| Steve Pearce | lf | 29.100 | Baltimore Orioles | Baltimore Orioles (MLB) | Designated for assignment |
| Chris Iannetta | C | 29.105 | Los Angeles Angels | Salt Lake (AAA) | Assigned to Salt Lake (AAA) for rehab |
| Dylan Axelrod | RP | 26.357 | Chicago White Sox | Charlotte (AAA) | Optioned to Charlotte (AAA) |
| Brett Myers | RP | 31.339 | Chicago White Sox | Chicago White Sox (MLB) | Traded from Astros to White Sox for Matt Heidenreich, Blair Walters and a PTNBL (Chris Devenski) |
| Matt Heidenreich | P | 21.186 | Houston Astros | Houston Astros (MLB) | Traded from White Sox to Astros with Blair Walters and PTNBL for Brett Myers |
| Blair Walters | P | 22.256 | Houston Astros | Houston Astros (MLB) | Traded from White Sox to Astros with Matt Heidenreich and PTNBL for Brett Myers |
| Roberto Hernandez | P | 31.326 | Cleveland Indians | Cleveland Indians (MLB) | Suspended 3 weeks by MLB for age and identity fraud |
| Stephen Pryor | P | 22.364 | Seattle Mariners | Seattle Mariners (MLB) | Activated from DL |
| Stephen Pryor | P | 22.364 | Seattle Mariners | Tacoma (AAA) | Optioned to Tacoma (AAA) |
| Jason Frasor | RP | 34.347 | Toronto Blue Jays | Toronto Blue Jays (MLB) | DL-15 Right forearm tightness |
| Randall Delgado | P | 22.163 | Atlanta Braves | Atlanta Braves (MLB) | Recalled from Gwinnett (AAA) |
| Randall Delgado | SP | 22.163 | Atlanta Braves | Gwinnett (AAA) | Optioned to Gwinnett (AAA) |
| Will Ohman | P | 34.343 | Cincinnati Reds | Cincinnati Reds (MLB) | Signed to minor league contract |
| Mark Hamburger | P | 25.167 | Houston Astros | Oklahoma City (AAA) | Claimed off waivers from Padres |
| John Lannan | SP | 27.298 | Washington Nationals | Syracuse (AAA) | Optioned to Syracuse (AAA) |
| Juan Cruz | RP | 33.280 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | DL-15 Right shoulder inflammation |
| Evan Meek | RP | 29.071 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | Recalled from Indianapolis (AAA) |
| Takashi Saito | RP | 42.158 | Arizona Diamondbacks | Arizona Diamondbacks (MLB) | Activated from DL |
| Cesar Ramos | P | 28.030 | Tampa Bay Rays | Tampa Bay Rays (MLB) | Recalled from Durham (AAA) |
| Cesar Ramos | RP | 28.030 | Tampa Bay Rays | Durham (AAA) | Optioned to Durham (AAA) |
| Luke Scott | dh | 34.027 | Tampa Bay Rays | Tampa Bay Rays (MLB) | DL-15 Right oblique strain |
| Kole Calhoun | rf | 24.282 | Los Angeles Angels | Salt Lake (AAA) | Optioned to Salt Lake (AAA) |
| Dan Haren | SP | 31.308 | Los Angeles Angels | Los Angeles Angels (MLB) | Activated from DL |
| Jeff Beliveau | RP | 25.186 | Chicago Cubs | Chicago Cubs (MLB) | Recalled from Iowa (AAA) |
| Rafael Dolis | RP | 24.194 | Chicago Cubs | Iowa (AAA) | Optioned to Iowa (AAA) |
| Miguel Batista | RP | 41.153 | New York Mets | New York Mets (MLB) | Designated for assignment |
