| Jake Peavy | SP | 32.061 | Boston Red Sox | Boston Red Sox (MLB) | Traded from White Sox to Red Sox in 3-team 7-player trade |
| Jose Iglesias | ss | 23.207 | Detroit Tigers | Detroit Tigers (MLB) | Traded from Red Sox to Tigers as part of 3-team 7-player trade |
| Avisail Garcia | lf | 22.049 | Chicago White Sox | Toledo (AAA) | Traded from Tigers to White Sox in 3-team 7-player trade |
| Brayan Villarreal | RP | 26.082 | Boston Red Sox | Boston Red Sox (MLB) | Traded from Tigers to Red Sox in 3-team 7-player trade |
| Frankie Montas | P | 20.132 | Chicago White Sox | Chicago White Sox (MLB) | Traded from Red Sox to White Sox in 3-team 7-player trade |
| Cleuluis Rondon | P | 19.109 | Chicago White Sox | Chicago White Sox (MLB) | Traded from Red Sox to White Sox in 3-team 7-player trade |
| Grant Green | 2b | 25.308 | Los Angeles Angels | Salt Lake (AAA) | Traded from Athletics to Angels for Albert Callaspo |
| Alberto Callaspo | 2b-dh | 30.103 | Oakland Athletics | Oakland Athletics (MLB) | Traded from Angels to Athletics for Grant Green |
| Cameron Maybin | cf | 26.118 | San Diego Padres | Tucson (AAA) | Assigned to Tucson (AAA) for rehab |
| Greg Miclat | SS-2B | 26.008 | Texas Rangers | Round Rock (AAA) | DL-7 Injured |
| Duane Below | RP | 27.258 | Miami Marlins | New Orleans (AAA) | Placed on temporary inactive list |
| Jon Link | P | 29.130 | Detroit Tigers | Toledo (AAA) | Placed on temporary inactive list |
| Jonathan Broxton | RP | 29.045 | Cincinnati Reds | Louisville (AAA) | Assigned to Louisville (AAA) for rehab |
| Joel Pineiro | P | 34.309 | | | Released by Orioles |
| Jeff Howell | C | 30.121 | Washington Nationals | Harrisburg (AA) | DL-7 Injured |
| Telvin Nash | 1B | 22.161 | Houston Astros | Lancaster (A+) | DL-7 Injured |
| Stephen Shackleford | P | 24.087 | Seattle Mariners | Jackson (AA) | DL-7 Injured |
| Jace Peterson | SS | 23.083 | San Diego Padres | Lake Elsinore (A+) | DL-7 Injured |
| Cory Brownsten | C | 25.058 | Atlanta Braves | Lynchburg (A+) | DL-7 Injured |
| Brett Lee | P | 22.314 | Minnesota Twins | Cedar Rapids (A) | DL-7 Injured |
| Andrew Ray | LF | 22.091 | Los Angeles Angels | Burlington (A) | DL-7 Injured |
| Michael Reed | OF | 20.255 | Milwaukee Brewers | Wisconsin (A) | DL-7 Injured |
| Lewis Brinson | OF | 19.084 | Texas Rangers | Hickory (A) | DL-7 Injured |
| Williams Louico | P | 23.112 | Baltimore Orioles | Aberdeen (A-) | Placed on temporary inactive list |
| Derek Hansen | P | 22.344 | | | Announced retirement |
| Shawon Dunston | CF | 20.176 | Chicago Cubs | Boise (A-) | DL-7 Injured |
| Carson Goldsmith | P | 23.006 | Minnesota Twins | Elizabethton (Rk) | DL-7 Injured |
| Kyler Burke | P | 25.102 | Chicago Cubs | Daytona (A+) | Activated from DL |
| Devin Shines | CF | 24.077 | Los Angeles Dodgers | Rancho Cucamonga (A+) | Activated from DL |
