| Jeremy Accardo | RP | 30.240 | Cleveland Indians | Cleveland Indians (MLB) | Designated for assignment |
| Chris Seddon | RP | 28.297 | Cleveland Indians | Cleveland Indians (MLB) | Contract purchased from Columbus (AAA) |
| Endy Chavez | lf | 34.179 | Baltimore Orioles | Baltimore Orioles (MLB) | Designated for assignment |
| Nate McLouth | lf | 30.281 | Baltimore Orioles | Baltimore Orioles (MLB) | Contract purchased from Norfolk (AAA) |
| Travis Hafner | dh | 35.063 | Cleveland Indians | Cleveland Indians (MLB) | Activated from Paternity Leave List |
| Vinny Rottino | lf | 32.120 | Cleveland Indians | Columbus (AAA) | Optioned to Columbus (AAA) |
| Stephen Fife | SP | 25.305 | Los Angeles Dodgers | Albuquerque (AAA) | Optioned to Albuquerque (AAA) |
| Sandy Leon | c | 23.145 | Washington Nationals | Syracuse (AAA) | Optioned to Syracuse (AAA) |
| Michael Cuddyer | rf | 33.131 | Colorado Rockies | Colorado Rockies (MLB) | DL-15 Strained right oblique |
| Edgmer Escalona | RP | 25.303 | Colorado Rockies | Colorado Rockies (MLB) | Recalled from Colorado Springs (AAA) |
| Christian Friedrich | SP | 25.028 | Colorado Rockies | Colorado Rockies (MLB) | DL-15 Stress fracture in lower back |
| Matt McBride | 1b | 27.074 | Colorado Rockies | Colorado Rockies (MLB) | Contract purchased from Colorado Springs (AAA) |
| Emilio Bonifacio | 2b | 27.104 | Miami Marlins | Miami Marlins (MLB) | DL-15 Sprained left thumb |
| Nick Green | 3b-2b | 33.329 | Miami Marlins | Miami Marlins (MLB) | Contract purchased from New Orleans (AAA) |
| Evan Reed | P | 26.217 | Miami Marlins | New Orleans (AAA) | Optioned to New Orleans (AAA) |
| Jake Fox | 1B-C | 30.016 | Philadelphia Phillies | Lehigh Valley (AAA) | Signed to minor league contract |
| Beamer Weems | SS | 25.008 | San Diego Padres | Tucson (AAA) | Activated from DL |
| Rodrigo Lopez | P | 36.235 | Chicago Cubs | Iowa (AAA) | DL-7 Right shoulder straing |
| Cole Garner | LF-RF | 27.233 | New York Yankees | Scranton/Wilkes-Barre (AAA) | DL-7 Injured |
| Tony Thomas | 2B | 26.026 | Boston Red Sox | Pawtucket (AAA) | DL-7 Right calf strain |
| P.J. Walters | P | 27.146 | Minnesota Twins | Rochester (AAA) | Assigned to Rochester (AAA) for rehab |
| Ryan Flannery | P | 26.211 | New York Yankees | Trenton (AA) | DL-7 Left knee bursitis |
| Josh Romanski | P | 25.291 | New York Yankees | Trenton (AA) | Activated from DL |
| Jason Urquidez | P | 29.327 | Boston Red Sox | Portland (AA) | Activated from temporary inactive list |
| Lendy Castillo | P | 23.119 | Chicago Cubs | Tennessee (AA) | Assigned to Tennessee (AA) for rehab |
| Jordan Kreke | 2B | 25.076 | Houston Astros | Corpus Christi (AA) | Placed on temporarily inactive list |
| Andy Simunic | 2B-RF | 26.363 | Houston Astros | Corpus Christi (AA) | Activated from DL |
| Joey Wong | 3B-SS | 24.115 | Colorado Rockies | Modesto (A+) | Activated from DL |
| Mark Tracy | 1B | 24.217 | Colorado Rockies | Modesto (A+) | DL-7 Injured |
| Carlos Lugo | C | 22.258 | - | | Released by Angels |
| Marcus Semien | SS | 21.322 | Chicago White Sox | Winston-Salem (A+) | Activated from DL |
| Steven Souza | 1B | 23.103 | Washington Nationals | Potomac (A+) | DL-7 Injured |
| Cesar Puello | RF-CF | 21.126 | New York Mets | St. Lucie (A+) | Activated from DL |
| Jose Mojica | SS | 23.222 | New York Yankees | Tampa (A+) | DL-7 Injured |
| Joe Bonfe | 1B | 24.221 | New York Mets | St. Lucie (A+) | DL-7 Injured |
| Toby DeMello | C | 22.214 | Seattle Mariners | Clinton (A) | DL-7 Injured |
| Carlos Willoughby | 2B | 23.266 | San Francisco Giants | Augusta (A) | Activated from DL |
| Joel De La Cruz | P | 23.057 | New York Yankees | Charleston (sc) (A) | DL-7 Injured |