| Elvin Ramirez | RP | 24.286 | New York Mets | New York Mets (MLB) | Recalled from Buffalo (AAA) |
| Laynce Nix | rf | 31.265 | Philadelphia Phillies | Philadelphia Phillies (MLB) | Activated from DL |
| Jason Pridie | rf | 28.287 | Philadelphia Phillies | Philadelphia Phillies (MLB) | Designated for assignment |
| Eric Stults | SP | 32.226 | San Diego Padres | San Diego Padres (MLB) | Activated from DL |
| Nick Vincent | RP | 26.010 | San Diego Padres | Tucson (AAA) | Optioned to Tucson (AAA) |
| Bryan Shaw | RP | 24.257 | Arizona Diamondbacks | Reno (AAA) | Optioned to Reno (AAA) |
| Brandon Gomes | P | 28.007 | Tampa Bay Rays | Tampa Bay Rays (MLB) | Recalled from Durham (AAA) |
| J.C. Romero | P | 36.048 | Cleveland Indians | Columbus (AAA) | Signed to minor league contract |
| Justin Germano | SP | 29.350 | Chicago Cubs | Chicago Cubs (MLB) | Activated |
| Pedro Hernandez | SP | 23.101 | Chicago White Sox | Charlotte (AAA) | Optioned to Charlotte (AAA) |
| Francisley Bueno | RP | 31.139 | Kansas City Royals | Omaha (AAA) | Optioned to Omaha (AAA) |
| Brian Broderick | P | 25.324 | - | | Released by Cardinals |
| Joe Becker | 3B-2B | 26.256 | Los Angeles Dodgers | Albuquerque (AAA) | Activated from DL |
| Brian Cavazos-Galvez | 1B-LF | 25.066 | Los Angeles Dodgers | Albuquerque (AAA) | DL-7 Left ankle sprain |
| Chris Dominguez | 3B | 25.242 | San Francisco Giants | Fresno (AAA) | DL-7 Injured |
| Nicholas Additon | P | 24.219 | St. Louis Cardinals | Memphis (AAA) | Activated from DL |
| Ryan Feierabend | P | 26.334 | - | | Released by Reds |
| Pedro Villarreal | P | 24.226 | Cincinnati Reds | Louisville (AAA) | DL-7 Injured |
| Doug Mathis | P | 29.045 | Boston Red Sox | Pawtucket (AAA) | Placed on temporarily inactive list |
| Yohan Pino | P | 28.209 | Toronto Blue Jays | New Hampshire (AA) | Activated from DL |
| Drew Hedman | 1B | 26.002 | Boston Red Sox | Portland (AA) | DL-7 Injured |
| Kolbrin Vitek | 3B | 23.112 | Boston Red Sox | Portland (AA) | Activated from DL |
| Andre Rienzo | P | 24.047 | Chicago White Sox | Birmingham (AA) | DL-7 Injured |
| Dan Lazzaroni | OF | 23.364 | San Diego Padres | San Antonio (AA) | DL-7 Injured |
| Kirk Clark | P | 24.003 | - | | Released by Astros |
| Charlie Mirabal | SS | 25.111 | Los Angeles Dodgers | Rancho Cucamonga (A+) | Activated from DL |
| Alexis Aguilar | 2B-3B | 21.035 | Los Angeles Dodgers | Rancho Cucamonga (A+) | DL-7 RIght hamstring |
| Stephen Smith | P | 26.068 | Los Angeles Dodgers | Rancho Cucamonga (A+) | DL-7 Right knee |
| Mayckol Guaipe | P | 21.345 | Seattle Mariners | Clinton (A) | Activated from DL |
| Chad Thompson | P | 21.166 | Milwaukee Brewers | Wisconsin (A) | DL-7 Injured |
| Jordan Pries | P | 22.176 | Seattle Mariners | Clinton (A) | DL-7 Injured |
| Chris Schaeffer | C | 24.246 | Toronto Blue Jays | Lansing (A) | Activated from DL |
