| Chris Dickerson | dh | 31.000 | Baltimore Orioles | Baltimore Orioles (MLB) | Contract purchased from Norfolk (AAA) |
| Chad Billingsley | P | 28.255 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Activated from DL |
| Tim Federowicz | C | 25.249 | Los Angeles Dodgers | Albuquerque (AAA) | Optioned to Albuquerque (AAA) |
| Cale Iorg | SS | 27.216 | Baltimore Orioles | Baltimore Orioles (MLB) | Signed to minor league contract |
| Stephen Drew | ss | 30.025 | Boston Red Sox | Boston Red Sox (MLB) | Activated from DL |
| John Lackey | P | 34.169 | Boston Red Sox | Boston Red Sox (MLB) | DL-15 Right biceps strain |
| Jose Iglesias | ss | 23.095 | Boston Red Sox | Pawtucket (AAA) | Optioned to Pawtucket (AAA) |
| Alex Wilson | RP | 26.158 | Boston Red Sox | Boston Red Sox (MLB) | Recalled from Pawtucket (AAA) |
| Brad Hawpe | 1B | 33.293 | Los Angeles Angels | Los Angeles Angels (MLB) | Signed to minor league contract |
| Carlos Carrasco | P | 26.020 | Cleveland Indians | Columbus (AAA) | Optioned to Columbus (AAA) |
| Corey Kluber | SP | 27.000 | Cleveland Indians | Cleveland Indians (MLB) | Recalled from Columbus (AAA) |
| Andy Parrino | 2b | 27.161 | Oakland Athletics | Oakland Athletics (MLB) | Recalled from Sacramento (AAA) |
| Scott Sizemore | 2b | 28.096 | Oakland Athletics | Oakland Athletics (MLB) | DL-15 Sprained left knee |
| Matt Harrison | SP | 27.237 | Texas Rangers | Texas Rangers (MLB) | DL-15 Inflamed nerve in lower back |
| Casper Wells | rf | 28.138 | Toronto Blue Jays | Toronto Blue Jays (MLB) | Claimed off waivers from Mariners by Blue Jays |
| Alex Burnett | RP | 25.259 | Toronto Blue Jays | Buffalo (AAA) | Designated for assignment |
| Luis Ayala | RP | 35.088 | Atlanta Braves | Atlanta Braves (MLB) | Traded from Orioles to Braves for Chris Jones |
| Christopher Jones | P | 24.203 | Baltimore Orioles | Baltimore Orioles (MLB) | Traded from Braves to Orioles for Luis Ayala |
| Logan Ondrusek | RP | 28.056 | Cincinnati Reds | Cincinnati Reds (MLB) | Recalled from Pensacola (AA) |
| Sean Marshall | RP | 30.223 | Cincinnati Reds | Cincinnati Reds (MLB) | DL-15 Left shoulder tendinitis |
| Lucas Luetge | RP | 26.045 | Seattle Mariners | Tacoma (AAA) | Optioned to Tacoma (AAA) |
| Bobby LaFromboise | P | 26.289 | Seattle Mariners | Seattle Mariners (MLB) | Recalled from Tacoma (AAA) |
| Justin Grimm | SP | 24.237 | Texas Rangers | Texas Rangers (MLB) | Recalled from Round Rock (AAA) |
| Anthony Gallas | LF | 25.118 | Cleveland Indians | Carolina (A+) | Assigned to Carolina (A+) |
| Nick Natoli | SS-2B | 25.084 | Boston Red Sox | Salem (A+) | Assigned to Salem (A+) |
| Roberto Perez | C | 24.108 | Cleveland Indians | Columbus (AAA) | Assigned to Columbus (AAA) |
| Joey Paciorek | C | 24.202 | Milwaukee Brewers | Nashville (AAA) | Assigned to Nashville (AAA) |
| Travis Adair | 2B-3B | 25.109 | Baltimore Orioles | Frederick (A+) | Assigned to Frederick (A+) |
| Adrian Nieto | C | 23.149 | Washington Nationals | Potomac (A+) | Assigned to Potomac (A+) |
| Jason Esposito | 3B | 22.265 | Baltimore Orioles | Frederick (A+) | Assigned to Frederick (A+) |
| Royce Bolinger | OF | 22.241 | Texas Rangers | Myrtle Beach (A+) | Assigned to Myrtle Beach (A+) |
