| Justin Morneau | 1b | 31.070 | Minnesota Twins | Minnesota Twins (MLB) | Activated from Paternity Leave List |
| Chris Parmelee | 1b | 24.151 | Minnesota Twins | Rochester (AAA) | Optioned to Rochester (AAA) |
| Barry Enright | P | 26.116 | Los Angeles Angels | Salt Lake (AAA) | Traded from Diamondbacks to Angels for future considerations |
| Justin Smoak | 1b | 25.231 | Seattle Mariners | Tacoma (AAA) | Optioned to Tacoma (AAA) |
| Brian Broderick | P | 25.326 | Washington Nationals | Washington Nationals (MLB) | Signed to minor league contract |
| Pedro Beato | RP | 25.270 | New York Mets | Buffalo (AAA) | Optioned to Buffalo (AAA) |
| Brian Schneider | C | 35.240 | Philadelphia Phillies | Clearwater (A+) | Assigned to Clearwater (A+) for rehab |
| Manny Acosta | RP | 31.084 | New York Mets | New York Mets (MLB) | Contract purchased from Buffalo (AAA) |
| Mike Carp | 1b | 26.024 | Seattle Mariners | Seattle Mariners (MLB) | Activated from DL |
| Danny Worth | 2b | 26.297 | Detroit Tigers | Toledo (AAA) | Optioned to Toledo (AAA) |
| Matt Talley | P | 22.350 | Chicago White Sox | Kannapolis (A) | Signed to minor league contract |
| Lonnie Chisenhall | 3B | 23.293 | Cleveland Indians | Cleveland Indians (MLB) | Transferred to 60-day DL |
| Brent Lillibridge | ss | 28.310 | Cleveland Indians | Cleveland Indians (MLB) | Traded from Red Sox to Indians for Jose de la Torre |
| Jose De La Torre | P | 26.280 | Boston Red Sox | Portland (AA) | Traded from Indians to Red Sox for Brent Lillibridge |
| Al Alburquerque | P | 26.044 | Detroit Tigers | Lakeland (A+) | Assigned to Lakeland (A+) for rehab |
| Lucas Duda | rf | 26.171 | New York Mets | Buffalo (AAA) | Optioned to Buffalo (AAA) |
| Matt Harvey | SP | 23.119 | New York Mets | New York Mets (MLB) | Contract purchased from Buffalo (AAA) |
| Jason Pridie | rf | 28.289 | Philadelphia Phillies | Lehigh Valley (AAA) | Outrighted to Lehigh Valley (AAA) |
| Sam Fuld | lf | 30.246 | Tampa Bay Rays | Tampa Bay Rays (MLB) | Activated from DL |
| Brandon Gomes | P | 28.009 | Tampa Bay Rays | Durham (AAA) | Optioned to Durham (AAA) |
| Nelson Figueroa | P | 38.067 | Boston Red Sox | Pawtucket (AAA) | Signed to minor league contract |
| Jeff Baisley | 3B | 29.217 | Chicago White Sox | Charlotte (AAA) | DL-7 Injured |
| Brendan Wise | P | 26.196 | Minnesota Twins | Rochester (AAA) | DL-7 Injured |
| Aaron Kurcz | P | 21.350 | Boston Red Sox | Portland (AA) | DL-7 Injured |
| Michael Choice | CF | 22.256 | Oakland Athletics | Midland (AA) | DL-7 Fractured hand |
| Angel Franco | 2B | 22.062 | Kansas City Royals | Wilmington (A+) | DL-7 Hamstring |
| Maverick Lasker | P | 22.157 | Milwaukee Brewers | Wisconsin (A) | Activated from DL |
| Peter Birdwell | P | 25.171 | - | | Announced retirement |
| Jason Kendall | C | 38.028 | - | | Announced retirement |
| Trayvon Robinson | lf | 24.327 | Seattle Mariners | Seattle Mariners (MLB) | Recalled from Tacoma (AAA) |
| Craig Hansen | P | 28.252 | New York Mets | New York Mets (MLB) | Signed to minor league contract |
| Jason Giambi | 1B | 41.197 | Colorado Rockies | Colorado Rockies (MLB) | DL-15 Viral syndrome |
| Edwar Cabrera | SP | 24.278 | Colorado Rockies | Colorado Rockies (MLB) | Recalled from Colorado Springs (AAA) |