| Nick Avila | P | 23.327 | Detroit Tigers | West Michigan (A) | DL-7 Right shoulder inflammation |
| Dave Filak | P | 22.240 | Atlanta Braves | Rome (A) | Activated from DL |
| Jarrett Miller | P | 22.297 | Atlanta Braves | Rome (A) | DL-7 Right oblique strain |
| Kylin Turnbull | P | 22.313 | Washington Nationals | Hagerstown (A) | DL-7 Injured |
| Carlos Quentin | lf | 29.328 | San Diego Padres | San Diego Padres (MLB) | Signed to 3-year contract extension ($27m) thru 2015 |
| Donnie Veal | RP | 27.307 | Chicago White Sox | Charlotte (AAA) | Optioned to Charlotte (AAA) |
| Jean Segura | ss | 22.127 | Los Angeles Angels | Los Angeles Angels (MLB) | Recalled from Arkansas (AA) |
| David Carpenter | RP | 24.325 | Los Angeles Angels | Salt Lake (AAA) | Optioned to Salt Lake (AAA) |
| Andy Dirks | LF-CF | 26.179 | Detroit Tigers | Toledo (AAA) | Assigned to Toledo (AAA) for rehab |
| Lou Montanez | LF | 30.219 | St. Louis Cardinals | Memphis (AAA) | Activated from DL |
| Zack Cox | 3B | 23.074 | St. Louis Cardinals | Memphis (AAA) | DL-7 Injured |
| Nevin Ashley | C | 27.342 | Tampa Bay Rays | Durham (AAA) | Activated from DL |
| Romulo Sanchez | P | 28.085 | Tampa Bay Rays | Durham (AAA) | DL-7 Injured |
| Jumbo Diaz | P | 28.146 | Pittsburgh Pirates | Indianapolis (AAA) | Activated from DL |
| Noel Arguelles | P | 22.191 | Kansas City Royals | Northwest Arkansas (AA) | Placed on temporarily inactive list |
| Erick Abreu | P | 28.348 | Houston Astros | Corpus Christi (AA) | DL-7 Injured |
| Kurt Yacko | P | 24.335 | Colorado Rockies | Modesto (A+) | DL-7 Injured |
| Joey Wong | 3B-SS | 24.101 | Colorado Rockies | Modesto (A+) | DL-7 Injured |
| Kevin Moran | P | 23.015 | Chicago White Sox | Winston-Salem (A+) | DL-7 Injured |
| Kurt Wunderlich | P | 22.334 | - | | Released by Athletics |
| Ryan Cuneo | 1B | 23.285 | Chicago Cubs | Arizona Cubs (Rk) | |
| Juan Ciriaco | SS-LF | 28.342 | San Francisco Giants | Fresno (AAA) | Assigned to Fresno (AAA) |
| Jason Donald | ss | 27.321 | Cleveland Indians | Columbus (AAA) | Assigned to Columbus (AAA) |
| Dustin Harrington | 3B | 23.250 | Chicago Cubs | Tennessee (AA) | Assigned to Tennessee (AA) |
| Rob Kral | C | 23.116 | San Diego Padres | Tucson (AAA) | Assigned to Tucson (AAA) |
| Roberto De La Cruz | 3B | 21.254 | Colorado Rockies | Tri-City (A-) | Assigned to Tri-City (A-) |
| Carlos Perez | C | 21.268 | Houston Astros | Lancaster (A+) | Assigned to Lancaster (A+) |
| Kennys Vargas | 1B | 21.355 | Minnesota Twins | Beloit (A) | |
| Gustavo Gonzalez | SS | 21.180 | Philadelphia Phillies | Williamsport (A-) | Assigned to Williamsport (A-) |
| Jose Ortiz | C | 18.041 | Texas Rangers | Arizona Rangers (Rk) | |
| Alberto Mineo | | 17.364 | Chicago Cubs | Arizona Cubs (Rk) | |