| Zach Cone | CF | 23.117 | Texas Rangers | Myrtle Beach (A+) | Assigned to Myrtle Beach (A+) |
| Kevin Torres | 1B-C | 23.045 | Texas Rangers | Myrtle Beach (A+) | Assigned to Myrtle Beach (A+) |
| William Beckwith | 1B | 22.234 | Atlanta Braves | Lynchburg (A+) | Assigned to Lynchburg (A+) |
| Cutter Dykstra | 2B-LF | 23.285 | Washington Nationals | Potomac (A+) | Assigned to Potomac (A+) |
| Mark Tracy | 1B | 25.100 | Chicago White Sox | Winston-Salem (A+) | Assigned to Winston-Salem (A+) |
| Joe De Pinto | 2B | 24.007 | Chicago White Sox | Winston-Salem (A+) | Assigned to Winston-Salem (A+) |
| Cole Leonida | C | 24.106 | Washington Nationals | Potomac (A+) | Assigned to Potomac (A+) |
| Grant Buckner | 1B | 25.020 | Chicago White Sox | Winston-Salem (A+) | Assigned to Winston-Salem (A+) |
| Bill Rice | LF | 24.215 | Chicago White Sox | Winston-Salem (A+) | Assigned to Winston-Salem (A+) |
| Caleb Ramsey | LF | 24.185 | Washington Nationals | Potomac (A+) | Assigned to Potomac (A+) |
| Zane Chavez | C | 26.101 | Baltimore Orioles | Frederick (A+) | |
| Jerrud Sabourin | 1B | 23.159 | Cleveland Indians | Carolina (A+) | Assigned to Carolina (A+) |
| Tim Ferguson | LF-CF | 24.167 | Kansas City Royals | Wilmington (A+) | Assigned to Wilmington (A+) |
| Robby Hefflinger | LF | 23.097 | Atlanta Braves | Lynchburg (A+) | Assigned to Lynchburg (A+) |
| Tyler Naquin | OF | 21.352 | Cleveland Indians | Carolina (A+) | Assigned to Carolina (A+) |
| Mike Ohlman | C | 22.117 | Baltimore Orioles | Frederick (A+) | Assigned to Frederick (A+) |
| Mike Planeta | CF | 23.175 | Baltimore Orioles | Frederick (A+) | Assigned to Frederick (A+) |
| Kenny Swab | C | 24.233 | Kansas City Royals | Wilmington (A+) | Assigned to Wilmington (A+) |
| Justin Trapp | 2B | 22.185 | Kansas City Royals | Wilmington (A+) | Assigned to Wilmington (A+) |
| Randolph Oduber | RF | 24.023 | Washington Nationals | Potomac (A+) | Assigned to Potomac (A+) |
| Kenny Diekroeger | SS | 22.156 | Kansas City Royals | Wilmington (A+) | Assigned to Wilmington (A+) |
| Michael Taylor | CF | 22.015 | Washington Nationals | Potomac (A+) | Assigned to Potomac (A+) |
| Pat Cantwell | C | 23.000 | Texas Rangers | Myrtle Beach (A+) | Assigned to Myrtle Beach (A+) |
| Martin Medina | 1B-C | 23.017 | Chicago White Sox | Winston-Salem (A+) | Assigned to Winston-Salem (A+) |
| Jake Lowery | C | 22.263 | Cleveland Indians | Carolina (A+) | Assigned to Carolina (A+) |
| Kyle Kubitza | 3B | 22.269 | Atlanta Braves | Lynchburg (A+) | Assigned to Lynchburg (A+) |
| Cory Brownsten | C | 24.311 | Atlanta Braves | Lynchburg (A+) | Assigned to Lynchburg (A+) |
| Ross Heffley | IF | 23.079 | Atlanta Braves | Lynchburg (A+) | Assigned to Lynchburg (A+) |
| Fernando De Los Santos | 2B | 23.082 | Atlanta Braves | Lynchburg (A+) | Assigned to Lynchburg (A+) |
| Jose Garcia | SS | 21.353 | Boston Red Sox | Salem (A+) | Assigned to Salem (A+) |
| Chris Curley | 3B | 25.229 | Chicago White Sox | Winston-Salem (A+) | Assigned to Winston-Salem (A+) |
| Henry Ramos | CF-RF | 20.360 | Boston Red Sox | Salem (A+) | Assigned to Salem (A+) |
| Garin Cecchini | 3B | 21.356 | Boston Red Sox | Salem (A+) | Assigned to Salem (A+) |