| Rony Rodriguez | IF | 23.152 | Chicago Cubs | Boise (A-) | Activated from DL |
| Alberth Martinez | CF | 22.189 | San Diego Padres | Fort Wayne (A) | Activated from DL |
| Luis Marte | RP | 26.339 | Detroit Tigers | Detroit Tigers (MLB) | Recalled from Toledo (AAA) |
| Luis Marte | RP | 26.339 | Detroit Tigers | Detroit Tigers (MLB) | DL-15 Right shoulder [Recovery from surgery] |
| Kelly Shoppach | c | 33.093 | | | Released by Nationals |
| Brock Holt | 3b | 25.050 | Boston Red Sox | Boston Red Sox (MLB) | Recalled from Pawtucket (AAA) |
| Jordan Danks | rf | 26.358 | Chicago White Sox | Chicago White Sox (MLB) | Recalled from Charlotte (AAA) |
| Adam Rosales | ss | 30.072 | Oakland Athletics | Oakland Athletics (MLB) | Designated for Assignment |
| Scooter Gennett | 2b | 23.091 | Milwaukee Brewers | Nashville (AAA) | Optioned to Nashville (AAA) |
| Jake Arrieta | SP | 27.147 | Chicago Cubs | Iowa (AAA) | Optioned to Iowa (AAA) |
| Brandon Cumpton | SP | 24.257 | Pittsburgh Pirates | Indianapolis (AAA) | Optioned to Indianapolis (AAA) |
| Tyler Lyons | SP | 25.161 | St. Louis Cardinals | Memphis (AAA) | Optioned to Memphis (AAA) |
| Brandon Inge | 2b | 36.073 | | | Released by Pirates |
| Chris Nelson | 3b | 27.331 | Los Angeles Angels | Los Angeles Angels (MLB) | Contract purchased from Salt Lake (AAA) |
| Vinnie Pestano | RP | 28.161 | Cleveland Indians | Columbus (AAA) | Optioned to Columbus (AAA) |
| Justin Maxwell | rf | 29.268 | Kansas City Royals | Kansas City Royals (MLB) | Traded from Astros to Royals for Kyle Smith |
| Kyle Smith | P | 20.324 | Houston Astros | Houston Astros (MLB) | Traded from Royals to Astros for Justin Maxwell |
| Adron Chambers | rf-lf | 26.296 | St. Louis Cardinals | St. Louis Cardinals (MLB) | Recalled from Memphis (AAA) |
| Yadier Molina | c | 31.018 | St. Louis Cardinals | St. Louis Cardinals (MLB) | DL-15 Sprained right knee [Playing through it since June] |
| Brock Peterson | lf | 29.254 | St. Louis Cardinals | St. Louis Cardinals (MLB) | Recalled from Memphis (AAA) |
| Shane Robinson | cf | 28.274 | St. Louis Cardinals | St. Louis Cardinals (MLB) | DL-15 Strained right shoulder [-] |
| Ian Kennedy | SP | 28.224 | San Diego Padres | San Diego Padres (MLB) | Traded from Diamondbacks to Padres for Joe Thatcher and Matt Stites |
| Joe Thatcher | RP | 32.112 | Arizona Diamondbacks | Arizona Diamondbacks (MLB) | Traded from Padres with Matt Stites to Diamondbacks for Ian Kennedy |
| Matt Stites | P | 23.064 | Arizona Diamondbacks | Arizona Diamondbacks (MLB) | Traded from Padres with Joe Thatcher to Diamondbacks for Ian Kennedy |
| Nate Adcock | RP | 25.157 | Arizona Diamondbacks | Reno (AAA) | Outrighted to Reno (AAA) |
| Jairo Asencio | RP | 30.062 | Baltimore Orioles | Norfolk (AAA) | Outrighted to Norfolk (AAA) |