| Walker Gourley | 2B-3B | 21.038 | Pittsburgh Pirates | State College (A-) | Activated from DL |
| Gavi Nivar | LF-CF | 22.323 | Pittsburgh Pirates | State College (A-) | DL-7 Injured |
| Geoff Rowan | C | 22.279 | Tampa Bay Rays | Hudson Valley (A-) | DL-7 Injured |
| David Rollins | P | 22.227 | Houston Astros | Lexington (A) | Activated from DL |
| Jeff Baker | rf-3b | 31.045 | Detroit Tigers | Detroit Tigers (MLB) | Traded from Cubs to Tigers for 2 PTBNL |
| Ryan Raburn | lf | 31.110 | Detroit Tigers | Detroit Tigers (MLB) | DL-15 Sprained right thumb |
| Danny Worth | 2b | 26.309 | Detroit Tigers | Detroit Tigers (MLB) | Recalled from Toledo (AAA) |
| Pedro Figueroa | RP | 26.255 | Oakland Athletics | Oakland Athletics (MLB) | Recalled from Sacramento (AAA) |
| AJ Griffin | SP | 24.190 | Oakland Athletics | Oakland Athletics (MLB) | DL-15 Strained right shoulder |
| Evan Scribner | RP | 27.017 | Oakland Athletics | Oakland Athletics (MLB) | Recalled from Sacramento (AAA) |
| Michael Taylor | rf | 26.229 | Oakland Athletics | Sacramento (AAA) | Optioned to Sacramento (AAA) |
| Tony Campana | lf | 26.067 | Chicago Cubs | Iowa (AAA) | Optioned to Iowa (AAA) |
| Brett Jackson | cf | 24.003 | Chicago Cubs | Chicago Cubs (MLB) | Contract purchased from Iowa (AAA) |
| Josh Vitters | 3b | 22.343 | Chicago Cubs | Chicago Cubs (MLB) | Recalled from Iowa (AAA) |
| Mike Fontenot | 3b | 32.057 | - | | Released by Phillies |
| Cory Burns | RP | 24.301 | San Diego Padres | Tucson (AAA) | Optioned to Tucson (AAA) |
| Miles Mikolas | RP | 23.347 | San Diego Padres | San Diego Padres (MLB) | Recalled from Tucson (AAA) |
| Tyler Chatwood | SP | 22.232 | Colorado Rockies | Colorado Rockies (MLB) | Recalled from Tulsa (AA) |
| Jonathan Sanchez | SP | 29.259 | Colorado Rockies | Colorado Rockies (MLB) | DL-15 Left biceps tendinitis |
| Danny Valencia | 3b | 27.320 | Boston Red Sox | Pawtucket (AAA) | Traded from Twins to Red Sox for Jeremias Pineda |
| Jesse Chavez | RP | 28.350 | Toronto Blue Jays | Las Vegas (AAA) | Optioned to Las Vegas (AAA) |
| Chad Jenkins | SP-RP | 24.227 | Toronto Blue Jays | Toronto Blue Jays (MLB) | Contract purchased from New Hampshire (AA) |
| Johan Santana | SP | 33.145 | New York Mets | Brooklyn (A-) | Assigned to Brooklyn (A-) for rehab |
| Eric Junge | P | 35.212 | Colorado Rockies | Colorado Rockies (MLB) | Signed to minor league contract |
| Yuniesky Betancourt | 3b | 30.186 | Kansas City Royals | Kansas City Royals (MLB) | Designated for assignment |
| Tony Abreu | 2b | 27.265 | Kansas City Royals | Kansas City Royals (MLB) | Contract purchased from Omaha (AAA) |
| Tsuyoshi Nishioka | 2b | 28.009 | Minnesota Twins | Minnesota Twins (MLB) | Recalled from Rochester (AAA) |
| Jamie Johnson | CF | 25.101 | Detroit Tigers | Toledo (AAA) | Assigned to Toledo (AAA) |
| Zelous Wheeler | 3B | 25.201 | Baltimore Orioles | Bowie (AA) | Assigned to Bowie (AA) |
| Luis Sanz | C | 24.260 | Detroit Tigers | Erie (AA) | Assigned to Erie (AA) |
| DJ Jarrad | P | 23.171 | Chicago White Sox | Kannapolis (A) | Assigned to Kannapolis (A) |
| David Villasuso | C | 22.217 | Seattle Mariners | Clinton (A) | Assigned to Clinton (A) |
| Cody Gabella | 2B | 20.244 | San Diego Padres | Arizona Padres (Rk) | Assigned to Arizona Padres (Rk) |
| Bob Stumpo | C | 25.019 | Philadelphia Phillies | Clearwater (A+) | Assigned to Clearwater (A+) |
| Roberto Reyes | RF | 23.087 | St. Louis Cardinals | Palm Beach (A+) | Assigned to Palm Beach (A+) |
| Hirotoshi Onaka | LF-RF | 24.025 | Texas Rangers | Hickory (A) | Assigned to Hickory (A) |