| Jake Skole | CF | 21.084 | Texas Rangers | Myrtle Beach (A+) | Assigned to Myrtle Beach (A+) |
| Connor Narron | 3B | 21.150 | Baltimore Orioles | Frederick (A+) | Assigned to Frederick (A+) |
| Kellin Deglan | C | 20.342 | Texas Rangers | Myrtle Beach (A+) | Assigned to Myrtle Beach (A+) |
| Trever Adams | 1B | 24.192 | Texas Rangers | Myrtle Beach (A+) | Assigned to Myrtle Beach (A+) |
| Joey Demichele | IF | 22.064 | Chicago White Sox | Winston-Salem (A+) | Assigned to Winston-Salem (A+) |
| Will Skinner | LF-RF | 23.305 | Atlanta Braves | Lynchburg (A+) | Assigned to Lynchburg (A+) |
| Jorge Bonifacio | RF | 19.310 | Kansas City Royals | Wilmington (A+) | Assigned to Wilmington (A+) |
| Keury De la cruz | CF | 21.134 | Boston Red Sox | Salem (A+) | Assigned to Salem (A+) |
| Sammy Diaz | 2B | 22.041 | Cincinnati Reds | Bakersfield (A+) | Assigned to Bakersfield (A+) |
| Daniel Mateo | 2B-3B | 21.244 | Kansas City Royals | Wilmington (A+) | Assigned to Wilmington (A+) |
| Elmer Reyes | 2B | 22.135 | Atlanta Braves | Lynchburg (A+) | Assigned to Lynchburg (A+) |
| Luis Sardinas | SS | 19.329 | Texas Rangers | Myrtle Beach (A+) | Assigned to Myrtle Beach (A+) |
| Vance Albitz | SS | 25.070 | St. Louis Cardinals | Springfield (AA) | Assigned to Springfield (AA) |
| Bryson Myles | RF | 23.204 | Cleveland Indians | Carolina (A+) | Assigned to Carolina (A+) |
| Jack Lopez | SS | 20.115 | Kansas City Royals | Wilmington (A+) | Assigned to Wilmington (A+) |
| Francisco Lindor | SS | 19.147 | Cleveland Indians | Carolina (A+) | Assigned to Carolina (A+) |
| Blake Swihart | C | 21.007 | Boston Red Sox | Salem (A+) | Assigned to Salem (A+) |
| Jordan Smith | 3B | 22.279 | Cleveland Indians | Carolina (A+) | Assigned to Carolina (A+) |
| Rougned Odor | 2B | 19.066 | Texas Rangers | Myrtle Beach (A+) | Assigned to Myrtle Beach (A+) |
| Charlie Valerio | C | 22.154 | Cleveland Indians | Carolina (A+) | Assigned to Carolina (A+) |
| Parker Morin | C | 21.283 | Kansas City Royals | Wilmington (A+) | Assigned to Wilmington (A+) |
| Courtney Hawkins | OF | 19.149 | Chicago White Sox | Winston-Salem (A+) | Assigned to Winston-Salem (A+) |
| Joey Wendle | 2B | 22.349 | Cleveland Indians | Carolina (A+) | Assigned to Carolina (A+) |
| Nicky Delmonico | 1B-2B | 20.272 | Baltimore Orioles | Frederick (A+) | |
| Nelson Figueroa | P | 38.327 | Arizona Diamondbacks | Reno (AAA) | Assigned to Reno (AAA) |
| Matt Bischoff | P | 25.325 | Baltimore Orioles | Frederick (A+) | Assigned to Frederick (A+) |
| Jarrett Casey | P | 25.166 | Chicago White Sox | Winston-Salem (A+) | Assigned to Winston-Salem (A+) |
| Aaron Cook | P | 34.061 | Colorado Rockies | Colorado Springs (AAA) | Assigned to Colorado Springs (AAA) |
| Caleb Cotham | P | 25.156 | New York Yankees | Trenton (AA) | Assigned to Trenton (AA) |
| Andy Loomis | P | 27.136 | Baltimore Orioles | Bowie (AA) | Assigned to Bowie (AA) |
| Ryan Woolley | P | 25.059 | Atlanta Braves | Lynchburg (A+) | Assigned to Lynchburg (A+) |
| Jason Berken | P | 29.135 | Chicago White Sox | Charlotte (AAA) | Assigned to Charlotte (AAA) |
| Tyler Herron | P | 26.248 | Washington Nationals | Potomac (A+) | Assigned to Potomac (A+) |
| Jonathan Edwards | P | 25.093 | Texas Rangers | Myrtle Beach (A+) | Assigned to Myrtle Beach (A+) |
