| 1981-04-08 | Box | vs PHI | 1 | W 3-2 | 1-0 | 51,716 | 2:43 | Tom Hume | Sparky Lyle | none | | 1981-04-10 | Box | at ATL | 2 | L 3-5 | 1-1 | 34,929 | 2:43 | Gene Garber | Mario Soto | Rick Camp | | 1981-04-11 | Box | at ATL | 3 | W 3-2 | 2-1 | 15,973 | 2:47 | Doug Bair | Gene Garber | none | | 1981-04-12 | Box | at ATL | 4 | L 2-3 | 2-2 | 12,227 | 2:42 | Larry Bradford | Tom Hume | Rick Mahler | | 1981-04-13 | Box | at SDN | 5 | W 7-1 | 3-2 | 36,391 | 2:39 | Tom Seaver | Rick Wise | none | | 1981-04-14 | Box | at SDN | 6 | W 4-0 | 4-2 | 12,198 | 2:06 | Bruce Berenyi | John Curtis | none | | 1981-04-15 | Box | at SDN | 7 | W 10-1 | 5-2 | 10,801 | 2:49 | Mario Soto | Steve Mura | none | | 1981-04-17 | Box | vs SLN | 8 | L 5-9 | 5-3 | 22,961 | 2:53 | Lary Sorensen | Mike LaCoss | none | | 1981-04-18 | Box | vs SLN | 9 | L 4-10 | 5-4 | 22,529 | 2:53 | Bob Shirley | Tom Seaver | none | | 1981-04-21 | Box | vs ATL | 10 | L 1-10 | 5-5 | 24,022 | 2:48 | Tommy Boggs | Mario Soto | none | | 1981-04-22 | Box | vs ATL | 11 | L 3-7 | 5-6 | 15,735 | 2:27 | Gaylord Perry | Mike LaCoss | none | | 1981-04-23 | Box | at HOU | 12 | W 5-4 | 6-6 | 23,173 | 3:06 | Joe Price | Dave Smith | Paul Moskau | | 1981-04-24 | Box | at HOU | 13 | W 3-0 | 7-6 | 27,087 | 2:23 | Frank Pastore | Joe Niekro | none | | 1981-04-25 | Box | at HOU | 14 | W 2-1 | 8-6 | 19,957 | 2:45 | Bruce Berenyi | Nolan Ryan | Tom Hume | | 1981-04-26 | Box | at HOU | 15 | L 0-1 | 8-7 | 23,428 | 2:21 | Bob Knepper | Mario Soto | none | | 1981-04-28 | Box | vs SDN | 16 | W 11-2 | 9-7 | 13,103 | 2:52 | Tom Seaver | Tim Lollar | none | | 1981-04-29 | Box | vs SDN | 17 | W 8-5 | 10-7 | 12,291 | 2:39 | Paul Moskau | John Littlefield | Tom Hume | | 1981-04-30 | Box | vs SDN | 18 | W 4-3 | 11-7 | 12,794 | 2:43 | Mike LaCoss | Steve Mura | Tom Hume | | 1981-05-01 | Box | at SLN | 19 | L 6-7 | 11-8 | 21,315 | 2:48 | Bob Forsch | Mario Soto | Bruce Sutter | | 1981-05-02 | Box | at SLN | 20 | L 3-7 | 11-9 | 16,677 | 2:13 | Bob Shirley | Bruce Berenyi | none | | 1981-05-03 | Box | at SLN | 21 | L 4-5 | 11-10 | 21,855 | 3:12 | Joe Edelen | Tom Hume | none | | 1981-05-06 | Box | vs PIT | 22 | W 9-8 | 12-10 | 14,551 | 2:48 | Tom Hume | Grant Jackson | none | | 1981-05-07 (1) | Box | vs PIT | 23 | L 1-3 | 12-11 | | 2:48 | Rick Rhoden | Mario Soto | Enrique Romo | | 1981-05-07 (2) | Box | vs PIT | 24 | L 1-7 | 12-12 | 20,301 | 2:42 | Eddie Solomon | Mike LaCoss | none | | 1981-05-08 | Box | vs HOU | 25 | W 4-0 | 13-12 | 31,961 | 2:21 | Tom Seaver | Don Sutton | none | | 1981-05-09 | Box | vs HOU | 26 | W 9-5 | 14-12 | 30,860 | 2:38 | Bruce Berenyi | Joaquin Andujar | none | | 1981-05-10 | Box | vs HOU | 27 | L 5-7 | 14-13 | 31,903 | 2:44 | Joe Niekro | Frank Pastore | Frank LaCorte | | 1981-05-11 | Box | vs HOU | 28 | L 0-5 | 14-14 | 11,795 | 2:36 | Nolan Ryan | Mike LaCoss | none | | 1981-05-12 | Box | vs CHN | 29 | W 2-1 | 15-14 | 12,016 | 2:41 | Mario Soto | Dick Tidrow | none | | 1981-05-13 | Box | vs CHN | 30 | W 8-3 | 16-14 | 12,528 | 2:33 | Tom Seaver | Mike Krukow | none | | 1981-05-14 | Box | vs CHN | 31 | W 6-1 | 17-14 | 11,098 | 2:26 | Bruce Berenyi | Rick Reuschel | none | | 1981-05-15 | Box | at PIT | 32 | W 4-1 | 18-14 | 10,592 | 2:46 | Joe Price | Enrique Romo | Tom Hume | | 1981-05-16 | Box | at PIT | 33 | W 4-0 | 19-14 | 11,890 | 2:29 | Mike LaCoss | Rod Scurry | none | | 1981-05-17 | Box | at PIT | 34 | W 4-3 | 20-14 | 11,775 | 2:20 | Mario Soto | Eddie Solomon | none | | 1981-05-19 | Box | at CHN | 35 | W 5-0 | 21-14 | 5,896 | 2:22 | Tom Seaver | Rick Reuschel | Paul Moskau | | 1981-05-20 | Box | at CHN | 36 | W 10-7 | 22-14 | 5,914 | 3:18 | Joe Price | Lee Smith | Tom Hume | | 1981-05-21 | Box | at CHN | 37 | L 1-5 | 22-15 | 7,132 | 2:08 | Randy Martz | Frank Pastore | none | | 1981-05-22 | Box | vs LAN | 38 | L 2-4 | 22-16 | 27,943 | 3:15 | Dave Stewart | Doug Bair | none | | 1981-05-23 | Box | vs LAN | 39 | L 6-9 | 22-17 | 40,928 | 3:17 | Dave Stewart | Paul Moskau | Bobby Castillo | | 1981-05-24 (1) | Box | vs LAN | 40 | W 3-2 | 23-17 | | 2:33 | Paul Moskau | Bob Welch | Joe Price | | 1981-05-24 (2) | Box | vs LAN | 41 | L 3-10 | 23-18 | 36,113 | 3:12 | Bobby Castillo | Bruce Berenyi | none | | 1981-05-25 | Box | vs SFN | 42 | W 6-3 | 24-18 | 15,684 | 2:15 | Geoff Combe | Al Holland | none | | 1981-05-27 | Box | vs SFN | 43 | W 3-2 | 25-18 | 12,223 | 2:30 | Mario Soto | Doyle Alexander | none | | 1981-05-28 | Box | vs SFN | 44 | W 7-4 | 26-18 | 20,077 | 2:48 | Joe Price | Gary Lavelle | none | | 1981-05-29 | Box | at LAN | 45 | L 2-5 | 26-19 | 45,749 | 2:44 | Bob Welch | Mike LaCoss | Steve Howe | | 1981-05-30 | Box | at LAN | 46 | W 9-1 | 27-19 | 43,582 | 2:46 | Frank Pastore | Burt Hooton | none | | 1981-05-31 | Box | at LAN | 47 | L 4-16 | 27-20 | 46,411 | 3:08 | Dave Goltz | Mario Soto | none | | 1981-06-01 | Box | at SFN | 48 | W 8-5 | 28-20 | 4,620 | 3:09 | Tom Hume | Greg Minton | none | | 1981-06-02 | Box | at SFN | 49 | L 7-15 | 28-21 | 19,007 | 3:16 | Eddie Whitson | Mike LaCoss | Al Holland | | | 1981-06-03 | Box | at SFN | 50 | W 6-2 | 29-21 | 7,114 | 2:40 | Frank Pastore | Vida Blue | none | | 1981-06-05 | Box | vs MON | 51 | W 6-3 | 30-21 | 21,298 | 2:37 | Mario Soto | Steve Rogers | none | | 1981-06-06 | Box | vs MON | 52 | W 9-3 | 31-21 | 26,016 | 2:17 | Tom Seaver | Charlie Lea | none | | 1981-06-07 | Box | vs MON | 53 | W 2-0 | 32-21 | 40,010 | 1:57 | Bruce Berenyi | Ray Burris | none | | 1981-06-09 | Box | at NYN | 54 | W 8-4 | 33-21 | 12,313 | 2:56 | Tom Hume | Pete Falcone | none | | 1981-06-10 | Box | at NYN | 55 | W 2-0 | 34-21 | 9,732 | 2:14 | Mario Soto | Randy Jones | none | | 1981-06-11 | Box | at NYN | 56 | W 5-2 | 35-21 | 18,612 | 2:36 | Tom Seaver | Pat Zachry | none | | 1981-08-10 | Box | at LAN | 57 | L 0-4 | 35-22 | 35,120 | 2:08 | Jerry Reuss | Frank Pastore | Steve Howe | | 1981-08-11 | Box | at LAN | 58 | W 7-6 | 36-22 | 45,817 | 2:50 | Scott Brown | Terry Forster | Tom Hume | | 1981-08-12 | Box | at LAN | 59 | L 5-8 | 36-23 | 36,494 | 2:48 | Dave Stewart | Tom Seaver | Steve Howe | | 1981-08-14 (1) | Box | vs SFN | 60 | L 0-4 | 36-24 | | 2:13 | Eddie Whitson | Bruce Berenyi | none | | 1981-08-14 (2) | Box | vs SFN | 61 | W 7-6 | 37-24 | 22,404 | 3:13 | Tom Hume | Al Holland | none | | 1981-08-15 | Box | vs SFN | 62 | L 2-5 | 37-25 | 20,671 | 2:30 | Doyle Alexander | Frank Pastore | Greg Minton | | 1981-08-16 | Box | vs SFN | 63 | W 2-1 | 38-25 | 20,309 | 2:46 | Mario Soto | Tom Griffin | Tom Hume | | 1981-08-18 | Box | vs PHI | 64 | W 3-1 | 39-25 | 25,363 | 2:07 | Tom Seaver | Steve Carlton | Tom Hume | | 1981-08-19 | Box | vs PHI | 65 | W 6-3 | 40-25 | 23,133 | 2:53 | Tom Hume | Sparky Lyle | none | | 1981-08-21 | Box | vs NYN | 66 | W 2-0 | 41-25 | 20,410 | 2:09 | Mario Soto | Pat Zachry | none | | 1981-08-22 | Box | vs NYN | 67 | L 4-7 | 41-26 | 25,949 | 2:53 | Dan Boitano | Frank Pastore | Neil Allen | | 1981-08-23 | Box | vs NYN | 68 | L 2-3 | 41-27 | 20,761 | 2:38 | Neil Allen | Tom Hume | none | | 1981-08-24 | Box | vs NYN | 69 | W 2-0 | 42-27 | 19,506 | 2:04 | Bruce Berenyi | Mike Scott | none | | 1981-08-25 | Box | at MON | 70 | L 1-9 | 42-28 | 40,162 | 2:40 | Scott Sanderson | Mike LaCoss | none | | 1981-08-26 | Box | at MON | 71 | L 0-6 | 42-29 | 23,126 | 2:12 | Bill Gullickson | Mario Soto | none | | 1981-08-27 | Box | at MON | 72 | L 0-12 | 42-30 | 30,874 | 2:19 | Ray Burris | Frank Pastore | none | | 1981-08-28 | Box | at NYN | 73 | W 5-2 | 43-30 | 23,061 | 2:33 | Tom Seaver | Neil Allen | none | | 1981-08-29 | Box | at NYN | 74 | L 2-3 | 43-31 | 44,598 | 2:20 | Mike Scott | Bruce Berenyi | Neil Allen | | 1981-08-30 | Box | at NYN | 75 | W 6-3 | 44-31 | 18,770 | 2:53 | Mike LaCoss | Greg Harris | none | | 1981-08-31 | Box | vs MON | 76 | W 9-8 | 45-31 | 20,506 | 2:55 | Doug Bair | Bill Lee | none | | 1981-09-01 | Box | vs MON | 77 | L 3-4 | 45-32 | 15,978 | 2:35 | Charlie Lea | Joe Price | Jeff Reardon | | 1981-09-02 | Box | vs MON | 78 | W 7-0 | 46-32 | 12,926 | 2:22 | Tom Seaver | Stan Bahnsen | none | | 1981-09-03 | Box | at PHI | 79 | W 9-3 | 47-32 | 26,540 | 2:54 | Bruce Berenyi | Mark Davis | none | | 1981-09-04 | Box | at PHI | 80 | L 6-7 | 47-33 | 25,020 | 3:01 | Sparky Lyle | Doug Bair | Tug McGraw | | 1981-09-05 | Box | at PHI | 81 | L 4-5 | 47-34 | 41,845 | 2:43 | Ron Reed | Mario Soto | none | | 1981-09-06 | Box | at PHI | 82 | W 5-4 | 48-34 | 30,366 | 2:17 | Tom