| Felipe Blanco | SS | 18.239 | San Diego Padres | Arizona Padres (Rk) | Assigned to Arizona Padres (Rk) |
| Tim Saunders | SS | 22.080 | Chicago Cubs | Peoria (A) | Assigned to Peoria (A) |
| Eric Junge | P | 35.212 | Colorado Rockies | Colorado Springs (AAA) | Assigned to Colorado Springs (AAA) |
| Nick Masset | P | 30.080 | Cincinnati Reds | Louisville (AAA) | Assigned to Louisville (AAA) for rehab |
| Joshua Fields | P | 26.351 | Boston Red Sox | Pawtucket (AAA) | Assigned to Pawtucket (AAA) |
| Roberto Hernandez | P | 31.340 | Cleveland Indians | Lake County (A) | Assigned to Lake County (A) |
| Zach Clark | P | 29.025 | Baltimore Orioles | Norfolk (AAA) | Assigned to Norfolk (AAA) |
| Andrew Bailey | P | 28.066 | Boston Red Sox | Portland (AA) | Assigned to Portland (AA) for rehab |
| Garrett Mock | P | 29.102 | Houston Astros | Oklahoma City (AAA) | Assigned to Oklahoma City (AAA) |
| Pat Egan | P | 27.284 | Baltimore Orioles | Norfolk (AAA) | Assigned to Norfolk (AAA) |
| Justin Marks | P | 24.206 | Kansas City Royals | Arizona Royals (Rk) | Assigned to Arizona Royals (Rk) |
| Patrick Keating | P | 25.057 | Kansas City Royals | Arizona Royals (Rk) | Assigned to Arizona Royals (Rk) |
| Matt Wickswat | P | 26.001 | Chicago White Sox | Birmingham (AA) | Assigned to Birmingham (AA) |
| Mike Blazek | P | 23.142 | St. Louis Cardinals | Springfield (AA) | Assigned to Springfield (AA) |
| Adam Smith | P | 22.233 | New York Yankees | Charleston (sc) (A) | Assigned to Charleston (Sc) (A) |
| Nick Bucci | P | 22.020 | Milwaukee Brewers | Brevard County (A+) | Assigned to Brevard County (A+) |
| Collin Cargill | P | 24.304 | Miami Marlins | Jacksonville (AA) | Assigned to Jacksonville (AA) |
| Danny Salazar | P | 22.206 | Cleveland Indians | Akron (AA) | Assigned to Akron (AA) |
| Jeff Ibarra | P | 24.353 | San Diego Padres | Arizona Padres (Rk) | |
| Will Locante | P | 22.184 | Arizona Diamondbacks | Yakima (A-) | Assigned to Yakima (A-) |
| Jeff Johnson | P | 22.177 | Cleveland Indians | Carolina (A+) | Assigned to Carolina (A+) |
| Wilson Eusebio | P | 23.350 | Washington Nationals | Hagerstown (A) | Activated from DL |
| CJ Riefenhauser | P | 22.187 | Tampa Bay Rays | Montgomery (AA) | Assigned to Montgomery (AA) |
| Daniel Petitti | C | 24.085 | Oakland Athletics | Arizona Athletics (Rk) | Assigned to Arizona Athletics (Rk) |
| Martin Agosta | P | 21.120 | San Francisco Giants | Arizona Giants (Rk) | |
| Aaron Sookee | P | 21.061 | Los Angeles Angels | Arizona Angels (Rk) | Assigned to Arizona Angels (Rk) |
| Zach Fowler | P | 23.159 | Baltimore Orioles | Frederick (A+) | Assigned to Frederick (A+) |
| Euclides Leyer | P | 19.220 | Chicago White Sox | Kannapolis (A) | Assigned to Kannapolis (A) |
| Joe Karlik | | 23.114 | Kansas City Royals | Burlington (Rk) | Assigned to Burlington (Rk) |
| Anderson Gerdel | | 19.136 | St. Louis Cardinals | Palm Beach (A+) | Assigned to Palm Beach (A+) |
| Jack Cust | DH | 33.201 | Toronto Blue Jays | Las Vegas (AAA) | Signed to minor league contract |
| Xavier Nady | 1B | 33.264 | San Francisco Giants | Fresno (AAA) | Signed to minor league contract |
| Jake Opitz | 3B-1B | 26.008 | Philadelphia Phillies | Reading (AA) | Signed to minor league contract |
| Ray Kruml | RF-CF | 27.000 | St. Louis Cardinals | Springfield (AA) | Signed to minor league contract |
| Jeremias Pineda | CF | 21.262 | Minnesota Twins | Gulf Coast Twins (Rk) | Traded from Red Sox to Twins for Danny Valencia |
| Raudel Lazo | | 23.115 | Miami Marlins | Jupiter (A+) | Assigned to Jupiter (A+) |
| David Rodriguez | C | 16.162 | Tampa Bay Rays | Tampa Bay Rays (MLB) | Signed as undrafted free agent (Venezuela) |