| Jeremy Erben | P | 25.208 | Chicago White Sox | Winston-Salem (A+) | Assigned to Winston-Salem (A+) |
| Joshua Stinson | RP | 25.027 | Baltimore Orioles | Norfolk (AAA) | Assigned to Norfolk (AAA) |
| Eric Beaulac | P | 26.148 | Baltimore Orioles | Frederick (A+) | Assigned to Frederick (A+) |
| Nate Striz | P | 24.177 | Boston Red Sox | Salem (A+) | Assigned to Salem (A+) |
| Taylor Jordan | P | 24.083 | Washington Nationals | Potomac (A+) | Assigned to Potomac (A+) |
| Cody Winiarski | P | 23.226 | Chicago White Sox | Winston-Salem (A+) | |
| Navery Moore | P | 22.243 | Atlanta Braves | Lynchburg (A+) | Assigned to Lynchburg (A+) |
| Kyle Stroup | P | 23.028 | Boston Red Sox | Salem (A+) | |
| John Lamb | P | 22.274 | Kansas City Royals | Wilmington (A+) | Assigned to Wilmington (A+) |
| David Peterson | P | 23.096 | Atlanta Braves | Lynchburg (A+) | Assigned to Lynchburg (A+) |
| Malcolm Culver | P | 23.060 | Kansas City Royals | Wilmington (A+) | Assigned to Wilmington (A+) |
| Ross Seaton | P | 23.204 | Houston Astros | Oklahoma City (AAA) | Assigned to Oklahoma City (AAA) |
| Jesse Beal | P | 22.272 | Baltimore Orioles | Frederick (A+) | Assigned to Frederick (A+) |
| Mark Pope | P | 23.224 | Atlanta Braves | Lynchburg (A+) | Assigned to Lynchburg (A+) |
| Marcel Prado | P | 25.140 | Baltimore Orioles | Frederick (A+) | Assigned to Frederick (A+) |
| Colin Bates | P | 25.031 | Washington Nationals | Potomac (A+) | Assigned to Potomac (A+) |
| Greg Holt | P | 23.295 | Washington Nationals | Potomac (A+) | Assigned to Potomac (A+) |
| Gene Escat | P | 23.219 | Baltimore Orioles | Frederick (A+) | Assigned to Frederick (A+) |
| Sam Selman | P | 22.147 | Kansas City Royals | Wilmington (A+) | Assigned to Wilmington (A+) |
| Keyvius Sampson | P | 22.094 | San Diego Padres | Tucson (AAA) | Assigned to Tucson (AAA) |
| Miguel Pena | P | 22.168 | Boston Red Sox | Salem (A+) | Assigned to Salem (A+) |
| Will Lamb | P | 22.213 | Texas Rangers | Myrtle Beach (A+) | Assigned to Myrtle Beach (A+) |
| Michael Roth | 1B-P | 23.054 | Los Angeles Angels | Arkansas (AA) | Assigned to Arkansas (AA) |
| Mike Augliera | P | 22.306 | Boston Red Sox | Salem (A+) | Assigned to Salem (A+) |
| Andrew Triggs | P | 24.025 | Kansas City Royals | Wilmington (A+) | Assigned to Wilmington (A+) |
| Jacob Lee | IF-P | 23.167 | Cleveland Indians | Carolina (A+) | Assigned to Carolina (A+) |
| AJ Holland | P | 23.116 | Atlanta Braves | Lynchburg (A+) | Assigned to Lynchburg (A+) |
| Matty Ott | P | 22.355 | Boston Red Sox | Salem (A+) | Assigned to Salem (A+) |
| Derek Self | P | 23.086 | Washington Nationals | Potomac (A+) | Assigned to Potomac (A+) |
| Noe Ramirez | P-IF | 23.109 | Boston Red Sox | Salem (A+) | Assigned to Salem (A+) |
| Spencer Patton | P | 25.050 | Kansas City Royals | Wilmington (A+) | Assigned to Wilmington (A+) |
| James Hoyt | P | 26.192 | Atlanta Braves | Lynchburg (A+) | Assigned to Lynchburg (A+) |
| Orangel Arenas | P | 24.010 | Los Angeles Angels | Salt Lake (AAA) | Assigned to Salt Lake (AAA) |
| Ronan Pacheco | P | 24.255 | Atlanta Braves | Lynchburg (A+) | Assigned to Lynchburg (A+) |