| Pedro Toribio | | 22.001 | Los Angeles Angels | Arizona Angels (Rk) | |
| Raul Linares | | 21.291 | Los Angeles Angels | Arizona Angels (Rk) | |
| Ricardo Lizcano | | 21.327 | St. Louis Cardinals | Johnson City (Rk) | |
| Jhimmy Lopez | | 19.337 | Texas Rangers | Arizona Rangers (Rk) | |
| Shane Loux | RP | 32.344 | San Francisco Giants | Arizona Giants (Rk) | Assigned to Arizona Giants (Rk) for rehab |
| Will Ohman | P | 34.343 | Cincinnati Reds | Louisville (AAA) | Assigned to Louisville (AAA) |
| Adam Liberatore | P | 25.071 | Tampa Bay Rays | Durham (AAA) | Assigned to Durham (AAA) |
| Jeff Stevens | P | 28.321 | New York Mets | Buffalo (AAA) | Assigned to Buffalo (AAA) |
| Michael Solbach | P | 26.356 | Colorado Rockies | Modesto (A+) | Assigned to Modesto (A+) |
| Christopher Wilson | P | 25.237 | San Francisco Giants | Richmond (AA) | Assigned to Richmond (AA) |
| Jake Petricka | P | 24.047 | Chicago White Sox | Birmingham (AA) | Assigned to Birmingham (AA) |
| Andrew Taylor | P | 25.338 | Los Angeles Angels | Salt Lake (AAA) | Assigned to Salt Lake (AAA) |
| Ty'relle Harris | P | 25.222 | Chicago Cubs | Iowa (AAA) | Assigned to Iowa (AAA) |
| Chris Hernandez | P | 23.220 | Boston Red Sox | Pawtucket (AAA) | Assigned to Pawtucket (AAA) |
| Will Clinard | P | 22.261 | Detroit Tigers | West Michigan (A) | Assigned to West Michigan (A) |
| Garrett Bush | P | 21.284 | Los Angeles Angels | Arizona Angels (Rk) | Assigned to Arizona Angels (Rk) |
| Mariel Checo | P | 22.279 | New York Yankees | Staten Island (A-) | Assigned to Staten Island (A-) |
| Brandon Kaye | P | 23.340 | Toronto Blue Jays | Dunedin (A+) | Assigned to Dunedin (A+) |
| Tyler Bremer | P | 22.227 | Chicago Cubs | Arizona Cubs (Rk) | |
| Kevin Vance | P | 22.014 | Chicago White Sox | Winston-Salem (A+) | Assigned to Winston-Salem (A+) |
| Euris Quezada | P | 23.107 | Houston Astros | Lexington (A) | Assigned to Lexington (A) |
| Christopher Hanna | P | 20.137 | Chicago White Sox | Kannapolis (A) | Assigned to Kannapolis (A) |
| Bret Montgomery | P | 26.350 | Los Angeles Dodgers | Rancho Cucamonga (A+) | Assigned to Rancho Cucamonga (A+) |
| Chris Rearick | P | 24.230 | Tampa Bay Rays | Montgomery (AA) | Assigned to Montgomery (AA) |
| Nate Hyatt | IF-P | 21.299 | Atlanta Braves | Rome (A) | Assigned to Rome (A) |
| Clario Perez | | 19.326 | Pittsburgh Pirates | State College (A-) | Assigned to State College (A-) |
| Yency Almonte | P | 18.048 | Los Angeles Angels | Arizona Angels (Rk) | Assigned to AZL Angels (Rk) |
| Nick Travieso | P | 18.172 | Texas Rangers | Arizona Rangers (Rk) | Assigned to Arizona Rangers (Rk) |
| Paul Schwendel | | 22.347 | Texas Rangers | Hickory (A) | Assigned to Hickory (A) |
| Christopher Thomas | P | 24.128 | St. Louis Cardinals | Gulf Coast Cardinals (Rk) | Assigned to Gulf Coast Cardinals (Rk) |