| Jason Hammel | SP | 30.332 | Baltimore Orioles | Baltimore Orioles (MLB) | DL-15 Right forearm tenderness [Discomfort began in spring training] |
| Bud Norris | SP | 28.151 | Baltimore Orioles | Baltimore Orioles (MLB) | Traded from Astros to Orioles for LJ Hoes and Josh Hader |
| LJ Hoes | rf | 23.148 | Houston Astros | Houston Astros (MLB) | Traded from Orioles with Josh Hader to Astros for Bud Norris |
| Steve Pearce | lf | 30.109 | Baltimore Orioles | Baltimore Orioles (MLB) | Activated from DL |
| Drew Butera | c | 29.357 | Los Angeles Dodgers | Albuquerque (AAA) | Traded from Twins to Dodgers for future considerations |
| Matt Moore | SP | 24.043 | Tampa Bay Rays | Tampa Bay Rays (MLB) | DL-15 Left elbow soreness [-] |
| Ryan Roberts | 2b | 32.315 | Tampa Bay Rays | Tampa Bay Rays (MLB) | Recalled from Durham (AAA) |
| B.J. Upton | cf | 28.344 | Atlanta Braves | Gwinnett (AAA) | Assigned to Gwinnett (AAA) for rehab |
| Mike O'Neill | LF | 25.170 | St. Louis Cardinals | Memphis (AAA) | Assigned to Memphis (AAA) |
| Scott Cousins | lf | 28.190 | Los Angeles Angels | Salt Lake (AAA) | Activated from DL |
| Evan Frey | LF-RF | 27.054 | Tampa Bay Rays | Durham (AAA) | Assigned to Durham (AAA) |
| Kris Watts | C | 29.016 | Washington Nationals | Syracuse (AAA) | Activated from DL |
| Travis D'Arnaud | C | 24.171 | New York Mets | Binghamton (AA) | Assigned to Binghamton (AA) |
| Edinson Rincon | 3B | 22.354 | Kansas City Royals | Arizona Royals (Rk) | Assigned to Arizona Royals (Rk) |
| Brandon Short | CF-LF | 24.325 | Cincinnati Reds | Pensacola (AA) | Signed to minor league contract |
| Ronald Bermudez | RF-CF | 25.055 | Boston Red Sox | Pawtucket (AAA) | Assigned to Pawtucket (AAA) |
| Chris Burke | P-IF | 23.096 | San Diego Padres | Lake Elsinore (A+) | Assigned to Lake Elsinore (A+) |
| Lance Roenicke | OF | 25.053 | Milwaukee Brewers | Wisconsin (A) | Assigned to Wisconsin (A) |
| Jacob Wilson | IF | 23.002 | St. Louis Cardinals | Palm Beach (A+) | Assigned to Palm Beach (A+) |
| Kyle Attl | SS | 21.350 | Washington Nationals | Auburn (A-) | Assigned to Auburn (A-) |
| Matt Vinson | OF | 22.288 | Arizona Diamondbacks | Missoula (Rk) | Assigned to Missoula (Rk) |
| Jairo Rodriguez | C | 24.341 | Minnesota Twins | Cedar Rapids (A) | Assigned to Cedar Rapids (A) |
| Saquan Johnson | LF | 20.155 | Texas Rangers | Arizona Rangers (Rk) | Assigned to Arizona Rangers (Rk) |
| Anthony Nunez | C | 23.179 | Atlanta Braves | Lynchburg (A+) | Assigned to Lynchburg (A+) |
| Wilmer Difo | SS | 21.120 | Washington Nationals | Gulf Coast Nationals (Rk) | Assigned to Gulf Coast Nationals (Rk) |
| Deiner Lopez | | 19.062 | Boston Red Sox | Lowell (A-) | Assigned to Lowell (A-) |
| Juan Herrera | 2B | 20.033 | St. Louis Cardinals | State College (A-) | Assigned to State College (A-) |
| Calten Daal | SS | 19.364 | Texas Rangers | Arizona Rangers (Rk) | |
