| 1981-04-09 | Box | at LAN | 1 | L 0-2 | 0-1 | 50,511 | 2:17 | Fernando Valenzuela | Joe Niekro | none | | 1981-04-11 | Box | at LAN | 2 | L 4-7 | 0-2 | 51,691 | 2:56 | Burt Hooton | Don Sutton | none | | 1981-04-12 | Box | at LAN | 3 | L 2-3 | 0-3 | 50,734 | 2:16 | Rick Sutcliffe | Vern Ruhle | Steve Howe | | 1981-04-13 | Box | vs ATL | 4 | L 1-2 | 0-4 | 34,961 | 2:57 | Rick Camp | Joe Sambito | Larry Bradford | | 1981-04-14 | Box | vs ATL | 5 | W 8-2 | 1-4 | 21,440 | 2:38 | Joe Niekro | Bob Walk | none | | 1981-04-15 | Box | vs ATL | 6 | W 2-0 | 2-4 | 22,365 | 2:00 | Nolan Ryan | Tommy Boggs | Frank LaCorte | | 1981-04-17 | Box | vs PIT | 7 | L 3-4 | 2-5 | 39,119 | 2:28 | Rick Rhoden | Don Sutton | Enrique Romo | | 1981-04-18 | Box | vs PIT | 8 | L 3-6 | 2-6 | 29,790 | 3:06 | Grant Jackson | Dave Smith | none | | 1981-04-19 | Box | vs PIT | 9 | L 0-2 | 2-7 | 30,394 | 2:21 | Rod Scurry | Joe Niekro | Eddie Solomon | | 1981-04-20 | Box | vs LAN | 10 | L 2-5 | 2-8 | 21,730 | 2:34 | Burt Hooton | Joaquin Andujar | Dave Goltz | | 1981-04-21 | Box | vs LAN | 11 | W 1-0 | 3-8 | 21,904 | 1:48 | Bob Knepper | Jerry Reuss | none | | 1981-04-22 | Box | vs LAN | 12 | L 0-1 | 3-9 | 22,830 | 2:24 | Fernando Valenzuela | Don Sutton | none | | 1981-04-23 | Box | vs CIN | 13 | L 4-5 | 3-10 | 23,173 | 3:06 | Joe Price | Dave Smith | Paul Moskau | | 1981-04-24 | Box | vs CIN | 14 | L 0-3 | 3-11 | 27,087 | 2:23 | Frank Pastore | Joe Niekro | none | | 1981-04-25 | Box | vs CIN | 15 | L 1-2 | 3-12 | 19,957 | 2:45 | Bruce Berenyi | Nolan Ryan | Tom Hume | | 1981-04-26 | Box | vs CIN | 16 | W 1-0 | 4-12 | 23,428 | 2:21 | Bob Knepper | Mario Soto | none | | 1981-04-28 | Box | at ATL | 17 | W 2-1 | 5-12 | 8,669 | 2:34 | Don Sutton | John Montefusco | Dave Smith | | 1981-04-29 | Box | at ATL | 18 | W 5-4 | 6-12 | 8,334 | 3:18 | Frank LaCorte | Rick Camp | none | | 1981-04-30 | Box | at ATL | 19 | W 5-1 | 7-12 | 10,006 | 2:19 | Joe Niekro | Tommy Boggs | none | | 1981-05-01 | Box | at PIT | 20 | W 5-3 | 8-12 | 7,012 | 3:01 | Joe Sambito | Eddie Solomon | none | | 1981-05-02 | Box | at PIT | 21 | L 4-5 | 8-13 | 21,993 | 3:56 | Eddie Solomon | Dave Smith | none | | 1981-05-03 | Box | at PIT | 22 | W 3-1 | 9-13 | 10,438 | 3:15 | Don Sutton | Jim Bibby | Dave Smith | | 1981-05-04 | Box | at CHN | 23 | W 5-4 | 10-13 | 2,941 | 3:02 | Joaquin Andujar | Mike Krukow | Joe Sambito | | 1981-05-05 | Box | at CHN | 24 | W 4-3 | 11-13 | 2,092 | 2:41 | Dave Smith | Lee Smith | none | | 1981-05-06 | Box | at CHN | 25 | L 1-2 | 11-14 | 2,572 | 3:27 | Lee Smith | Frank LaCorte | none | | 1981-05-07 | Box | at CHN | 26 | W 6-0 | 12-14 | 3,112 | 2:40 | Bob Knepper | Randy Martz | none | | 1981-05-08 | Box | at CIN | 27 | L 0-4 | 12-15 | 31,961 | 2:21 | Tom Seaver | Don Sutton | none | | 1981-05-09 | Box | at CIN | 28 | L 5-9 | 12-16 | 30,860 | 2:38 | Bruce Berenyi | Joaquin Andujar | none | | 1981-05-10 | Box | at CIN | 29 | W 7-5 | 13-16 | 31,903 | 2:44 | Joe Niekro | Frank Pastore | Frank LaCorte | | 1981-05-11 | Box | at CIN | 30 | W 5-0 | 14-16 | 11,795 | 2:36 | Nolan Ryan | Mike LaCoss | none | | 1981-05-12 | Box | vs SLN | 31 | L 2-3 | 14-17 | 20,020 | 2:26 | Bruce Sutter | Joe Sambito | Jim Kaat | | 1981-05-13 | Box | vs SLN | 32 | W 3-0 | 15-17 | 21,705 | 2:24 | Don Sutton | Bob Shirley | none | | 1981-05-14 | Box | vs SLN | 33 | L 6-7 | 15-18 | 20,042 | 2:54 | Jim Otten | Joe Sambito | Bruce Sutter | | 1981-05-15 | Box | vs CHN | 34 | W 5-0 | 16-18 | 23,718 | 2:16 | Joe Niekro | Bill Caudill | none | | 1981-05-16 | Box | vs CHN | 35 | W 6-1 | 17-18 | 43,726 | 2:48 | Nolan Ryan | Randy Martz | Joe Sambito | | 1981-05-17 | Box | vs CHN | 36 | W 6-1 | 18-18 | 34,068 | 2:34 | Bob Knepper | Mike Krukow | none | | 1981-05-19 | Box | at SLN | 37 | L 12-15 | 18-19 | 14,585 | 3:03 | Jim Kaat | Bobby Sprowl | none | | 1981-05-20 | Box | at SLN | 38 | W 4-3 | 19-19 | 19,175 | 2:47 | Joe Niekro | Bruce Sutter | Joe Sambito | | 1981-05-21 | Box | at SLN | 39 | L 1-3 | 19-20 | 19,823 | 2:13 | John Martin | Nolan Ryan | none | | 1981-05-22 | Box | vs SFN | 40 | L 3-6 | 19-21 | 30,377 | 4:38 | Greg Minton | Joaquin Andujar | none | | 1981-05-23 | Box | vs SFN | 41 | W 5-3 | 20-21 | 38,586 | 3:09 | Frank LaCorte | Eddie Whitson | none | | 1981-05-24 | Box | vs SFN | 42 | L 1-2 | 20-22 | 34,922 | 2:26 | Vida Blue | Don Sutton | Greg Minton | | 1981-05-25 | Box | vs SDN | 43 | W 6-3 | 21-22 | 19,025 | 2:41 | Joe Niekro | Steve Mura | Joe Sambito | | 1981-05-26 | Box | vs SDN | 44 | W 1-0 | 22-22 | 17,709 | 2:23 | Nolan Ryan | Juan Eichelberger | Joe Sambito | | 1981-05-27 | Box | vs SDN | 45 | W 1-0 | 23-22 | 21,256 | 1:50 | Bob Knepper | Chris Welsh | none | | 1981-05-29 | Box | at SFN | 46 | L 1-3 | 23-23 | 8,397 | 2:22 | Vida Blue | Don Sutton | Al Holland | | 1981-05-30 | Box | at SFN | 47 | W 9-8 | 24-23 | 8,869 | 4:33 | Joaquin Andujar | Fred Breining | Vern Ruhle | | 1981-05-31 | Box | at SFN | 48 | L 1-6 | 24-24 | 20,626 | 2:34 | Tom Griffin | Nolan Ryan | Al Holland | | 1981-06-02 | Box | at SDN | 49 | W 2-1 | 25-24 | 9,671 | 2:19 | Frank LaCorte | Chris Welsh | Joe Sambito | | | 1981-06-03 | Box | at SDN | 50 | W 6-1 | 26-24 | 10,023 | 2:25 | Don Sutton | Rick Wise | none | | 1981-06-04 | Box | at SDN | 51 | L 5-7 | 26-25 | 12,403 | 2:31 | Steve Mura | Joe Niekro | Gary Lucas | | 1981-06-05 | Box | vs NYN | 52 | W 3-0 | 27-25 | 28,085 | 2:09 | Nolan Ryan | Randy Jones | none | | 1981-06-06 | Box | vs NYN | 53 | W 6-2 | 28-25 | 42,478 | 2:17 | Vern Ruhle | Pat Zachry | Dave Smith | | 1981-06-07 | Box | vs NYN | 54 | L 1-3 | 28-26 | 29,873 | 2:13 | Mike Scott | Bob Knepper | Neil Allen | | 1981-06-08 | Box | at PHI | 55 | L 3-4 | 28-27 | 31,664 | 2:41 | Dick Ruthven | Don Sutton | Tug McGraw | | 1981-06-09 | Box | at PHI | 56 | L 