| Dan Jennings | RP | 25.098 | Miami Marlins | Miami Marlins (MLB) | Recalled from New Orleans (AAA) |
| Bryan Petersen | lf | 26.106 | Miami Marlins | Miami Marlins (MLB) | Recalled from New Orleans (AAA) |
| Ryan Roberts | 3b | 31.308 | Arizona Diamondbacks | Arizona Diamondbacks (MLB) | Designated for assignment |
| John McDonald | ss | 37.303 | Arizona Diamondbacks | Arizona Diamondbacks (MLB) | Activated from DL |
| Evan Longoria | 3B | 26.290 | Tampa Bay Rays | Durham (AAA) | Transferred to 60-day DL |
| Wandy Rodriguez | SP | 33.187 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | Traded from Astros to Pirates for Rudy Owens, Robbie Grossman and Colton Cain |
| Colton Cain | P | 21.169 | Houston Astros | Houston Astros (MLB) | Traded from Pirates with Robbie Grossman and Rudy Owens to Astros for Wandy Rodriguez |
| Robbie Grossman | RF | 22.311 | Houston Astros | Houston Astros (MLB) | Traded from Pirates with Colton Cain and Rudy Owens to Astros for Wandy Rodriguez |
| Rudy Owens | P | 24.219 | Houston Astros | Houston Astros (MLB) | Traded from Pirates with Robbie Grossman and Colton Cain to Astros for Wandy Rodriguez |
| Wil Ledezma | P | 31.184 | - | | Released by Dodgers |
| Jeff Marquez | P | 27.348 | - | | Released by Mariners |
| Chris Pettit | LF | 27.343 | Colorado Rockies | Colorado Springs (AAA) | Signed to minor league contract |
| Shane Loux | P | 32.346 | San Francisco Giants | Fresno (AAA) | Assigned to Fresno (AAA) for rehab |
| Wil Nieves | C | 34.302 | Colorado Rockies | Colorado Springs (AAA) | Assigned to Colorado Springs (AAA) for rehab |
| Tyler Henson | RF | 24.222 | Los Angeles Dodgers | Albuquerque (AAA) | Activated from DL |
| Eric Hurley | P | 26.310 | Minnesota Twins | Rochester (AAA) | Signed to minor league contract |
| Brandon Allen | 1B | 26.162 | Tampa Bay Rays | Durham (AAA) | Placed on temporarily inactive list |
| Pat Misch | P | 30.340 | Philadelphia Phillies | Lehigh Valley (AAA) | DL-7 Left elbow strain |
| Ryan Adams | 2B | 25.094 | Baltimore Orioles | Norfolk (AAA) | Activated from DL |
| Scott Gorgen | P | 25.178 | St. Louis Cardinals | Springfield (AA) | DL-7 Injured |
| Myrio Richard | LF | 23.331 | Oakland Athletics | Stockton (A+) | Activated from DL |
| Paul McAnulty | LF-1B | 31.181 | Los Angeles Angels | Arkansas (AA) | Assigned to Arkansas (AA) |
| Jarrad Page | OF | 27.278 | San Francisco Giants | San Jose (A+) | |
| Jonathan Lucroy | C | 26.041 | Milwaukee Brewers | Nashville (AAA) | Assigned to Nashville (AAA) for rehab |
| Bryan Pounds | 3B | 26.293 | Detroit Tigers | Erie (AA) | Assigned to Erie (AA) |
| Shawn O'Malley | 2B | 24.209 | Tampa Bay Rays | Montgomery (AA) | Assigned to Montgomery (AA) |
| Jared Mitchell | CF | 23.284 | Chicago White Sox | Charlotte (AAA) | Assigned to Charlotte (AAA) |
| Jamie Johnson | CF | 25.089 | Detroit Tigers | Erie (AA) | Assigned to Erie (AA) |
| Aaron Luna | LF | 25.118 | St. Louis Cardinals | Palm Beach (A+) | Assigned to Palm Beach (A+) |
| Mikie Mahtook | CF | 22.236 | Tampa Bay Rays | Montgomery (AA) | Assigned to Montgomery (AA) |
| Gabriel Noriega | SS-2B | 21.314 | Seattle Mariners | High Desert (A+) | Assigned to High Desert (A+) |
| Steven Liddle | 1B-RF | 24.243 | Minnesota Twins | Fort Myers (A+) | Assigned to Fort Myers (A+) |
| Kyle Hoppy | RF | 21.077 | Philadelphia Phillies | Williamsport (A-) | Assigned to Williamsport (A-) |