Hume | Sparky Lyle | Joe Price | | 1981-09-07 | Box | vs SDN | 83 | W 8-7 | 49-34 | 14,443 | 2:29 | Tom Seaver | Eric Show | Joe Price | | 1981-09-08 | Box | vs SDN | 84 | L 1-6 | 49-35 | 11,739 | 2:23 | Juan Eichelberger | Bruce Berenyi | none | | 1981-09-09 | Box | vs SDN | 85 | W 5-4 | 50-35 | 16,328 | 2:27 | Tom Hume | John Urrea | none | | 1981-09-11 | Box | vs LAN | 86 | W 3-2 | 51-35 | 25,237 | 2:42 | Joe Price | Alejandro Pena | none | | 1981-09-12 | Box | vs LAN | 87 | W 6-5 | 52-35 | 34,090 | 3:32 | Mike LaCoss | Ted Power | none | | 1981-09-13 | Box | vs LAN | 88 | L 2-4 | 52-36 | 27,858 | 3:07 | Bobby Castillo | Frank Pastore | Dave Stewart | | 1981-09-14 | Box | at HOU | 89 | W 4-2 | 53-36 | 19,742 | 2:30 | Bruce Berenyi | Vern Ruhle | none | | 1981-09-15 | Box | at HOU | 90 | W 4-0 | 54-36 | 16,354 | 2:26 | Charlie Leibrandt | Nolan Ryan | none | | 1981-09-16 | Box | at SFN | 91 | L 7-12 | 54-37 | 4,168 | 2:51 | Fred Breining | Mario Soto | none | | 1981-09-17 | Box | at SFN | 92 | W 1-0 | 55-37 | 4,721 | 2:53 | Tom Seaver | Al Holland | Tom Hume | | 1981-09-18 | Box | at LAN | 93 | W 5-4 | 56-37 | 44,258 | 2:48 | Joe Price | Dave Stewart | Tom Hume | | 1981-09-19 | Box | at LAN | 94 | W 7-3 | 57-37 | 48,352 | 3:22 | Joe Edelen | Burt Hooton | none | | 1981-09-20 | Box | at LAN | 95 | W 5-1 | 58-37 | 39,560 | 2:45 | Mario Soto | Ted Power | none | | 1981-09-21 | Box | at SDN | 96 | L 0-6 | 58-38 | 5,501 | 2:17 | Chris Welsh | Charlie Leibrandt | none | | 1981-09-22 | Box | at SDN | 97 | W 3-2 | 59-38 | 4,764 | 2:30 | Tom Seaver | Juan Eichelberger | Tom Hume | | 1981-09-23 | Box | at SDN | 98 | W 5-1 | 60-38 | 4,831 | 2:13 | Frank Pastore | Rick Wise | Joe Price | | 1981-09-25 | Box | at ATL | 99 | W 10-2 | 61-38 | 7,817 | 2:57 | Mario Soto | Tommy Boggs | none | | 1981-09-26 | Box | at ATL | 100 | W 2-0 | 62-38 | 5,117 | 2:25 | Bruce Berenyi | Phil Niekro | Tom Hume | | 1981-09-27 | Box | at ATL | 101 | W 4-2 | 63-38 | 7,455 | 2:25 | Tom Seaver | Gaylord Perry | Mike LaCoss | | 1981-09-28 | Box | vs SFN | 102 | L 0-4 | 63-39 | 12,944 | 2:34 | Alan Hargesheimer | Frank Pastore | none | | 1981-09-29 | Box | vs SFN | 103 | W 4-3 | 64-39 | 13,117 | 2:40 | Tom Hume | Greg Minton | none | | 1981-09-30 | Box | vs HOU | 104 | W 5-2 | 65-39 | 24,394 | 2:14 | Mario Soto | Vern Ruhle | Tom Hume | | 1981-10-01 | Box | vs HOU | 105 | L 1-8 | 65-40 | 26,484 | 3:12 | Nolan Ryan | Bruce Berenyi | none | | 1981-10-02 | Box | vs ATL | 106 | L 5-11 | 65-41 | 14,793 | 2:58 | Gaylord Perry | Frank Pastore | none | | 1981-10-03 | Box | vs ATL | 107 | L 3-4 | 65-42 | 17,544 | 2:32 | Rick Mahler | Tom Hume | Rick Camp | | 1981-10-04 | Box | vs ATL | 108 | W 3-0 | 66-42 | 31,764 | 1:57 | Mario Soto | Tommy Boggs | none | |
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