| Kameron Loe | RP | 31.323 | Atlanta Braves | Atlanta Braves (MLB) | Designated for Assignment |
| Paul Maholm | SP | 31.035 | Atlanta Braves | Atlanta Braves (MLB) | DL-15 Bruised left wrist [-] |
| Brandon Gomes | RP | 29.015 | Tampa Bay Rays | Charlotte (A+) | Transferred to 60-day DL |
| Josh Zeid | RP | 26.128 | Houston Astros | Houston Astros (MLB) | Contract purchased from Oklahoma City (AAA) |
| Tony Abreu | 2b | 28.259 | San Francisco Giants | San Francisco Giants (MLB) | DL-15 Left knee bursitis |
| Roger Kieschnick | lf | 26.190 | San Francisco Giants | San Francisco Giants (MLB) | Recalled from Fresno (AAA) |
| Brett Pill | lf | 28.324 | San Francisco Giants | San Francisco Giants (MLB) | Recalled from Fresno (AAA) |
| Kensuke Tanaka | lf | 32.071 | San Francisco Giants | Fresno (AAA) | Optioned to Fresno (AAA) |
| Jose Felix | C | 27.250 | Texas Rangers | Round Rock (AAA) | DL-7 Injured |
| Chase Lambin | 2B | 34.023 | Kansas City Royals | Omaha (AAA) | DL-7 Right calf strain |
| Curtis Granderson | rf | 32.136 | New York Yankees | Trenton (AA) | Assigned to Trenton (AA) for rehab |
| Chorye Spoone | P | 27.317 | Toronto Blue Jays | New Hampshire (AA) | DL-7 Injured |
| Brian Van Kirk | LF | 27.354 | Toronto Blue Jays | New Hampshire (AA) | suspended for 50 games for a violation of the Minor League Drug Prevention and Treatment Program |
| Denny Almonte | CF | 24.309 | Seattle Mariners | Jackson (AA) | DL-7 Injured |
| Tyler Rahmatulla | 2B | 23.154 | St. Louis Cardinals | Springfield (AA) | DL-7 Injured |
| Damien Magnifico | P | 22.067 | Milwaukee Brewers | Brevard County (A+) | DL-7 Injured |
| Miguel Abreu | SS-3B | 28.258 | Philadelphia Phillies | Clearwater (A+) | DL-7 Injured |
| Austin Bibens-Dirkx | P | 28.092 | Toronto Blue Jays | Dunedin (A+) | Activated from temporarily inactive list |
| Daniel Carela | P | 25.316 | | | Released by Phillies |
| Clayton Schulz | P | 23.053 | Kansas City Royals | Lexington (A) | Activated from temporarily inactive list |
| Mike Mason | P | 23.118 | Colorado Rockies | Asheville (A) | Placed on temporary inactive list |
| Phil Wetherell | P | 23.294 | New York Yankees | Charleston (sc) (A) | DL-60 Injured [-] |
| Roderick Bernadina | RF | 20.354 | Baltimore Orioles | Delmarva (A) | DL-7 Injured |
| Luis Niebla | P | 22.207 | New York Yankees | Charleston (sc) (A) | DL-7 Injured |
| Derek Jones | OF | 23.057 | Colorado Rockies | Asheville (A) | Activated from temporarily inactive list |
| Torsten Boss | IF | 22.215 | Baltimore Orioles | Delmarva (A) | DL-7 Injured |
| Reyes Moronta | P | 20.205 | San Francisco Giants | Salem-Keizer (A-) | DL-60 Injured [-] |
| Zach Good | P | 21.052 | | | Released by Red Sox |
| Scooter Gennett | 2b | 23.090 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Recalled from Nashville (AAA) |
| Todd Cunningham | lf | 24.132 | Atlanta Braves | Atlanta Braves (MLB) | Contract purchased from Gwinnett (AAA) |
| Reed Johnson | lf | 36.234 | Atlanta Braves | Atlanta Braves (MLB) | DL-15 Left knee tendinitis [Running hard to 1b] |
| Jake Arrieta | SP | 27.146 | Chicago Cubs | Chicago Cubs (MLB) | Recalled from Iowa (AAA) |