3-10 | 28-28 | 33,978 | 2:17 | Marty Bystrom | Joe Niekro | Ron Reed | | 1981-06-10 | Box | at PHI | 57 | L 4-5 | 28-29 | 57,386 | 2:22 | Steve Carlton | Frank LaCorte | Tug McGraw | | 1981-08-10 | Box | at SFN | 58 | W 6-5 | 29-29 | 11,115 | 3:08 | Joe Sambito | Fred Breining | Frank LaCorte | | 1981-08-11 | Box | at SFN | 59 | L 2-3 | 29-30 | 12,354 | 2:36 | Tom Griffin | Joe Niekro | Greg Minton | | 1981-08-12 | Box | at SFN | 60 | W 5-4 | 30-30 | 8,707 | 2:51 | Joe Sambito | Al Holland | Billy Smith | | 1981-08-13 | Box | at SDN | 61 | L 1-9 | 30-31 | 4,899 | 2:29 | Chris Welsh | Bob Knepper | none | | 1981-08-14 | Box | at SDN | 62 | W 5-1 | 31-31 | 8,414 | 2:24 | Nolan Ryan | Tim Lollar | none | | 1981-08-15 | Box | at SDN | 63 | W 5-0 | 32-31 | 5,852 | 1:59 | Don Sutton | Juan Eichelberger | none | | 1981-08-16 | Box | at SDN | 64 | W 3-0 | 33-31 | 5,880 | 2:16 | Joe Niekro | Steve Mura | Dave Smith | | 1981-08-17 | Box | vs MON | 65 | L 2-6 | 33-32 | 24,203 | 2:19 | Ray Burris | Vern Ruhle | Woodie Fryman | | 1981-08-18 | Box | vs MON | 66 | W 4-2 | 34-32 | 23,306 | 2:04 | Bob Knepper | Steve Rogers | Joe Sambito | | 1981-08-19 | Box | vs MON | 67 | W 9-1 | 35-32 | 27,169 | 2:39 | Nolan Ryan | Scott Sanderson | Dave Smith | | 1981-08-21 | Box | at PHI | 68 | L 4-5 | 35-33 | 31,693 | 2:41 | Sparky Lyle | Vern Ruhle | Tug McGraw | | 1981-08-22 | Box | at PHI | 69 | L 4-8 | 35-34 | 35,199 | 2:16 | Dick Ruthven | Joe Niekro | none | | 1981-08-23 | Box | at PHI | 70 | L 0-6 | 35-35 | 30,630 | 1:51 | Steve Carlton | Bob Knepper | none | | 1981-08-25 | Box | at NYN | 71 | L 1-2 | 35-36 | 15,622 | 2:32 | Mike Marshall | Joe Sambito | none | | 1981-08-26 | Box | at NYN | 72 | W 9-3 | 36-36 | 16,731 | 2:34 | Don Sutton | Pat Zachry | none | | 1981-08-27 | Box | at NYN | 73 | L 2-3 | 36-37 | 17,488 | 2:28 | Mike Marshall | Joe Sambito | Neil Allen | | 1981-08-28 | Box | vs PHI | 74 | W 3-2 | 37-37 | 29,482 | 2:37 | Dave Smith | Sparky Lyle | none | | 1981-08-29 (1) | Box | vs PHI | 75 | W 6-1 | 38-37 | | 2:22 | Vern Ruhle | Mark Davis | none | | 1981-08-29 (2) | Box | vs PHI | 76 | W 2-1 | 39-37 | 33,327 | 2:01 | Billy Smith | Dickie Noles | Frank LaCorte | | 1981-08-30 | Box | vs PHI | 77 | W 5-4 | 40-37 | 23,102 | 2:53 | Dave Smith | Sparky Lyle | none | | 1981-08-31 | Box | vs NYN | 78 | W 6-1 | 41-37 | 10,669 | 2:27 | Don Sutton | Pat Zachry | none | | 1981-09-01 | Box | vs NYN | 79 | W 3-2 | 42-37 | 16,339 | 2:39 | Joe Sambito | Mike Marshall | none | | 1981-09-02 | Box | vs NYN | 80 | W 8-0 | 43-37 | 18,938 | 2:21 | Bob Knepper | Mike Scott | none | | 1981-09-03 | Box | at MON | 81 | W 2-1 | 44-37 | 24,833 | 2:20 | Vern Ruhle | Scott Sanderson | Dave Smith | | 1981-09-04 | Box | at MON | 82 | W 5-0 | 45-37 | 32,580 | 2:54 | Nolan Ryan | Bill Gullickson | Joe Sambito | | 1981-09-05 | Box | at MON | 83 | L 2-5 | 45-38 | 30,471 | 2:13 | Ray Burris | Don Sutton | none | | 1981-09-06 | Box | at MON | 84 | W 4-3 | 46-38 | 47,193 | 3:33 | Frank LaCorte | Elias Sosa | none | | 1981-09-07 | Box | at ATL | 85 | W 3-2 | 47-38 | 7,358 | 2:40 | Dave Smith | Rick Camp | Joe Sambito | | 1981-09-08 | Box | at ATL | 86 | L 2-3 | 47-39 | 2,800 | 2:13 | Rick Camp | Billy Smith | none | | 1981-09-09 | Box | at ATL | 87 | L 0-9 | 47-40 | 4,482 | 2:34 | Phil Niekro | Nolan Ryan | none | | 1981-09-11 | Box | vs SFN | 88 | W 6-0 | 48-40 | 23,677 | 2:30 | Don Sutton | Vida Blue | none | | 1981-09-12 | Box | vs SFN | 89 | W 5-2 | 49-40 | 35,867 | 2:39 | Joe Niekro | Eddie Whitson | Dave Smith | | 1981-09-13 | Box | vs SFN | 90 | W 3-0 | 50-40 | 19,642 | 2:32 | Bob Knepper | Doyle Alexander | Frank LaCorte | | 1981-09-14 | Box | vs CIN | 91 | L 2-4 | 50-41 | 19,742 | 2:30 | Bruce Berenyi | Vern Ruhle | none | | 1981-09-15 | Box | vs CIN | 92 | L 0-4 | 50-42 | 16,354 | 2:26 | Charlie Leibrandt | Nolan Ryan | none | | 1981-09-16 | Box | at SDN | 93 | W 5-2 | 51-42 | 4,241 | 2:35 | Don Sutton | Tim Lollar | Joe Sambito | | 1981-09-17 | Box | at SDN | 94 | W 9-0 | 52-42 | 2,428 | 2:14 | Joe Niekro | Steve Mura | none | | 1981-09-18 | Box | at SFN | 95 | L 2-5 | 52-43 | 8,183 | 2:26 | Doyle Alexander | Bob Knepper | Al Holland | | 1981-09-19 | Box | at SFN | 96 | W 8-1 | 53-43 | 11,522 | 2:26 | Vern Ruhle | Tom Griffin | none | | 1981-09-20 | Box | at SFN | 97 | W 7-3 | 54-43 | 16,824 | 3:04 | Nolan Ryan | Gary Lavelle | none | | 1981-09-22 | Box | vs ATL | 98 | W 3-0 | 55-43 | 22,564 | 2:16 | Don Sutton | Gaylord Perry | none | | 1981-09-23 | Box | vs ATL | 99 | L 1-3 | 55-44 | 24,142 | 2:13 | Rick Mahler | Joe Niekro | none | | 1981-09-24 | Box | vs ATL | 100 | W 5-3 | 56-44 | 23,341 | 2:17 | Bob Knepper | Larry McWilliams | Dave Smith | | 1981-09-25 | Box | vs LAN | 101 | L 0-3 | 56-45 | 35,481 | 2:18 | Burt Hooton | Vern Ruhle | none | | 1981-09-26 | Box | vs LAN | 102 | W 5-0 | 57-45 | 32,115 | 2:46 | Nolan Ryan | Ted Power | none | | 1981-09-27 | Box | vs LAN | 103 | W 4-1 | 58-45 | 41,686 | 2:23 | Don Sutton | Fernando Valenzuela | none | | 1981-09-28 | Box | vs SDN | 104 | W 2-1 | 59-45 | 21,576 | 2:07 | Joe Sambito | Juan Eichelberger | none | | 1981-09-29 | Box | vs SDN | 105 | L 1-2 | 59-46 | 34,732 | 2:19 | Rick Wise | Bob Knepper | Gary Lucas | | 1981-09-30 | Box | at CIN | 106 | L 2-5 | 59-47 | 24,394 | 2:14 | Mario Soto | Vern Ruhle | Tom Hume | | 1981-10-01 | Box | at CIN | 107 | W 8-1 | 60-47 | 26,484 | 3:12 | Nolan Ryan | Bruce Berenyi | none | | 1981-10-02 | Box | at LAN | 108 | L 1-6 | 60-48 | 46,108 | 2:30 | Jerry Reuss | Don Sutton | none | | 1981-10-03 | Box | at LAN | 109 | L 2-7 | 60-49 | 42,272 | 2:43 | Bob Welch | Joe Niekro | none | | 1981-10-04 | Box | at LAN | 110 | W 5-3 | 61-49 | 47,072 | 3:17 | Dave Smith | Dave Goltz | none | |
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