| Gonzalez Germen | P | 25.200 | New York Mets | Las Vegas (AAA) | Assigned to Las Vegas (AAA) |
| Alec Asher | P | 21.189 | Texas Rangers | Myrtle Beach (A+) | Assigned to Myrtle Beach (A+) |
| AJ Cole | P | 21.096 | Washington Nationals | Potomac (A+) | Assigned to Potomac (A+) |
| Kylin Turnbull | P | 23.210 | Washington Nationals | Potomac (A+) | Assigned to Potomac (A+) |
| Owen Dew | P | 24.196 | Cleveland Indians | Carolina (A+) | |
| Jerad Eickhoff | P | 22.282 | Texas Rangers | Myrtle Beach (A+) | Assigned to Myrtle Beach (A+) |
| Christian Meza | P | 22.250 | Washington Nationals | Potomac (A+) | Assigned to Potomac (A+) |
| Cody Anderson | P | 22.208 | Cleveland Indians | Carolina (A+) | Assigned to Carolina (A+) |
| Bryan Blough | P | 23.224 | Chicago White Sox | Winston-Salem (A+) | Assigned to Winston-Salem (A+) |
| Ryan Harvey | P | 22.069 | Texas Rangers | Myrtle Beach (A+) | Assigned to Myrtle Beach (A+) |
| Nate Hyatt | IF-P | 22.196 | Atlanta Braves | Lynchburg (A+) | Assigned to Lynchburg (A+) |
| Kellen Moen | P | 24.315 | Kansas City Royals | Wilmington (A+) | Assigned to Wilmington (A+) |
| Robby Scott | P | 23.224 | Boston Red Sox | Salem (A+) | Assigned to Salem (A+) |
| Kyle Zimmer | P | 21.210 | Kansas City Royals | Wilmington (A+) | Assigned to Wilmington (A+) |
| Angel Baez | P | 22.055 | Kansas City Royals | Wilmington (A+) | Assigned to Wilmington (A+) |
| Wilson Rivera | P | 23.162 | Atlanta Braves | Lynchburg (A+) | Assigned to Lynchburg (A+) |
| Duke Von Schamann | P | 21.312 | Los Angeles Dodgers | Rancho Cucamonga (A+) | Assigned to Rancho Cucamonga (A+) |
| Jarrett Miller | P | 23.194 | Atlanta Braves | Lynchburg (A+) | Assigned to Lynchburg (A+) |
| Kyle Smith | P | 20.212 | Kansas City Royals | Wilmington (A+) | Assigned to Wilmington (A+) |
| Henry Owens | P | 20.263 | Boston Red Sox | Salem (A+) | Assigned to Salem (A+) |
| Zach Davies | P | 20.062 | Baltimore Orioles | Frederick (A+) | Assigned to Frederick (A+) |
| Shawn Morimando | P | 20.141 | Cleveland Indians | Carolina (A+) | Assigned to Carolina (A+) |
| Richie Mirowski | P | 23.345 | Washington Nationals | Potomac (A+) | Assigned to Potomac (A+) |
| Ben Hawkins | P | 23.157 | Washington Nationals | Potomac (A+) | Assigned to Potomac (A+) |
| Nefi Ogando | P | 23.311 | Boston Red Sox | Salem (A+) | Assigned to Salem (A+) |
| Victor Payano | P | 20.175 | Texas Rangers | Myrtle Beach (A+) | Assigned to Myrtle Beach (A+) |
| Enosil Tejeda | P | 23.293 | Cleveland Indians | Carolina (A+) | Assigned to Carolina (A+) |
| Cody Fassold | P | 24.190 | Kansas City Royals | Wilmington (A+) | Assigned to Wilmington (A+) |
| William Cuevas | P | 22.178 | Boston Red Sox | Salem (A+) | Assigned to Salem (A+) |
| Adalberto Mejia | | 19.294 | San Francisco Giants | San Jose (A+) | Assigned to San Jose (A+) |
| Brandon Alger | P | 21.281 | San Diego Padres | Lake Elsinore (A+) | Assigned to Lake Elsinore (A+) |
| Royce Consigli | RF-LF | 21.216 | | | Signed by Quebec (CanAm) |
| Jeff Kaplan | P | 27.275 | | | Signed by Quebec (CanAm) |
| Drew Robinson | 3B | 20.355 | Texas Rangers | Myrtle Beach (A+) | Assigned to Myrtle Beach (A) |
| Steven Upchurch | P | 23.208 | Chicago White Sox | Winston-Salem (A+) | DL-7 Injured |