| Mike Blazek | RP | 24.136 | St. Louis Cardinals | St. Louis Cardinals (MLB) | Recalled from Memphis (AAA) |
| Keith Butler | RP | 24.181 | St. Louis Cardinals | St. Louis Cardinals (MLB) | Recalled from Memphis (AAA) |
| Tyler Lyons | SP | 25.160 | St. Louis Cardinals | St. Louis Cardinals (MLB) | Recalled from Memphis (AAA) |
| Marc Rzepczynski | RP | 27.356 | St. Louis Cardinals | Memphis (AAA) | Optioned to Memphis (AAA) |
| Fernando Salas | RP | 28.061 | St. Louis Cardinals | Memphis (AAA) | Optioned to Memphis (AAA) |
| Andre Rienzo | SP | 25.055 | Chicago White Sox | Chicago White Sox (MLB) | Recalled from Charlotte (AAA) |
| Blake Tekotte | cf | 26.067 | Chicago White Sox | Charlotte (AAA) | Optioned to Charlotte (AAA) |
| Luke Putkonen | RP | 27.081 | Detroit Tigers | Toledo (AAA) | Optioned to Toledo (AAA) |
| Brian Wilson | P | 31.136 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Signed to 1-year contract for 2013 ($1m) |
| Brian Wilson | P | 31.136 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | DL-15 Right elbow [Recovery from surgery] |
| Cody Asche | 3b | 23.030 | Philadelphia Phillies | Philadelphia Phillies (MLB) | Contract purchased from Lehigh Valley (AAA) |
| Steve Susdorf | lf | 27.124 | Philadelphia Phillies | Philadelphia Phillies (MLB) | Designated for Assignment |
| Brandon Cumpton | SP | 24.256 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | Recalled from Indianapolis (AAA) |
| Jose Veras | RP | 32.283 | Detroit Tigers | Detroit Tigers (MLB) | Traded from Astros to Tigers for Danry Vaszuez and PTBNL (David Paulino) |
| Joe Martinez | RP | 30.154 | Cleveland Indians | Columbus (AAA) | Designated for Assignment |
| Marc Rzepczynski | RP | 27.356 | Cleveland Indians | Cleveland Indians (MLB) | Traded from Cardinals to Indians for Juan Herrera |
| Juan Herrera | 2B | 20.032 | St. Louis Cardinals | St. Louis Cardinals (MLB) | Traded from Indians to Cardinals for Mark Rzepczynski |
| Miles Mikolas | RP | 24.341 | San Diego Padres | San Diego Padres (MLB) | Recalled from Tucson (AAA) |
| Sean O'Sullivan | SP-RP | 25.333 | San Diego Padres | San Diego Padres (MLB) | Placed on paternity leave list |
| Jairo Asencio | RP | 30.061 | Baltimore Orioles | Norfolk (AAA) | Designated for Assignment |
| Steve Clevenger | 3b | 27.116 | Baltimore Orioles | Aberdeen (A-) | Assigned to Aberdeen (A-) |
| Tyler Henson | LF-2B | 25.228 | Philadelphia Phillies | Lehigh Valley (AAA) | Assigned to Lehigh Valley (AAA) |
| Alex Buchholz | 3B | 25.304 | Texas Rangers | Round Rock (AAA) | Assigned to Round Rock (AAA) |
| Lance Zawadzki | IF | 28.065 | Toronto Blue Jays | New Hampshire (AA) | Assigned to New Hampshire (AA) |
| Sandy Leon | c | 24.139 | Washington Nationals | Harrisburg (AA) | Activated from DL |
| Jose Pirela | SS | 23.251 | New York Yankees | Trenton (AA) | Assigned to Trenton (AA) |
| Tim Ferguson | LF-CF | 24.278 | Kansas City Royals | Wilmington (A+) | Assigned to Wilmington (A+) |
| Chad Wright | CF | 24.003 | Detroit Tigers | Lakeland (A+) | Assigned to Lakeland (A+) |
| Ty Linton | LF | 22.194 | Arizona Diamondbacks | Hillsboro (A-) | Assigned to Hillsboro (A-) |
