned to Tulsa (AA) |
| Chase Anselment | C-OF | 22.307 | Atlanta Braves | Rome (A) | Assigned to Rome (A) |
| Stephen McGee | C | 22.192 | Los Angeles Angels | Orem (Rk) | Assigned to Orem (Rk) |
| Luis Sardinas | SS | 20.094 | Texas Rangers | Frisco (AA) | Assigned to Frisco (AA) |
| Chance Ross | IF | 23.171 | Los Angeles Angels | Inland Empire (A+) | Assigned to Inland Empire (A+) |
| Ronald Luna | SS | 21.000 | Atlanta Braves | Danville (Rk) | Assigned to Danville (Rk) |
| Jose Solano | | 21.156 | Houston Astros | Greeneville (Rk) | Assigned to Greeneville (Rk) |
| Yeral Sanchez | | 28.031 | New York Yankees | Trenton (AA) | Assigned to Trenton (AA) |
| Aristides Aquino | | 19.118 | Cincinnati Reds | Billings (Rk) | Assigned to Billings (Rk) |
| Cesar Carrasco | | 19.319 | Arizona Diamondbacks | South Bend (A) | Assigned to South Bend (A) |
| Kyle Farnsworth | RP | 37.126 | Pittsburgh Pirates | Indianapolis (AAA) | Assigned to Indianapolis (AAA) |
| Kyle Bellows | 3B | 24.364 | Cleveland Indians | Arizona Indians (Rk) | Assigned to Arizona Indians (Rk) |
| Ryan Buch | P | 25.284 | Colorado Rockies | Modesto (A+) | Assigned to Modesto (A+) |
| Dontrelle Willis | P | 31.218 | Los Angeles Angels | Salt Lake (AAA) | Assigned to Salt Lake (AAA) |
| Brian Garman | P | 25.030 | Milwaukee Brewers | Arizona Brewers (Rk) | Assigned to Arizona Brewers (Rk) |
| Scott Gracey | P | 26.307 | Toronto Blue Jays | Buffalo (AAA) | Assigned to Buffalo (AAA) |
| Michael Morrison | P | 25.245 | Detroit Tigers | Lakeland (A+) | Assigned to Lakeland (A+) |
| Stephen Smith | P | 27.095 | Los Angeles Dodgers | Chattanooga (AA) | Assigned to Chattanooga (AA) |
| Austin Fleet | P | 26.123 | San Francisco Giants | San Jose (A+) | Assigned to San Jose (A+) |
| Elih Villanueva | P | 27.022 | Miami Marlins | New Orleans (AAA) | Assigned to New Orleans (AAA) |
| Jose Lugo | P | 29.130 | Atlanta Braves | Lynchburg (A+) | Assigned to Lynchburg (A+) |
| Drew Carpenter | P | 28.092 | Oakland Athletics | Midland (AA) | Assigned to Midland (AA) |
| Austin Bibens-Dirkx | P | 28.111 | Toronto Blue Jays | New Hampshire (AA) | Assigned to New Hampshire (AA) |
| Kelvin Castro | 2B | 25.248 | New York Yankees | Charleston (sc) (A) | Assigned to Charleston (Sc) (A) |
| Michael Olmsted | P | 26.108 | Milwaukee Brewers | Huntsville (AA) | Assigned to Huntsville (AA) |
| Sean Nolin | SP | 23.235 | Toronto Blue Jays | Buffalo (AAA) | Assigned to Buffalo (AAA) |
| Danny Sandbrink | P | 24.056 | San Francisco Giants | Augusta (A) | Assigned to Augusta (A) |
| Taylor Hill | P | 24.159 | Washington Nationals | Harrisburg (AA) | Assigned to Harrisburg (AA) |
| Scottie Allen | P | 22.046 | New York Yankees | Trenton (AA) | Assigned to Trenton (AA) |
| Dylan Floro | P | 22.234 | Tampa Bay Rays | Charlotte (A+) | Assigned to Charlotte (A+) |
| Ben Grisz | P | 23.204 | Washington Nationals | Auburn (A-) | Assigned to Auburn (A-) |
| Zach Woods | P | 25.277 | New York Yankees | Tampa (A+) | Assigned to Tampa (A+) |
| Gerardo Olivares | C | 25.004 | Boston Red Sox | Salem (A+) | Assigned to Salem (A+) |
| Michael Bolaski | 3B | 21.195 | Los Angeles Angels | Arizona Angels (Rk) | Assigned to Arizona Angels (Rk) |
| Aaron Blair | P | 21.084 | Arizona Diamondbacks | South Bend (A) | Assigned to South Bend (A) |
| Keith Couch | P | 23.286 | Boston Red Sox | Portland (AA) | Assigned to Portland (AA) |
| Blake Hauser | P | 22.126 | Seattle Mariners | High Desert (A+) | Assigned to High Desert (A+) |
| Colton Turner | P | 22.213 | Toronto Blue Jays | Vancouver (A-) | Assigned to Vancouver (A-) |
| Sergio Gomez | P | 19.359 | Boston Red Sox | Greenville (A) | Assigned to Greenville (A) |
| Ryan Fasano | P | 23.281 | Milwaukee Brewers | Wisconsin (A) | Assigned to Wisconsin (A) |
| Ryan Doran | P | 23.013 | Arizona Diamondbacks | Hillsboro (A-) | Assigned to Hillsboro (A-) |
| Chris Razo | P | 23.057 | Milwaukee Brewers | Helena (Rk) | Assigned to Helena (Rk) |
| Jacob Newberry | | 22.312 | Kansas City Royals | Burlington (Rk) | Assigned to Burlington (Rk) |
| Jarred Smith | IF | 20.152 | Texas Rangers | Arizona Rangers (Rk) | |
| Stephen Gonsalves | P | 19.041 | Minnesota Twins | Elizabethton (Rk) | Assigned to Elizabethton (Rk) |
| Chris Dula | P | 21.012 | Texas Rangers | Arizona Rangers (Rk) | |
| Clinton Hollon | P | 18.237 | Toronto Blue Jays | Bluefield (Rk) | Assigned to Bluefield (Rk) |
| William Rankin | P | 24.109 | | | Released by Rockies |
| Carlos Aponte | 3B-2B | 22.190 | Pittsburgh Pirates | West Virginia (A) | Assigned to West Virginia (A) |