| Mac Williamson | OF | 22.009 | San Francisco Giants | Salem-Keizer (A-) | Assigned to Salem-Keizer (A-) |
| Tyler Jones | C | 22.334 | Seattle Mariners | Arizona Mariners (Rk) | |
| Angelberth Montilla | RF | 23.104 | Washington Nationals | Hagerstown (A) | Assigned to Hagerstown (A) |
| Jhonny Gomez | 1B | 22.215 | Texas Rangers | Myrtle Beach (A+) | Assigned to Myrtle Beach (A+) |
| Brad Miller | SS | 22.279 | Seattle Mariners | Jackson (AA) | Assigned to Jackson (AA) |
| Dan Vogelbach | 1B | 19.219 | Chicago Cubs | Boise (A-) | Assigned to Boise (A-) |
| Gregory Lorenzo | CF | 21.054 | Baltimore Orioles | Aberdeen (A-) | Assigned to Aberdeen (A-) |
| Max Moroff | SS | 19.072 | Pittsburgh Pirates | Gulf Coast Pirates (Rk) | Assigned to Gulf Coast Pirates (Rk) |
| Carlos Tocci | | 16.336 | Philadelphia Phillies | Gulf Coast Phillies (Rk) | |
| Peter Moylan | P | 33.234 | Atlanta Braves | Mississippi (AA) | Assigned to Mississippi (AA) for rehab |
| Brian Fuentes | RP | 36.350 | St. Louis Cardinals | Springfield (AA) | Assigned to Springfield (AA) |
| Matt Packer | P | 24.331 | Cleveland Indians | Akron (AA) | Assigned to Akron (AA) |
| Kris Johnson | P | 27.283 | Pittsburgh Pirates | Altoona (AA) | Assigned to Altoona (AA) |
| Marcus Hatley | P | 24.120 | Chicago Cubs | Iowa (AAA) | Assigned to Iowa (AAA) |
| Brian Schlitter | P | 26.215 | Chicago Cubs | Tennessee (AA) | Assigned to Tennessee (AA) |
| Scott Alexander | P | 23.014 | Kansas City Royals | Arizona Royals (Rk) | Assigned to Arizona Royals (Rk) |
| Seth Blair | P | 23.143 | St. Louis Cardinals | Gulf Coast Cardinals (Rk) | |
| Luis Sanz | C | 24.248 | Detroit Tigers | Lakeland (A+) | Assigned to Lakeland (A+) |
| Asher Wojciechowski | P | 23.215 | Houston Astros | Corpus Christi (AA) | Assigned to Corpus Christi (AA) |
| Boone Whiting | P | 22.338 | St. Louis Cardinals | Gulf Coast Cardinals (Rk) | |
| Chia-Jen Lo | P | 26.108 | Houston Astros | Lancaster (A+) | Assigned to Lancaster (A+) |
| Scott Snodgress | P | 22.307 | Chicago White Sox | Winston-Salem (A+) | Assigned to Winston-Salem (A+) |
| Jose Gonzalez | P | 22.171 | Minnesota Twins | New Britain (AA) | Assigned to New Britain (AA) |
| Adys Portillo | P | 20.217 | San Diego Padres | San Antonio (AA) | Assigned to San Antonio (AA) |
| Roberto Padilla | P | 22.025 | Colorado Rockies | Tri-City (A-) | Assigned to Tri-City (A-) |
| Charlie Haslup | P | 20.336 | New York Yankees | Staten Island (A-) | |
| Ryan Longstreth | P | 22.099 | Detroit Tigers | Connecticut (A-) | Assigned to Connecticut (A-) |
| Carson Goldsmith | P | 21.364 | Minnesota Twins | Gulf Coast Twins (Rk) | |
| Ryan McNeil | P | 18.173 | Chicago Cubs | Arizona Cubs (Rk) | Assigned to Arizona Cubs (Rk) |
| Donovan Drake | | 23.298 | Atlanta Braves | Gulf Coast Braves (Rk) | |
| Justin D'Alessandro | | 22.300 | Toronto Blue Jays | Gulf Coast Blue Jays (Rk) | |
| Alex Roy | | 16.362 | Seattle Mariners | Arizona Mariners (Rk) | |
| Willy Paredes | | 23.172 | Arizona Diamondbacks | Visalia (A+) | |
| Darnell McDonald | rf | 33.249 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Assigned to Scranton/Wilkes-Barre (AAA) |
| Andy LaRoche | 2B-3B | 28.346 | Cleveland Indians | Columbus (AAA) | Signed to Minor League Contract |