| Brady Steiger | IF | 22.214 | New York Yankees | Gulf Coast Yankees (Rk) | Signed as undrafted free agent out of college |
| Jorge Bonifacio | RF | 20.056 | Kansas City Royals | Northwest Arkansas (AA) | Assigned to Northwest Arkansas (AA) |
| Raph Rhymes | OF | 23.281 | Detroit Tigers | West Michigan (A) | Assigned to West Michigan (A) |
| Phil Ervin | OF | 21.013 | Cincinnati Reds | Clinton (A) | Assigned to Clinton (A) |
| Alen Hanson | SS | 20.281 | Pittsburgh Pirates | Altoona (AA) | Assigned to Altoona (AA) |
| Chris Garia | | 20.226 | Texas Rangers | Hickory (A) | Assigned to Hickory (A) |
| Jhohan Acevedo | | 20.124 | St. Louis Cardinals | Johnson City (Rk) | Assigned to Johnson City (Rk) |
| Joseph Odom | C | 21.203 | Atlanta Braves | Danville (Rk) | Assigned to Danville (Rk) |
| Kevin Encarnacion | OF | 21.250 | Chicago Cubs | Boise (A-) | Assigned to Boise (A-) |
| Eduard Pinto | | 18.280 | Texas Rangers | Spokane (A-) | Assigned to Spokane (A-) |
| Ryan Vogelsong | SP | 36.008 | San Francisco Giants | Richmond (AA) | Assigned to Richmond (AA) for rehab |
| Cory Rasmus | RP | 25.267 | Los Angeles Angels | Salt Lake (AAA) | Assigned to Salt Lake (AAA) |
| Trevor Cahill | SP | 25.151 | Arizona Diamondbacks | Reno (AAA) | Assigned to Reno (AAA) for rehab |
| Sam Dyson | P | 25.084 | Miami Marlins | Gulf Coast Marlins (Rk) | Assigned to Gulf Coast Marlins (Rk) |
| Alex Wilson | RP | 26.269 | Boston Red Sox | Pawtucket (AAA) | Assigned to Pawtucket (AAA) for rehab |
| Brad Hand | P | 23.132 | Miami Marlins | New Orleans (AAA) | Assigned to New Orleans (AAA) |
| Lester Oliveros | P | 25.063 | Minnesota Twins | Gulf Coast Twins (Rk) | Assigned to Gulf Coast Twins (Rk) |
| Corey Baker | P | 23.249 | St. Louis Cardinals | Palm Beach (A+) | Assigned to Palm Beach (A+) |
| Drew Hutchison | P | 22.342 | Toronto Blue Jays | New Hampshire (AA) | Assigned to New Hampshire (AA) for rehab |
| Mike Sylvestri | C | 23.046 | Washington Nationals | Gulf Coast Nationals (Rk) | Assigned to Gulf Coast Nationals (Rk) |
| Reid Redman | IF | 24.250 | Miami Marlins | Batavia (A-) | Signed to minor league contract |
| Rigoberto Arrebato | P | 27.176 | New York Yankees | Tampa (A+) | Assigned to Tampa (A+) |
| Jacob Newberry | | 22.293 | Colorado Rockies | Asheville (A) | Assigned to Asheville (A) |
| Shane Dawson | P | 19.324 | Toronto Blue Jays | Vancouver (A-) | Assigned to Vancouver (A-) |
| Jake Drehoff | P | 21.055 | Boston Red Sox | Gulf Coast Red Sox (Rk) | |
| Jake Brentz | P | 18.319 | Toronto Blue Jays | Gulf Coast Blue Jays (Rk) | |
| Phillip Kish | | 23.334 | Toronto Blue Jays | Bluefield (Rk) | Assigned to Bluefield (Rk) |
| Greg Golson | RF-CF | 27.316 | Atlanta Braves | Gwinnett (AAA) | Signed to minor league contract |
| Danry Vasquez | RF | 19.203 | Houston Astros | Quad Cities (A) | Traded from Tigers to Astros for Jose Veras |
| Will West | P | 21.007 | | | Released by Brewers |
| Stefan Sabol | C | 21.179 | New York Mets | Savannah (A) | DL-7 Strained right shoulder |
| Arismendy Ozoria | P | 22.357 | Los Angeles Dodgers | Rancho Cucamonga (A+) | Assigned to Rancho Cucamonga (A+) |