| Dan Fiorito | SS | 22.345 | New York Yankees | Tampa (A+) | Assigned to Tampa (A+) |
| Raysheron Michel | | 20.243 | Seattle Mariners | Arizona Mariners (Rk) | Assigned to Arizona Mariners (Rk) |
| Matt Harrison | SP | 27.349 | Texas Rangers | Frisco (AA) | Assigned to Frisco (AA) for rehab |
| Mark Rogers | SP | 27.182 | Milwaukee Brewers | Arizona Brewers (Rk) | Assigned to Arizona Brewers (Rk) for rehab |
| Trey Barham | P | 27.266 | Oakland Athletics | Stockton (A+) | Assigned to Stockton (A+) |
| Ramon Garcia | P | 28.274 | Detroit Tigers | Erie (AA) | Assigned to Erie (AA) |
| Marcos Mateo | P | 29.104 | Chicago Cubs | Iowa (AAA) | Assigned to Iowa (AAA) |
| Deryk Hooker | P | 24.040 | St. Louis Cardinals | Memphis (AAA) | Assigned to Memphis (AAA) |
| Zach Russell | P | 24.004 | St. Louis Cardinals | Springfield (AA) | Assigned to Springfield (AA) |
| Brayan Villarreal | RP | 26.082 | Boston Red Sox | Pawtucket (AAA) | Assigned to Pawtucket (AAA) |
| Kramer Champlin | P | 23.145 | Toronto Blue Jays | Dunedin (A+) | Assigned to Dunedin (A+) |
| Jeff Antigua | P | 23.038 | Chicago Cubs | Tennessee (AA) | Assigned to Tennessee (AA) |
| Carlos Frias | P | 23.260 | Los Angeles Dodgers | Chattanooga (AA) | Assigned to Chattanooga (AA) |
| Scott Lyman | P | 23.132 | Miami Marlins | Jupiter (A+) | Assigned to Jupiter (A+) |
| Ryan Dull | P | 23.302 | Oakland Athletics | Midland (AA) | Assigned to Midland (AA) |
| Edward Concepcion | P | 24.301 | San Francisco Giants | Augusta (A) | Assigned to Augusta (A) |
| Josh Carr | P | 23.247 | Detroit Tigers | Gulf Coast Tigers (East) (Rk) | Assigned to Gulf Coast Tigers (Rk) |
| Luis Ordosgoitti | P | 20.312 | Houston Astros | Gulf Coast Astros (Rk) | Assigned to Gulf Coast Astros (Rk) |
| Arismendy Ozoria | P | 22.358 | Los Angeles Dodgers | Rancho Cucamonga (A+) | Assigned to Rancho Cucamonga (A+) |
| Adalberto Mejia | P | 20.041 | San Francisco Giants | San Jose (A+) | Assigned to San Jose (A+) |
| Gerardo Concepcion | P | 21.152 | Chicago Cubs | Arizona Cubs (Rk) | Assigned to Arizona Cubs (Rk) |
| Dominique Vattuone | p | 22.169 | Oakland Athletics | Vermont (A-) | Assigned to Vermont (A-) |
| Taylor Mangum | P | 24.149 | Milwaukee Brewers | Brevard County (A+) | Assigned to Brevard County (A+) |
| J.B. Wendelken | P | 20.129 | Chicago White Sox | Kannapolis (A) | Traded from Red Sox to White Sox in 3-team 7-player trade |
| Frankie Montas | P | 20.132 | Chicago White Sox | Kannapolis (A) | Assigned to Kannapolis (A) |
| Christian Perdomo | P | 19.264 | Boston Red Sox | Gulf Coast Red Sox (Rk) | |
| Bernardo Reyes | P | 18.009 | Los Angeles Dodgers | Arizona Dodgers (Rk) | |
| Jordan Cooper | P | 24.082 | Cleveland Indians | Akron (AA) | DL-7 Injured |
| Jonathan Martijn | OF | 19.158 | Cincinnati Reds | Arizona Reds (Rk) | DL-60 Injured |
